Incidental Mutation 'IGL02508:Meis3'
ID 296470
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Meis3
Ensembl Gene ENSMUSG00000041420
Gene Name Meis homeobox 3
Synonyms Mrg2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # IGL02508
Quality Score
Status
Chromosome 7
Chromosomal Location 15909015-15920429 bp(+) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) T to A at 15912722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135388 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002495] [ENSMUST00000176342] [ENSMUST00000176446] [ENSMUST00000176506] [ENSMUST00000177156] [ENSMUST00000177540]
AlphaFold P97368
Predicted Effect probably null
Transcript: ENSMUST00000002495
SMART Domains Protein: ENSMUSP00000002495
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 230 244 N/A INTRINSIC
HOX 265 330 9.15e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175946
Predicted Effect probably benign
Transcript: ENSMUST00000176342
SMART Domains Protein: ENSMUSP00000135302
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176446
Predicted Effect probably null
Transcript: ENSMUST00000176506
SMART Domains Protein: ENSMUSP00000134918
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 213 227 N/A INTRINSIC
HOX 248 313 9.15e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177156
SMART Domains Protein: ENSMUSP00000135103
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 230 244 N/A INTRINSIC
Pfam:Homeobox_KN 283 313 2e-12 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000177540
SMART Domains Protein: ENSMUSP00000135388
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183527
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700061I17Rik T A 3: 116,870,764 (GRCm39) noncoding transcript Het
Adgrv1 A T 13: 81,583,675 (GRCm39) probably benign Het
AI429214 T G 8: 37,461,240 (GRCm39) D129E probably benign Het
Alx1 G A 10: 102,858,054 (GRCm39) T215M probably damaging Het
Arhgap39 A G 15: 76,609,184 (GRCm39) *1079Q probably null Het
Brca2 T C 5: 150,466,773 (GRCm39) V2179A possibly damaging Het
Cdcp3 A G 7: 130,824,559 (GRCm39) E91G probably damaging Het
Celsr1 G A 15: 85,914,818 (GRCm39) Q1052* probably null Het
Chd5 A G 4: 152,447,481 (GRCm39) E510G probably damaging Het
Cntnap2 A G 6: 46,211,254 (GRCm39) D556G probably damaging Het
Cux2 G A 5: 121,998,885 (GRCm39) P1352S possibly damaging Het
Cyp4a31 A T 4: 115,428,261 (GRCm39) Y319F probably damaging Het
Dcaf12 C T 4: 41,296,310 (GRCm39) probably null Het
Dcc C A 18: 71,503,773 (GRCm39) A942S probably benign Het
Dyrk1a A T 16: 94,486,042 (GRCm39) D463V probably damaging Het
Eln T A 5: 134,733,422 (GRCm39) probably benign Het
Fbxl13 A G 5: 21,761,803 (GRCm39) probably null Het
Fndc3b T C 3: 27,512,900 (GRCm39) Y742C probably damaging Het
Furin G A 7: 80,042,269 (GRCm39) T442I probably benign Het
Gli1 T C 10: 127,172,961 (GRCm39) Q155R probably benign Het
Glra3 A G 8: 56,538,179 (GRCm39) E218G probably benign Het
Grb10 C T 11: 11,896,767 (GRCm39) V236M probably damaging Het
Grhl2 T C 15: 37,310,009 (GRCm39) probably benign Het
Hgfac A T 5: 35,204,564 (GRCm39) M579L probably damaging Het
Ifi202b A T 1: 173,802,338 (GRCm39) D165E probably benign Het
Klhl26 A T 8: 70,905,381 (GRCm39) D95E probably damaging Het
Klk12 T C 7: 43,419,113 (GRCm39) V26A probably benign Het
Lrp2 C T 2: 69,333,774 (GRCm39) G1489D probably benign Het
Lrrtm1 A T 6: 77,221,574 (GRCm39) S344C probably damaging Het
