Incidental Mutation 'IGL02506:Kdm5a'
| ID |
296356 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Kdm5a
|
| Ensembl Gene |
ENSMUSG00000030180 |
| Gene Name |
lysine demethylase 5A |
| Synonyms |
Rbbp2, Jarid1a, RBP2 |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL02506
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
120341085-120421535 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 120409110 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1598
(S1598P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005108
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005108]
|
| AlphaFold |
Q3UXZ9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000005108
AA Change: S1598P
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000005108
Gene: ENSMUSG00000030180
AA Change: S1598P
| Domain | Start | End | E-Value | Type |
|---|
|
JmjN
|
18 |
59 |
4.06e-20 |
SMART |
|
ARID
|
81 |
170 |
4.76e-35 |
SMART |
|
BRIGHT
|
85 |
175 |
2.48e-31 |
SMART |
|
PHD
|
295 |
341 |
1.16e-14 |
SMART |
|
Blast:JmjC
|
384 |
436 |
2e-22 |
BLAST |
|
JmjC
|
437 |
603 |
5.88e-73 |
SMART |
|
low complexity region
|
638 |
651 |
N/A |
INTRINSIC |
|
Pfam:zf-C5HC2
|
676 |
729 |
1.3e-21 |
PFAM |
|
Pfam:PLU-1
|
740 |
1072 |
1.2e-104 |
PFAM |
|
low complexity region
|
1091 |
1119 |
N/A |
INTRINSIC |
|
PHD
|
1163 |
1216 |
1.37e-11 |
SMART |
|
low complexity region
|
1269 |
1280 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1414 |
N/A |
INTRINSIC |
|
low complexity region
|
1494 |
1512 |
N/A |
INTRINSIC |
|
coiled coil region
|
1534 |
1579 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124525
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132599
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142791
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body size, abnormal involuntary movement and quantitative changes in the hematopoietic stem cell and myeloid progenitor compartments, consistent with enhanced survival and increased cycling. Neonatalsurvival is sensitive to genetic background. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg8 |
A |
G |
17: 84,999,916 (GRCm39) |
E189G |
possibly damaging |
Het |
| Acad11 |
T |
C |
9: 103,968,931 (GRCm39) |
|
probably null |
Het |
| Adcy7 |
G |
T |
8: 89,044,571 (GRCm39) |
R488L |
probably damaging |
Het |
| Akt1 |
C |
T |
12: 112,625,714 (GRCm39) |
|
probably benign |
Het |
| Ano9 |
C |
T |
7: 140,682,167 (GRCm39) |
|
probably benign |
Het |
| Arhgap15 |
A |
G |
2: 43,953,820 (GRCm39) |
D182G |
possibly damaging |
Het |
| Asxl3 |
T |
A |
18: 22,585,456 (GRCm39) |
V127D |
probably benign |
Het |
| Cacna1g |
A |
G |
11: 94,319,955 (GRCm39) |
M1407T |
probably damaging |
Het |
| Card9 |
A |
C |
2: 26,244,427 (GRCm39) |
|
probably benign |
Het |
| Cdh5 |
A |
G |
8: 104,864,454 (GRCm39) |
N472D |
probably damaging |
Het |
| Ceacam2 |
T |
A |
7: 25,227,379 (GRCm39) |
T343S |
probably benign |
Het |
| Cic |
T |
A |
7: 24,990,282 (GRCm39) |
C1928S |
probably benign |
Het |
| Clk3 |
C |
T |
9: 57,661,927 (GRCm39) |
W31* |
probably null |
Het |
| Cntn4 |
A |
G |
6: 106,595,349 (GRCm39) |
T489A |
probably benign |
Het |
| Crispld1 |
G |
A |
1: 17,826,529 (GRCm39) |
R431H |
probably damaging |
Het |
| Crmp1 |
T |
A |
5: 37,436,199 (GRCm39) |
|
probably benign |
Het |
| Cyld |
