Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02502:Slc22a26'

296131

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc22a26

Ensembl Gene

ENSMUSG00000053303

Gene Name

solute carrier family 22 (organic cation transporter), member 26

Synonyms

BC014805

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL02502

Quality Score

Status

Chromosome

Chromosomal Location

7758406-7780032 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to T at 7768125 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113607 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065634] [ENSMUST00000120522]

AlphaFold

Q91WJ2

Predicted Effect

probably null
Transcript: ENSMUST00000065634

SMART Domains

Protein: ENSMUSP00000064809
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	96	528	1.1e-23	PFAM
Pfam:MFS_1	124	370	7.8e-17	PFAM
Pfam:MFS_1	350	547	2.1e-12	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000120522

SMART Domains

Protein: ENSMUSP00000113607
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	94	527	4.9e-23	PFAM
Pfam:MFS_1	124	358	1.2e-15	PFAM
Pfam:MFS_1	349	547	2.4e-12	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acoxl	A	G	2: 127,917,804 (GRCm39)	N216S	probably damaging	Het
Akap12	A	G	10: 4,303,163 (GRCm39)	D96G	probably damaging	Het
Akna	A	G	4: 63,286,440 (GRCm39)	V1353A	probably benign	Het
Ambra1	A	G	2: 91,730,877 (GRCm39)	D914G	probably damaging	Het
Ap1s3	A	G	1: 79,601,439 (GRCm39)	V84A	possibly damaging	Het
Arhgef6	T	C	X: 56,325,623 (GRCm39)	E282G	probably damaging	Het
C2cd2	G	T	16: 97,677,590 (GRCm39)	S378Y	possibly damaging	Het
Cd101	C	A	3: 100,919,141 (GRCm39)	A654S	probably damaging	Het
Cep295	A	C	9: 15,262,209 (GRCm39)		probably benign	Het
Csn1s1	A	G	5: 87,828,784 (GRCm39)	I283V	probably benign	Het
Cst3	A	G	2: 148,717,065 (GRCm39)		probably benign	Het
Cyp2b9	T	C	7: 25,887,239 (GRCm39)		probably null	Het
Dffb	A	G	4: 154,050,073 (GRCm39)		probably benign	Het
Dnah10	A	G	5: 124,898,351 (GRCm39)	Y3711C	probably damaging	Het
Eif4g2	T	C	7: 110,680,748 (GRCm39)	S3G	probably damaging	Het
Erbb3	C	T	10: 128,406,153 (GRCm39)	R1088H	probably benign	Het
Evpl	T	C	11: 116,113,544 (GRCm39)	D1382G	probably damaging	Het
Fam168a	A	G	7: 100,473,417 (GRCm39)	D102G	probably damaging	Het
Fbxo7	A	G	10: 85,869,161 (GRCm39)	Y284C	probably damaging	Het
G6pd2	T	C	5: 61,966,971 (GRCm39)	Y249H	probably damaging	Het
Gm1123	A	T	9: 98,891,443 (GRCm39)	Y335*	probably null	Het
Gm5624	C	T	14: 44,797,296 (GRCm39)		probably null	Het
Hectd1	A	T	12: 51,844,635 (GRCm39)	M536K	possibly damaging	Het
Ikbkg	T	A	X: 73,487,433 (GRCm39)	V334E	probably benign	Het
Ipo7	T	C	7: 109,650,257 (GRCm39)	L769P	probably damaging	Het
Jmjd1c	A	T	10: 67,061,640 (GRCm39)	K1331I	probably benign	Het
Krt32	T	C	11: 99,978,749 (GRCm39)	K102E	probably damaging	Het
Lrrc34	A	T	3: 30,699,394 (GRCm39)	N20K	probably benign	Het
Lrrc47	A	G	4: 154,100,471 (GRCm39)	E349G	probably benign	Het
Mdn1	A	G	4: 32,670,579 (GRCm39)	I415V	possibly damaging	Het
Myh10	A	G	11: 68,705,198 (GRCm39)		probably null	Het
Nbeal2	A	G	9: 110,462,836 (GRCm39)	S1376P	probably damaging	Het
Nfx1	T	C	4: 40,976,345 (GRCm39)		probably benign	Het
Nherf4	G	A	9: 44,160,948 (GRCm39)	A206V	probably benign	Het
Notch3	A	T	17: 32,377,252 (GRCm39)	C246*	probably null	Het
Nr3c2	A	G	8: 77,969,143 (GRCm39)	Y976C	probably damaging	Het
Or51b17	A	G	7: 103,542,696 (GRCm39)	V82A	probably damaging	Het
Or52n4b	T	A	7: 108,143,846 (GRCm39)	M36K	probably damaging	Het
Or5b122	A	G	19: 13,563,112 (GRCm39)	Y105C	probably damaging	Het
P2rx7	C	T	5: 122,819,050 (GRCm39)	R491C	possibly damaging	Het
Phex	T	A	X: 155,966,823 (GRCm39)	Y625F	possibly damaging	Het
Pkhd1	T	C	1: 20,462,389 (GRCm39)	D2055G	probably damaging	Het
Pmm2	T	C	16: 8,463,227 (GRCm39)		probably benign	Het
Prdm15	T	C	16: 97,640,539 (GRCm39)	D16G	probably damaging	Het
Prune2	T	A	19: 17,101,245 (GRCm39)	C2250S	probably benign	Het
Rasgef1a	T	A	6: 118,057,443 (GRCm39)	F48Y	probably benign	Het
Rhoq	T	C	17: 87,271,077 (GRCm39)	V15A	probably damaging	Het
Rnf216	G	A	5: 143,054,622 (GRCm39)	A585V	probably damaging	Het
Septin9	T	A	11: 117,181,488 (GRCm39)	I96N	probably damaging	Het
Shprh	T	A	10: 11,070,101 (GRCm39)	D1492E	possibly damaging	Het
Tek	T	G	4: 94,741,818 (GRCm39)		probably null	Het
Tenm3	T	C	8: 48,741,051 (GRCm39)	E782G	probably damaging	Het
Trmt5	A	G	12: 73,328,001 (GRCm39)	C401R	probably benign	Het
Tspear	T	G	10: 77,688,792 (GRCm39)		probably benign	Het
Ubr5	G	A	15: 38,030,933 (GRCm39)	T414I	probably benign	Het
Vcl	A	T	14: 21,069,453 (GRCm39)	T710S	probably damaging	Het
Vmn2r25	A	T	6: 123,816,392 (GRCm39)	D396E	probably damaging	Het
Wtip	A	G	7: 33,818,094 (GRCm39)		probably null	Het
Zap70	A	G	1: 36,817,887 (GRCm39)		probably benign	Het

