Incidental Mutation 'R0350:Prss37'
ID 29650
Institutional Source Beutler Lab
Gene Symbol Prss37
Ensembl Gene ENSMUSG00000029909
Gene Name serine protease 37
Synonyms 1700016G05Rik
MMRRC Submission 038557-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0350 (G1)
Quality Score 204
Status Not validated
Chromosome 6
Chromosomal Location 40491757-40496418 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 40491893 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 229 (E229G)
Ref Sequence ENSEMBL: ENSMUSP00000031967 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031967]
AlphaFold Q9DAA4
Predicted Effect probably damaging
Transcript: ENSMUST00000031967
AA Change: E229G

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000031967
Gene: ENSMUSG00000029909
AA Change: E229G

DomainStartEndE-ValueType
Tryp_SPc 15 228 2.31e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148195
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 95.2%
  • 20x: 89.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with impaired zona binding and migration from the uterus into the oviduct. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd13 T A 8: 10,037,600 (GRCm39) Y66N probably damaging Het
Apol6 C T 15: 76,935,147 (GRCm39) Q139* probably null Het
Armh1 C A 4: 117,072,753 (GRCm39) E244* probably null Het
Cd1d1 A T 3: 86,904,880 (GRCm39) H219Q probably benign Het
Cdca2 A G 14: 67,950,568 (GRCm39) L121P probably benign Het
Cdin1 T C 2: 115,607,411 (GRCm39) Y255H possibly damaging Het
Cog4 T A 8: 111,580,328 (GRCm39) L133I possibly damaging Het
Csf1 T C 3: 107,655,922 (GRCm39) M370V probably benign Het
Ddi2 G A 4: 141,412,834 (GRCm39) T26M probably benign Het
Dhcr7 A G 7: 143,391,507 (GRCm39) D32G probably damaging Het
Efcab3 T C 11: 104,581,706 (GRCm39) V16A probably benign Het
Exd1 T C 2: 119,354,047 (GRCm39) N337S possibly damaging Het
Flii T C 11: 60,612,683 (GRCm39) D227G probably damaging Het
Hsf1 A G 15: 76,384,679 (GRCm39) T485A probably benign Het
Igfn1 G A 1: 135,884,505 (GRCm39) R2614* probably null Het
Iqch T C 9: 63,408,158 (GRCm39) T630A probably benign Het
Itgal T A 7: 126,921,253 (GRCm39) D770E probably damaging Het
Mroh1 T A 15: 76,316,449 (GRCm39) V759E probably damaging Het
Mrps17 A G 5: 129,795,209 (GRCm39) probably benign Het
Mtpap A G 18: 4,396,195 (GRCm39) S496G possibly damaging Het
Nkd1 T A 8: 89,311,844 (GRCm39) Y39* probably null Het
Nmd3 A G 3: 69,650,907 (GRCm39) Y359C probably damaging Het
Nr1h3 G A 2: 91,022,170 (GRCm39) L153F possibly damaging Het
Nuf2 T A 1: 169,341,112 (GRCm39) probably null Het
Or4b1b T C 2: 90,112,926 (GRCm39) probably null Het
Or4c113 T A 2: 88,885,700 (GRCm39) K23N probably benign Het
Or8b12i A T 9: 20,082,032 (GRCm39) Y278* probably null Het
Pnn T C 12: 59,113,903 (GRCm39) probably null Het
Ppm1j A G 3: 104,690,687 (GRCm39) D230G probably benign Het
Ppp1r15a A T 7: 45,172,442 (GRCm39) L650Q probably damaging Het
Rbm19 T C 5: 120,266,372 (GRCm39) V465A possibly damaging Het
Rubcnl G T 14: 75,278,331 (GRCm39) V372F probably damaging Het
Sema6a G T 18: 47,403,785 (GRCm39) D595E probably benign Het
Slc35c1 A G 2: 92,289,377 (GRCm39) F43S probably damaging Het
Slc39a5 C T 10: 128,232,619 (GRCm39) probably null Het
Slco4c1 A G 1: 96,756,574 (GRCm39) F583L probably benign Het
Sox9 A G 11: 112,675,702 (GRCm39) Y297C probably damaging Het
Taf1b A G 12: 24,564,884 (GRCm39) D167G possibly damaging Het
Trpm6 T C 19: 18,861,321 (GRCm39) probably null Het
Uba6 A C 5: 86,292,237 (GRCm39) V402G possibly damaging Het
Usp43 T C 11: 67,767,324 (GRCm39) Y682C probably damaging Het
Vmn1r195 A G 13: 22,463,403 (GRCm39) D291G probably damaging Het
Xpr1 A T 1: 155,206,214 (GRCm39) F156Y probably damaging Het
Yju2b C T 8: 84,987,277 (GRCm39) E99K probably damaging Het
Zfp318 T A 17: 46,724,124 (GRCm39) H2042Q probably benign Het
Zfp937 T A 2: 150,081,222 (GRCm39) D417E possibly damaging Het
Other mutations in Prss37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02282:Prss37 APN 6 40,492,317 (GRCm39) missense possibly damaging 0.81
IGL03110:Prss37 APN 6 40,495,984 (GRCm39) missense probably benign 0.00
R0201:Prss37 UTSW 6 40,493,283 (GRCm39) missense probably damaging 1.00
R2118:Prss37 UTSW 6 40,492,294 (GRCm39) nonsense probably null
R2120:Prss37 UTSW 6 40,492,294 (GRCm39) nonsense probably null
R2124:Prss37 UTSW 6 40,492,294 (GRCm39) nonsense probably null
R2504:Prss37 UTSW 6 40,494,760 (GRCm39) splice site probably null
R4711:Prss37 UTSW 6 40,492,381 (GRCm39) missense probably benign 0.21
R4938:Prss37 UTSW 6 40,491,917 (GRCm39) missense possibly damaging 0.81
R4983:Prss37 UTSW 6 40,493,070 (GRCm39) missense probably benign 0.01
R6652:Prss37 UTSW 6 40,496,090 (GRCm39) start gained probably benign
R8111:Prss37 UTSW 6 40,494,747 (GRCm39) missense probably benign 0.00
R8425:Prss37 UTSW 6 40,493,052 (GRCm39) nonsense probably null
R8859:Prss37 UTSW 6 40,491,897 (GRCm39) missense probably damaging 1.00
R9297:Prss37 UTSW 6 40,491,909 (GRCm39) missense probably damaging 1.00
R9318:Prss37 UTSW 6 40,491,909 (GRCm39) missense probably damaging 1.00
R9778:Prss37 UTSW 6 40,494,713 (GRCm39) missense probably damaging 0.99
X0063:Prss37 UTSW 6 40,493,149 (GRCm39) missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- AAGATATAGGCTCCCAGGGTGCTG -3'
(R):5'- AAGCTCCCGTGATGACGGACAAAG -3'

Sequencing Primer
(F):5'- AGGGTGCTGCATTCCAAAC -3'
(R):5'- GCCACAGAAACTCCTTATGTGTC -3'
Posted On 2013-04-24