Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02491:Zfp13'

295637

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp13

Ensembl Gene

ENSMUSG00000062012

Gene Name

zinc finger protein 13

Synonyms

Krox-8, Zfp-13

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

IGL02491

Quality Score

Status

Chromosome

Chromosomal Location

23794818-23818461 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 23795072 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 493 (A493T)

Ref Sequence

ENSEMBL: ENSMUSP00000054595 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057029] [ENSMUST00000115516] [ENSMUST00000227952]

AlphaFold

P10754

Predicted Effect

probably benign
Transcript: ENSMUST00000057029
AA Change: A493T

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: A493T

Domain	Start	End	E-Value	Type
KRAB	117	179	7.54e-10	SMART
ZnF_C2H2	259	281	7.37e-4	SMART
ZnF_C2H2	287	309	1.2e-3	SMART
ZnF_C2H2	315	337	5.9e-3	SMART
ZnF_C2H2	343	365	1.26e-2	SMART
ZnF_C2H2	371	393	9.73e-4	SMART
ZnF_C2H2	399	421	2.12e-4	SMART
ZnF_C2H2	427	449	1.18e-2	SMART
ZnF_C2H2	455	477	6.52e-5	SMART
low complexity region	480	503	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000115516
AA Change: A500T

SMART Domains

Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: A500T

Domain	Start	End	E-Value	Type
KRAB	124	186	7.54e-10	SMART
ZnF_C2H2	266	288	7.37e-4	SMART
ZnF_C2H2	294	316	1.2e-3	SMART
ZnF_C2H2	322	344	5.9e-3	SMART
ZnF_C2H2	350	372	1.26e-2	SMART
ZnF_C2H2	378	400	9.73e-4	SMART
ZnF_C2H2	406	428	2.12e-4	SMART
ZnF_C2H2	434	456	1.18e-2	SMART
ZnF_C2H2	462	484	6.52e-5	SMART
low complexity region	487	510	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226550

