Incidental Mutation 'IGL02507:Or9s27'
ID 296367
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or9s27
Ensembl Gene ENSMUSG00000046300
Gene Name olfactory receptor family 9 subfamily S member 27
Synonyms MOR208-4, Olfr1412, GA_x6K02T2R7CC-81165686-81164721
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL02507
Quality Score
Chromosome 1
Chromosomal Location 92516054-92517019 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 92516648 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 199 (S199P)
Ref Sequence ENSEMBL: ENSMUSP00000150943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062964] [ENSMUST00000190505]
AlphaFold Q8VET3
Predicted Effect possibly damaging
Transcript: ENSMUST00000062964
AA Change: S199P

PolyPhen 2 Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000060291
Gene: ENSMUSG00000046300
AA Change: S199P

transmembrane domain 10 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.8e-47 PFAM
Pfam:7tm_1 48 321 1.4e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000190505
AA Change: S199P

PolyPhen 2 Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204141
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,349,388 (GRCm39) Y3654C probably damaging Het
Aldh1l2 A C 10: 83,328,448 (GRCm39) Y756* probably null Het
Arhgef12 T C 9: 42,903,859 (GRCm39) E733G probably damaging Het
Art5 A T 7: 101,748,699 (GRCm39) M1K probably null Het
Atp1a2 A T 1: 172,113,338 (GRCm39) D448E probably damaging Het
Atp6v1b1 C T 6: 83,733,837 (GRCm39) T356I possibly damaging Het
Celsr1 A G 15: 85,784,889 (GRCm39) probably benign Het
Cep89 A G 7: 35,134,990 (GRCm39) Y686C probably damaging Het
Cgrrf1 T A 14: 47,090,901 (GRCm39) Y212* probably null Het
Chrnb1 T C 11: 69,675,916 (GRCm39) Y442C probably damaging Het
Clcn1 T C 6: 42,284,007 (GRCm39) probably benign Het
Clcn7 G A 17: 25,363,443 (GRCm39) V40M probably damaging Het
Cntn1 A G 15: 92,148,860 (GRCm39) Y369C possibly damaging Het
Csmd1 T C 8: 17,584,992 (GRCm39) probably benign Het
Dpy19l2 A T 9: 24,542,563 (GRCm39) C446S probably benign Het
Edem3 G A 1: 151,687,407 (GRCm39) E782K probably benign Het
Efcab15 T A 11: 103,090,275 (GRCm39) Q287L probably damaging Het
Ephb3 T A 16: 21,039,389 (GRCm39) probably benign Het
Fndc4 T C 5: 31,452,090 (GRCm39) D109G probably damaging Het
Fras1 T C 5: 96,805,267 (GRCm39) V1303A possibly damaging Het
Gcn1 T C 5: 115,723,940 (GRCm39) L532P probably benign Het
Gm5150 A G 3: 16,017,485 (GRCm39) L262P probably damaging Het
Hbb-bs T C 7: 103,477,091 (GRCm39) probably benign Het
Krt74 A G 15: 101,669,059 (GRCm39) noncoding transcript Het
Myo1a T C 10: 127,548,478 (GRCm39) V375A probably damaging Het
Nup160 A T 2: 90,560,079 (GRCm39) Q1268L probably benign Het
Or4k42 G A 2: 111,319,768 (GRCm39) T245M possibly damaging Het
Or51ag1 G T 7: 103,155,925 (GRCm39) S76* probably null Het
Or5d16 G A 2: 87,773,262 (GRCm39) R237* probably null Het
Pan3 T C 5: 147,463,406 (GRCm39) S497P probably damaging Het
Pex5 T C 6: 124,390,264 (GRCm39) T138A probably benign Het
Pik3ap1 A G 19: 41,270,451 (GRCm39) probably benign Het
Ptchd4 A T 17: 42,627,764 (GRCm39) H75L possibly damaging Het
Rag2 A T 2: 101,461,055 (GRCm39) H455L probably damaging Het
Rergl T A 6: 139,470,351 (GRCm39) E159V probably damaging Het
Rrn3 A G 16: 13,606,721 (GRCm39) N109S probably benign Het
Scn1a A T 2: 66,108,157 (GRCm39) V1523D probably damaging Het
Sec23a A G 12: 59,053,884 (GRCm39) V38A probably benign Het
Slc15a2 G A 16: 36,602,021 (GRCm39) T92M possibly damaging Het
Slc2a2 A G 3: 28,781,260 (GRCm39) T433A probably benign Het
Sptan1 A G 2: 29,906,067 (GRCm39) D1671G probably damaging Het
Stab1 A G 14: 30,861,167 (GRCm39) probably benign Het
Stau2 A T 1: 16,556,293 (GRCm39) I22N possibly damaging Het
Strn3 A T 12: 51,708,410 (GRCm39) Y123* probably null Het
Tmem205 A G 9: 21,837,607 (GRCm39) V13A possibly damaging Het
Trub1 G A 19: 57,472,009 (GRCm39) probably benign Het
Ttn A G 2: 76,568,699 (GRCm39) V27398A possibly damaging Het
Vill A G 9: 118,899,845 (GRCm39) E343G possibly damaging Het
Zgpat T C 2: 181,008,029 (GRCm39) F189L probably damaging Het
Other mutations in Or9s27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01472:Or9s27 APN 1 92,516,694 (GRCm39) missense possibly damaging 0.52
IGL02177:Or9s27 APN 1 92,516,479 (GRCm39) missense possibly damaging 0.96
IGL02888:Or9s27 APN 1 92,516,925 (GRCm39) missense probably damaging 1.00
IGL03001:Or9s27 APN 1 92,516,273 (GRCm39) missense probably damaging 1.00
R1771:Or9s27 UTSW 1 92,516,837 (GRCm39) missense probably benign 0.03
R1780:Or9s27 UTSW 1 92,516,111 (GRCm39) missense probably benign 0.01
R2215:Or9s27 UTSW 1 92,516,708 (GRCm39) missense probably benign 0.00
R2437:Or9s27 UTSW 1 92,516,688 (GRCm39) missense possibly damaging 0.46
R3176:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3177:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3276:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3277:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R4475:Or9s27 UTSW 1 92,516,301 (GRCm39) missense probably benign 0.00
R4892:Or9s27 UTSW 1 92,516,643 (GRCm39) missense probably benign 0.05
R5910:Or9s27 UTSW 1 92,516,429 (GRCm39) missense probably damaging 1.00
R6808:Or9s27 UTSW 1 92,516,768 (GRCm39) missense probably damaging 0.99
R7130:Or9s27 UTSW 1 92,516,634 (GRCm39) missense probably benign 0.10
R7476:Or9s27 UTSW 1 92,516,986 (GRCm39) missense probably benign
R9695:Or9s27 UTSW 1 92,516,595 (GRCm39) missense probably benign 0.01
Z1088:Or9s27 UTSW 1 92,516,273 (GRCm39) missense probably damaging 1.00
Z1177:Or9s27 UTSW 1 92,516,100 (GRCm39) nonsense probably null
Posted On 2015-04-16