Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02503:Vmn2r10'

296136

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r10

Ensembl Gene

ENSMUSG00000067010

Gene Name

vomeronasal 2, receptor 10

Synonyms

V2r16, VR16

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL02503

Quality Score

Status

Chromosome

Chromosomal Location

108993412-109006471 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 109003475 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 91 (Y91C)

Ref Sequence

ENSEMBL: ENSMUSP00000078162 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]

AlphaFold

K7N621

Predicted Effect

probably damaging
Transcript: ENSMUST00000079163
AA Change: Y91C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: Y91C

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	8.5e-29	PFAM
Pfam:NCD3G	506	560	3.8e-17	PFAM
Pfam:7tm_3	593	828	4e-55	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176594

SMART Domains

Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy4	A	T	14: 55,771,505	W822R	probably damaging	Het
Ago4	A	T	4: 126,496,805	Y807*	probably null	Het
Alkbh8	G	A	9: 3,347,852	G215D	probably damaging	Het
Cfap57	C	T	4: 118,569,348		probably null	Het
Cspg4	G	A	9: 56,897,403	V1833M	probably damaging	Het
Cyp4f17	T	C	17: 32,524,966		probably null	Het
Dapk1	T	A	13: 60,761,807	Y1411*	probably null	Het
Dmrtc1b	T	A	X: 102,714,760	S199T	possibly damaging	Het
Elk4	A	G	1: 132,014,539	N50D	probably damaging	Het
Filip1l	T	A	16: 57,571,575	V604E	probably benign	Het
Fmo3	A	T	1: 162,968,864	H46Q	probably benign	Het
Fndc1	T	A	17: 7,771,516	Y1116F	unknown	Het
Fpr-rs3	T	A	17: 20,624,555	N108I	probably damaging	Het
Glmn	A	T	5: 107,562,778	M316K	probably damaging	Het
Gm5591	C	A	7: 38,520,009	R480I	probably damaging	Het
Gm8122	G	T	14: 43,235,188	R39S	unknown	Het
Gprasp1	T	A	X: 135,802,530	Y1157*	probably null	Het
Hist2h2be	A	G	3: 96,221,223	T20A	probably benign	Het
Hsf1	T	C	15: 76,498,670	L370P	probably benign	Het
Iqsec1	T	A	6: 90,668,788	I809F	probably damaging	Het
Itsn1	G	T	16: 91,889,204	M54I	possibly damaging	Het
Klra2	T	C	6: 131,230,094	N184S	probably benign	Het
Lifr	T	A	15: 7,185,623	V737E	probably damaging	Het
Lrpprc	T	C	17: 84,726,339	T1037A	probably benign	Het
Map3k13	A	T	16: 21,908,704	I439F	possibly damaging	Het
Megf8	T	C	7: 25,363,563	V2448A	possibly damaging	Het
Mthfd1l	T	A	10: 4,083,824	V737D	probably damaging	Het
Mtm1	A	G	X: 71,299,670	T386A	probably damaging	Het
Muc5b	T	C	7: 141,867,667	V4298A	probably benign	Het
Olfr1053	C	T	2: 86,314,639	G216R	possibly damaging	Het
Olfr1123	T	G	2: 87,418,292	F81L	probably benign	Het
Olfr1143	A	T	2: 87,802,520	I44F	probably benign	Het
Plch1	A	G	3: 63,697,864	S1531P	probably damaging	Het
Poc1b	T	A	10: 99,144,348		probably benign	Het
Rictor	T	A	15: 6,786,443	N1065K	probably benign	Het
Rpsa	A	G	9: 120,128,593	E35G	possibly damaging	Het
Scfd1	T	A	12: 51,422,921	D416E	possibly damaging	Het
Sdad1	A	T	5: 92,301,802		probably benign	Het
Skor1	A	G	9: 63,146,115	S191P	probably damaging	Het
Slc28a2	T	C	2: 122,458,212	F600L	probably benign	Het
Tmem229b-ps	A	G	10: 53,475,154		noncoding transcript	Het
Top2b	A	G	14: 16,407,163	M678V	possibly damaging	Het
Ttn	T	C	2: 76,786,763	N8092S	probably damaging	Het
Ttn	C	T	2: 76,741,689	V26287I	probably damaging	Het
Tulp4	T	A	17: 6,213,391	I345N	probably damaging	Het
U2surp	C	T	9: 95,502,569	V21I	probably benign	Het
Ubr5	T	C	15: 38,018,320	T859A	possibly damaging	Het
Ubr5	T	C	15: 38,018,314	K861E	probably damaging	Het
Unc13d	A	G	11: 116,068,802	V617A	possibly damaging	Het
Vmn2r120	T	A	17: 57,509,385	I657F	probably benign	Het
Wwc2	T	C	8: 47,849,383	R931G	unknown	Het

