Incidental Mutation 'IGL02514:Olfr322'
ID296680
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr322
Ensembl Gene ENSMUSG00000063549
Gene Nameolfactory receptor 322
SynonymsGA_x6K02T2NKPP-754816-754257, OTTMUSG00000005755, Olfr216, Olfr322-ps1, Olfr179, GA_x6K02SYUPNB-557-3, MOR256-64, GA_x6K02SYUNE5-2-727
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL02514
Quality Score
Status
Chromosome11
Chromosomal Location58658782-58669528 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 58665643 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 28 (F28S)
Ref Sequence ENSEMBL: ENSMUSP00000149062 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072030] [ENSMUST00000213232] [ENSMUST00000213793] [ENSMUST00000214392] [ENSMUST00000214400] [ENSMUST00000216442] [ENSMUST00000217399]
Predicted Effect probably damaging
Transcript: ENSMUST00000072030
AA Change: F28S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071913
Gene: ENSMUSG00000063549
AA Change: F28S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 25 305 2.7e-6 PFAM
Pfam:7tm_4 31 308 3.5e-48 PFAM
Pfam:7tm_1 41 290 3.2e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157597
Predicted Effect probably damaging
Transcript: ENSMUST00000213232
AA Change: F28S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000213793
AA Change: F28S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000214392
AA Change: F28S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000214400
AA Change: F28S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216442
AA Change: F28S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000217399
AA Change: F28S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310009B15Rik A T 1: 138,852,171 C114* probably null Het
4933421I07Rik A G 7: 42,447,557 M110T probably damaging Het
Amer1 A G X: 95,426,511 V667A possibly damaging Het
Casr C T 16: 36,500,325 G487E probably damaging Het
Catsperd G A 17: 56,661,271 G552D probably damaging Het
Ceacam3 A G 7: 17,162,981 D624G possibly damaging Het
Celsr2 A G 3: 108,397,510 V2208A probably benign Het
Clca4a G A 3: 144,955,071 S664F probably damaging Het
Ddx23 A T 15: 98,658,318 S40T unknown Het
Dhodh G A 8: 109,606,264 R58* probably null Het
Dhx36 A G 3: 62,500,898 L173S possibly damaging Het
Dnaaf5 C T 5: 139,174,117 probably benign Het
Dnah3 T C 7: 119,966,247 D2546G probably damaging Het
Eef2 T G 10: 81,179,593 I316S probably benign Het
Efcab6 T C 15: 84,032,942 D139G possibly damaging Het
Efcab6 A T 15: 83,871,311 probably benign Het
Eif4g3 T A 4: 138,126,194 I357N possibly damaging Het
Elovl2 G A 13: 41,194,771 T44M probably benign Het
Fam92a T G 4: 12,164,080 probably benign Het
Fbln1 T A 15: 85,244,262 C553* probably null Het
Fip1l1 T C 5: 74,571,152 V310A probably damaging Het
Gast A G 11: 100,336,892 D100G probably benign Het
Gk G A X: 85,713,364 probably benign Het
Gm1330 G A 2: 148,999,385 probably benign Het
Hspg2 C A 4: 137,569,576 T4355K probably benign Het
Ipo7 T C 7: 110,048,828 V639A possibly damaging Het
Lrrc7 T C 3: 158,160,292 M1271V probably damaging Het
Msantd1 T A 5: 34,921,543 S141T probably damaging Het
Myo9b T C 8: 71,291,006 I237T probably damaging Het
Olfr1129 G A 2: 87,575,193 M36I probably benign Het
Olfr1286 A C 2: 111,420,772 Y60D probably damaging Het
Olfr532 A T 7: 140,419,594 Y60N probably damaging Het
Pan2 A T 10: 128,310,741 M416L possibly damaging Het
Pank4 T C 4: 154,970,465 F209L probably damaging Het
Pcdhb13 A T 18: 37,442,991 I141L possibly damaging Het
Pik3r2 A G 8: 70,770,592 Y422H probably benign Het
Pramef17 T C 4: 143,993,202 K198E probably benign Het
Prdm4 A T 10: 85,907,917 I158N probably damaging Het
Prl T G 13: 27,059,394 L14R probably damaging Het
Rabl6 C A 2: 25,608,176 A23S probably damaging Het
Rbm15b T A 9: 106,884,977 H664L probably damaging Het
Rhobtb1 T A 10: 69,289,641 H618Q probably benign Het
Slc15a1 T C 14: 121,487,040 K140R probably damaging Het
Slc6a17 A G 3: 107,495,677 S145P possibly damaging Het
Snx31 T C 15: 36,525,582 T324A probably damaging Het
Spatc1l T C 10: 76,569,656 probably benign Het
Taar7b A G 10: 24,000,984 N349S probably benign Het
Tbx19 T C 1: 165,153,704 I74V probably benign Het
Tmtc2 G A 10: 105,190,099 T836I possibly damaging Het
Vmn2r72 C A 7: 85,738,699 M552I possibly damaging Het
Vsig10l A G 7: 43,463,914 T199A probably benign Het
Washc4 A T 10: 83,570,083 E481V probably damaging Het
Zc3h15 T A 2: 83,653,381 N33K probably damaging Het
Other mutations in Olfr322
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01960:Olfr322 APN 11 58665865 missense probably benign 0.05
IGL02823:Olfr322 APN 11 58665967 missense possibly damaging 0.95
R0449:Olfr322 UTSW 11 58665963 missense probably benign 0.02
R0600:Olfr322 UTSW 11 58666160 missense probably damaging 1.00
R0865:Olfr322 UTSW 11 58665652 missense possibly damaging 0.84
R1601:Olfr322 UTSW 11 58666077 missense probably damaging 0.97
R2062:Olfr322 UTSW 11 58665982 missense probably damaging 1.00
R5642:Olfr322 UTSW 11 58666399 missense possibly damaging 0.55
R6232:Olfr322 UTSW 11 58665931 missense possibly damaging 0.95
R7383:Olfr322 UTSW 11 58666185 missense possibly damaging 0.94
Posted On2015-04-16