Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02510:Tsga10'

296508

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tsga10

Ensembl Gene

ENSMUSG00000060771

Gene Name

testis specific 10

Synonyms

4933432N21Rik, Mtsga10

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

IGL02510

Quality Score

Status

Chromosome

Chromosomal Location

37754776-37866429 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 37760985 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 608 (R608Q)

Ref Sequence

ENSEMBL: ENSMUSP00000085391 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041815] [ENSMUST00000088072] [ENSMUST00000114902]

Predicted Effect

probably benign
Transcript: ENSMUST00000041815
AA Change: R678Q

PolyPhen 2 Score 0.175 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000048859
Gene: ENSMUSG00000060771
AA Change: R678Q

Domain	Start	End	E-Value	Type
low complexity region	5	17	N/A	INTRINSIC
coiled coil region	24	85	N/A	INTRINSIC
coiled coil region	110	249	N/A	INTRINSIC
Blast:SPEC	294	391	5e-6	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000088072
AA Change: R608Q

PolyPhen 2 Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000085391
Gene: ENSMUSG00000060771
AA Change: R608Q

Domain	Start	End	E-Value	Type
low complexity region	5	17	N/A	INTRINSIC
coiled coil region	24	85	N/A	INTRINSIC
coiled coil region	110	249	N/A	INTRINSIC
Blast:SPEC	294	391	5e-6	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000114902
AA Change: R678Q

PolyPhen 2 Score 0.175 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000110552
Gene: ENSMUSG00000060771
AA Change: R678Q

Domain	Start	End	E-Value	Type
low complexity region	5	17	N/A	INTRINSIC
coiled coil region	24	85	N/A	INTRINSIC
coiled coil region	110	249	N/A	INTRINSIC
Blast:SPEC	294	391	5e-6	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts4	G	A	1: 171,251,390	S193N	probably benign	Het
Arrdc1	C	A	2: 24,935,100	V16F	probably damaging	Het
Bsx	A	T	9: 40,874,221	Q15L	possibly damaging	Het
Casp8ap2	A	G	4: 32,639,704	T253A	probably benign	Het
Cdkl3	T	C	11: 52,011,270	L102P	probably damaging	Het
Cgnl1	G	T	9: 71,725,357	N237K	probably benign	Het
Cldn14	T	A	16: 93,919,956	M1L	probably damaging	Het
Col1a2	C	T	6: 4,516,398	R171C	unknown	Het
Col7a1	C	A	9: 108,973,231		probably benign	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Dhrs2	G	A	14: 55,236,075	V64M	probably damaging	Het
Disp3	G	A	4: 148,252,701	H886Y	probably benign	Het
Dst	G	A	1: 34,229,251		probably null	Het
Fnbp4	T	C	2: 90,751,475	V215A	probably benign	Het
Fzd9	A	G	5: 135,249,615	L472P	probably damaging	Het
Gm5096	A	G	18: 87,757,529	Q392R	probably benign	Het
Hpd	C	T	5: 123,181,910	R15Q	possibly damaging	Het
Htra2	A	G	6: 83,051,611	V412A	probably damaging	Het
Ift80	A	G	3: 68,898,543	F722S	probably benign	Het
Kcnq2	T	C	2: 181,081,361	T741A	probably benign	Het
Kl	A	C	5: 150,989,001	E738D	probably damaging	Het
Klra4	T	A	6: 130,059,543	I178L	probably damaging	Het
Klra9	T	C	6: 130,191,222	E27G	probably benign	Het
Kntc1	T	C	5: 123,819,062	Y2145H	probably benign	Het
Mbd5	T	A	2: 49,257,029	M417K	probably benign	Het
Med31	C	T	11: 72,212,056	M75I	probably benign	Het
Mpeg1	A	T	19: 12,461,424	D82V	probably damaging	Het
Msto1	A	G	3: 88,910,345	Y439H	probably damaging	Het
Olfr23	G	A	11: 73,941,005	G253E	probably damaging	Het
Olfr332	T	C	11: 58,490,539	Y72C	probably damaging	Het
Olfr344	T	C	2: 36,568,681	S28P	possibly damaging	Het
Olfr488	T	A	7: 108,256,141		probably benign	Het
Prtg	G	A	9: 72,890,869	V706M	probably damaging	Het
Sfxn2	G	T	19: 46,588,272	A186S	probably benign	Het
Slc12a5	A	T	2: 164,982,808		probably benign	Het
Slc7a3	T	C	X: 101,082,833	E222G	probably benign	Het
Stox1	A	T	10: 62,664,047	H911Q	probably benign	Het
Sult3a2	A	T	10: 33,766,439	N289K	probably benign	Het
Supt20	A	G	3: 54,715,524		probably benign	Het
Tchh	A	G	3: 93,444,078	E275G	unknown	Het
Tectb	A	T	19: 55,191,511	N263I	probably damaging	Het
Ttyh3	A	G	5: 140,629,464	Y390H	probably damaging	Het
Utf1	C	A	7: 139,944,016	S48*	probably null	Het
Zfp358	G	A	8: 3,496,786	G456D	probably benign	Het
Zufsp	A	G	10: 33,930,154		probably null	Het

