Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02503:Sdad1'

296186

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sdad1

Ensembl Gene

ENSMUSG00000029415

Gene Name

SDA1 domain containing 1

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.968) question?

Stock #

IGL02503

Quality Score

Status

Chromosome

Chromosomal Location

92284010-92310479 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to T at 92301802 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000144014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031364] [ENSMUST00000201143] [ENSMUST00000202870]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000031364

SMART Domains

Protein: ENSMUSP00000031364
Gene: ENSMUSG00000029415

Domain	Start	End	E-Value	Type
Pfam:NUC130_3NT	62	113	3.3e-28	PFAM
low complexity region	116	126	N/A	INTRINSIC
low complexity region	146	163	N/A	INTRINSIC
low complexity region	224	239	N/A	INTRINSIC
low complexity region	254	278	N/A	INTRINSIC
Pfam:SDA1	409	532	2.4e-41	PFAM
Pfam:SDA1	519	685	2.8e-36	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000157998

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000201084

Predicted Effect

probably benign
Transcript: ENSMUST00000201143

SMART Domains

Protein: ENSMUSP00000144446
Gene: ENSMUSG00000029415

Domain	Start	End	E-Value	Type
Pfam:NUC130_3NT	62	113	5.3e-24	PFAM
low complexity region	116	126	N/A	INTRINSIC
low complexity region	146	163	N/A	INTRINSIC
low complexity region	224	239	N/A	INTRINSIC
low complexity region	254	277	N/A	INTRINSIC
Pfam:SDA1	408	531	3.9e-37	PFAM
Pfam:SDA1	518	684	4.6e-32	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000201532

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000202604

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000202680

Predicted Effect

probably benign
Transcript: ENSMUST00000202870

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy4	A	T	14: 55,771,505	W822R	probably damaging	Het
Ago4	A	T	4: 126,496,805	Y807*	probably null	Het
Alkbh8	G	A	9: 3,347,852	G215D	probably damaging	Het
Cfap57	C	T	4: 118,569,348		probably null	Het
Cspg4	G	A	9: 56,897,403	V1833M	probably damaging	Het
Cyp4f17	T	C	17: 32,524,966		probably null	Het
Dapk1	T	A	13: 60,761,807	Y1411*	probably null	Het
Dmrtc1b	T	A	X: 102,714,760	S199T	possibly damaging	Het
Elk4	A	G	1: 132,014,539	N50D	probably damaging	Het
Filip1l	T	A	16: 57,571,575	V604E	probably benign	Het
Fmo3	A	T	1: 162,968,864	H46Q	probably benign	Het
Fndc1	T	A	17: 7,771,516	Y1116F	unknown	Het
Fpr-rs3	T	A	17: 20,624,555	N108I	probably damaging	Het
Glmn	A	T	5: 107,562,778	M316K	probably damaging	Het
Gm5591	C	A	7: 38,520,009	R480I	probably damaging	Het
Gm8122	G	T	14: 43,235,188	R39S	unknown	Het
Gprasp1	T	A	X: 135,802,530	Y1157*	probably null	Het
Hist2h2be	A	G	3: 96,221,223	T20A	probably benign	Het
Hsf1	T	C	15: 76,498,670	L370P	probably benign	Het
Iqsec1	T	A	6: 90,668,788	I809F	probably damaging	Het
Itsn1	G	T	16: 91,889,204	M54I	possibly damaging	Het
Klra2	T	C	6: 131,230,094	N184S	probably benign	Het
Lifr	T	A	15: 7,185,623	V737E	probably damaging	Het
Lrpprc	T	C	17: 84,726,339	T1037A	probably benign	Het
Map3k13	A	T	16: 21,908,704	I439F	possibly damaging	Het
Megf8	T	C	7: 25,363,563	V2448A	possibly damaging	Het
Mthfd1l	T	A	10: 4,083,824	V737D	probably damaging	Het
Mtm1	A	G	X: 71,299,670	T386A	probably damaging	Het
Muc5b	T	C	7: 141,867,667	V4298A	probably benign	Het
Olfr1053	C	T	2: 86,314,639	G216R	possibly damaging	Het
Olfr1123	T	G	2: 87,418,292	F81L	probably benign	Het
Olfr1143	A	T	2: 87,802,520	I44F	probably benign	Het
Plch1	A	G	3: 63,697,864	S1531P	probably damaging	Het
Poc1b	T	A	10: 99,144,348		probably benign	Het
Rictor	T	A	15: 6,786,443	N1065K	probably benign	Het
Rpsa	A	G	9: 120,128,593	E35G	possibly damaging	Het
Scfd1	T	A	12: 51,422,921	D416E	possibly damaging	Het
Skor1	A	G	9: 63,146,115	S191P	probably damaging	Het
Slc28a2	T	C	2: 122,458,212	F600L	probably benign	Het
Tmem229b-ps	A	G	10: 53,475,154		noncoding transcript	Het
Top2b	A	G	14: 16,407,163	M678V	possibly damaging	Het
Ttn	T	C	2: 76,786,763	N8092S	probably damaging	Het
Ttn	C	T	2: 76,741,689	V26287I	probably damaging	Het
Tulp4	T	A	17: 6,213,391	I345N	probably damaging	Het
U2surp	C	T	9: 95,502,569	V21I	probably benign	Het
Ubr5	T	C	15: 38,018,320	T859A	possibly damaging	Het
Ubr5	T	C	15: 38,018,314	K861E	probably damaging	Het
Unc13d	A	G	11: 116,068,802	V617A	possibly damaging	Het
Vmn2r10	T	C	5: 109,003,475	Y91C	probably damaging	Het
Vmn2r120	T	A	17: 57,509,385	I657F	probably benign	Het
Wwc2	T	C	8: 47,849,383	R931G	unknown	Het