Other mutations in Vmn2r10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00816:Vmn2r10	APN	5	109002585	missense	possibly damaging	0.75
IGL01618:Vmn2r10	APN	5	109002479	missense	probably damaging	1.00
IGL01624:Vmn2r10	APN	5	109006246	missense	possibly damaging	0.83
IGL01941:Vmn2r10	APN	5	108995954	missense	probably damaging	1.00
IGL01959:Vmn2r10	APN	5	108997705	missense	probably benign	0.00
IGL01973:Vmn2r10	APN	5	108995677	missense	probably damaging	1.00
IGL01985:Vmn2r10	APN	5	109006259	missense	probably benign	0.21
IGL02451:Vmn2r10	APN	5	108995922	nonsense	probably null
IGL03275:Vmn2r10	APN	5	109003377	missense	probably benign	0.00
R0035:Vmn2r10	UTSW	5	108997601	splice site	probably benign
R0395:Vmn2r10	UTSW	5	109001993	missense	probably damaging	1.00
R0454:Vmn2r10	UTSW	5	109003461	missense	probably benign	0.25
R0648:Vmn2r10	UTSW	5	108995916	missense	probably benign	0.00
R1251:Vmn2r10	UTSW	5	108996024	missense	probably benign	0.01
R1580:Vmn2r10	UTSW	5	109006251	missense	possibly damaging	0.82
R1845:Vmn2r10	UTSW	5	109001995	nonsense	probably null
R1986:Vmn2r10	UTSW	5	109006254	nonsense	probably null
R2137:Vmn2r10	UTSW	5	109003544	missense	possibly damaging	0.87
R2495:Vmn2r10	UTSW	5	108996095	missense	probably damaging	1.00
R3932:Vmn2r10	UTSW	5	109002222	missense	possibly damaging	0.47
R3933:Vmn2r10	UTSW	5	109002222	missense	possibly damaging	0.47
R4899:Vmn2r10	UTSW	5	109003458	missense	probably damaging	1.00
R4992:Vmn2r10	UTSW	5	108997726	missense	possibly damaging	0.89
R5124:Vmn2r10	UTSW	5	109006420	missense	probably benign	0.01
R5145:Vmn2r10	UTSW	5	108995895	missense	possibly damaging	0.64
R5156:Vmn2r10	UTSW	5	108995600	missense	probably benign	0.11
R5265:Vmn2r10	UTSW	5	108995720	missense	probably damaging	1.00
R5311:Vmn2r10	UTSW	5	109006255	missense	probably damaging	1.00
R5321:Vmn2r10	UTSW	5	108995639	missense	probably damaging	1.00
R5666:Vmn2r10	UTSW	5	108999044	nonsense	probably null
R5670:Vmn2r10	UTSW	5	108999044	nonsense	probably null
R5872:Vmn2r10	UTSW	5	109003511	missense	possibly damaging	0.84
R6004:Vmn2r10	UTSW	5	108999078	missense	probably benign	0.30
R6108:Vmn2r10	UTSW	5	108995801	missense	probably damaging	1.00
R6332:Vmn2r10	UTSW	5	109003462	missense	probably damaging	1.00
R6599:Vmn2r10	UTSW	5	108996078	missense	probably benign	0.09
R6651:Vmn2r10	UTSW	5	108995622	missense	probably null	0.22
R6891:Vmn2r10	UTSW	5	109001979	missense	probably damaging	1.00
R7023:Vmn2r10	UTSW	5	109002028	missense	probably damaging	0.96
R7146:Vmn2r10	UTSW	5	109003334	missense	probably damaging	1.00
R7941:Vmn2r10	UTSW	5	108996440	missense	probably damaging	1.00
R8058:Vmn2r10	UTSW	5	109002089	missense	probably benign	0.00
R8478:Vmn2r10	UTSW	5	108995770	missense	probably damaging	1.00
R8526:Vmn2r10	UTSW	5	108997706	missense	possibly damaging	0.51
R8698:Vmn2r10	UTSW	5	109003524	missense	probably benign	0.00
R8796:Vmn2r10	UTSW	5	108996051	missense	possibly damaging	0.74
R8854:Vmn2r10	UTSW	5	108996260	missense	probably benign	0.20
R8871:Vmn2r10	UTSW	5	108999033	missense	possibly damaging	0.67
R8893:Vmn2r10	UTSW	5	108995811	missense	probably benign	0.09
R8907:Vmn2r10	UTSW	5	109001925	missense	probably benign
R8957:Vmn2r10	UTSW	5	109001914	missense	possibly damaging	0.60
R8976:Vmn2r10	UTSW	5	108997613	missense	probably damaging	1.00
R9155:Vmn2r10	UTSW	5	108996346	missense	probably benign	0.10
R9308:Vmn2r10	UTSW	5	108997610	nonsense	probably null
R9800:Vmn2r10	UTSW	5	109002538	missense	probably damaging	0.99
Z1088:Vmn2r10	UTSW	5	108996113	missense	probably damaging	1.00
Z1176:Vmn2r10	UTSW	5	109001988	missense	probably damaging	1.00

Posted On

2015-04-16