Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02502:Slc22a26'

296131

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc22a26

Ensembl Gene

ENSMUSG00000053303

Gene Name

solute carrier family 22 (organic cation transporter), member 26

Synonyms

BC014805

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL02502

Quality Score

Status

Chromosome

Chromosomal Location

7781041-7802667 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to T at 7790760 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113607 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065634] [ENSMUST00000120522]

AlphaFold

Q91WJ2

Predicted Effect

probably null
Transcript: ENSMUST00000065634

SMART Domains

Protein: ENSMUSP00000064809
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	96	528	1.1e-23	PFAM
Pfam:MFS_1	124	370	7.8e-17	PFAM
Pfam:MFS_1	350	547	2.1e-12	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000120522

SMART Domains

Protein: ENSMUSP00000113607
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	94	527	4.9e-23	PFAM
Pfam:MFS_1	124	358	1.2e-15	PFAM
Pfam:MFS_1	349	547	2.4e-12	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acoxl	A	G	2: 128,075,884	N216S	probably damaging	Het
Akap12	A	G	10: 4,353,163	D96G	probably damaging	Het
Akna	A	G	4: 63,368,203	V1353A	probably benign	Het
Ambra1	A	G	2: 91,900,532	D914G	probably damaging	Het
Ap1s3	A	G	1: 79,623,722	V84A	possibly damaging	Het
Arhgef6	T	C	X: 57,280,263	E282G	probably damaging	Het
C2cd2	G	T	16: 97,876,390	S378Y	possibly damaging	Het
Cd101	C	A	3: 101,011,825	A654S	probably damaging	Het
Cep295	A	C	9: 15,350,913		probably benign	Het
Csn1s1	A	G	5: 87,680,925	I283V	probably benign	Het
Cst3	A	G	2: 148,875,145		probably benign	Het
Cyp2b9	T	C	7: 26,187,814		probably null	Het
Dffb	A	G	4: 153,965,616		probably benign	Het
Dnah10	A	G	5: 124,821,287	Y3711C	probably damaging	Het
Eif4g2	T	C	7: 111,081,541	S3G	probably damaging	Het
Erbb3	C	T	10: 128,570,284	R1088H	probably benign	Het
Evpl	T	C	11: 116,222,718	D1382G	probably damaging	Het
Fam168a	A	G	7: 100,824,210	D102G	probably damaging	Het
Fbxo7	A	G	10: 86,033,297	Y284C	probably damaging	Het
G6pd2	T	C	5: 61,809,628	Y249H	probably damaging	Het
Gm1123	A	T	9: 99,009,390	Y335*	probably null	Het
Gm5624	C	T	14: 44,559,839		probably null	Het
Hectd1	A	T	12: 51,797,852	M536K	possibly damaging	Het
Ikbkg	T	A	X: 74,443,827	V334E	probably benign	Het
Ipo7	T	C	7: 110,051,050	L769P	probably damaging	Het
Jmjd1c	A	T	10: 67,225,861	K1331I	probably benign	Het
Krt32	T	C	11: 100,087,923	K102E	probably damaging	Het
Lrrc34	A	T	3: 30,645,245	N20K	probably benign	Het
Lrrc47	A	G	4: 154,016,014	E349G	probably benign	Het
Mdn1	A	G	4: 32,670,579	I415V	possibly damaging	Het
Myh10	A	G	11: 68,814,372		probably null	Het
Nbeal2	A	G	9: 110,633,768	S1376P	probably damaging	Het
Nfx1	T	C	4: 40,976,345		probably benign	Het
Notch3	A	T	17: 32,158,278	C246*	probably null	Het
Nr3c2	A	G	8: 77,242,514	Y976C	probably damaging	Het
Olfr1484	A	G	19: 13,585,748	Y105C	probably damaging	Het
Olfr503	T	A	7: 108,544,639	M36K	probably damaging	Het
Olfr64	A	G	7: 103,893,489	V82A	probably damaging	Het
P2rx7	C	T	5: 122,680,987	R491C	possibly damaging	Het
Pdzd3	G	A	9: 44,249,651	A206V	probably benign	Het
Phex	T	A	X: 157,183,827	Y625F	possibly damaging	Het
Pkhd1	T	C	1: 20,392,165	D2055G	probably damaging	Het
Pmm2	T	C	16: 8,645,363		probably benign	Het
Prdm15	T	C	16: 97,839,339	D16G	probably damaging	Het
Prune2	T	A	19: 17,123,881	C2250S	probably benign	Het
Rasgef1a	T	A	6: 118,080,482	F48Y	probably benign	Het
Rhoq	T	C	17: 86,963,649	V15A	probably damaging	Het
Rnf216	G	A	5: 143,068,867	A585V	probably damaging	Het
Sept9	T	A	11: 117,290,662	I96N	probably damaging	Het
Shprh	T	A	10: 11,194,357	D1492E	possibly damaging	Het
Tek	T	G	4: 94,853,581		probably null	Het
Tenm3	T	C	8: 48,288,016	E782G	probably damaging	Het
Trmt5	A	G	12: 73,281,227	C401R	probably benign	Het
Tspear	T	G	10: 77,852,958		probably benign	Het
Ubr5	G	A	15: 38,030,689	T414I	probably benign	Het
Vcl	A	T	14: 21,019,385	T710S	probably damaging	Het
Vmn2r25	A	T	6: 123,839,433	D396E	probably damaging	Het
Wtip	A	G	7: 34,118,669		probably null	Het
Zap70	A	G	1: 36,778,806		probably benign	Het

Other mutations in Slc22a26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Slc22a26	APN	19	7782836	missense	probably damaging	0.99
IGL00338:Slc22a26	APN	19	7782975	missense	probably benign	0.25
IGL00736:Slc22a26	APN	19	7790162	missense	possibly damaging	0.50
IGL01085:Slc22a26	APN	19	7790099	missense	probably benign	0.02
IGL01581:Slc22a26	APN	19	7802184	missense	probably benign	0.15
IGL02658:Slc22a26	APN	19	7788248	missense	probably benign	0.25
IGL02936:Slc22a26	APN	19	7791105	missense	probably damaging	0.99
IGL03162:Slc22a26	APN	19	7802101	missense	probably benign	0.00
R0034:Slc22a26	UTSW	19	7802253	missense	probably benign	0.03
R0633:Slc22a26	UTSW	19	7788210	critical splice donor site	probably null
R0676:Slc22a26	UTSW	19	7796144	splice site	probably benign
R2156:Slc22a26	UTSW	19	7802115	missense	probably damaging	1.00
R4043:Slc22a26	UTSW	19	7788329	critical splice acceptor site	probably null
R4781:Slc22a26	UTSW	19	7790135	missense	probably benign	0.34
R4896:Slc22a26	UTSW	19	7791054	missense	probably benign	0.14
R4999:Slc22a26	UTSW	19	7802181	missense	probably damaging	1.00
R5125:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R5178:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R6161:Slc22a26	UTSW	19	7786447	missense	possibly damaging	0.50
R6494:Slc22a26	UTSW	19	7802286	missense	probably damaging	1.00
R6512:Slc22a26	UTSW	19	7802500	start gained	probably benign
R6724:Slc22a26	UTSW	19	7802361	missense	probably benign	0.14
R7323:Slc22a26	UTSW	19	7790894	missense	probably damaging	0.97
R7375:Slc22a26	UTSW	19	7783144	splice site	probably null
R7558:Slc22a26	UTSW	19	7785286	missense	possibly damaging	0.94
R7634:Slc22a26	UTSW	19	7802587	splice site	probably null
R8772:Slc22a26	UTSW	19	7790112	missense	probably benign	0.27
R8905:Slc22a26	UTSW	19	7782966	missense	probably damaging	0.97
R8937:Slc22a26	UTSW	19	7791025	splice site	probably benign
R9059:Slc22a26	UTSW	19	7785194	missense	probably benign	0.01
R9659:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02
R9788:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02

Posted On

2015-04-16