Incidental Mutation 'IGL02504:Cyp3a25'
ID 296189
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp3a25
Ensembl Gene ENSMUSG00000029630
Gene Name cytochrome P450, family 3, subfamily a, polypeptide 25
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL02504
Quality Score
Status
Chromosome 5
Chromosomal Location 145914004-145946428 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 145930141 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 155 (I155L)
Ref Sequence ENSEMBL: ENSMUSP00000065585 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068317] [ENSMUST00000138870] [ENSMUST00000145062]
AlphaFold O09158
Predicted Effect probably benign
Transcript: ENSMUST00000068317
AA Change: I155L

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000065585
Gene: ENSMUSG00000029630
AA Change: I155L

DomainStartEndE-ValueType
Pfam:p450 38 493 9.4e-129 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138870
SMART Domains Protein: ENSMUSP00000116077
Gene: ENSMUSG00000029630

DomainStartEndE-ValueType
Pfam:p450 38 126 2e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000145062
SMART Domains Protein: ENSMUSP00000123615
Gene: ENSMUSG00000029630

DomainStartEndE-ValueType
Pfam:p450 38 148 3.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153808
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago4 T A 4: 126,411,232 (GRCm39) N142I probably benign Het
Asf1b A G 8: 84,682,458 (GRCm39) M1V probably null Het
Astn1 T C 1: 158,329,978 (GRCm39) C278R probably damaging Het
Ccdc162 A T 10: 41,428,384 (GRCm39) L692Q probably damaging Het
Cd207 T A 6: 83,654,788 (GRCm39) probably benign Het
Chd5 T A 4: 152,447,779 (GRCm39) N548K probably damaging Het
Col7a1 G A 9: 108,809,743 (GRCm39) G2659D unknown Het
Cpa6 A T 1: 10,559,144 (GRCm39) Y75N probably benign Het
Cspg4 G T 9: 56,793,056 (GRCm39) V264L probably benign Het
Dock6 A G 9: 21,757,951 (GRCm39) I51T probably benign Het
Dse G T 10: 34,028,796 (GRCm39) Q765K probably benign Het
Fam219b A T 9: 57,445,351 (GRCm39) M87L probably benign Het
Fat3 G A 9: 15,871,094 (GRCm39) R3766C probably damaging Het
Fcnb A C 2: 27,966,606 (GRCm39) M309R probably damaging Het
Fnbp4 C A 2: 90,598,887 (GRCm39) N670K probably damaging Het
Fsip2 T A 2: 82,809,199 (GRCm39) N1839K possibly damaging Het
G6pc2 A G 2: 69,056,939 (GRCm39) H195R probably damaging Het
Gm14179 A T 11: 99,634,003 (GRCm39) Het
Grm5 A G 7: 87,779,980 (GRCm39) N1172S probably benign Het
Hsd17b14 A G 7: 45,205,799 (GRCm39) T64A possibly damaging Het
Hspb7 G T 4: 141,149,131 (GRCm39) E12D probably benign Het
Kdm2a T C 19: 4,406,799 (GRCm39) N155D possibly damaging Het
Klhl24 A T 16: 19,934,693 (GRCm39) R389* probably null Het
Kmt2b A G 7: 30,285,968 (GRCm39) probably benign Het
Krt4 T A 15: 101,827,727 (GRCm39) I469F unknown Het
Mto1 A T 9: 78,368,209 (GRCm39) D451V probably damaging Het
Muc5b A T 7: 141,400,177 (GRCm39) D477V unknown Het