A |
G |
8: 89,456,218 (GRCm39) |
T423A |
possibly damaging |
Het |
| Cyp3a44 |
A |
T |
5: 145,736,198 (GRCm39) |
I84N |
probably damaging |
Het |
| D2hgdh |
A |
G |
1: 93,757,507 (GRCm39) |
N141D |
probably damaging |
Het |
| Dip2b |
T |
A |
15: 100,055,162 (GRCm39) |
L341Q |
probably damaging |
Het |
| F3 |
C |
T |
3: 121,525,323 (GRCm39) |
T53I |
possibly damaging |
Het |
| Fam227b |
T |
A |
2: 125,845,831 (GRCm39) |
Y386F |
probably benign |
Het |
| Fmn1 |
A |
T |
2: 113,355,640 (GRCm39) |
T694S |
unknown |
Het |
| Gcnt2 |
T |
A |
13: 41,040,856 (GRCm39) |
V5E |
probably benign |
Het |
| Herpud1 |
G |
T |
8: 95,121,270 (GRCm39) |
E355* |
probably null |
Het |
| Igf1r |
T |
C |
7: 67,843,144 (GRCm39) |
S752P |
probably benign |
Het |
| Iqsec1 |
T |
C |
6: 90,649,057 (GRCm39) |
I687V |
possibly damaging |
Het |
| Klk1b9 |
A |
G |
7: 43,445,063 (GRCm39) |
E185G |
probably benign |
Het |
| Myo16 |
G |
T |
8: 10,440,217 (GRCm39) |
R423L |
probably damaging |
Het |
| Myo7b |
T |
C |
18: 32,100,207 (GRCm39) |
E1609G |
probably damaging |
Het |
| Nom1 |
T |
A |
5: 29,644,814 (GRCm39) |
|
probably benign |
Het |
| Nomo1 |
A |
G |
7: 45,727,480 (GRCm39) |
I1040V |
possibly damaging |
Het |
| Or8b39 |
G |
A |
9: 37,996,741 (GRCm39) |
G203D |
probably damaging |
Het |
| Paqr9 |
T |
C |
9: 95,442,748 (GRCm39) |
V246A |
probably benign |
Het |
| Pfkfb4 |
A |
T |
9: 108,859,404 (GRCm39) |
D437V |
probably benign |
Het |
| Phldb1 |
G |
T |
9: 44,622,223 (GRCm39) |
D797E |
probably benign |
Het |
| Pkd1l3 |
A |
G |
8: 110,374,132 (GRCm39) |
E1399G |
probably damaging |
Het |
| Plekhs1 |
G |
A |
19: 56,460,198 (GRCm39) |
C97Y |
probably damaging |
Het |
| Plscr4 |
A |
T |
9: 92,372,044 (GRCm39) |
I272L |
possibly damaging |
Het |
| Prlhr |
A |
C |
19: 60,456,366 (GRCm39) |
Y67D |
probably damaging |
Het |
| Rab3gap2 |
A |
G |
1: 184,984,221 (GRCm39) |
|
probably benign |
Het |
| Rad23b |
T |
C |
4: 55,382,511 (GRCm39) |
V238A |
probably benign |
Het |
| Sel1l2 |
T |
C |
2: 140,117,380 (GRCm39) |
T164A |
possibly damaging |
Het |
| Serpinh1 |
T |
A |
7: 98,996,199 (GRCm39) |
K295M |
probably damaging |
Het |
| Slc45a4 |
T |
C |
15: 73,453,687 (GRCm39) |
E770G |
probably benign |
Het |
| Spag4 |
T |
C |
2: 155,911,142 (GRCm39) |
L390P |
probably damaging |
Het |
| Stip1 |
A |
G |
19: 7,012,857 (GRCm39) |
|
probably benign |
Het |
| Tacr1 |
A |
G |
6: 82,380,739 (GRCm39) |
N50S |
probably damaging |
Het |
| Tg |
T |
C |
15: 66,613,443 (GRCm39) |
V433A |
possibly damaging |
Het |
| Ubap1l |
T |
A |
9: 65,276,493 (GRCm39) |
|
probably benign |
Het |
| Usp40 |
A |
T |
1: 87,909,738 (GRCm39) |
I572K |
probably damaging |
Het |
| Vps13b |
G |
T |
15: 35,917,308 (GRCm39) |
E3717D |
probably damaging |
Het |
| Wdr81 |
T |
C |
11: 75,335,232 (GRCm39) |
N1778S |
probably benign |
Het |
| Ylpm1 |
T |
A |
12: 85,095,965 (GRCm39) |
F1162Y |
probably damaging |
Het |
| Zbtb10 |
T |
A |
3: 9,330,297 (GRCm39) |
F552I |
probably damaging |
Het |
| Zfp507 |
T |
C |
7: 35,475,891 (GRCm39) |
I811V |
probably damaging |
Het |
| Zfp663 |
A |
T |
2: 165,195,871 (GRCm39) |
V116D |
probably benign |
Het |
|
| Other mutations in Kdm5a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00540:Kdm5a
|
APN |
6 |
120,362,680 (GRCm39) |
critical splice donor site |