Other mutations in Tsga10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00573:Tsga10	APN	1	37807070	missense	probably damaging	0.99
IGL00579:Tsga10	APN	1	37835453	missense	probably damaging	1.00
IGL00837:Tsga10	APN	1	37801911	splice site	probably benign
IGL01577:Tsga10	APN	1	37835457	missense	possibly damaging	0.85
IGL01727:Tsga10	APN	1	37835274	missense	probably damaging	1.00
IGL02037:Tsga10	APN	1	37807017	missense	probably benign	0.05
R0346:Tsga10	UTSW	1	37840519	missense	possibly damaging	0.65
R0789:Tsga10	UTSW	1	37801787	missense	possibly damaging	0.87
R0961:Tsga10	UTSW	1	37761428	critical splice donor site	probably null
R1370:Tsga10	UTSW	1	37835453	missense	probably damaging	1.00
R1440:Tsga10	UTSW	1	37819599	missense	probably damaging	1.00
R1827:Tsga10	UTSW	1	37835580	missense	probably damaging	1.00
R2504:Tsga10	UTSW	1	37815677	missense	probably damaging	1.00
R3104:Tsga10	UTSW	1	37801791	missense	probably damaging	1.00
R3105:Tsga10	UTSW	1	37801791	missense	probably damaging	1.00
R3106:Tsga10	UTSW	1	37801791	missense	probably damaging	1.00
R3824:Tsga10	UTSW	1	37834197	missense	possibly damaging	0.73
R3825:Tsga10	UTSW	1	37834197	missense	possibly damaging	0.73
R4560:Tsga10	UTSW	1	37807082	missense	probably benign	0.00
R4773:Tsga10	UTSW	1	37835525	missense	probably damaging	1.00
R4927:Tsga10	UTSW	1	37801850	missense	probably damaging	1.00
R5036:Tsga10	UTSW	1	37783968	missense	possibly damaging	0.65
R5326:Tsga10	UTSW	1	37761517	missense	probably damaging	1.00
R5345:Tsga10	UTSW	1	37763311	missense	probably damaging	1.00
R5503:Tsga10	UTSW	1	37760947	makesense	probably null
R5542:Tsga10	UTSW	1	37761517	missense	probably damaging	1.00
R5793:Tsga10	UTSW	1	37835459	missense	probably damaging	1.00
R6340:Tsga10	UTSW	1	37835185	intron	probably benign
R7096:Tsga10	UTSW	1	37840614	missense	probably damaging	0.98
R7130:Tsga10	UTSW	1	37783884	missense	probably damaging	1.00
R7401:Tsga10	UTSW	1	37834187	missense	probably null	1.00
R7649:Tsga10	UTSW	1	37835148	missense	unknown
R7773:Tsga10	UTSW	1	37835242	missense	unknown

Posted On

2015-04-16