Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02496:Vmn1r8'

295807

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r8

Ensembl Gene

ENSMUSG00000061208

Gene Name

vomeronasal 1 receptor 8

Synonyms

V1rc32

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02496

Quality Score

Status

Chromosome

Chromosomal Location

57012898-57014110 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 57013556 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 202 (L202F)

Ref Sequence

ENSEMBL: ENSMUSP00000154298 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078186] [ENSMUST00000227706] [ENSMUST00000228690]

AlphaFold

Q8R2C2

Predicted Effect

probably damaging
Transcript: ENSMUST00000078186
AA Change: L202F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000093561
Gene: ENSMUSG00000061208
AA Change: L202F

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	1.2e-58	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000227706
AA Change: L202F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228690
AA Change: L202F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	G	1: 71,327,712 (GRCm39)	H1456P	possibly damaging	Het
Abcg1	C	A	17: 31,324,578 (GRCm39)	H274Q	probably damaging	Het
Adamts4	G	A	1: 171,078,512 (GRCm39)	R44Q	probably benign	Het
Amigo2	A	T	15: 97,143,494 (GRCm39)	C309*	probably null	Het
Ccdc88c	A	C	12: 100,919,552 (GRCm39)	S446A	probably benign	Het
Cd9	A	T	6: 125,449,458 (GRCm39)	V28E	probably damaging	Het
Cops2	A	T	2: 125,678,163 (GRCm39)		probably benign	Het
Csn1s1	C	T	5: 87,825,453 (GRCm39)		probably benign	Het
Cul9	G	T	17: 46,851,302 (GRCm39)	R373S	possibly damaging	Het
D630045J12Rik	G	T	6: 38,126,640 (GRCm39)	H1457N	probably damaging	Het
Dennd2b	C	A	7: 109,155,442 (GRCm39)	R436L	possibly damaging	Het
Dnah9	A	G	11: 65,920,189 (GRCm39)	S2235P	probably damaging	Het
Efr3b	C	T	12: 4,033,391 (GRCm39)	V139I	probably benign	Het
Fbxo10	A	T	4: 45,043,883 (GRCm39)	W647R	probably damaging	Het
Flnb	T	A	14: 7,930,919 (GRCm38)		probably benign	Het
Flnc	G	T	6: 29,440,684 (GRCm39)	V301L	probably damaging	Het
Hfm1	T	C	5: 107,049,627 (GRCm39)	S445G	probably benign	Het
Hif3a	A	G	7: 16,773,603 (GRCm39)		probably benign	Het
Hsd17b4	T	C	18: 50,288,220 (GRCm39)	Y217H	probably damaging	Het
Iba57	T	C	11: 59,049,772 (GRCm39)	T192A	probably benign	Het
Igkv5-48	A	T	6: 69,703,671 (GRCm39)	I78N	probably damaging	Het
Inhbe	A	T	10: 127,186,797 (GRCm39)	W128R	probably damaging	Het
Ism1	T	C	2: 139,599,121 (GRCm39)	C365R	probably damaging	Het
Kif19a	A	T	11: 114,670,470 (GRCm39)	T127S	probably damaging	Het
Kmt2d	C	A	15: 98,755,439 (GRCm39)		probably benign	Het
Mmp20	A	G	9: 7,654,042 (GRCm39)	R321G	probably damaging	Het
Msl2	T	C	9: 100,977,854 (GRCm39)	M76T	possibly damaging	Het
Nme9	T	C	9: 99,351,684 (GRCm39)	C223R	probably damaging	Het
Nucb1	G	T	7: 45,144,467 (GRCm39)		probably benign	Het
Ocrl	G	A	X: 47,022,315 (GRCm39)	D262N	probably benign	Het
Or13a18	A	C	7: 140,190,081 (GRCm39)	M1L	probably benign	Het
Or5b98	T	A	19: 12,931,556 (GRCm39)	I201N	possibly damaging	Het
Or6b1	A	C	6: 42,815,738 (GRCm39)	I308L	probably benign	Het
P4ha1	A	G	10: 59,206,824 (GRCm39)		probably null	Het
Parp8	T	C	13: 116,998,838 (GRCm39)		probably benign	Het
Pcdhb6	A	G	18: 37,468,507 (GRCm39)	D476G	probably damaging	Het
Pikfyve	A	G	1: 65,303,535 (GRCm39)	E1685G	possibly damaging	Het
Plod2	T	A	9: 92,489,147 (GRCm39)	L714Q	probably damaging	Het
Plscr2	A	G	9: 92,171,716 (GRCm39)	I103V	probably benign	Het
Plscr3	C	A	11: 69,738,209 (GRCm39)		probably benign	Het
Pmaip1	A	G	18: 66,596,370 (GRCm39)	R80G	probably damaging	Het
Ppm1d	C	T	11: 85,230,492 (GRCm39)	P370L	possibly damaging	Het
Prr36	C	A	8: 4,266,407 (GRCm39)	E48*	probably null	Het
Ptgir	G	A	7: 16,641,409 (GRCm39)	V234I	possibly damaging	Het
Ptk7	A	T	17: 46,901,070 (GRCm39)	V219E	probably benign	Het
Rab39b	T	A	X: 74,618,609 (GRCm39)	I74F	probably damaging	Het
Rasal2	A	T	1: 156,977,449 (GRCm39)	M1075K	possibly damaging	Het
Rpl37a	G	A	1: 72,750,885 (GRCm39)	A20T	probably null	Het
Serpinb10	A	C	1: 107,466,155 (GRCm39)		probably null	Het
Sipa1l1	T	A	12: 82,471,868 (GRCm39)	Y1283N	probably damaging	Het
Slc22a23	T	A	13: 34,528,468 (GRCm39)	I105F	possibly damaging	Het
Slc25a20	T	A	9: 108,559,599 (GRCm39)	I221N	probably damaging	Het
Smarcal1	A	T	1: 72,659,247 (GRCm39)	H691L	probably damaging	Het
Smo	A	C	6: 29,758,480 (GRCm39)	T542P	probably damaging	Het
Spats2	T	A	15: 99,071,329 (GRCm39)	I51N	probably damaging	Het
Spon1	G	T	7: 113,635,897 (GRCm39)	V704L	probably benign	Het
Tex9	T	A	9: 72,389,774 (GRCm39)	Q112L	probably benign	Het
Tgfbr2	T	C	9: 115,919,486 (GRCm39)	E580G	probably benign	Het
Top2b	T	A	14: 16,387,335 (GRCm38)	V141E	probably benign	Het
Trhde	A	T	10: 114,636,466 (GRCm39)	L247*	probably null	Het
Umodl1	G	T	17: 31,217,628 (GRCm39)	V1145F	probably damaging	Het
Vasp	C	A	7: 18,992,748 (GRCm39)		probably benign	Het
Vmn2r111	T	C	17: 22,787,837 (GRCm39)	T505A	probably benign	Het
Wdr27	A	G	17: 15,112,693 (GRCm39)		probably benign	Het
Wfdc1	T	G	8: 120,406,909 (GRCm39)	V109G	probably damaging	Het
Zan	C	A	5: 137,463,056 (GRCm39)	E708*	probably null	Het
Zbtb1	T	A	12: 76,432,169 (GRCm39)	F52I	possibly damaging	Het
Zfp236	A	G	18: 82,648,117 (GRCm39)	S1015P	probably damaging	Het
Zfp532	T	C	18: 65,757,113 (GRCm39)	S349P	probably damaging	Het
Znfx1	A	T	2: 166,889,550 (GRCm39)	C731S	possibly damaging	Het