Pcsk5 A G 19: 17,455,236 (GRCm39) probably null Het
Ppil4 T A 10: 7,696,748 (GRCm39) Y420* probably null Het
Ppp2r5d A T 17: 47,011,019 (GRCm39) D27E probably benign Het
Prkd2 T C 7: 16,591,757 (GRCm39) L596P probably damaging Het
Prr30 T C 14: 101,436,056 (GRCm39) I169V probably benign Het
Rtl9 A T X: 141,885,287 (GRCm39) T900S probably benign Het
Sash1 A G 10: 8,605,676 (GRCm39) S905P probably benign Het
Scn2a G A 2: 65,514,228 (GRCm39) G304D probably benign Het
Scp2d1 T C 2: 144,665,877 (GRCm39) L72P probably damaging Het
Septin2 T A 1: 93,428,203 (GRCm39) H166Q probably benign Het
Sgcb A G 5: 73,801,718 (GRCm39) I49T probably damaging Het
Smyd4 T A 11: 75,281,507 (GRCm39) W327R probably damaging Het
Sptbn1 C T 11: 30,092,293 (GRCm39) E491K probably damaging Het
Tcaf1 A T 6: 42,656,213 (GRCm39) H254Q probably benign Het
Tll1 A C 8: 64,523,271 (GRCm39) D480E possibly damaging Het
Tlr3 G A 8: 45,850,944 (GRCm39) T127M probably damaging Het
Trio A T 15: 27,847,476 (GRCm39) C929* probably null Het
Ttn C T 2: 76,628,494 (GRCm39) W12809* probably null Het
Ugt2b35 T A 5: 87,149,400 (GRCm39) M217K possibly damaging Het
Unc13b T C 4: 43,263,031 (GRCm39) V4261A probably damaging Het
Uqcrc2 T C 7: 120,242,254 (GRCm39) I82T probably benign Het
Usp21 A G 1: 171,112,596 (GRCm39) I266T probably benign Het
Veph1 A T 3: 66,079,551 (GRCm39) H321Q probably damaging Het
Vmn1r29 A C 6: 58,284,655 (GRCm39) Y125S probably benign Het
Other mutations in Cyp3a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Cyp3a25 APN 5 145,938,273 (GRCm39) nonsense probably null
IGL00430:Cyp3a25 APN 5 145,930,170 (GRCm39) missense probably damaging 1.00
IGL00803:Cyp3a25 APN 5 145,938,253 (GRCm39) splice site probably benign
IGL00928:Cyp3a25 APN 5 145,923,764 (GRCm39) missense possibly damaging 0.94
IGL01557:Cyp3a25 APN 5 145,921,711 (GRCm39) missense probably damaging 1.00
IGL01997:Cyp3a25 APN 5 145,931,766 (GRCm39) missense possibly damaging 0.92
IGL02140:Cyp3a25 APN 5 145,946,273 (GRCm39) splice site probably benign
IGL02267:Cyp3a25 APN 5 145,935,362 (GRCm39) missense possibly damaging 0.48
IGL02272:Cyp3a25 APN 5 145,930,075 (GRCm39) intron probably benign
IGL02327:Cyp3a25 APN 5 145,923,731 (GRCm39) missense possibly damaging 0.50
IGL02411:Cyp3a25 APN 5 145,938,257 (GRCm39) critical splice donor site probably benign
IGL02653:Cyp3a25 APN 5 145,939,920 (GRCm39) missense possibly damaging 0.95
R0378:Cyp3a25 UTSW 5 145,923,652 (GRCm39) missense probably damaging 1.00
R0403:Cyp3a25 UTSW 5 145,935,323 (GRCm39) missense probably damaging 1.00
R0685:Cyp3a25 UTSW 5 145,935,356 (GRCm39) missense probably damaging 1.00
R0725:Cyp3a25 UTSW 5 145,931,746 (GRCm39) missense probably damaging 1.00
R0798:Cyp3a25 UTSW 5 145,928,343 (GRCm39) missense probably damaging 0.98
R1061:Cyp3a25 UTSW 5 145,923,643 (GRCm39) missense probably benign
R1519:Cyp3a25 UTSW 5 145,938,257 (GRCm39) critical splice donor site probably null
R1628:Cyp3a25 UTSW 5 145,938,273 (GRCm39) nonsense probably null
R1822:Cyp3a25 UTSW 5 145,921,763 (GRCm39) missense probably damaging 1.00
R1824:Cyp3a25 UTSW 5 145,921,763 (GRCm39) missense probably damaging 1.00
R1864:Cyp3a25 UTSW 5 145,931,739 (GRCm39) missense probably damaging 0.98
R2062:Cyp3a25 UTSW 5 145,923,779 (GRCm39) splice site probably benign
R2401:Cyp3a25 UTSW 5 145,923,778 (GRCm39) critical splice acceptor site probably null
R2516:Cyp3a25 UTSW 5 145,939,837 (GRCm39) splice site probably null
R3080:Cyp3a25 UTSW 5 145,935,341 (GRCm39) missense probably benign 0.33
R3236:Cyp3a25 UTSW 5 145,939,938 (GRCm39) splice site probably benign
R3694:Cyp3a25 UTSW 5 145,926,786 (GRCm39) splice site probably null
R3730:Cyp3a25 UTSW 5 145,939,891 (GRCm39) missense probably damaging 1.00
R4112:Cyp3a25 UTSW 5 145,939,841 (GRCm39) missense probably benign 0.18
R4258:Cyp3a25 UTSW 5 145,928,248 (GRCm39) missense probably damaging 1.00
R4651:Cyp3a25 UTSW 5 145,931,701 (GRCm39) missense probably benign 0.01
R4788:Cyp3a25 UTSW 5 145,921,892 (GRCm39) nonsense probably null
R4899:Cyp3a25 UTSW 5 145,914,481 (GRCm39) missense possibly damaging 0.59
R4926:Cyp3a25 UTSW 5 145,928,266 (GRCm39) missense probably damaging 1.00
R4952:Cyp3a25 UTSW 5 145,928,334 (GRCm39) missense probably benign 0.01
R5270:Cyp3a25 UTSW 5 145,918,312 (GRCm39) missense probably benign 0.36
R5595:Cyp3a25 UTSW 5 145,931,673 (GRCm39) critical splice donor site probably null
R5659:Cyp3a25 UTSW 5 145,928,356 (GRCm39) missense possibly damaging 0.69
R5787:Cyp3a25 UTSW 5 145,935,313 (GRCm39) missense probably benign 0.14
R6307:Cyp3a25 UTSW 5 145,931,766 (GRCm39) missense possibly damaging 0.92
R6380:Cyp3a25 UTSW 5 145,935,357 (GRCm39) missense probably damaging 0.99
R7055:Cyp3a25 UTSW 5 145,929,801 (GRCm39) missense probably benign 0.00
R7140:Cyp3a25 UTSW 5 145,939,855 (GRCm39) missense probably benign
R7189:Cyp3a25 UTSW 5 145,939,870 (GRCm39) missense probably benign 0.37
R7201:Cyp3a25 UTSW 5 145,939,868 (GRCm39) missense probably benign 0.00
R7201:Cyp3a25 UTSW 5 145,928,257 (GRCm39) missense probably benign 0.22
R7332:Cyp3a25 UTSW 5 145,929,817 (GRCm39) missense probably damaging 1.00
R7404:Cyp3a25 UTSW 5 145,923,635 (GRCm39) missense probably damaging 1.00
R7548:Cyp3a25 UTSW 5 145,923,735 (GRCm39) missense probably damaging 0.98
R7607:Cyp3a25 UTSW 5 145,921,791 (GRCm39) missense possibly damaging 0.87
R8022:Cyp3a25 UTSW 5 145,914,478 (GRCm39) missense probably benign 0.33
R8266:Cyp3a25 UTSW 5 145,929,796 (GRCm39) missense probably damaging 1.00
R8894:Cyp3a25 UTSW 5 145,931,670 (GRCm39) splice site probably benign
R9249:Cyp3a25 UTSW 5 145,928,356 (GRCm39) missense possibly damaging 0.69
R9588:Cyp3a25 UTSW 5 145,921,699 (GRCm39) missense probably benign
R9691:Cyp3a25 UTSW 5 145,931,732 (GRCm39) missense probably benign 0.41
R9694:Cyp3a25 UTSW 5 145,923,685 (GRCm39) nonsense probably null
Posted On 2015-04-16