Other mutations in Sdad1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00786:Sdad1	APN	5	92303773	splice site	probably null
IGL01355:Sdad1	APN	5	92302679	missense	probably damaging	1.00
IGL01635:Sdad1	APN	5	92297160	missense	probably damaging	0.98
IGL02166:Sdad1	APN	5	92291762	missense	probably benign	0.03
IGL02739:Sdad1	APN	5	92290072	missense	probably benign	0.43
PIT4468001:Sdad1	UTSW	5	92291918	missense	probably damaging	1.00
R0583:Sdad1	UTSW	5	92305064	missense	probably damaging	0.97
R1169:Sdad1	UTSW	5	92298233	missense	probably benign	0.32
R1496:Sdad1	UTSW	5	92309823	missense	possibly damaging	0.94
R1844:Sdad1	UTSW	5	92305296	nonsense	probably null
R1848:Sdad1	UTSW	5	92292651	critical splice donor site	probably null
R2419:Sdad1	UTSW	5	92305818	missense	possibly damaging	0.69
R2497:Sdad1	UTSW	5	92300099	missense	probably benign	0.00
R2509:Sdad1	UTSW	5	92305825	missense	probably benign	0.12
R4043:Sdad1	UTSW	5	92302694	missense	probably damaging	0.96
R4384:Sdad1	UTSW	5	92298257	missense	probably benign	0.01
R4477:Sdad1	UTSW	5	92297160	missense	probably damaging	0.98
R4478:Sdad1	UTSW	5	92297160	missense	probably damaging	0.98
R4734:Sdad1	UTSW	5	92304977	missense	possibly damaging	0.61
R4749:Sdad1	UTSW	5	92304977	missense	possibly damaging	0.61
R5135:Sdad1	UTSW	5	92303934	missense	probably benign	0.00
R5288:Sdad1	UTSW	5	92286825	makesense	probably null
R6331:Sdad1	UTSW	5	92303930	missense	probably damaging	1.00
R7038:Sdad1	UTSW	5	92298190	critical splice donor site	probably null
R7099:Sdad1	UTSW	5	92293973	missense	possibly damaging	0.89
R7420:Sdad1	UTSW	5	92305737	missense	possibly damaging	0.91
R7425:Sdad1	UTSW	5	92300121	missense	probably benign	0.10
R7714:Sdad1	UTSW	5	92302679	missense	probably damaging	1.00
R8048:Sdad1	UTSW	5	92300089	missense	probably benign	0.01
R8198:Sdad1	UTSW	5	92291952	missense	probably damaging	0.96
R8347:Sdad1	UTSW	5	92298229	missense	probably benign	0.00
R8693:Sdad1	UTSW	5	92304998	missense	probably benign	0.09
R8696:Sdad1	UTSW	5	92289786	missense	probably damaging	1.00
R8746:Sdad1	UTSW	5	92289925	missense	probably benign
R9004:Sdad1	UTSW	5	92291961	missense	probably benign	0.00
R9166:Sdad1	UTSW	5	92298221	nonsense	probably null
R9732:Sdad1	UTSW	5	92291083	missense	probably benign	0.00

Posted On

2015-04-16