Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02496:Zfp236'

295843

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp236

Ensembl Gene

ENSMUSG00000041258

Gene Name

zinc finger protein 236

Synonyms

LOC240456

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02496

Quality Score

Status

Chromosome

Chromosomal Location

82593593-82692883 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 82629992 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1015 (S1015P)

Ref Sequence

ENSEMBL: ENSMUSP00000138557 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171071] [ENSMUST00000182122] [ENSMUST00000183048]

AlphaFold

S4R299

Predicted Effect

probably damaging
Transcript: ENSMUST00000171071
AA Change: S967P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000130004
Gene: ENSMUSG00000041258
AA Change: S967P

Domain	Start	End	E-Value	Type
ZnF_C2H2	39	61	2.24e-3	SMART
ZnF_C2H2	68	90	2.29e0	SMART
ZnF_C2H2	95	117	1.26e-2	SMART
ZnF_C2H2	123	145	6.67e-2	SMART
ZnF_C2H2	155	177	6.42e-4	SMART
ZnF_C2H2	199	221	1.75e-5	SMART
ZnF_C2H2	227	249	1.52e-5	SMART
ZnF_C2H2	255	278	8.94e-3	SMART
low complexity region	290	309	N/A	INTRINSIC
low complexity region	403	426	N/A	INTRINSIC
ZnF_C2H2	436	458	1.98e-4	SMART
ZnF_C2H2	464	486	9.58e-3	SMART
ZnF_C2H2	492	514	6.42e-4	SMART
ZnF_C2H2	520	542	1.18e-2	SMART
low complexity region	592	605	N/A	INTRINSIC
ZnF_C2H2	611	633	1.62e0	SMART
ZnF_C2H2	639	661	5.21e-4	SMART
ZnF_C2H2	667	689	6.78e-3	SMART
ZnF_C2H2	695	717	7.37e-4	SMART
low complexity region	720	733	N/A	INTRINSIC
ZnF_C2H2	922	944	5.21e-4	SMART
ZnF_C2H2	950	972	1.04e-3	SMART
ZnF_C2H2	978	1000	8.6e-5	SMART
ZnF_C2H2	1006	1028	2.75e-3	SMART
low complexity region	1030	1039	N/A	INTRINSIC
ZnF_C2H2	1122	1144	7.78e-3	SMART
ZnF_C2H2	1150	1172	3.63e-3	SMART
ZnF_C2H2	1178	1200	6.88e-4	SMART
ZnF_C2H2	1206	1228	5.42e-2	SMART
low complexity region	1243	1258	N/A	INTRINSIC
low complexity region	1462	1477	N/A	INTRINSIC
ZnF_C2H2	1612	1635	7.15e-2	SMART
ZnF_C2H2	1641	1663	2.91e-2	SMART
ZnF_C2H2	1677	1699	7.26e-3	SMART
ZnF_C2H2	1705	1727	1.84e-4	SMART
ZnF_C2H2	1733	1756	2.95e-3	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182122
AA Change: S1015P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138557
Gene: ENSMUSG00000041258
AA Change: S1015P

Domain	Start	End	E-Value	Type
ZnF_C2H2	39	61	2.24e-3	SMART
ZnF_C2H2	68	90	2.29e0	SMART
ZnF_C2H2	95	117	1.26e-2	SMART
ZnF_C2H2	123	145	6.67e-2	SMART
ZnF_C2H2	155	177	6.42e-4	SMART
ZnF_C2H2	199	221	1.75e-5	SMART
ZnF_C2H2	227	249	1.52e-5	SMART
ZnF_C2H2	255	278	8.94e-3	SMART
ZnF_C2H2	287	310	9.58e-3	SMART
low complexity region	338	357	N/A	INTRINSIC
low complexity region	451	474	N/A	INTRINSIC
ZnF_C2H2	484	506	1.98e-4	SMART
ZnF_C2H2	512	534	9.58e-3	SMART
ZnF_C2H2	540	562	6.42e-4	SMART
ZnF_C2H2	568	590	1.18e-2	SMART
low complexity region	640	653	N/A	INTRINSIC
ZnF_C2H2	659	681	1.62e0	SMART
ZnF_C2H2	687	709	5.21e-4	SMART
ZnF_C2H2	715	737	6.78e-3	SMART
ZnF_C2H2	743	765	7.37e-4	SMART
low complexity region	768	781	N/A	INTRINSIC
ZnF_C2H2	970	992	5.21e-4	SMART
ZnF_C2H2	998	1020	1.04e-3	SMART
ZnF_C2H2	1026	1048	8.6e-5	SMART
ZnF_C2H2	1054	1076	2.75e-3	SMART
low complexity region	1078	1087	N/A	INTRINSIC
ZnF_C2H2	1170	1192	7.78e-3	SMART
ZnF_C2H2	1198	1220	3.63e-3	SMART
ZnF_C2H2	1226	1248	6.88e-4	SMART
ZnF_C2H2	1254	1276	5.42e-2	SMART
low complexity region	1291	1306	N/A	INTRINSIC
low complexity region	1510	1525	N/A	INTRINSIC
ZnF_C2H2	1660	1683	7.15e-2	SMART
ZnF_C2H2	1689	1711	2.91e-2	SMART
ZnF_C2H2	1725	1747	7.26e-3	SMART
ZnF_C2H2	1753	1775	1.84e-4	SMART
ZnF_C2H2	1781	1804	2.95e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183048