Other mutations in Slc22a26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Slc22a26	APN	19	7,760,201 (GRCm39)	missense	probably damaging	0.99
IGL00338:Slc22a26	APN	19	7,760,340 (GRCm39)	missense	probably benign	0.25
IGL00736:Slc22a26	APN	19	7,767,527 (GRCm39)	missense	possibly damaging	0.50
IGL01085:Slc22a26	APN	19	7,767,464 (GRCm39)	missense	probably benign	0.02
IGL01581:Slc22a26	APN	19	7,779,549 (GRCm39)	missense	probably benign	0.15
IGL02658:Slc22a26	APN	19	7,765,613 (GRCm39)	missense	probably benign	0.25
IGL02936:Slc22a26	APN	19	7,768,470 (GRCm39)	missense	probably damaging	0.99
IGL03162:Slc22a26	APN	19	7,779,466 (GRCm39)	missense	probably benign	0.00
R0034:Slc22a26	UTSW	19	7,779,618 (GRCm39)	missense	probably benign	0.03
R0633:Slc22a26	UTSW	19	7,765,575 (GRCm39)	critical splice donor site	probably null
R0676:Slc22a26	UTSW	19	7,773,509 (GRCm39)	splice site	probably benign
R2156:Slc22a26	UTSW	19	7,779,480 (GRCm39)	missense	probably damaging	1.00
R4043:Slc22a26	UTSW	19	7,765,694 (GRCm39)	critical splice acceptor site	probably null
R4781:Slc22a26	UTSW	19	7,767,500 (GRCm39)	missense	probably benign	0.34
R4896:Slc22a26	UTSW	19	7,768,419 (GRCm39)	missense	probably benign	0.14
R4999:Slc22a26	UTSW	19	7,779,546 (GRCm39)	missense	probably damaging	1.00
R5125:Slc22a26	UTSW	19	7,767,540 (GRCm39)	missense	possibly damaging	0.62
R5178:Slc22a26	UTSW	19	7,767,540 (GRCm39)	missense	possibly damaging	0.62
R6161:Slc22a26	UTSW	19	7,763,812 (GRCm39)	missense	possibly damaging	0.50
R6494:Slc22a26	UTSW	19	7,779,651 (GRCm39)	missense	probably damaging	1.00
R6512:Slc22a26	UTSW	19	7,779,865 (GRCm39)	start gained	probably benign
R6724:Slc22a26	UTSW	19	7,779,726 (GRCm39)	missense	probably benign	0.14
R7323:Slc22a26	UTSW	19	7,768,259 (GRCm39)	missense	probably damaging	0.97
R7375:Slc22a26	UTSW	19	7,760,509 (GRCm39)	splice site	probably null
R7558:Slc22a26	UTSW	19	7,762,651 (GRCm39)	missense	possibly damaging	0.94
R7634:Slc22a26	UTSW	19	7,779,952 (GRCm39)	splice site	probably null
R8772:Slc22a26	UTSW	19	7,767,477 (GRCm39)	missense	probably benign	0.27
R8905:Slc22a26	UTSW	19	7,760,331 (GRCm39)	missense	probably damaging	0.97
R8937:Slc22a26	UTSW	19	7,768,390 (GRCm39)	splice site	probably benign
R9059:Slc22a26	UTSW	19	7,762,559 (GRCm39)	missense	probably benign	0.01
R9659:Slc22a26	UTSW	19	7,763,798 (GRCm39)	missense	probably benign	0.02
R9788:Slc22a26	UTSW	19	7,763,798 (GRCm39)	missense	probably benign	0.02

Posted On

2015-04-16