Lzts1 G A 8: 69,593,500 (GRCm39) R36* probably null Het
Mapkap1 T C 2: 34,408,681 (GRCm39) probably benign Het
Mtmr14 T A 6: 113,217,267 (GRCm39) C60S probably damaging Het
Nfkb1 T A 3: 135,296,579 (GRCm39) Y789F probably damaging Het
Nup54 G A 5: 92,565,398 (GRCm39) Q440* probably null Het
Ogdhl T G 14: 32,067,131 (GRCm39) M861R probably damaging Het
Or13c7b T C 4: 43,821,289 (GRCm39) E24G possibly damaging Het
Or4d10 G T 19: 12,051,251 (GRCm39) H248Q possibly damaging Het
Or4k42 C T 2: 111,320,180 (GRCm39) A108T probably damaging Het
Or52w1 A T 7: 105,017,743 (GRCm39) H61L possibly damaging Het
Or6c69b A G 10: 129,626,660 (GRCm39) V266A probably benign Het
Pde6c A G 19: 38,145,948 (GRCm39) K412R probably benign Het
Pex5l T C 3: 33,047,051 (GRCm39) probably benign Het
Pigr A T 1: 130,778,595 (GRCm39) I760L probably benign Het
Pramel28 T C 4: 143,691,590 (GRCm39) N378D probably benign Het
Prr14l G A 5: 32,988,286 (GRCm39) A403V probably benign Het
Prrt3 T C 6: 113,471,268 (GRCm39) D968G probably damaging Het
Psmc5 T C 11: 106,153,869 (GRCm39) I401T possibly damaging Het
Ralyl T A 3: 14,172,332 (GRCm39) probably benign Het
Samd9l T C 6: 3,374,798 (GRCm39) E821G probably damaging Het
Serpinb3a T A 1: 106,973,802 (GRCm39) I370F probably damaging Het
Setd1a A G 7: 127,396,870 (GRCm39) probably benign Het
Slco2a1 T A 9: 102,951,615 (GRCm39) F381L probably benign Het
Strada A G 11: 106,059,182 (GRCm39) Y199H probably benign Het
Stxbp2 T C 8: 3,682,531 (GRCm39) I40T probably damaging Het
Tbx3 T C 5: 119,816,877 (GRCm39) V358A possibly damaging Het
Tenm3 A G 8: 48,752,674 (GRCm39) L896S probably benign Het
Tmem132a A G 19: 10,835,882 (GRCm39) S883P probably damaging Het
Trio A G 15: 27,818,190 (GRCm39) I496T possibly damaging Het
Unc79 C T 12: 103,078,535 (GRCm39) R1548W probably damaging Het
Unc79 T C 12: 103,078,277 (GRCm39) probably benign Het
Vmn2r9 T C 5: 108,996,067 (GRCm39) M194V possibly damaging Het
Other mutations in Meis3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01014:Meis3 APN 7 15,912,872 (GRCm39) critical splice acceptor site probably benign 0.00
IGL03125:Meis3 APN 7 15,912,695 (GRCm39) missense probably damaging 1.00
IGL03383:Meis3 APN 7 15,917,744 (GRCm39) missense probably damaging 1.00
R0032:Meis3 UTSW 7 15,916,210 (GRCm39) unclassified probably benign
R1147:Meis3 UTSW 7 15,917,701 (GRCm39) unclassified probably benign
R1471:Meis3 UTSW 7 15,911,496 (GRCm39) nonsense probably null
R3054:Meis3 UTSW 7 15,916,378 (GRCm39) missense probably damaging 1.00
R3927:Meis3 UTSW 7 15,911,419 (GRCm39) missense probably benign 0.06
R5314:Meis3 UTSW 7 15,917,989 (GRCm39) missense probably damaging 0.99
R6713:Meis3 UTSW 7 15,916,255 (GRCm39) nonsense probably null
R6847:Meis3 UTSW 7 15,917,789 (GRCm39) missense probably damaging 1.00
R7218:Meis3 UTSW 7 15,918,626 (GRCm39) missense probably benign
R7517:Meis3 UTSW 7 15,911,743 (GRCm39) missense probably damaging 1.00
R7540:Meis3 UTSW 7 15,911,418 (GRCm39) nonsense probably null
R7699:Meis3 UTSW 7 15,911,481 (GRCm39) missense probably benign
R7700:Meis3 UTSW 7 15,911,481 (GRCm39) missense probably benign
R7790:Meis3 UTSW 7 15,916,322 (GRCm39) missense probably benign 0.37
R8902:Meis3 UTSW 7 15,911,887 (GRCm39) missense probably benign 0.17
R8909:Meis3 UTSW 7 15,919,385 (GRCm39) missense possibly damaging 0.83
R9095:Meis3 UTSW 7 15,917,764 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16