probably null |
0.00 |
|
IGL00706:Kdm5a
|
APN |
6 |
120,383,597 (GRCm39) |
missense |
possibly damaging |
0.44 |
|
IGL01361:Kdm5a
|
APN |
6 |
120,375,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01402:Kdm5a
|
APN |
6 |
120,367,640 (GRCm39) |
nonsense |
probably null |
0.00 |
|
IGL01924:Kdm5a
|
APN |
6 |
120,371,216 (GRCm39) |
critical splice donor site |
probably null |
0.00 |
|
IGL01935:Kdm5a
|
APN |
6 |
120,385,284 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02165:Kdm5a
|
APN |
6 |
120,392,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Kdm5a
|
APN |
6 |
120,383,691 (GRCm39) |
splice site |
probably benign |
|
|
IGL02604:Kdm5a
|
APN |
6 |
120,408,941 (GRCm39) |
missense |
probably benign |
|
|
IGL02633:Kdm5a
|
APN |
6 |
120,341,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Kdm5a
|
APN |
6 |
120,367,605 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03009:Kdm5a
|
APN |
6 |
120,407,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03027:Kdm5a
|
APN |
6 |
120,351,951 (GRCm39) |
splice site |
probably null |
|
|
IGL03164:Kdm5a
|
APN |
6 |
120,415,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03236:Kdm5a
|
APN |
6 |
120,415,949 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03276:Kdm5a
|
APN |
6 |
120,379,669 (GRCm39) |
splice site |
probably benign |
|
|
Anastasia
|
UTSW |
6 |
120,407,192 (GRCm39) |
nonsense |
probably null |
|
|
Augmented
|
UTSW |
6 |
120,406,977 (GRCm39) |
intron |
probably benign |
|
|
Calla_lily
|
UTSW |
6 |
120,381,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
crocus
|
UTSW |
6 |
120,375,999 (GRCm39) |
missense |
probably null |
0.98 |
|
Magnolia
|
UTSW |
6 |
120,375,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Saffron
|
UTSW |
6 |
120,366,581 (GRCm39) |
missense |
probably benign |
0.19 |
|
Selbst
|
UTSW |
6 |
120,365,066 (GRCm39) |
nonsense |
probably null |
|
|
R0320:Kdm5a
|
UTSW |
6 |
120,366,581 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0462:Kdm5a
|
UTSW |
6 |
120,379,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0601:Kdm5a
|
UTSW |
6 |
120,379,632 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0628:Kdm5a
|
UTSW |
6 |
120,392,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1024:Kdm5a
|
UTSW |
6 |
120,375,999 (GRCm39) |
missense |
probably null |
0.98 |
|
R2013:Kdm5a
|
UTSW |
6 |
120,408,951 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2015:Kdm5a
|
UTSW |
6 |
120,408,951 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2061:Kdm5a
|
UTSW |
6 |
120,358,578 (GRCm39) |
missense |
probably benign |
|
|
R2188:Kdm5a
|
UTSW |
6 |
120,383,601 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R3923:Kdm5a
|
UTSW |
6 |
120,358,625 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4013:Kdm5a
|
UTSW |
6 |
120,371,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4016:Kdm5a
|
UTSW |
6 |
120,371,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Kdm5a
|
UTSW |
6 |
120,371,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4030:Kdm5a
|
UTSW |
6 |
120,382,074 (GRCm39) |
nonsense |
probably null |
|
|
R4646:Kdm5a
|
UTSW |
6 |
120,351,938 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4737:Kdm5a
|
UTSW |
6 |
120,382,976 (GRCm39) |
intron |
probably benign |
|
|
R4779:Kdm5a
|
UTSW |
6 |
120,346,060 (GRCm39) |
