Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02491:Or10ak7'

295627

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10ak7

Ensembl Gene

ENSMUSG00000111259

Gene Name

olfactory receptor family 10 subfamily AK member 7

Synonyms

Olfr1519, MOR259-1, MOR259-13, GA_x6K02T2QD9B-18602750-18603691, MOR259-1, Olfr1328

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL02491

Quality Score

Status

Chromosome

Chromosomal Location

118791096-118792037 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 118791358 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Histidine at position 229 (L229H)

Ref Sequence

ENSEMBL: ENSMUSP00000149039 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081960] [ENSMUST00000215312]

AlphaFold

A0A1L1SQF6

Predicted Effect

probably damaging
Transcript: ENSMUST00000081960
AA Change: L227H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000080626
Gene: ENSMUSG00000111259
AA Change: L227H

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	1.1e-53	PFAM
Pfam:7TM_GPCR_Srsx	36	306	9.1e-8	PFAM
Pfam:7tm_1	42	291	1.7e-26	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215312
AA Change: L229H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	T	C	11: 110,067,794 (GRCm39)		probably benign	Het
Acacb	T	A	5: 114,330,166 (GRCm39)	I443N	probably damaging	Het
C1qtnf3	A	T	15: 10,972,067 (GRCm39)	I118F	possibly damaging	Het
Carmil3	C	T	14: 55,741,974 (GRCm39)	A1148V	probably benign	Het
Ccdc62	A	T	5: 124,099,378 (GRCm39)	S677C	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Col11a2	C	A	17: 34,283,181 (GRCm39)		probably benign	Het
Cpsf7	A	G	19: 10,517,001 (GRCm39)	I368V	possibly damaging	Het
Csmd2	T	C	4: 128,428,050 (GRCm39)	S2934P	probably benign	Het
Csmd3	A	G	15: 47,777,511 (GRCm39)		probably benign	Het
Cubn	A	G	2: 13,326,039 (GRCm39)	Y2709H	probably damaging	Het
Cyp2d12	T	A	15: 82,442,682 (GRCm39)	L375Q	possibly damaging	Het
Etv4	A	T	11: 101,674,791 (GRCm39)		probably null	Het
Exph5	T	A	9: 53,286,343 (GRCm39)	D1141E	possibly damaging	Het
Fbxo16	T	A	14: 65,558,736 (GRCm39)	H298Q	probably benign	Het
Fbxw21	T	A	9: 108,972,887 (GRCm39)	Y349F	probably benign	Het
Foxs1	G	A	2: 152,774,721 (GRCm39)	R111C	probably damaging	Het
Galnt15	T	A	14: 31,778,273 (GRCm39)	L436Q	probably damaging	Het
Gbf1	T	C	19: 46,250,979 (GRCm39)		probably benign	Het
Gm8237	A	T	14: 5,863,577 (GRCm38)	C29*	probably null	Het
Hcn1	A	G	13: 117,946,576 (GRCm39)	D317G	unknown	Het
Itgam	A	G	7: 127,715,190 (GRCm39)	N877D	possibly damaging	Het
Kcnma1	T	C	14: 23,361,757 (GRCm39)	R1047G	probably damaging	Het
Klhdc3	T	C	17: 46,988,226 (GRCm39)	R180G	possibly damaging	Het
Lpcat2	T	C	8: 93,600,879 (GRCm39)	V241A	probably damaging	Het
Mnat1	A	G	12: 73,170,682 (GRCm39)	N24S	probably null	Het
Mprip	A	G	11: 59,660,857 (GRCm39)	T967A	probably benign	Het
Mtf1	T	C	4: 124,732,372 (GRCm39)	F477L	probably benign	Het
Naaladl1	A	G	19: 6,159,748 (GRCm39)	E393G	possibly damaging	Het
Or2at1	A	G	7: 99,416,540 (GRCm39)	E57G	possibly damaging	Het
Or5e1	A	G	7: 108,354,321 (GRCm39)	K86R	probably damaging	Het
Pcdhb6	A	T	18: 37,468,735 (GRCm39)	D552V	probably damaging	Het
Pglyrp3	C	T	3: 91,921,944 (GRCm39)	S4F	possibly damaging	Het
Pramel13	A	T	4: 144,121,322 (GRCm39)	M234K	probably damaging	Het
Prss27	A	T	17: 24,263,229 (GRCm39)		probably benign	Het
Slc5a9	A	G	4: 111,753,549 (GRCm39)	S51P	probably damaging	Het
Slc6a4	A	G	11: 76,918,034 (GRCm39)	Y592C	probably damaging	Het
Slc7a13	T	A	4: 19,841,404 (GRCm39)	V417D	probably damaging	Het
Spring1	T	C	5: 118,397,160 (GRCm39)	Y130H	probably benign	Het
Syne2	A	G	12: 76,118,953 (GRCm39)	T5857A	probably benign	Het
Thap1	A	C	8: 26,650,885 (GRCm39)	S52R	probably damaging	Het
Thsd4	T	C	9: 59,907,301 (GRCm39)	N158S	probably damaging	Het
Tmem147	A	T	7: 30,427,626 (GRCm39)		probably benign	Het
Trdmt1	G	A	2: 13,521,483 (GRCm39)	A311V	probably benign	Het
U2surp	T	A	9: 95,372,273 (GRCm39)	R296S	probably damaging	Het
Upf2	A	G	2: 6,030,975 (GRCm39)	D805G	unknown	Het
Usp34	T	A	11: 23,382,630 (GRCm39)	H2057Q	probably damaging	Het
Vmn2r110	T	A	17: 20,816,400 (GRCm39)	D41V	probably damaging	Het
Vmn2r16	T	A	5: 109,487,703 (GRCm39)	L192*	probably null	Het
Vnn3	T	A	10: 23,741,816 (GRCm39)	S374T	probably benign	Het
Wdr62	A	C	7: 29,942,184 (GRCm39)	D1089E	probably benign	Het
Xdh	T	A	17: 74,193,459 (GRCm39)	D1279V	probably damaging	Het
Zfp13	C	T	17: 23,795,072 (GRCm39)	A493T	probably benign	Het
Zfp518b	A	G	5: 38,831,123 (GRCm39)	I294T	possibly damaging	Het
Zfp983	G	A	17: 21,876,528 (GRCm39)		probably null	Het

