Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02490:Trav15-1-dv6-1'

295584

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trav15-1-dv6-1

Ensembl Gene

ENSMUSG00000094016

Gene Name

T cell receptor alpha variable 15-1-DV6-1

Synonyms

Gm16591

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL02490

Quality Score

Status

Chromosome

Chromosomal Location

53797133-53797704 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 53797588 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Alanine at position 79 (E79A)

Ref Sequence

ENSEMBL: ENSMUSP00000143712 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103653] [ENSMUST00000200101]

AlphaFold

Q5R1D2

Predicted Effect

probably benign
Transcript: ENSMUST00000103653
AA Change: E78A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000100430
Gene: ENSMUSG00000094016
AA Change: E78A

Domain	Start	End	E-Value	Type
IGv	37	113	4.32e-8	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000200101
AA Change: E79A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000143712
Gene: ENSMUSG00000094016
AA Change: E79A

Domain	Start	End	E-Value	Type
IGv	38	114	4.32e-8	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427D06Rik	A	G	6: 89,078,559 (GRCm39)		noncoding transcript	Het
Adam5	A	T	8: 25,271,720 (GRCm39)	Y562*	probably null	Het
Akr1d1	T	C	6: 37,535,423 (GRCm39)	V269A	probably damaging	Het
Anks4b	A	G	7: 119,773,241 (GRCm39)	T34A	probably damaging	Het
Arhgef40	A	G	14: 52,226,652 (GRCm39)	N232S	probably damaging	Het
Cdc40	C	T	10: 40,717,767 (GRCm39)	V379I	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cdh13	A	G	8: 119,822,062 (GRCm39)	D307G	probably damaging	Het
Ces1h	A	G	8: 94,083,627 (GRCm39)		probably null	Het
Chchd6	T	A	6: 89,361,656 (GRCm39)	H249L	possibly damaging	Het
Clxn	T	A	16: 14,734,810 (GRCm39)	V60E	probably benign	Het
Cul1	T	C	6: 47,491,820 (GRCm39)	V392A	probably damaging	Het
Cwc15	A	T	9: 14,413,320 (GRCm39)	D34V	probably damaging	Het
Cyp2c39	T	C	19: 39,527,446 (GRCm39)	I264T	probably damaging	Het
Dapk1	A	G	13: 60,897,148 (GRCm39)	D789G	probably damaging	Het
Dcdc2a	T	A	13: 25,291,635 (GRCm39)	Y207N	probably damaging	Het
Flt3	T	A	5: 147,268,106 (GRCm39)	N960Y	probably damaging	Het
Fmn1	C	T	2: 113,359,817 (GRCm39)		probably benign	Het
Foxm1	T	A	6: 128,350,314 (GRCm39)	C400*	probably null	Het
Ftmt	A	C	18: 52,464,760 (GRCm39)	R25S	probably benign	Het
Guca1b	T	C	17: 47,700,190 (GRCm39)		probably benign	Het
Hectd4	A	T	5: 121,456,676 (GRCm39)	K680N	possibly damaging	Het
Hephl1	C	A	9: 14,964,981 (GRCm39)	R1138L	probably benign	Het
Il1rl2	T	A	1: 40,395,972 (GRCm39)		probably benign	Het
Ints2	A	T	11: 86,124,009 (GRCm39)	I593K	possibly damaging	Het
Iqcg	T	A	16: 32,855,937 (GRCm39)	K213*	probably null	Het
