Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02492:Cxcl3'

295705

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cxcl3

Ensembl Gene

ENSMUSG00000029379

Gene Name

C-X-C motif chemokine ligand 3

Synonyms

Dcip1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02492

Quality Score

Status

Chromosome

Chromosomal Location

90933960-90935952 bp(+) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

A to G at 90934199 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000031326 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031326]

AlphaFold

Q6W5C0

Predicted Effect

probably null
Transcript: ENSMUST00000031326

SMART Domains

Protein: ENSMUSP00000031326
Gene: ENSMUSG00000029379

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
SCY	33	93	6.32e-16	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000201840

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013]

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atm	A	G	9: 53,367,159 (GRCm39)	L2482P	probably damaging	Het
Bcl11b	T	C	12: 107,881,945 (GRCm39)	Y718C	probably damaging	Het
Bltp1	A	G	3: 37,102,262 (GRCm39)	E1320G	probably benign	Het
Ccrl2	A	G	9: 110,884,871 (GRCm39)	I209T	probably benign	Het
Cd200r2	A	G	16: 44,729,903 (GRCm39)	K149R	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Col18a1	A	G	10: 76,907,855 (GRCm39)		probably benign	Het
Cops5	T	A	1: 10,097,377 (GRCm39)	T291S	probably benign	Het
Csmd1	C	A	8: 16,052,597 (GRCm39)	V2176F	probably benign	Het
Ctse	C	A	1: 131,595,972 (GRCm39)	S221R	probably damaging	Het
Cyp51	C	T	5: 4,154,304 (GRCm39)	V2I	probably benign	Het
Dennd5a	A	G	7: 109,532,844 (GRCm39)	F285L	probably benign	Het
Dst	T	G	1: 34,191,274 (GRCm39)		probably benign	Het
Frzb	A	T	2: 80,254,935 (GRCm39)		probably benign	Het
Gm5070	A	T	3: 95,318,354 (GRCm39)		noncoding transcript	Het
Gm9637	A	G	14: 19,402,182 (GRCm38)		noncoding transcript	Het
Grip1	A	G	10: 119,765,945 (GRCm39)		probably benign	Het
Itga4	C	T	2: 79,086,001 (GRCm39)		probably benign	Het
Ltbp2	A	T	12: 84,856,439 (GRCm39)	I675N	probably damaging	Het
Or4n4b	T	G	14: 50,536,060 (GRCm39)	K235N	probably damaging	Het
Pcdhb20	G	T	18: 37,639,453 (GRCm39)	V660L	probably benign	Het
Prex2	T	G	1: 11,194,069 (GRCm39)	L484R	possibly damaging	Het
Prkg1	A	T	19: 30,701,602 (GRCm39)	V305D	probably damaging	Het
Rab44	A	G	17: 29,365,023 (GRCm39)		probably benign	Het
Smpd4	C	T	16: 17,457,215 (GRCm39)	A391V	probably damaging	Het
Smyd4	T	C	11: 75,294,252 (GRCm39)	L711P	probably benign	Het
Spag16	T	G	1: 69,926,688 (GRCm39)	M261R	probably benign	Het
Steap1	A	G	5: 5,790,561 (GRCm39)	V129A	possibly damaging	Het
Tbcd	A	T	11: 121,387,960 (GRCm39)	I364L	probably benign	Het
Trmt13	C	T	3: 116,376,192 (GRCm39)	D400N	possibly damaging	Het
Vps13a	A	G	19: 16,625,001 (GRCm39)	S2753P	probably damaging	Het
Xirp2	T	G	2: 67,346,511 (GRCm39)	S2917R	probably damaging	Het
Zfp983	G	A	17: 21,876,528 (GRCm39)		probably null	Het

Other mutations in Cxcl3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R5668:Cxcl3	UTSW	5	90,935,299 (GRCm39)	missense	unknown
R5938:Cxcl3	UTSW	5	90,934,175 (GRCm39)	intron	probably benign
R5945:Cxcl3	UTSW	5	90,934,175 (GRCm39)	intron	probably benign
R5947:Cxcl3	UTSW	5	90,934,175 (GRCm39)	intron	probably benign
R7173:Cxcl3	UTSW	5	90,934,008 (GRCm39)	start gained	probably benign
R7214:Cxcl3	UTSW	5	90,934,219 (GRCm39)	missense	probably damaging	1.00
R7490:Cxcl3	UTSW	5	90,934,516 (GRCm39)	missense	unknown
R7573:Cxcl3	UTSW	5	90,934,105 (GRCm39)	missense	probably benign	0.00
R8753:Cxcl3	UTSW	5	90,934,071 (GRCm39)	small deletion	probably benign

Posted On

2015-04-16