Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02510:Or5p64'

296520

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5p64

Ensembl Gene

ENSMUSG00000096465

Gene Name

olfactory receptor family 5 subfamily P member 64

Synonyms

Olfr488, MOR204-15, GA_x6K02T2PBJ9-10586187-10585243

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.207) question?

Stock #

IGL02510

Quality Score

Status

Chromosome

Chromosomal Location

107854399-107855343 bp(-) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

T to A at 107855348 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149427 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072968] [ENSMUST00000211345] [ENSMUST00000211508] [ENSMUST00000215173]

AlphaFold

Q8VG02

Predicted Effect

probably benign
Transcript: ENSMUST00000072968

SMART Domains

Protein: ENSMUSP00000072735
Gene: ENSMUSG00000096465

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	311	5.7e-53	PFAM
Pfam:7tm_1	44	293	2.6e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211345

Predicted Effect

probably benign
Transcript: ENSMUST00000211508

Predicted Effect

probably benign
Transcript: ENSMUST00000215173

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts4	G	A	1: 171,078,959 (GRCm39)	S193N	probably benign	Het
Arrdc1	C	A	2: 24,825,112 (GRCm39)	V16F	probably damaging	Het
Bhmt1b	A	G	18: 87,775,653 (GRCm39)	Q392R	probably benign	Het
Bsx	A	T	9: 40,785,517 (GRCm39)	Q15L	possibly damaging	Het
Casp8ap2	A	G	4: 32,639,704 (GRCm39)	T253A	probably benign	Het
Cdkl3	T	C	11: 51,902,097 (GRCm39)	L102P	probably damaging	Het
Cgnl1	G	T	9: 71,632,639 (GRCm39)	N237K	probably benign	Het
Cldn14	T	A	16: 93,716,844 (GRCm39)	M1L	probably damaging	Het
Col1a2	C	T	6: 4,516,398 (GRCm39)	R171C	unknown	Het
Col7a1	C	A	9: 108,802,299 (GRCm39)		probably benign	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Dhrs2	G	A	14: 55,473,532 (GRCm39)	V64M	probably damaging	Het
Disp3	G	A	4: 148,337,158 (GRCm39)	H886Y	probably benign	Het
Dst	G	A	1: 34,268,332 (GRCm39)		probably null	Het
Fnbp4	T	C	2: 90,581,819 (GRCm39)	V215A	probably benign	Het
Fzd9	A	G	5: 135,278,469 (GRCm39)	L472P	probably damaging	Het
Hpd	C	T	5: 123,319,973 (GRCm39)	R15Q	possibly damaging	Het
Htra2	A	G	6: 83,028,592 (GRCm39)	V412A	probably damaging	Het
Ift80	A	G	3: 68,805,876 (GRCm39)	F722S	probably benign	Het
Kcnq2	T	C	2: 180,723,154 (GRCm39)	T741A	probably benign	Het
Kl	A	C	5: 150,912,466 (GRCm39)	E738D	probably damaging	Het
Klra4	T	A	6: 130,036,506 (GRCm39)	I178L	probably damaging	Het
Klra9	T	C	6: 130,168,185 (GRCm39)	E27G	probably benign	Het
Kntc1	T	C	5: 123,957,125 (GRCm39)	Y2145H	probably benign	Het
Mbd5	T	A	2: 49,147,041 (GRCm39)	M417K	probably benign	Het
Med31	C	T	11: 72,102,882 (GRCm39)	M75I	probably benign	Het
Mpeg1	A	T	19: 12,438,788 (GRCm39)	D82V	probably damaging	Het
Msto1	A	G	3: 88,817,652 (GRCm39)	Y439H	probably damaging	Het
Or1e17	G	A	11: 73,831,831 (GRCm39)	G253E	probably damaging	Het
Or1j15	T	C	2: 36,458,693 (GRCm39)	S28P	possibly damaging	Het
Or2av9	T	C	11: 58,381,365 (GRCm39)	Y72C	probably damaging	Het
Prtg	G	A	9: 72,798,151 (GRCm39)	V706M	probably damaging	Het
Sfxn2	G	T	19: 46,576,711 (GRCm39)	A186S	probably benign	Het
Slc12a5	A	T	2: 164,824,728 (GRCm39)		probably benign	Het
Slc7a3	T	C	X: 100,126,439 (GRCm39)	E222G	probably benign	Het
Stox1	A	T	10: 62,499,826 (GRCm39)	H911Q	probably benign	Het
Sult3a2	A	T	10: 33,642,435 (GRCm39)	N289K	probably benign	Het
Supt20	A	G	3: 54,622,945 (GRCm39)		probably benign	Het
Tchh	A	G	3: 93,351,385 (GRCm39)	E275G	unknown	Het
Tectb	A	T	19: 55,179,943 (GRCm39)	N263I	probably damaging	Het
Tsga10	C	T	1: 37,800,066 (GRCm39)	R608Q	possibly damaging	Het
Ttyh3	A	G	5: 140,615,219 (GRCm39)	Y390H	probably damaging	Het
Utf1	C	A	7: 139,523,929 (GRCm39)	S48*	probably null	Het
Zfp358	G	A	8: 3,546,786 (GRCm39)	G456D	probably benign	Het
Zup1	A	G	10: 33,806,150 (GRCm39)		probably null	Het

