Incidental Mutation 'IGL02496:Or13a18'
ID 295821
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or13a18
Ensembl Gene ENSMUSG00000093942
Gene Name olfactory receptor family 13 subfamily A member 18
Synonyms IB7, IF5, ID12, GA_x6K02T2PBJ9-42759973-42760905, Olfr46, MOR253-8
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL02496
Quality Score
Chromosome 7
Chromosomal Location 140181253-140191037 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to C at 140190081 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 1 (M1L)
Ref Sequence ENSEMBL: ENSMUSP00000072445 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072655] [ENSMUST00000211771] [ENSMUST00000214180]
AlphaFold Q8VGJ4
Predicted Effect probably benign
Transcript: ENSMUST00000072655
AA Change: M1L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000072445
Gene: ENSMUSG00000093942
AA Change: M1L

Pfam:7tm_4 39 315 1.1e-50 PFAM
Pfam:7TM_GPCR_Srsx 43 209 5.9e-8 PFAM
Pfam:7tm_1 49 298 3.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211771
Predicted Effect probably benign
Transcript: ENSMUST00000214180
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T G 1: 71,327,712 (GRCm39) H1456P possibly damaging Het
Abcg1 C A 17: 31,324,578 (GRCm39) H274Q probably damaging Het
Adamts4 G A 1: 171,078,512 (GRCm39) R44Q probably benign Het
Amigo2 A T 15: 97,143,494 (GRCm39) C309* probably null Het
Ccdc88c A C 12: 100,919,552 (GRCm39) S446A probably benign Het
Cd9 A T 6: 125,449,458 (GRCm39) V28E probably damaging Het
Cops2 A T 2: 125,678,163 (GRCm39) probably benign Het
Csn1s1 C T 5: 87,825,453 (GRCm39) probably benign Het
Cul9 G T 17: 46,851,302 (GRCm39) R373S possibly damaging Het
D630045J12Rik G T 6: 38,126,640 (GRCm39) H1457N probably damaging Het
Dennd2b C A 7: 109,155,442 (GRCm39) R436L possibly damaging Het
Dnah9 A G 11: 65,920,189 (GRCm39) S2235P probably damaging Het
Efr3b C T 12: 4,033,391 (GRCm39) V139I probably benign Het
Fbxo10 A T 4: 45,043,883 (GRCm39) W647R probably damaging Het
Flnb T A 14: 7,930,919 (GRCm38) probably benign Het
Flnc G T 6: 29,440,684 (GRCm39) V301L probably damaging Het
Hfm1 T C 5: 107,049,627 (GRCm39) S445G probably benign Het
Hif3a A G 7: 16,773,603 (GRCm39) probably benign Het
Hsd17b4 T C 18: 50,288,220 (GRCm39) Y217H probably damaging Het
Iba57 T C 11: 59,049,772 (GRCm39) T192A probably benign Het
Igkv5-48 A T 6: 69,703,671 (GRCm39) I78N probably damaging Het
Inhbe A T 10: 127,186,797 (GRCm39) W128R probably damaging Het
Ism1 T C 2: 139,599,121 (GRCm39) C365R probably damaging Het
Kif19a A T 11: 114,670,470 (GRCm39) T127S probably damaging Het
Kmt2d C A 15: 98,755,439 (GRCm39) probably benign Het
Mmp20 A G 9: 7,654,042 (GRCm39) R321G probably damaging Het
Msl2 T C 9: 100,977,854 (GRCm39) M76T possibly damaging Het
Nme9 T C 9: 99,351,684 (GRCm39) C223R probably damaging Het
Nucb1 G T 7: 45,144,467 (GRCm39) probably benign Het
Ocrl G A X: 47,022,315 (GRCm39) D262N probably benign Het
Or5b98 T A 19: 12,931,556 (GRCm39) I201N possibly damaging Het
Or6b1 A C 6: 42,815,738 (GRCm39) I308L probably benign Het
P4ha1 A G 10: 59,206,824 (GRCm39) probably null Het
Parp8 T C 13: 116,998,838 (GRCm39) probably benign Het
Pcdhb6 A G 18: 37,468,507 (GRCm39) D476G probably damaging Het
Pikfyve A G 1: 65,303,535 (GRCm39) E1685G possibly damaging Het
Plod2 T A 9: 92,489,147 (GRCm39) L714Q probably damaging Het
Plscr2 A G 9: 92,171,716 (GRCm39) I103V probably benign Het
Plscr3 C A 11: 69,738,209 (GRCm39) probably benign Het
Pmaip1 A G 18: 66,596,370 (GRCm39) R80G probably damaging Het
Ppm1d C T 11: 85,230,492 (GRCm39) P370L possibly damaging Het
Prr36 C A 8: 4,266,407 (GRCm39) E48* probably null Het
Ptgir G A 7: 16,641,409 (GRCm39) V234I possibly damaging Het
Ptk7 A T 17: 46,901,070 (GRCm39) V219E probably benign Het
