Incidental Mutation 'IGL02510:Zfp358'
ID296493
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp358
Ensembl Gene ENSMUSG00000047264
Gene Namezinc finger protein 358
SynonymsZfend
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.144) question?
Stock #IGL02510
Quality Score
Status
Chromosome8
Chromosomal Location3493138-3497208 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 3496786 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Aspartic acid at position 456 (G456D)
Ref Sequence ENSEMBL: ENSMUSP00000146953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004683] [ENSMUST00000061508] [ENSMUST00000160338] [ENSMUST00000207318] [ENSMUST00000208306] [ENSMUST00000208423]
Predicted Effect probably benign
Transcript: ENSMUST00000004683
SMART Domains Protein: ENSMUSP00000004683
Gene: ENSMUSG00000004567

DomainStartEndE-ValueType
low complexity region 30 39 N/A INTRINSIC
transmembrane domain 70 92 N/A INTRINSIC
transmembrane domain 299 321 N/A INTRINSIC
transmembrane domain 348 370 N/A INTRINSIC
Pfam:PKD_channel 378 524 2.1e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000061508
AA Change: G456D

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000060344
Gene: ENSMUSG00000047264
AA Change: G456D

DomainStartEndE-ValueType
low complexity region 24 49 N/A INTRINSIC
ZnF_C2H2 154 176 1.47e-3 SMART
ZnF_C2H2 182 204 2.95e-3 SMART
ZnF_C2H2 210 232 1.67e-2 SMART
ZnF_C2H2 238 260 3.63e-3 SMART
ZnF_C2H2 266 288 2.4e-3 SMART
ZnF_C2H2 294 316 1.4e-4 SMART
ZnF_C2H2 322 344 4.01e-5 SMART
ZnF_C2H2 350 372 2.4e-3 SMART
ZnF_C2H2 378 400 1.84e-4 SMART
low complexity region 422 430 N/A INTRINSIC
low complexity region 447 473 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000160338
SMART Domains Protein: ENSMUSP00000123717
Gene: ENSMUSG00000004567

DomainStartEndE-ValueType
low complexity region 30 39 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000207318
Predicted Effect probably benign
Transcript: ENSMUST00000208306
Predicted Effect probably benign
Transcript: ENSMUST00000208423
AA Change: G456D

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208739
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts4 G A 1: 171,251,390 S193N probably benign Het
Arrdc1 C A 2: 24,935,100 V16F probably damaging Het
Bsx A T 9: 40,874,221 Q15L possibly damaging Het
Casp8ap2 A G 4: 32,639,704 T253A probably benign Het
Cdkl3 T C 11: 52,011,270 L102P probably damaging Het
Cgnl1 G T 9: 71,725,357 N237K probably benign Het
Cldn14 T A 16: 93,919,956 M1L probably damaging Het
Col1a2 C T 6: 4,516,398 R171C unknown Het
Col7a1 C A 9: 108,973,231 probably benign Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dhrs2 G A 14: 55,236,075 V64M probably damaging Het
Disp3 G A 4: 148,252,701 H886Y probably benign Het
Dst G A 1: 34,229,251 probably null Het
Fnbp4 T C 2: 90,751,475 V215A probably benign Het
Fzd9 A G 5: 135,249,615 L472P probably damaging Het
Gm5096 A G 18: 87,757,529 Q392R probably benign Het
Hpd C T 5: 123,181,910 R15Q possibly damaging Het
Htra2 A G 6: 83,051,611 V412A probably damaging Het
Ift80 A G 3: 68,898,543 F722S probably benign Het
Kcnq2 T C 2: 181,081,361 T741A probably benign Het
Kl A C 5: 150,989,001 E738D probably damaging Het
Klra4 T A 6: 130,059,543 I178L probably damaging Het
Klra9 T C 6: 130,191,222 E27G probably benign Het
Kntc1 T C 5: 123,819,062 Y2145H probably benign Het
Mbd5 T A 2: 49,257,029 M417K probably benign Het
Med31 C T 11: 72,212,056 M75I probably benign Het
Mpeg1 A T 19: 12,461,424 D82V probably damaging Het
Msto1 A G 3: 88,910,345 Y439H probably damaging Het
Olfr23 G A 11: 73,941,005 G253E probably damaging Het
Olfr332 T C 11: 58,490,539 Y72C probably damaging Het
Olfr344 T C 2: 36,568,681 S28P possibly damaging Het
Olfr488 T A 7: 108,256,141 probably benign Het
Prtg G A 9: 72,890,869 V706M probably damaging Het
Sfxn2 G T 19: 46,588,272 A186S probably benign Het
Slc12a5 A T 2: 164,982,808 probably benign Het
Slc7a3 T C X: 101,082,833 E222G probably benign Het
Stox1 A T 10: 62,664,047 H911Q probably benign Het
Sult3a2 A T 10: 33,766,439 N289K probably benign Het
Supt20 A G 3: 54,715,524 probably benign Het
Tchh A G 3: 93,444,078 E275G unknown Het
Tectb A T 19: 55,191,511 N263I probably damaging Het
Tsga10 C T 1: 37,760,985 R608Q possibly damaging Het
Ttyh3 A G 5: 140,629,464 Y390H probably damaging Het
Utf1 C A 7: 139,944,016 S48* probably null Het
Zufsp A G 10: 33,930,154 probably null Het
Other mutations in Zfp358
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01405:Zfp358 APN 8 3495663 missense probably benign 0.19
IGL02301:Zfp358 APN 8 3496858 missense probably benign
IGL02860:Zfp358 APN 8 3496074 missense probably damaging 1.00
R1018:Zfp358 UTSW 8 3496843 nonsense probably null
R1960:Zfp358 UTSW 8 3495742 missense possibly damaging 0.46
R2047:Zfp358 UTSW 8 3495934 missense probably damaging 1.00
R2202:Zfp358 UTSW 8 3496995 missense possibly damaging 0.80
R2354:Zfp358 UTSW 8 3495454 missense possibly damaging 0.95
R4688:Zfp358 UTSW 8 3495493 missense probably damaging 1.00
R4689:Zfp358 UTSW 8 3496146 unclassified probably null
R4876:Zfp358 UTSW 8 3496170 missense probably damaging 0.98
R5830:Zfp358 UTSW 8 3495846 missense probably benign 0.36
R6589:Zfp358 UTSW 8 3495907 missense probably damaging 0.99
R6834:Zfp358 UTSW 8 3495613 missense probably benign 0.19
Posted On2015-04-16