unclassified |
probably benign |
|
|
R4836:Kdm5a
|
UTSW |
6 |
120,389,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5129:Kdm5a
|
UTSW |
6 |
120,381,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Kdm5a
|
UTSW |
6 |
120,365,066 (GRCm39) |
nonsense |
probably null |
|
|
R5183:Kdm5a
|
UTSW |
6 |
120,406,977 (GRCm39) |
intron |
probably benign |
|
|
R5572:Kdm5a
|
UTSW |
6 |
120,389,336 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6110:Kdm5a
|
UTSW |
6 |
120,389,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6132:Kdm5a
|
UTSW |
6 |
120,351,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6198:Kdm5a
|
UTSW |
6 |
120,415,958 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6246:Kdm5a
|
UTSW |
6 |
120,408,871 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6336:Kdm5a
|
UTSW |
6 |
120,375,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6343:Kdm5a
|
UTSW |
6 |
120,359,894 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6612:Kdm5a
|
UTSW |
6 |
120,407,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6647:Kdm5a
|
UTSW |
6 |
120,389,422 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7068:Kdm5a
|
UTSW |
6 |
120,407,176 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7369:Kdm5a
|
UTSW |
6 |
120,408,965 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7380:Kdm5a
|
UTSW |
6 |
120,382,879 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7411:Kdm5a
|
UTSW |
6 |
120,403,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7521:Kdm5a
|
UTSW |
6 |
120,409,148 (GRCm39) |
nonsense |
probably null |
|
|
R7570:Kdm5a
|
UTSW |
6 |
120,404,803 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7647:Kdm5a
|
UTSW |
6 |
120,404,747 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7704:Kdm5a
|
UTSW |
6 |
120,404,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7796:Kdm5a
|
UTSW |
6 |
120,367,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7875:Kdm5a
|
UTSW |
6 |
120,375,979 (GRCm39) |
nonsense |
probably null |
|
|
R8265:Kdm5a
|
UTSW |
6 |
120,383,557 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8297:Kdm5a
|
UTSW |
6 |
120,358,516 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8336:Kdm5a
|
UTSW |
6 |
120,396,407 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8471:Kdm5a
|
UTSW |
6 |
120,407,192 (GRCm39) |
nonsense |
probably null |
|
|
R8872:Kdm5a
|
UTSW |
6 |
120,365,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8890:Kdm5a
|
UTSW |
6 |
120,366,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9028:Kdm5a
|
UTSW |
6 |
120,416,092 (GRCm39) |
missense |
probably benign |
|
|
R9064:Kdm5a
|
UTSW |
6 |
120,403,869 (GRCm39) |
small deletion |
probably benign |
|
|
R9114:Kdm5a
|
UTSW |
6 |
120,382,887 (GRCm39) |
nonsense |
probably null |
|
|
R9316:Kdm5a
|
UTSW |
6 |
120,381,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9353:Kdm5a
|
UTSW |
6 |
120,404,730 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9412:Kdm5a
|
UTSW |
6 |
120,365,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Kdm5a
|
UTSW |
6 |
120,365,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9431:Kdm5a
|
UTSW |
6 |
120,392,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9711:Kdm5a
|
UTSW |
6 |
120,367,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation