Incidental Mutation 'IGL00987:Acot9'
ID29609
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Acot9
Ensembl Gene ENSMUSG00000025287
Gene Nameacyl-CoA thioesterase 9
SynonymsMT-ACT48, 0610041P13Rik, U8, Acate2, p48
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.139) question?
Stock #IGL00987
Quality Score
Status
ChromosomeX
Chromosomal Location155262443-155297654 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 155295181 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 241 (I241T)
Ref Sequence ENSEMBL: ENSMUSP00000026324 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026324] [ENSMUST00000131332]
Predicted Effect probably benign
Transcript: ENSMUST00000026324
AA Change: I241T

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000026324
Gene: ENSMUSG00000025287
AA Change: I241T

DomainStartEndE-ValueType
SCOP:d1lo7a_ 108 222 1e-3 SMART
PDB:4IEN|D 277 400 8e-7 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126200
Predicted Effect probably benign
Transcript: ENSMUST00000131332
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp5g3 T A 2: 73,909,926 R19* probably null Het
Celf4 T C 18: 25,486,950 D420G probably damaging Het
Cideb C A 14: 55,754,560 R179L possibly damaging Het
Cmtr1 G A 17: 29,697,169 R591H probably benign Het
Dync1li2 A T 8: 104,442,498 S34T possibly damaging Het
Eri2 A G 7: 119,791,166 Y80H probably damaging Het
Eya2 A G 2: 165,754,481 E304G probably damaging Het
Fam135a A C 1: 24,055,898 L130V probably damaging Het
Fancb A T X: 164,991,598 K410N probably damaging Het
Gabpb2 A C 3: 95,200,191 V191G probably damaging Het
Gfm1 A G 3: 67,438,560 H197R possibly damaging Het
Gm11595 A G 11: 99,772,539 V105A unknown Het
Hectd3 T A 4: 116,999,643 D462E probably damaging Het
Herc1 G T 9: 66,408,052 V1139L probably benign Het
Itgal T C 7: 127,302,011 F190L probably damaging Het
Krt87 G A 15: 101,438,446 H109Y probably benign Het
Lmf2 T C 15: 89,354,568 Y115C probably benign Het
Papolg T A 11: 23,876,377 Y259F possibly damaging Het
Parn T C 16: 13,667,603 I10V probably benign Het
Pdcd11 T A 19: 47,114,550 probably benign Het
Phldb2 T A 16: 45,763,102 Q1003L possibly damaging Het
Pigg T A 5: 108,342,078 F850I probably damaging Het
Pkp4 T C 2: 59,308,357 L317P probably damaging Het
Polr2a T C 11: 69,743,794 probably benign Het
Prdm16 G A 4: 154,341,969 T453M possibly damaging Het
Rnf144b A T 13: 47,207,493 E36D possibly damaging Het
Ryr2 G A 13: 11,735,502 T1961I probably damaging Het
Sash1 T A 10: 8,751,413 K305I probably damaging Het
Tbc1d7 A T 13: 43,159,321 I32N probably damaging Het
Thop1 T C 10: 81,081,695 F623L probably damaging Het
Thsd7b G A 1: 129,613,279 G297R probably damaging Het
Tln1 C A 4: 43,551,297 probably benign Het
Vmn1r183 A G 7: 24,055,224 N151D probably damaging Het
Other mutations in Acot9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00589:Acot9 APN X 155295240 missense possibly damaging 0.50
IGL03218:Acot9 APN X 155295211 missense possibly damaging 0.48
R3745:Acot9 UTSW X 155271945 splice site probably benign
R4498:Acot9 UTSW X 155264068 nonsense probably null
Posted On2013-04-17