Kif1b	T	A	4: 149,288,665 (GRCm39)	S1259C	probably benign	Het
Klc1	C	T	12: 111,748,210 (GRCm39)	T371M	possibly damaging	Het
Loxl4	T	C	19: 42,593,269 (GRCm39)	T301A	probably benign	Het
Lrrc40	T	C	3: 157,768,336 (GRCm39)	L497P	probably damaging	Het
Masp2	C	T	4: 148,692,400 (GRCm39)	R298W	possibly damaging	Het
Myo5a	A	T	9: 75,043,737 (GRCm39)	Y242F	probably damaging	Het
Nup98	A	G	7: 101,801,573 (GRCm39)	V784A	probably damaging	Het
Or5w15	T	C	2: 87,568,299 (GRCm39)	Y123C	probably damaging	Het
Osbpl1a	G	T	18: 13,015,341 (GRCm39)		probably benign	Het
Pcdh10	A	G	3: 45,334,922 (GRCm39)	Y412C	probably damaging	Het
Pfkfb2	T	A	1: 130,628,589 (GRCm39)	Y339F	probably damaging	Het
Plcb2	T	C	2: 118,550,241 (GRCm39)	N172D	probably damaging	Het
Plec	T	C	15: 76,073,463 (GRCm39)	Y517C	probably damaging	Het
Plod2	G	T	9: 92,468,895 (GRCm39)	A207S	probably benign	Het
Plxdc1	A	T	11: 97,845,604 (GRCm39)	D229E	probably benign	Het
Ppp3cb	A	G	14: 20,581,726 (GRCm39)		probably null	Het
Procr	T	C	2: 155,595,352 (GRCm39)	L52P	probably damaging	Het
Psme2b	G	T	11: 48,836,946 (GRCm39)		probably benign	Het
Rgs22	G	A	15: 36,054,993 (GRCm39)	A727V	probably damaging	Het
Rock2	T	A	12: 16,998,564 (GRCm39)	W277R	probably damaging	Het
Rpl26	A	G	11: 68,795,216 (GRCm39)	D112G	probably damaging	Het
Rxfp1	C	A	3: 79,559,474 (GRCm39)		probably null	Het
Sdr39u1	G	A	14: 56,135,798 (GRCm39)	P98L	probably damaging	Het
Sgms1	T	C	19: 32,137,543 (GRCm39)	K8E	probably damaging	Het
Stk31	T	C	6: 49,394,469 (GRCm39)	V277A	probably benign	Het
Ttll6	A	T	11: 96,047,546 (GRCm39)	D715V	possibly damaging	Het
Ush2a	T	C	1: 188,542,561 (GRCm39)	S3376P	probably damaging	Het
Vmn2r109	T	A	17: 20,761,246 (GRCm39)	T704S	possibly damaging	Het
Zfp27	T	A	7: 29,594,360 (GRCm39)	H535L	possibly damaging	Het
Zfp609	A	T	9: 65,611,250 (GRCm39)	V571D	possibly damaging	Het
Zfp874a	A	T	13: 67,590,819 (GRCm39)	Y288*	probably null	Het
Zfp993	T	C	4: 146,742,074 (GRCm39)	S133P	probably damaging	Het

Other mutations in Trav15-1-dv6-1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01011:Trav15-1-dv6-1	APN	14	53,797,492 (GRCm39)	missense	possibly damaging	0.94
IGL02270:Trav15-1-dv6-1	APN	14	53,797,455 (GRCm39)	missense	possibly damaging	0.81
IGL03205:Trav15-1-dv6-1	APN	14	53,797,485 (GRCm39)	missense	probably damaging	1.00
R4607:Trav15-1-dv6-1	UTSW	14	53,797,511 (GRCm39)	missense	probably benign	0.01
R6188:Trav15-1-dv6-1	UTSW	14	53,797,414 (GRCm39)	missense	probably damaging	0.99
R8518:Trav15-1-dv6-1	UTSW	14	53,797,666 (GRCm39)	missense	probably benign
R8857:Trav15-1-dv6-1	UTSW	14	53,797,615 (GRCm39)	missense	probably damaging	1.00
R9178:Trav15-1-dv6-1	UTSW	14	53,797,519 (GRCm39)	missense	probably damaging	1.00
Z1177:Trav15-1-dv6-1	UTSW	14	53,797,402 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16