Incidental Mutation 'IGL02513:Or2b6'
ID 296646
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2b6
Ensembl Gene ENSMUSG00000036658
Gene Name olfactory receptor family 2 subfamily B member 6
Synonyms GA_x6K02T2QHY8-11597382-11598323, MOR256-11, Olfr11
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.350) question?
Stock # IGL02513
Quality Score
Status
Chromosome 13
Chromosomal Location 21822750-21823691 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21823510 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 61 (F61S)
Ref Sequence ENSEMBL: ENSMUSP00000146091 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043081] [ENSMUST00000205631]
AlphaFold Q60890
Predicted Effect probably damaging
Transcript: ENSMUST00000043081
AA Change: F61S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000043099
Gene: ENSMUSG00000036658
AA Change: F61S

DomainStartEndE-ValueType
Pfam:7tm_4 31 311 4.9e-51 PFAM
Pfam:7tm_1 41 290 7.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205631
AA Change: F61S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apob G T 12: 8,042,979 (GRCm39) V787F probably benign Het
Atg14 T C 14: 47,786,451 (GRCm39) I268V probably benign Het
Atg14 T A 14: 47,783,081 (GRCm39) probably benign Het
Atm A T 9: 53,408,562 (GRCm39) probably benign Het
Ccdc9 A G 7: 16,018,434 (GRCm39) probably benign Het
Cers6 T C 2: 68,899,013 (GRCm39) F217S probably benign Het
Crebbp A C 16: 3,944,469 (GRCm39) probably null Het
Csmd1 T A 8: 16,049,869 (GRCm39) probably benign Het
Dmac2l A T 12: 69,787,819 (GRCm39) Y85F probably benign Het
Eml1 T A 12: 108,496,571 (GRCm39) V609E probably damaging Het
Fryl A G 5: 73,222,636 (GRCm39) S204P probably damaging Het
Gpr152 A G 19: 4,192,843 (GRCm39) D128G probably damaging Het
Itgal T A 7: 126,927,844 (GRCm39) V1013D possibly damaging Het
Kctd18 A G 1: 58,004,559 (GRCm39) Y112H probably damaging Het
Kdm4d T A 9: 14,375,850 (GRCm39) T3S probably benign Het
Lrp1b C T 2: 41,000,765 (GRCm39) probably null Het
Mex3c T A 18: 73,723,360 (GRCm39) D484E possibly damaging Het
Nalf1 T A 8: 9,257,930 (GRCm39) D406V probably benign Het
Nat14 T C 7: 4,927,050 (GRCm39) V74A possibly damaging Het
Pabpc2 C T 18: 39,908,193 (GRCm39) T486I probably benign Het
Pgm2 A G 5: 64,260,289 (GRCm39) probably benign Het
Pkn3 T A 2: 29,973,149 (GRCm39) I353N probably damaging Het
Rbm44 T A 1: 91,083,260 (GRCm39) S594R possibly damaging Het
Rrbp1 C T 2: 143,830,350 (GRCm39) A606T possibly damaging Het
Tcof1 A G 18: 60,964,850 (GRCm39) V623A possibly damaging Het
Tg A G 15: 66,577,123 (GRCm39) E1482G probably benign Het
Uba1 A G X: 20,541,885 (GRCm39) T546A probably benign Het
Vmn2r37 T C 7: 9,220,934 (GRCm39) K310E probably benign Het
Zbtb38 A T 9: 96,569,126 (GRCm39) W653R probably damaging Het
Zdhhc19 A T 16: 32,318,440 (GRCm39) I99F probably damaging Het
Zfp236 T C 18: 82,648,239 (GRCm39) Y974C probably damaging Het
Other mutations in Or2b6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0513:Or2b6 UTSW 13 21,823,119 (GRCm39) missense probably benign 0.26
R0928:Or2b6 UTSW 13 21,823,126 (GRCm39) missense probably damaging 1.00
R1440:Or2b6 UTSW 13 21,823,560 (GRCm39) missense probably benign 0.11
R1673:Or2b6 UTSW 13 21,823,214 (GRCm39) missense probably damaging 1.00
R1705:Or2b6 UTSW 13 21,823,331 (GRCm39) missense probably damaging 1.00
R2080:Or2b6 UTSW 13 21,823,606 (GRCm39) missense probably damaging 0.99
R2187:Or2b6 UTSW 13 21,823,555 (GRCm39) missense probably damaging 0.99
R2283:Or2b6 UTSW 13 21,823,190 (GRCm39) missense probably damaging 1.00
R2340:Or2b6 UTSW 13 21,822,757 (GRCm39) missense probably benign 0.03
R3690:Or2b6 UTSW 13 21,823,508 (GRCm39) missense probably damaging 1.00
R4108:Or2b6 UTSW 13 21,822,952 (GRCm39) missense probably damaging 1.00
R4739:Or2b6 UTSW 13 21,823,340 (GRCm39) missense possibly damaging 0.90
R4740:Or2b6 UTSW 13 21,823,340 (GRCm39) missense possibly damaging 0.90
R5335:Or2b6 UTSW 13 21,822,949 (GRCm39) missense probably damaging 1.00
R5790:Or2b6 UTSW 13 21,823,046 (GRCm39) missense probably benign
R6320:Or2b6 UTSW 13 21,823,418 (GRCm39) missense probably damaging 1.00
R7406:Or2b6 UTSW 13 21,823,316 (GRCm39) missense probably benign 0.16
R7508:Or2b6 UTSW 13 21,822,779 (GRCm39) missense probably benign 0.19
R8054:Or2b6 UTSW 13 21,823,119 (GRCm39) missense probably benign 0.26
Posted On 2015-04-16