Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02503:Or10ag2'

296148

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10ag2

Ensembl Gene

ENSMUSG00000043274

Gene Name

olfactory receptor family 10 subfamily AG member 2

Synonyms

Olfr1123, MOR264-17, GA_x6K02T2Q125-48917235-48918206

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.281) question?

Stock #

IGL02503

Quality Score

Status

Chromosome

Chromosomal Location

87248394-87249365 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 87248636 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 81 (F81L)

Ref Sequence

ENSEMBL: ENSMUSP00000058786 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054974] [ENSMUST00000216208]

AlphaFold

A2AT85

Predicted Effect

probably benign
Transcript: ENSMUST00000054974
AA Change: F81L

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000058786
Gene: ENSMUSG00000043274
AA Change: F81L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	44	321	4.4e-52	PFAM
Pfam:7tm_1	54	303	2.6e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213950

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214663

Predicted Effect

probably benign
Transcript: ENSMUST00000216208
AA Change: F79L

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy4	A	T	14: 56,008,962 (GRCm39)	W822R	probably damaging	Het
Ago4	A	T	4: 126,390,598 (GRCm39)	Y807*	probably null	Het
Alkbh8	G	A	9: 3,347,852 (GRCm39)	G215D	probably damaging	Het
Cfap57	C	T	4: 118,426,545 (GRCm39)		probably null	Het
Cspg4	G	A	9: 56,804,687 (GRCm39)	V1833M	probably damaging	Het
Cyp4f17	T	C	17: 32,743,940 (GRCm39)		probably null	Het
Dapk1	T	A	13: 60,909,621 (GRCm39)	Y1411*	probably null	Het
Dmrtc1b	T	A	X: 101,758,366 (GRCm39)	S199T	possibly damaging	Het
Elk4	A	G	1: 131,942,277 (GRCm39)	N50D	probably damaging	Het
Filip1l	T	A	16: 57,391,938 (GRCm39)	V604E	probably benign	Het
Fmo3	A	T	1: 162,796,433 (GRCm39)	H46Q	probably benign	Het
Fndc1	T	A	17: 7,990,348 (GRCm39)	Y1116F	unknown	Het
Fpr-rs3	T	A	17: 20,844,817 (GRCm39)	N108I	probably damaging	Het
Glmn	A	T	5: 107,710,644 (GRCm39)	M316K	probably damaging	Het
Gm5591	C	A	7: 38,219,433 (GRCm39)	R480I	probably damaging	Het
Gm8122	G	T	14: 43,092,645 (GRCm39)	R39S	unknown	Het
Gprasp1	T	A	X: 134,703,279 (GRCm39)	Y1157*	probably null	Het
H2bc21	A	G	3: 96,128,539 (GRCm39)	T20A	probably benign	Het
Hsf1	T	C	15: 76,382,870 (GRCm39)	L370P	probably benign	Het
Iqsec1	T	A	6: 90,645,770 (GRCm39)	I809F	probably damaging	Het
Itsn1	G	T	16: 91,686,092 (GRCm39)	M54I	possibly damaging	Het
Klra2	T	C	6: 131,207,057 (GRCm39)	N184S	probably benign	Het
Lifr	T	A	15: 7,215,104 (GRCm39)	V737E	probably damaging	Het
Lrpprc	T	C	17: 85,033,767 (GRCm39)	T1037A	probably benign	Het
Map3k13	A	T	16: 21,727,454 (GRCm39)	I439F	possibly damaging	Het
Megf8	T	C	7: 25,062,988 (GRCm39)	V2448A	possibly damaging	Het
Mthfd1l	T	A	10: 4,033,824 (GRCm39)	V737D	probably damaging	Het
Mtm1	A	G	X: 70,343,276 (GRCm39)	T386A	probably damaging	Het
Muc5b	T	C	7: 141,421,404 (GRCm39)	V4298A	probably benign	Het
Or5w18	A	T	2: 87,632,864 (GRCm39)	I44F	probably benign	Het
Or8k21	C	T	2: 86,144,983 (GRCm39)	G216R	possibly damaging	Het
Plch1	A	G	3: 63,605,285 (GRCm39)	S1531P	probably damaging	Het
Poc1b	T	A	10: 98,980,210 (GRCm39)		probably benign	Het
Rictor	T	A	15: 6,815,924 (GRCm39)	N1065K	probably benign	Het
Rpsa	A	G	9: 119,957,659 (GRCm39)	E35G	possibly damaging	Het
Scfd1	T	A	12: 51,469,704 (GRCm39)	D416E	possibly damaging	Het
Sdad1	A	T	5: 92,449,661 (GRCm39)		probably benign	Het
Skor1	A	G	9: 63,053,397 (GRCm39)	S191P	probably damaging	Het
Slc28a2	T	C	2: 122,288,693 (GRCm39)	F600L	probably benign	Het
Tmem229b-ps	A	G	10: 53,351,250 (GRCm39)		noncoding transcript	Het
Top2b	A	G	14: 16,407,163 (GRCm38)	M678V	possibly damaging	Het
Ttn	T	C	2: 76,617,107 (GRCm39)	N8092S	probably damaging	Het
Ttn	C	T	2: 76,572,033 (GRCm39)	V26287I	probably damaging	Het
Tulp4	T	A	17: 6,263,666 (GRCm39)	I345N	probably damaging	Het
U2surp	C	T	9: 95,384,622 (GRCm39)	V21I	probably benign	Het
Ubr5	T	C	15: 38,018,564 (GRCm39)	T859A	possibly damaging	Het
Ubr5	T	C	15: 38,018,558 (GRCm39)	K861E	probably damaging	Het
Unc13d	A	G	11: 115,959,628 (GRCm39)	V617A	possibly damaging	Het
Vmn2r10	T	C	5: 109,151,341 (GRCm39)	Y91C	probably damaging	Het
Vmn2r120	T	A	17: 57,816,385 (GRCm39)	I657F	probably benign	Het
Wwc2	T	C	8: 48,302,418 (GRCm39)	R931G	unknown	Het