Rab39b T A X: 74,618,609 (GRCm39) I74F probably damaging Het
Rasal2 A T 1: 156,977,449 (GRCm39) M1075K possibly damaging Het
Rpl37a G A 1: 72,750,885 (GRCm39) A20T probably null Het
Serpinb10 A C 1: 107,466,155 (GRCm39) probably null Het
Sipa1l1 T A 12: 82,471,868 (GRCm39) Y1283N probably damaging Het
Slc22a23 T A 13: 34,528,468 (GRCm39) I105F possibly damaging Het
Slc25a20 T A 9: 108,559,599 (GRCm39) I221N probably damaging Het
Smarcal1 A T 1: 72,659,247 (GRCm39) H691L probably damaging Het
Smo A C 6: 29,758,480 (GRCm39) T542P probably damaging Het
Spats2 T A 15: 99,071,329 (GRCm39) I51N probably damaging Het
Spon1 G T 7: 113,635,897 (GRCm39) V704L probably benign Het
Tex9 T A 9: 72,389,774 (GRCm39) Q112L probably benign Het
Tgfbr2 T C 9: 115,919,486 (GRCm39) E580G probably benign Het
Top2b T A 14: 16,387,335 (GRCm38) V141E probably benign Het
Trhde A T 10: 114,636,466 (GRCm39) L247* probably null Het
Umodl1 G T 17: 31,217,628 (GRCm39) V1145F probably damaging Het
Vasp C A 7: 18,992,748 (GRCm39) probably benign Het
Vmn1r8 G T 6: 57,013,556 (GRCm39) L202F probably damaging Het
Vmn2r111 T C 17: 22,787,837 (GRCm39) T505A probably benign Het
Wdr27 A G 17: 15,112,693 (GRCm39) probably benign Het
Wfdc1 T G 8: 120,406,909 (GRCm39) V109G probably damaging Het
Zan C A 5: 137,463,056 (GRCm39) E708* probably null Het
Zbtb1 T A 12: 76,432,169 (GRCm39) F52I possibly damaging Het
Zfp236 A G 18: 82,648,117 (GRCm39) S1015P probably damaging Het
Zfp532 T C 18: 65,757,113 (GRCm39) S349P probably damaging Het
Znfx1 A T 2: 166,889,550 (GRCm39) C731S possibly damaging Het
Other mutations in Or13a18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Or13a18 APN 7 140,190,666 (GRCm39) missense probably damaging 1.00
IGL02408:Or13a18 APN 7 140,190,844 (GRCm39) missense probably damaging 1.00
IGL03003:Or13a18 APN 7 140,190,283 (GRCm39) missense probably damaging 1.00
R0538:Or13a18 UTSW 7 140,190,297 (GRCm39) missense probably damaging 1.00
R1350:Or13a18 UTSW 7 140,190,622 (GRCm39) missense probably damaging 0.96
R1466:Or13a18 UTSW 7 140,190,882 (GRCm39) missense probably benign 0.01
R1466:Or13a18 UTSW 7 140,190,882 (GRCm39) missense probably benign 0.01
R2008:Or13a18 UTSW 7 140,190,498 (GRCm39) missense probably damaging 1.00
R4110:Or13a18 UTSW 7 140,190,178 (GRCm39) missense possibly damaging 0.89
R4110:Or13a18 UTSW 7 140,190,177 (GRCm39) missense probably benign 0.20
R4255:Or13a18 UTSW 7 140,190,500 (GRCm39) nonsense probably null
R4622:Or13a18 UTSW 7 140,190,611 (GRCm39) nonsense probably null
R4809:Or13a18 UTSW 7 140,190,987 (GRCm39) missense probably damaging 0.98
R4826:Or13a18 UTSW 7 140,190,232 (GRCm39) missense probably benign 0.02
R4989:Or13a18 UTSW 7 140,190,304 (GRCm39) missense possibly damaging 0.95
R5177:Or13a18 UTSW 7 140,190,102 (GRCm39) missense probably benign 0.00
R5261:Or13a18 UTSW 7 140,190,576 (GRCm39) missense probably benign 0.00
R5770:Or13a18 UTSW 7 140,190,856 (GRCm39) missense probably damaging 1.00
R5863:Or13a18 UTSW 7 140,190,544 (GRCm39) missense probably damaging 0.97
R6082:Or13a18 UTSW 7 140,190,594 (GRCm39) missense probably benign 0.00
R6705:Or13a18 UTSW 7 140,190,697 (GRCm39) missense probably damaging 0.99
R7216:Or13a18 UTSW 7 140,190,373 (GRCm39) missense possibly damaging 0.87
R7443:Or13a18 UTSW 7 140,190,961 (GRCm39) missense probably damaging 1.00
R7485:Or13a18 UTSW 7 140,190,091 (GRCm39) missense probably benign 0.02
R7806:Or13a18 UTSW 7 140,190,685 (GRCm39) missense probably benign 0.00
R8373:Or13a18 UTSW 7 140,190,208 (GRCm39) missense possibly damaging 0.88
R8884:Or13a18 UTSW 7 140,190,616 (GRCm39) missense probably damaging 1.00
R9278:Or13a18 UTSW 7 140,190,936 (GRCm39) missense probably damaging 1.00
R9595:Or13a18 UTSW 7 140,190,939 (GRCm39) missense probably damaging 0.97
Posted On 2015-04-16