Incidental Mutation 'IGL02502:Or51b17'
ID 296107
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or51b17
Ensembl Gene ENSMUSG00000063615
Gene Name olfactory receptor family 51 subfamily B member 17
Synonyms GA_x6K02T2PBJ9-6648196-6649143, Olfr64, 5'[b]2, MOR1-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.205) question?
Stock # IGL02502
Quality Score
Chromosome 7
Chromosomal Location 103542017-103543678 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103542696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 82 (V82A)
Ref Sequence ENSEMBL: ENSMUSP00000080444 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081748]
AlphaFold F8VPZ8
Predicted Effect probably damaging
Transcript: ENSMUST00000081748
AA Change: V82A

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000080444
Gene: ENSMUSG00000063615
AA Change: V82A

Pfam:7tm_4 29 307 2.4e-113 PFAM
Pfam:7TM_GPCR_Srsx 33 295 4.2e-6 PFAM
Pfam:7tm_1 39 290 1.1e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acoxl A G 2: 127,917,804 (GRCm39) N216S probably damaging Het
Akap12 A G 10: 4,303,163 (GRCm39) D96G probably damaging Het
Akna A G 4: 63,286,440 (GRCm39) V1353A probably benign Het
Ambra1 A G 2: 91,730,877 (GRCm39) D914G probably damaging Het
Ap1s3 A G 1: 79,601,439 (GRCm39) V84A possibly damaging Het
Arhgef6 T C X: 56,325,623 (GRCm39) E282G probably damaging Het
C2cd2 G T 16: 97,677,590 (GRCm39) S378Y possibly damaging Het
Cd101 C A 3: 100,919,141 (GRCm39) A654S probably damaging Het
Cep295 A C 9: 15,262,209 (GRCm39) probably benign Het
Csn1s1 A G 5: 87,828,784 (GRCm39) I283V probably benign Het
Cst3 A G 2: 148,717,065 (GRCm39) probably benign Het
Cyp2b9 T C 7: 25,887,239 (GRCm39) probably null Het
Dffb A G 4: 154,050,073 (GRCm39) probably benign Het
Dnah10 A G 5: 124,898,351 (GRCm39) Y3711C probably damaging Het
Eif4g2 T C 7: 110,680,748 (GRCm39) S3G probably damaging Het
Erbb3 C T 10: 128,406,153 (GRCm39) R1088H probably benign Het
Evpl T C 11: 116,113,544 (GRCm39) D1382G probably damaging Het
Fam168a A G 7: 100,473,417 (GRCm39) D102G probably damaging Het
Fbxo7 A G 10: 85,869,161 (GRCm39) Y284C probably damaging Het
G6pd2 T C 5: 61,966,971 (GRCm39) Y249H probably damaging Het
Gm1123 A T 9: 98,891,443 (GRCm39) Y335* probably null Het
Gm5624 C T 14: 44,797,296 (GRCm39) probably null Het
Hectd1 A T 12: 51,844,635 (GRCm39) M536K possibly damaging Het
Ikbkg T A X: 73,487,433 (GRCm39) V334E probably benign Het
Ipo7 T C 7: 109,650,257 (GRCm39) L769P probably damaging Het
Jmjd1c A T 10: 67,061,640 (GRCm39) K1331I probably benign Het
Krt32 T C 11: 99,978,749 (GRCm39) K102E probably damaging Het
Lrrc34 A T 3: 30,699,394 (GRCm39) N20K probably benign Het
Lrrc47 A G 4: 154,100,471 (GRCm39) E349G probably benign Het
Mdn1 A G 4: 32,670,579 (GRCm39) I415V possibly damaging Het
Myh10 A G 11: 68,705,198 (GRCm39) probably null Het
Nbeal2 A G 9: 110,462,836 (GRCm39) S1376P probably damaging Het
Nfx1 T C 4: 40,976,345 (GRCm39) probably benign Het
Nherf4 G A 9: 44,160,948 (GRCm39) A206V probably benign Het
Notch3 A T 17: 32,377,252 (GRCm39) C246* probably null Het
Nr3c2 A G 8: 77,969,143 (GRCm39) Y976C probably damaging Het