SMART Domains

Protein: ENSMUSP00000138179
Gene: ENSMUSG00000041258

Domain	Start	End	E-Value	Type
ZnF_C2H2	39	61	2.24e-3	SMART
ZnF_C2H2	68	90	2.29e0	SMART
ZnF_C2H2	95	117	1.26e-2	SMART
ZnF_C2H2	123	145	6.67e-2	SMART
ZnF_C2H2	155	177	6.42e-4	SMART
ZnF_C2H2	199	221	1.75e-5	SMART
ZnF_C2H2	227	249	1.52e-5	SMART
ZnF_C2H2	255	278	8.94e-3	SMART
ZnF_C2H2	287	310	9.58e-3	SMART
low complexity region	338	357	N/A	INTRINSIC
low complexity region	454	467	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	G	1: 71,288,553	H1456P	possibly damaging	Het
Abcg1	C	A	17: 31,105,604	H274Q	probably damaging	Het
Adamts4	G	A	1: 171,250,943	R44Q	probably benign	Het
Amigo2	A	T	15: 97,245,613	C309*	probably null	Het
Ccdc88c	A	C	12: 100,953,293	S446A	probably benign	Het
Cd9	A	T	6: 125,472,495	V28E	probably damaging	Het
Cops2	A	T	2: 125,836,243		probably benign	Het
Csn1s1	C	T	5: 87,677,594		probably benign	Het
Cul9	G	T	17: 46,540,376	R373S	possibly damaging	Het
D630045J12Rik	G	T	6: 38,149,705	H1457N	probably damaging	Het
Dnah9	A	G	11: 66,029,363	S2235P	probably damaging	Het
Efr3b	C	T	12: 3,983,391	V139I	probably benign	Het
Fbxo10	A	T	4: 45,043,883	W647R	probably damaging	Het
Flnb	T	A	14: 7,930,919		probably benign	Het
Flnc	G	T	6: 29,440,685	V301L	probably damaging	Het
Hfm1	T	C	5: 106,901,761	S445G	probably benign	Het
Hif3a	A	G	7: 17,039,678		probably benign	Het
Hsd17b4	T	C	18: 50,155,153	Y217H	probably damaging	Het
Iba57	T	C	11: 59,158,946	T192A	probably benign	Het
Igkv5-48	A	T	6: 69,726,687	I78N	probably damaging	Het
Inhbe	A	T	10: 127,350,928	W128R	probably damaging	Het
Ism1	T	C	2: 139,757,201	C365R	probably damaging	Het
Kif19a	A	T	11: 114,779,644	T127S	probably damaging	Het
Kmt2d	C	A	15: 98,857,558		probably benign	Het
Mmp20	A	G	9: 7,654,041	R321G	probably damaging	Het
Msl2	T	C	9: 101,100,655	M76T	possibly damaging	Het
Nme9	T	C	9: 99,469,631	C223R	probably damaging	Het
Nucb1	G	T	7: 45,495,043		probably benign	Het
Ocrl	G	A	X: 47,933,438	D262N	probably benign	Het
Olfr1450	T	A	19: 12,954,192	I201N	possibly damaging	Het
Olfr449	A	C	6: 42,838,804	I308L	probably benign	Het
Olfr46	A	C	7: 140,610,168	M1L	probably benign	Het
P4ha1	A	G	10: 59,371,002		probably null	Het
Parp8	T	C	13: 116,862,302		probably benign	Het
Pcdhb6	A	G	18: 37,335,454	D476G	probably damaging	Het
Pikfyve	A	G	1: 65,264,376	E1685G	possibly damaging	Het
Plod2	T	A	9: 92,607,094	L714Q	probably damaging	Het
Plscr2	A	G	9: 92,289,663	I103V	probably benign	Het
Plscr3	C	A	11: 69,847,383		probably benign	Het
Pmaip1	A	G	18: 66,463,299	R80G	probably damaging	Het
Ppm1d	C	T	11: 85,339,666	P370L	possibly damaging	Het
Prr36	C	A	8: 4,216,407	E48*	probably null	Het
Ptgir	G	A	7: 16,907,484	V234I	possibly damaging	Het
Ptk7	A	T	17: 46,590,144	V219E	probably benign	Het
Rab39b	T	A	X: 75,575,003	I74F	probably damaging	Het
Rasal2	A	T	1: 157,149,879	M1075K	possibly damaging	Het
Rpl37a	G	A	1: 72,711,726	A20T	probably null	Het
Serpinb10	A	C	1: 107,538,425		probably null	Het
Sipa1l1	T	A	12: 82,425,094	Y1283N	probably damaging	Het
Slc22a23	T	A	13: 34,344,485	I105F	possibly damaging	Het
Slc25a20	T	A	9: 108,682,400	I221N	probably damaging	Het
Smarcal1	A	T	1: 72,620,088	H691L	probably damaging	Het
Smo	A	C	6: 29,758,481	T542P	probably damaging	Het
Spats2	T	A	15: 99,173,448	I51N	probably damaging	Het
Spon1	G	T	7: 114,036,662	V704L	probably benign	Het
St5	C	A	7: 109,556,235	R436L	possibly damaging	Het
Tex9	T	A	9: 72,482,492	Q112L	probably benign	Het
Tgfbr2	T	C	9: 116,090,418	E580G	probably benign	Het
Top2b	T	A	14: 16,387,335	V141E	probably benign	Het
Trhde	A	T	10: 114,800,561	L247*	probably null	Het
Umodl1	G	T	17: 30,998,654	V1145F	probably damaging	Het
Vasp	C	A	7: 19,258,823		probably benign	Het
Vmn1r8	G	T	6: 57,036,571	L202F	probably damaging	Het
Vmn2r111	T	C	17: 22,568,856	T505A	probably benign	Het
Wdr27	A	G	17: 14,892,431		probably benign	Het
Wfdc1	T	G	8: 119,680,170	V109G	probably damaging	Het
Zan	C	A	5: 137,464,794	E708*	probably null	Het
Zbtb1	T	A	12: 76,385,395	F52I	possibly damaging	Het
Zfp532	T	C	18: 65,624,042	S349P	probably damaging	Het
Znfx1	A	T	2: 167,047,630	C731S	possibly damaging	Het

