Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02485:Mrgprb1'

295404

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgprb1

Ensembl Gene

ENSMUSG00000070547

Gene Name

MAS-related GPR, member B1

Synonyms

MrgB1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL02485

Quality Score

Status

Chromosome

Chromosomal Location

48444113-48456342 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 48447717 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Leucine at position 149 (R149L)

Ref Sequence

ENSEMBL: ENSMUSP00000091946 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094384] [ENSMUST00000188095] [ENSMUST00000188918]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094384
AA Change: R149L

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000091946
Gene: ENSMUSG00000070547
AA Change: R149L

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	50	227	5.5e-11	PFAM
Pfam:7tm_1	59	290	4.3e-10	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000188095

Predicted Effect

probably benign
Transcript: ENSMUST00000188918

SMART Domains

Protein: ENSMUSP00000140432
Gene: ENSMUSG00000070547

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	23	84	3e-6	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930430A15Rik	A	T	2: 111,228,325	V94E	probably damaging	Het
Agl	A	G	3: 116,779,080	S841P	probably benign	Het
BC003331	A	G	1: 150,363,489		probably null	Het
Cd59b	A	C	2: 104,081,104		probably benign	Het
Dopey2	T	C	16: 93,770,822	L1379P	probably damaging	Het
Ercc2	G	A	7: 19,394,045	A433T	possibly damaging	Het
Gm17175	T	C	14: 51,569,611		probably benign	Het
Gm5150	A	T	3: 15,990,752	I103N	probably damaging	Het
Igf1	A	G	10: 87,864,746	M11V	probably benign	Het
Incenp	T	C	19: 9,893,368	N299S	unknown	Het
Maneal	A	T	4: 124,856,770	S398T	probably damaging	Het
Map1a	A	G	2: 121,299,288	N195S	probably damaging	Het
Mars2	T	C	1: 55,237,591	F118L	possibly damaging	Het
Mast4	A	G	13: 102,735,496	S2263P	probably benign	Het
Myo1d	T	C	11: 80,666,581	D511G	probably damaging	Het
Ntan1	T	C	16: 13,834,676		probably benign	Het
Nxf2	A	G	X: 134,956,467	F158L	probably damaging	Het
Olfr1513	T	A	14: 52,350,044	M1L	possibly damaging	Het
Trpm1	C	T	7: 64,269,114	A734V	possibly damaging	Het
Upf2	G	A	2: 6,027,291	E883K	unknown	Het
Ush1c	T	C	7: 46,229,250	I83V	probably damaging	Het
Vmn2r60	C	A	7: 42,195,466	T751N	possibly damaging	Het
Zfp146	A	G	7: 30,162,590	I9T	probably benign	Het
Zfp592	G	A	7: 81,037,970		probably benign	Het
Zswim8	C	T	14: 20,711,887	L243F	probably damaging	Het

Other mutations in Mrgprb1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00540:Mrgprb1	APN	7	48447543	missense	probably damaging	0.99
IGL01141:Mrgprb1	APN	7	48448027	missense	probably benign	0.36
IGL01393:Mrgprb1	APN	7	48448006	missense	possibly damaging	0.48
IGL02430:Mrgprb1	APN	7	48447661	missense	possibly damaging	0.95
R0026:Mrgprb1	UTSW	7	48447204	missense	possibly damaging	0.66
R0051:Mrgprb1	UTSW	7	48447214	missense	probably benign	0.01
R0789:Mrgprb1	UTSW	7	48456184	splice site	probably benign
R1223:Mrgprb1	UTSW	7	48447687	missense	possibly damaging	0.61
R1327:Mrgprb1	UTSW	7	48447429	missense	possibly damaging	0.87
R1456:Mrgprb1	UTSW	7	48448029	missense	probably damaging	0.98
R1561:Mrgprb1	UTSW	7	48447125	splice site	probably null
R1567:Mrgprb1	UTSW	7	48447453	missense	probably damaging	0.97
R2030:Mrgprb1	UTSW	7	48447328	missense	possibly damaging	0.83
R2165:Mrgprb1	UTSW	7	48447322	missense	probably benign	0.00
R2885:Mrgprb1	UTSW	7	48447721	missense	probably damaging	1.00
R3108:Mrgprb1	UTSW	7	48447328	missense	possibly damaging	0.93
R3919:Mrgprb1	UTSW	7	48448081	missense	probably benign	0.03
R4021:Mrgprb1	UTSW	7	48447123	missense	possibly damaging	0.95
R4613:Mrgprb1	UTSW	7	48447708	missense	possibly damaging	0.91
R4809:Mrgprb1	UTSW	7	48447991	missense	possibly damaging	0.89
R5249:Mrgprb1	UTSW	7	48447477	missense	possibly damaging	0.91
R5425:Mrgprb1	UTSW	7	48447971	missense	possibly damaging	0.81
R5555:Mrgprb1	UTSW	7	48447775	missense	probably benign	0.06
R5595:Mrgprb1	UTSW	7	48447684	missense	probably damaging	0.99
R5982:Mrgprb1	UTSW	7	48447820	missense	probably benign	0.01
R6746:Mrgprb1	UTSW	7	48447897	missense	possibly damaging	0.82
R7066:Mrgprb1	UTSW	7	48447676	missense	probably benign	0.27
R7141:Mrgprb1	UTSW	7	48447687	missense	possibly damaging	0.61
R7633:Mrgprb1	UTSW	7	48447583	missense	probably benign	0.01
R8072:Mrgprb1	UTSW	7	48448147	nonsense	probably null
R8080:Mrgprb1	UTSW	7	48446910	splice site	probably null
R8112:Mrgprb1	UTSW	7	48447934	missense	probably damaging	0.97
R8493:Mrgprb1	UTSW	7	48447573	missense	probably damaging	0.99
R8817:Mrgprb1	UTSW	7	48447322	missense	probably benign	0.01

Posted On

2015-04-16