Other mutations in Or5p64

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01575:Or5p64	APN	7	107,854,742 (GRCm39)	missense	possibly damaging	0.89
IGL02943:Or5p64	APN	7	107,854,623 (GRCm39)	missense	possibly damaging	0.80
IGL02962:Or5p64	APN	7	107,854,910 (GRCm39)	missense	possibly damaging	0.78
PIT4472001:Or5p64	UTSW	7	107,855,310 (GRCm39)	missense	possibly damaging	0.46
R0980:Or5p64	UTSW	7	107,855,229 (GRCm39)	small deletion	probably benign
R0981:Or5p64	UTSW	7	107,855,229 (GRCm39)	small deletion	probably benign
R0981:Or5p64	UTSW	7	107,855,228 (GRCm39)	small deletion	probably benign
R1957:Or5p64	UTSW	7	107,854,403 (GRCm39)	nonsense	probably null
R3147:Or5p64	UTSW	7	107,854,883 (GRCm39)	missense	possibly damaging	0.89
R4163:Or5p64	UTSW	7	107,855,039 (GRCm39)	missense	probably benign	0.06
R4190:Or5p64	UTSW	7	107,855,330 (GRCm39)	missense	probably benign
R4911:Or5p64	UTSW	7	107,855,244 (GRCm39)	missense	possibly damaging	0.81
R5274:Or5p64	UTSW	7	107,854,842 (GRCm39)	missense	probably benign	0.02
R5684:Or5p64	UTSW	7	107,855,246 (GRCm39)	missense	possibly damaging	0.75
R6394:Or5p64	UTSW	7	107,854,970 (GRCm39)	missense	possibly damaging	0.95
R6467:Or5p64	UTSW	7	107,855,109 (GRCm39)	missense	probably damaging	0.99
R7173:Or5p64	UTSW	7	107,854,955 (GRCm39)	missense	possibly damaging	0.78
R7317:Or5p64	UTSW	7	107,854,425 (GRCm39)	missense	probably benign	0.00
R7348:Or5p64	UTSW	7	107,855,330 (GRCm39)	missense	probably benign
R7485:Or5p64	UTSW	7	107,855,045 (GRCm39)	missense	probably damaging	1.00
R9358:Or5p64	UTSW	7	107,854,799 (GRCm39)	missense	probably damaging	0.99
R9715:Or5p64	UTSW	7	107,855,198 (GRCm39)	missense	probably benign	0.45

Posted On

2015-04-16