Other mutations in Zfp236

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01016:Zfp236	APN	18	82668690	missense	probably benign	0.44
IGL01760:Zfp236	APN	18	82621422	missense	probably damaging	1.00
IGL01923:Zfp236	APN	18	82682219	missense	probably damaging	0.98
IGL01934:Zfp236	APN	18	82633120	missense	probably damaging	0.99
IGL01949:Zfp236	APN	18	82624396	missense	probably damaging	1.00
IGL02063:Zfp236	APN	18	82658151	missense	probably benign
IGL02513:Zfp236	APN	18	82630114	missense	probably damaging	1.00
IGL02626:Zfp236	APN	18	82657995	splice site	probably benign
IGL02880:Zfp236	APN	18	82624459	missense	probably benign	0.15
IGL03156:Zfp236	APN	18	82680702	missense	probably damaging	1.00
IGL03261:Zfp236	APN	18	82630608	missense	possibly damaging	0.93
R0047:Zfp236	UTSW	18	82680692	missense	probably damaging	1.00
R0052:Zfp236	UTSW	18	82639332	missense	probably damaging	1.00
R0194:Zfp236	UTSW	18	82656987	missense	probably damaging	1.00
R0207:Zfp236	UTSW	18	82640227	missense	probably damaging	1.00
R0234:Zfp236	UTSW	18	82629994	missense	probably damaging	1.00
R0234:Zfp236	UTSW	18	82629994	missense	probably damaging	1.00
R0302:Zfp236	UTSW	18	82658088	missense	probably damaging	0.99
R0730:Zfp236	UTSW	18	82640244	splice site	probably benign
R0755:Zfp236	UTSW	18	82620332	missense	probably damaging	1.00
R1202:Zfp236	UTSW	18	82628166	missense	probably benign	0.00
R1449:Zfp236	UTSW	18	82646005	missense	probably damaging	1.00
R1550:Zfp236	UTSW	18	82674424	missense	possibly damaging	0.81
R1785:Zfp236	UTSW	18	82621304	missense	probably benign	0.08
R1786:Zfp236	UTSW	18	82621304	missense	probably benign	0.08
R2042:Zfp236	UTSW	18	82633109	missense	probably damaging	1.00
R2132:Zfp236	UTSW	18	82621304	missense	probably benign	0.08
R2133:Zfp236	UTSW	18	82621304	missense	probably benign	0.08
R2247:Zfp236	UTSW	18	82604298	missense	possibly damaging	0.82
R2484:Zfp236	UTSW	18	82668637	missense	probably benign	0.05
R3715:Zfp236	UTSW	18	82632970	splice site	probably benign
R4003:Zfp236	UTSW	18	82680745	nonsense	probably null
R4031:Zfp236	UTSW	18	82624465	missense	probably damaging	1.00
R4482:Zfp236	UTSW	18	82644221	missense	probably benign	0.04
R4492:Zfp236	UTSW	18	82630000	missense	probably damaging	1.00
R4502:Zfp236	UTSW	18	82636954	missense	probably benign	0.13
R4561:Zfp236	UTSW	18	82620406	missense	probably damaging	1.00
R4649:Zfp236	UTSW	18	82597659	missense	probably damaging	1.00
R4902:Zfp236	UTSW	18	82609418	missense	possibly damaging	0.89
R5064:Zfp236	UTSW	18	82691576	critical splice donor site	probably null
R5084:Zfp236	UTSW	18	82609431	missense	probably damaging	1.00