Predicted Effect

probably benign
Transcript: ENSMUST00000227952

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228942

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	T	C	11: 110,067,794 (GRCm39)		probably benign	Het
Acacb	T	A	5: 114,330,166 (GRCm39)	I443N	probably damaging	Het
C1qtnf3	A	T	15: 10,972,067 (GRCm39)	I118F	possibly damaging	Het
Carmil3	C	T	14: 55,741,974 (GRCm39)	A1148V	probably benign	Het
Ccdc62	A	T	5: 124,099,378 (GRCm39)	S677C	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Col11a2	C	A	17: 34,283,181 (GRCm39)		probably benign	Het
Cpsf7	A	G	19: 10,517,001 (GRCm39)	I368V	possibly damaging	Het
Csmd2	T	C	4: 128,428,050 (GRCm39)	S2934P	probably benign	Het
Csmd3	A	G	15: 47,777,511 (GRCm39)		probably benign	Het
Cubn	A	G	2: 13,326,039 (GRCm39)	Y2709H	probably damaging	Het
Cyp2d12	T	A	15: 82,442,682 (GRCm39)	L375Q	possibly damaging	Het
Etv4	A	T	11: 101,674,791 (GRCm39)		probably null	Het
Exph5	T	A	9: 53,286,343 (GRCm39)	D1141E	possibly damaging	Het
Fbxo16	T	A	14: 65,558,736 (GRCm39)	H298Q	probably benign	Het
Fbxw21	T	A	9: 108,972,887 (GRCm39)	Y349F	probably benign	Het
Foxs1	G	A	2: 152,774,721 (GRCm39)	R111C	probably damaging	Het
Galnt15	T	A	14: 31,778,273 (GRCm39)	L436Q	probably damaging	Het
Gbf1	T	C	19: 46,250,979 (GRCm39)		probably benign	Het
Gm8237	A	T	14: 5,863,577 (GRCm38)	C29*	probably null	Het
Hcn1	A	G	13: 117,946,576 (GRCm39)	D317G	unknown	Het
Itgam	A	G	7: 127,715,190 (GRCm39)	N877D	possibly damaging	Het
Kcnma1	T	C	14: 23,361,757 (GRCm39)	R1047G	probably damaging	Het
Klhdc3	T	C	17: 46,988,226 (GRCm39)	R180G	possibly damaging	Het
Lpcat2	T	C	8: 93,600,879 (GRCm39)	V241A	probably damaging	Het
Mnat1	A	G	12: 73,170,682 (GRCm39)	N24S	probably null	Het
Mprip	A	G	11: 59,660,857 (GRCm39)	T967A	probably benign	Het
Mtf1	T	C	4: 124,732,372 (GRCm39)	F477L	probably benign	Het
Naaladl1	A	G	19: 6,159,748 (GRCm39)	E393G	possibly damaging	Het
Or10ak7	A	T	4: 118,791,358 (GRCm39)	L229H	probably damaging	Het
Or2at1	A	G	7: 99,416,540 (GRCm39)	E57G	possibly damaging	Het
Or5e1	A	G	7: 108,354,321 (GRCm39)	K86R	probably damaging	Het
Pcdhb6	A	T	18: 37,468,735 (GRCm39)	D552V	probably damaging	Het
Pglyrp3	C	T	3: 91,921,944 (GRCm39)	S4F	possibly damaging	Het
Pramel13	A	T	4: 144,121,322 (GRCm39)	M234K	probably damaging	Het
Prss27	A	T	17: 24,263,229 (GRCm39)		probably benign	Het
Slc5a9	A	G	4: 111,753,549 (GRCm39)	S51P	probably damaging	Het
Slc6a4	A	G	11: 76,918,034 (GRCm39)	Y592C	probably damaging	Het
Slc7a13	T	A	4: 19,841,404 (GRCm39)	V417D	probably damaging	Het
Spring1	T	C	5: 118,397,160 (GRCm39)	Y130H	probably benign	Het
Syne2	A	G	12: 76,118,953 (GRCm39)	T5857A	probably benign	Het
Thap1	A	C	8: 26,650,885 (GRCm39)	S52R	probably damaging	Het
Thsd4	T	C	9: 59,907,301 (GRCm39)	N158S	probably damaging	Het
Tmem147	A	T	7: 30,427,626 (GRCm39)		probably benign	Het
Trdmt1	G	A	2: 13,521,483 (GRCm39)	A311V	probably benign	Het
U2surp	T	A	9: 95,372,273 (GRCm39)	R296S	probably damaging	Het
Upf2	A	G	2: 6,030,975 (GRCm39)	D805G	unknown	Het
Usp34	T	A	11: 23,382,630 (GRCm39)	H2057Q	probably damaging	Het
Vmn2r110	T	A	17: 20,816,400 (GRCm39)	D41V	probably damaging	Het
Vmn2r16	T	A	5: 109,487,703 (GRCm39)	L192*	probably null	Het
Vnn3	T	A	10: 23,741,816 (GRCm39)	S374T	probably benign	Het
Wdr62	A	C	7: 29,942,184 (GRCm39)	D1089E	probably benign	Het
Xdh	T	A	17: 74,193,459 (GRCm39)	D1279V	probably damaging	Het
Zfp518b	A	G	5: 38,831,123 (GRCm39)	I294T	possibly damaging	Het
Zfp983	G	A	17: 21,876,528 (GRCm39)		probably null	Het

Other mutations in Zfp13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02236:Zfp13	APN	17	23,799,739 (GRCm39)	splice site	probably benign
IGL02447:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02449:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02450:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02466:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02468:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02471:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02473:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02474:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02475:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02511:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02558:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL03030:Zfp13	APN	17	23,799,819 (GRCm39)	missense	probably benign	0.01
IGL03388:Zfp13	APN	17	23,795,888 (GRCm39)	missense	probably benign	0.00
R0053:Zfp13	UTSW	17	23,795,122 (GRCm39)	missense	probably damaging	1.00
R0053:Zfp13	UTSW	17	23,795,122 (GRCm39)	missense	probably damaging	1.00
R1514:Zfp13	UTSW	17	23,795,386 (GRCm39)	missense	probably damaging	1.00
R2420:Zfp13	UTSW	17	23,795,186 (GRCm39)	missense	probably damaging	1.00
R3433:Zfp13	UTSW	17	23,795,602 (GRCm39)	missense	probably damaging	0.99
R4458:Zfp13	UTSW	17	23,800,150 (GRCm39)	missense	probably benign	0.01
R4650:Zfp13	UTSW	17	23,799,112 (GRCm39)	missense	probably damaging	1.00
R4824:Zfp13	UTSW	17	23,795,797 (GRCm39)	missense	possibly damaging	0.95
R5088:Zfp13	UTSW	17	23,796,035 (GRCm39)	nonsense	probably null
R5110:Zfp13	UTSW	17	23,799,834 (GRCm39)	missense	probably benign	0.02
R5384:Zfp13	UTSW	17	23,800,156 (GRCm39)	missense	probably damaging	1.00
R7302:Zfp13	UTSW	17	23,800,036 (GRCm39)	missense	probably damaging	1.00
R8443:Zfp13	UTSW	17	23,795,866 (GRCm39)	missense	probably benign
R9728:Zfp13	UTSW	17	23,799,788 (GRCm39)	missense	possibly damaging	0.80

Posted On

2015-04-16