Other mutations in Vmn1r8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01569:Vmn1r8	APN	6	57,013,272 (GRCm39)	missense	possibly damaging	0.70
IGL01820:Vmn1r8	APN	6	57,013,653 (GRCm39)	missense	possibly damaging	0.94
IGL02416:Vmn1r8	APN	6	57,013,605 (GRCm39)	missense	probably damaging	0.97
IGL02930:Vmn1r8	APN	6	57,013,579 (GRCm39)	missense	probably benign	0.03
IGL02954:Vmn1r8	APN	6	57,013,315 (GRCm39)	missense	probably benign	0.03
IGL03235:Vmn1r8	APN	6	57,013,746 (GRCm39)	nonsense	probably null
IGL03353:Vmn1r8	APN	6	57,013,776 (GRCm39)	missense	probably benign	0.03
PIT4494001:Vmn1r8	UTSW	6	57,013,712 (GRCm39)	missense	probably benign	0.01
R0656:Vmn1r8	UTSW	6	57,013,573 (GRCm39)	missense	probably benign	0.35
R1328:Vmn1r8	UTSW	6	57,013,278 (GRCm39)	missense	possibly damaging	0.94
R1846:Vmn1r8	UTSW	6	57,013,413 (GRCm39)	missense	probably benign	0.06
R2083:Vmn1r8	UTSW	6	57,013,325 (GRCm39)	missense	probably benign	0.21
R3683:Vmn1r8	UTSW	6	57,013,260 (GRCm39)	missense	probably damaging	1.00
R4134:Vmn1r8	UTSW	6	57,013,705 (GRCm39)	missense	probably benign
R4754:Vmn1r8	UTSW	6	57,012,952 (GRCm39)	start codon destroyed	probably null	1.00
R4857:Vmn1r8	UTSW	6	57,013,338 (GRCm39)	missense	probably benign	0.00
R5787:Vmn1r8	UTSW	6	57,013,244 (GRCm39)	missense	probably damaging	1.00
R6158:Vmn1r8	UTSW	6	57,013,274 (GRCm39)	missense	probably benign	0.00
R6711:Vmn1r8	UTSW	6	57,013,444 (GRCm39)	missense	probably damaging	1.00
R6971:Vmn1r8	UTSW	6	57,013,400 (GRCm39)	missense	probably damaging	1.00
R8066:Vmn1r8	UTSW	6	57,013,419 (GRCm39)	missense	probably benign	0.03
R8261:Vmn1r8	UTSW	6	57,013,158 (GRCm39)	missense	probably benign	0.00
R8526:Vmn1r8	UTSW	6	57,013,362 (GRCm39)	missense	probably benign	0.05
R8552:Vmn1r8	UTSW	6	57,013,138 (GRCm39)	missense	possibly damaging	0.76
R8692:Vmn1r8	UTSW	6	57,013,557 (GRCm39)	missense	probably benign	0.01
R8712:Vmn1r8	UTSW	6	57,013,665 (GRCm39)	missense	probably benign	0.07
R9306:Vmn1r8	UTSW	6	57,013,713 (GRCm39)	missense	probably benign	0.12

Posted On

2015-04-16