Other mutations in Or10ag2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00231:Or10ag2	APN	2	87,248,910 (GRCm39)	missense	possibly damaging	0.75
IGL01067:Or10ag2	APN	2	87,248,714 (GRCm39)	missense	probably benign	0.00
IGL01526:Or10ag2	APN	2	87,249,319 (GRCm39)	missense	probably damaging	0.99
IGL01580:Or10ag2	APN	2	87,248,880 (GRCm39)	missense	probably benign	0.06
IGL01986:Or10ag2	APN	2	87,248,880 (GRCm39)	missense	probably benign	0.00
IGL02527:Or10ag2	APN	2	87,249,181 (GRCm39)	missense	probably damaging	1.00
IGL02731:Or10ag2	APN	2	87,249,051 (GRCm39)	missense	probably benign	0.00
IGL03215:Or10ag2	APN	2	87,248,412 (GRCm39)	missense	probably benign	0.05
IGL03366:Or10ag2	APN	2	87,248,587 (GRCm39)	missense	possibly damaging	0.88
R0645:Or10ag2	UTSW	2	87,248,612 (GRCm39)	nonsense	probably null
R1857:Or10ag2	UTSW	2	87,248,992 (GRCm39)	missense	probably damaging	1.00
R2175:Or10ag2	UTSW	2	87,248,500 (GRCm39)	missense	probably damaging	1.00
R3691:Or10ag2	UTSW	2	87,248,514 (GRCm39)	missense	probably benign	0.20
R4082:Or10ag2	UTSW	2	87,248,801 (GRCm39)	nonsense	probably null
R4635:Or10ag2	UTSW	2	87,249,043 (GRCm39)	missense	probably benign	0.05
R4877:Or10ag2	UTSW	2	87,248,907 (GRCm39)	nonsense	probably null
R5190:Or10ag2	UTSW	2	87,249,187 (GRCm39)	missense	probably damaging	1.00
R5253:Or10ag2	UTSW	2	87,249,012 (GRCm39)	missense	possibly damaging	0.64
R6266:Or10ag2	UTSW	2	87,249,350 (GRCm39)	missense	probably benign	0.01
R6784:Or10ag2	UTSW	2	87,248,796 (GRCm39)	missense	probably benign	0.20
R6909:Or10ag2	UTSW	2	87,248,959 (GRCm39)	missense	probably damaging	1.00
R7255:Or10ag2	UTSW	2	87,249,286 (GRCm39)	missense	probably damaging	0.96
R8076:Or10ag2	UTSW	2	87,248,889 (GRCm39)	missense	probably benign	0.00
R8116:Or10ag2	UTSW	2	87,249,081 (GRCm39)	missense	probably damaging	1.00
R8315:Or10ag2	UTSW	2	87,248,995 (GRCm39)	missense	probably damaging	1.00
R8888:Or10ag2	UTSW	2	87,248,659 (GRCm39)	missense	probably benign	0.00
R8895:Or10ag2	UTSW	2	87,248,659 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16