Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02510:Zfp358'

296493

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp358

Ensembl Gene

ENSMUSG00000047264

Gene Name

zinc finger protein 358

Synonyms

Zfend

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.151) question?

Stock #

IGL02510

Quality Score

Status

Chromosome

Chromosomal Location

3493138-3497208 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 3496786 bp

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 456 (G456D)

Ref Sequence

ENSEMBL: ENSMUSP00000146953 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000004683] [ENSMUST00000061508] [ENSMUST00000160338] [ENSMUST00000207318] [ENSMUST00000208306] [ENSMUST00000208423]

Predicted Effect

probably benign
Transcript: ENSMUST00000004683

SMART Domains

Protein: ENSMUSP00000004683
Gene: ENSMUSG00000004567

Domain	Start	End	E-Value	Type
low complexity region	30	39	N/A	INTRINSIC
transmembrane domain	70	92	N/A	INTRINSIC
transmembrane domain	299	321	N/A	INTRINSIC
transmembrane domain	348	370	N/A	INTRINSIC
Pfam:PKD_channel	378	524	2.1e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000061508
AA Change: G456D

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000060344
Gene: ENSMUSG00000047264
AA Change: G456D

Domain	Start	End	E-Value	Type
low complexity region	24	49	N/A	INTRINSIC
ZnF_C2H2	154	176	1.47e-3	SMART
ZnF_C2H2	182	204	2.95e-3	SMART
ZnF_C2H2	210	232	1.67e-2	SMART
ZnF_C2H2	238	260	3.63e-3	SMART
ZnF_C2H2	266	288	2.4e-3	SMART
ZnF_C2H2	294	316	1.4e-4	SMART
ZnF_C2H2	322	344	4.01e-5	SMART
ZnF_C2H2	350	372	2.4e-3	SMART
ZnF_C2H2	378	400	1.84e-4	SMART
low complexity region	422	430	N/A	INTRINSIC
low complexity region	447	473	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160338

SMART Domains

Protein: ENSMUSP00000123717
Gene: ENSMUSG00000004567

Domain	Start	End	E-Value	Type
low complexity region	30	39	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000207318

Predicted Effect

probably benign
Transcript: ENSMUST00000208306

Predicted Effect

probably benign
Transcript: ENSMUST00000208423
AA Change: G456D

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208739

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts4	G	A	1: 171,251,390	S193N	probably benign	Het
Arrdc1	C	A	2: 24,935,100	V16F	probably damaging	Het
Bsx	A	T	9: 40,874,221	Q15L	possibly damaging	Het
Casp8ap2	A	G	4: 32,639,704	T253A	probably benign	Het
Cdkl3	T	C	11: 52,011,270	L102P	probably damaging	Het
Cgnl1	G	T	9: 71,725,357	N237K	probably benign	Het
Cldn14	T	A	16: 93,919,956	M1L	probably damaging	Het
Col1a2	C	T	6: 4,516,398	R171C	unknown	Het
Col7a1	C	A	9: 108,973,231		probably benign	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Dhrs2	G	A	14: 55,236,075	V64M	probably damaging	Het
Disp3	G	A	4: 148,252,701	H886Y	probably benign	Het
Dst	G	A	1: 34,229,251		probably null	Het
Fnbp4	T	C	2: 90,751,475	V215A	probably benign	Het
Fzd9	A	G	5: 135,249,615	L472P	probably damaging	Het
Gm5096	A	G	18: 87,757,529	Q392R	probably benign	Het
Hpd	C	T	5: 123,181,910	R15Q	possibly damaging	Het
Htra2	A	G	6: 83,051,611	V412A	probably damaging	Het
Ift80	A	G	3: 68,898,543	F722S	probably benign	Het
Kcnq2	T	C	2: 181,081,361	T741A	probably benign	Het
Kl	A	C	5: 150,989,001	E738D	probably damaging	Het
Klra4	T	A	6: 130,059,543	I178L	probably damaging	Het
Klra9	T	C	6: 130,191,222	E27G	probably benign	Het
Kntc1	T	C	5: 123,819,062	Y2145H	probably benign	Het
Mbd5	T	A	2: 49,257,029	M417K	probably benign	Het
Med31	C	T	11: 72,212,056	M75I	probably benign	Het
Mpeg1	A	T	19: 12,461,424	D82V	probably damaging	Het
Msto1	A	G	3: 88,910,345	Y439H	probably damaging	Het
Olfr23	G	A	11: 73,941,005	G253E	probably damaging	Het
Olfr332	T	C	11: 58,490,539	Y72C	probably damaging	Het
Olfr344	T	C	2: 36,568,681	S28P	possibly damaging	Het
Olfr488	T	A	7: 108,256,141		probably benign	Het
Prtg	G	A	9: 72,890,869	V706M	probably damaging	Het
Sfxn2	G	T	19: 46,588,272	A186S	probably benign	Het
Slc12a5	A	T	2: 164,982,808		probably benign	Het
Slc7a3	T	C	X: 101,082,833	E222G	probably benign	Het
Stox1	A	T	10: 62,664,047	H911Q	probably benign	Het
Sult3a2	A	T	10: 33,766,439	N289K	probably benign	Het
Supt20	A	G	3: 54,715,524		probably benign	Het
Tchh	A	G	3: 93,444,078	E275G	unknown	Het
Tectb	A	T	19: 55,191,511	N263I	probably damaging	Het
Tsga10	C	T	1: 37,760,985	R608Q	possibly damaging	Het
Ttyh3	A	G	5: 140,629,464	Y390H	probably damaging	Het
Utf1	C	A	7: 139,944,016	S48*	probably null	Het
Zufsp	A	G	10: 33,930,154		probably null	Het

Other mutations in Zfp358

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01405:Zfp358	APN	8	3495663	missense	probably benign	0.19
IGL02301:Zfp358	APN	8	3496858	missense	probably benign
IGL02860:Zfp358	APN	8	3496074	missense	probably damaging	1.00
R1018:Zfp358	UTSW	8	3496843	nonsense	probably null
R1960:Zfp358	UTSW	8	3495742	missense	possibly damaging	0.46
R2047:Zfp358	UTSW	8	3495934	missense	probably damaging	1.00
R2202:Zfp358	UTSW	8	3496995	missense	possibly damaging	0.80
R2354:Zfp358	UTSW	8	3495454	missense	possibly damaging	0.95
R4688:Zfp358	UTSW	8	3495493	missense	probably damaging	1.00
R4689:Zfp358	UTSW	8	3496146	splice site	probably null
R4876:Zfp358	UTSW	8	3496170	missense	probably damaging	0.98
R5830:Zfp358	UTSW	8	3495846	missense	probably benign	0.36
R6589:Zfp358	UTSW	8	3495907	missense	probably damaging	0.99
R6834:Zfp358	UTSW	8	3495613	missense	probably benign	0.19

Posted On

2015-04-16