R5090:Zfp236	UTSW	18	82618881	missense	probably benign	0.08
R5191:Zfp236	UTSW	18	82621423	missense	probably damaging	1.00
R5264:Zfp236	UTSW	18	82630094	missense	probably damaging	1.00
R5264:Zfp236	UTSW	18	82658073	missense	probably damaging	0.99
R5339:Zfp236	UTSW	18	82624366	missense	probably damaging	0.99
R5375:Zfp236	UTSW	18	82597688	missense	possibly damaging	0.93
R5445:Zfp236	UTSW	18	82682156	missense	probably benign	0.02
R5513:Zfp236	UTSW	18	82658022	missense	probably damaging	0.97
R5527:Zfp236	UTSW	18	82658034	missense	possibly damaging	0.51
R5628:Zfp236	UTSW	18	82657122	missense	probably damaging	1.00
R5758:Zfp236	UTSW	18	82671709	missense	probably damaging	1.00
R5890:Zfp236	UTSW	18	82640151	missense	possibly damaging	0.87
R6137:Zfp236	UTSW	18	82671794	missense	possibly damaging	0.89
R6193:Zfp236	UTSW	18	82604247	missense	probably damaging	1.00
R6198:Zfp236	UTSW	18	82657153	missense	probably damaging	1.00
R6239:Zfp236	UTSW	18	82657104	missense	possibly damaging	0.53
R6705:Zfp236	UTSW	18	82633737	missense	probably damaging	0.97
R6948:Zfp236	UTSW	18	82644062	missense	possibly damaging	0.94
R6989:Zfp236	UTSW	18	82628363	missense	probably damaging	1.00
R7002:Zfp236	UTSW	18	82691576	critical splice donor site	probably null
R7113:Zfp236	UTSW	18	82620337	missense	possibly damaging	0.82
R7261:Zfp236	UTSW	18	82609345	missense	possibly damaging	0.86
R7363:Zfp236	UTSW	18	82621331	missense	probably damaging	1.00
R7447:Zfp236	UTSW	18	82633690	missense	probably damaging	1.00
R7564:Zfp236	UTSW	18	82644241	nonsense	probably null
R7731:Zfp236	UTSW	18	82680673	missense	probably benign	0.27
R7857:Zfp236	UTSW	18	82668601	nonsense	probably null
R7860:Zfp236	UTSW	18	82674356	nonsense	probably null
R7904:Zfp236	UTSW	18	82609382	missense	possibly damaging	0.90
R7948:Zfp236	UTSW	18	82624415	missense	probably damaging	1.00
R7995:Zfp236	UTSW	18	82639336	missense	probably damaging	1.00
R8153:Zfp236	UTSW	18	82630027	missense	probably damaging	1.00
R8435:Zfp236	UTSW	18	82640241	missense	probably damaging	1.00
R8560:Zfp236	UTSW	18	82646215	missense	probably damaging	1.00
R8878:Zfp236	UTSW	18	82598997	missense	probably damaging	1.00
R8916:Zfp236	UTSW	18	82646226	missense	probably damaging	1.00
R9046:Zfp236	UTSW	18	82618917	missense	possibly damaging	0.89
R9076:Zfp236	UTSW	18	82620344	missense	possibly damaging	0.77
R9243:Zfp236	UTSW	18	82643925	intron	probably benign
R9594:Zfp236	UTSW	18	82646113	missense	probably damaging	1.00
R9642:Zfp236	UTSW	18	82604259	missense	probably benign	0.00
R9707:Zfp236	UTSW	18	82646203	missense	probably damaging	1.00
R9748:Zfp236	UTSW	18	82618883	missense	possibly damaging	0.89

Posted On

2015-04-16