Other mutations in Or10ak7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02685:Or10ak7	APN	4	118,791,134 (GRCm39)	missense	possibly damaging	0.61
IGL02886:Or10ak7	APN	4	118,792,027 (GRCm39)	missense	probably benign
IGL02899:Or10ak7	APN	4	118,791,859 (GRCm39)	missense	probably damaging	1.00
IGL02957:Or10ak7	APN	4	118,791,316 (GRCm39)	missense	probably damaging	1.00
PIT4453001:Or10ak7	UTSW	4	118,791,823 (GRCm39)	missense	probably benign
R0211:Or10ak7	UTSW	4	118,791,467 (GRCm39)	missense	probably benign	0.00
R0211:Or10ak7	UTSW	4	118,791,467 (GRCm39)	missense	probably benign	0.00
R1158:Or10ak7	UTSW	4	118,791,614 (GRCm39)	missense	probably damaging	1.00
R1450:Or10ak7	UTSW	4	118,791,707 (GRCm39)	missense	probably benign	0.01
R1682:Or10ak7	UTSW	4	118,791,778 (GRCm39)	missense	probably damaging	1.00
R1978:Or10ak7	UTSW	4	118,791,381 (GRCm39)	nonsense	probably null
R2363:Or10ak7	UTSW	4	118,791,230 (GRCm39)	missense	probably benign	0.02
R2364:Or10ak7	UTSW	4	118,791,230 (GRCm39)	missense	probably benign	0.02
R2365:Or10ak7	UTSW	4	118,791,230 (GRCm39)	missense	probably benign	0.02
R2507:Or10ak7	UTSW	4	118,791,122 (GRCm39)	missense	probably benign
R2912:Or10ak7	UTSW	4	118,791,898 (GRCm39)	missense	probably benign	0.28
R3937:Or10ak7	UTSW	4	118,791,880 (GRCm39)	missense	probably damaging	1.00
R4058:Or10ak7	UTSW	4	118,791,880 (GRCm39)	missense	probably damaging	1.00
R4089:Or10ak7	UTSW	4	118,791,230 (GRCm39)	missense	probably benign	0.02
R4090:Or10ak7	UTSW	4	118,791,230 (GRCm39)	missense	probably benign	0.02
R4419:Or10ak7	UTSW	4	118,791,586 (GRCm39)	missense	possibly damaging	0.56
R4717:Or10ak7	UTSW	4	118,791,626 (GRCm39)	missense	probably benign	0.45
R5570:Or10ak7	UTSW	4	118,791,263 (GRCm39)	missense	possibly damaging	0.88
R5591:Or10ak7	UTSW	4	118,791,658 (GRCm39)	missense	probably damaging	1.00
R6149:Or10ak7	UTSW	4	118,791,628 (GRCm39)	missense	probably damaging	1.00
R7202:Or10ak7	UTSW	4	118,791,215 (GRCm39)	missense	probably benign
R7214:Or10ak7	UTSW	4	118,791,146 (GRCm39)	missense	possibly damaging	0.88
R7391:Or10ak7	UTSW	4	118,791,198 (GRCm39)	missense	possibly damaging	0.61
R7666:Or10ak7	UTSW	4	118,791,461 (GRCm39)	missense	probably damaging	1.00
R7676:Or10ak7	UTSW	4	118,791,347 (GRCm39)	missense	probably damaging	1.00
R8053:Or10ak7	UTSW	4	118,791,308 (GRCm39)	missense	probably damaging	1.00
R8311:Or10ak7	UTSW	4	118,791,347 (GRCm39)	missense	probably damaging	0.97
R9540:Or10ak7	UTSW	4	118,792,034 (GRCm39)	missense	probably benign
Z1176:Or10ak7	UTSW	4	118,791,115 (GRCm39)	missense	probably benign	0.19

Posted On

2015-04-16