Or52n4b T A 7: 108,143,846 (GRCm39) M36K probably damaging Het
Or5b122 A G 19: 13,563,112 (GRCm39) Y105C probably damaging Het
P2rx7 C T 5: 122,819,050 (GRCm39) R491C possibly damaging Het
Phex T A X: 155,966,823 (GRCm39) Y625F possibly damaging Het
Pkhd1 T C 1: 20,462,389 (GRCm39) D2055G probably damaging Het
Pmm2 T C 16: 8,463,227 (GRCm39) probably benign Het
Prdm15 T C 16: 97,640,539 (GRCm39) D16G probably damaging Het
Prune2 T A 19: 17,101,245 (GRCm39) C2250S probably benign Het
Rasgef1a T A 6: 118,057,443 (GRCm39) F48Y probably benign Het
Rhoq T C 17: 87,271,077 (GRCm39) V15A probably damaging Het
Rnf216 G A 5: 143,054,622 (GRCm39) A585V probably damaging Het
Septin9 T A 11: 117,181,488 (GRCm39) I96N probably damaging Het
Shprh T A 10: 11,070,101 (GRCm39) D1492E possibly damaging Het
Slc22a26 A T 19: 7,768,125 (GRCm39) probably null Het
Tek T G 4: 94,741,818 (GRCm39) probably null Het
Tenm3 T C 8: 48,741,051 (GRCm39) E782G probably damaging Het
Trmt5 A G 12: 73,328,001 (GRCm39) C401R probably benign Het
Tspear T G 10: 77,688,792 (GRCm39) probably benign Het
Ubr5 G A 15: 38,030,933 (GRCm39) T414I probably benign Het
Vcl A T 14: 21,069,453 (GRCm39) T710S probably damaging Het
Vmn2r25 A T 6: 123,816,392 (GRCm39) D396E probably damaging Het
Wtip A G 7: 33,818,094 (GRCm39) probably null Het
Zap70 A G 1: 36,817,887 (GRCm39) probably benign Het
Other mutations in Or51b17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00934:Or51b17 APN 7 103,542,071 (GRCm39) nonsense probably null
IGL01597:Or51b17 APN 7 103,542,303 (GRCm39) missense probably benign 0.01
IGL01868:Or51b17 APN 7 103,542,583 (GRCm39) nonsense probably null
R0294:Or51b17 UTSW 7 103,542,137 (GRCm39) missense probably benign 0.09
R0534:Or51b17 UTSW 7 103,542,438 (GRCm39) missense probably benign 0.00
R0838:Or51b17 UTSW 7 103,542,622 (GRCm39) missense probably benign 0.00
R1350:Or51b17 UTSW 7 103,542,937 (GRCm39) missense probably benign 0.01
R1733:Or51b17 UTSW 7 103,542,118 (GRCm39) missense probably benign 0.40
R1768:Or51b17 UTSW 7 103,542,484 (GRCm39) missense probably benign 0.28
R1780:Or51b17 UTSW 7 103,542,762 (GRCm39) missense probably damaging 1.00
R1836:Or51b17 UTSW 7 103,542,592 (GRCm39) missense probably damaging 0.98
R1956:Or51b17 UTSW 7 103,542,925 (GRCm39) missense probably benign 0.01
R2075:Or51b17 UTSW 7 103,542,127 (GRCm39) missense probably damaging 0.96
R4677:Or51b17 UTSW 7 103,542,615 (GRCm39) missense probably damaging 1.00
R4884:Or51b17 UTSW 7 103,542,862 (GRCm39) missense probably benign 0.04
R4899:Or51b17 UTSW 7 103,542,672 (GRCm39) missense possibly damaging 0.54
R5753:Or51b17 UTSW 7 103,542,408 (GRCm39) missense probably damaging 1.00
R6351:Or51b17 UTSW 7 103,542,342 (GRCm39) nonsense probably null
R6997:Or51b17 UTSW 7 103,542,238 (GRCm39) missense probably benign 0.00
R8319:Or51b17 UTSW 7 103,542,636 (GRCm39) missense probably damaging 1.00
R8337:Or51b17 UTSW 7 103,542,256 (GRCm39) missense probably benign
R8984:Or51b17 UTSW 7 103,542,816 (GRCm39) missense probably benign 0.01
R9780:Or51b17 UTSW 7 103,542,631 (GRCm39) missense probably damaging 0.99
X0017:Or51b17 UTSW 7 103,542,358 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16