Incidental Mutation 'IGL02515:Or8g51'
ID 296717
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8g51
Ensembl Gene ENSMUSG00000056961
Gene Name olfactory receptor family 8 subfamily G member 51
Synonyms GA_x6K02T2PVTD-32400678-32399743, Olfr919, MOR171-23
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # IGL02515
Quality Score
Status
Chromosome 9
Chromosomal Location 38608725-38609672 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38609087 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 196 (T196A)
Ref Sequence ENSEMBL: ENSMUSP00000071372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071425] [ENSMUST00000215612] [ENSMUST00000217508]
AlphaFold Q8VF78
Predicted Effect probably benign
Transcript: ENSMUST00000071425
AA Change: T196A

PolyPhen 2 Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000071372
Gene: ENSMUSG00000056961
AA Change: T196A

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 9.8e-50 PFAM
Pfam:7tm_1 45 294 9e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215612
AA Change: T192A

PolyPhen 2 Score 0.156 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000217508
AA Change: T192A

PolyPhen 2 Score 0.156 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca A G 11: 84,153,229 (GRCm39) D879G probably benign Het
Atp6v0d2 A T 4: 19,880,063 (GRCm39) F278Y possibly damaging Het
Cip2a A G 16: 48,826,096 (GRCm39) T388A possibly damaging Het
Dapk3 T C 10: 81,025,763 (GRCm39) probably benign Het
Dpysl4 A T 7: 138,676,651 (GRCm39) D367V probably damaging Het
E330034G19Rik T A 14: 24,348,052 (GRCm39) D101E possibly damaging Het
Epb41l1 G A 2: 156,378,933 (GRCm39) E811K probably damaging Het
Fsd1 T A 17: 56,303,303 (GRCm39) V424E probably null Het
Ggt5 G A 10: 75,425,604 (GRCm39) V21I probably benign Het
Gm5239 A G 18: 35,669,787 (GRCm39) E51G probably damaging Het
Gpr156 A G 16: 37,826,041 (GRCm39) S753G probably damaging Het
Grid1 A T 14: 35,174,302 (GRCm39) Y648F probably damaging Het
Hmgcr T C 13: 96,803,020 (GRCm39) probably benign Het
Insc A G 7: 114,368,243 (GRCm39) D11G probably damaging Het
Mmp9 A G 2: 164,790,876 (GRCm39) D88G probably damaging Het
Mtmr10 C T 7: 63,987,259 (GRCm39) R600W probably damaging Het
Nlrc3 C A 16: 3,767,323 (GRCm39) probably benign Het
Or5b116 T A 19: 13,422,472 (GRCm39) I32N probably damaging Het
Pdcd11 A T 19: 47,113,516 (GRCm39) D1323V probably damaging Het
Rgl3 T C 9: 21,885,396 (GRCm39) R645G possibly damaging Het
Rnf2 A T 1: 151,347,446 (GRCm39) D137E probably benign Het
Smchd1 T C 17: 71,747,952 (GRCm39) H430R probably damaging Het
Sptb A G 12: 76,653,261 (GRCm39) V1534A possibly damaging Het
Stip1 T C 19: 6,999,487 (GRCm39) T432A probably benign Het
Tnfsf14 T C 17: 57,499,600 (GRCm39) D84G probably benign Het
Ube2o A G 11: 116,434,525 (GRCm39) V601A probably damaging Het
Vmn1r215 T C 13: 23,259,990 (GRCm39) I10T probably benign Het
Vtn A T 11: 78,392,480 (GRCm39) I353F probably damaging Het
Other mutations in Or8g51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01510:Or8g51 APN 9 38,609,201 (GRCm39) missense probably benign 0.00
IGL02745:Or8g51 APN 9 38,609,494 (GRCm39) missense probably damaging 0.99
H8562:Or8g51 UTSW 9 38,609,206 (GRCm39) missense probably damaging 1.00
R1960:Or8g51 UTSW 9 38,609,500 (GRCm39) missense probably benign 0.28
R1973:Or8g51 UTSW 9 38,609,164 (GRCm39) missense probably damaging 0.96
R3119:Or8g51 UTSW 9 38,608,955 (GRCm39) nonsense probably null
R4543:Or8g51 UTSW 9 38,608,841 (GRCm39) missense possibly damaging 0.93
R4752:Or8g51 UTSW 9 38,609,266 (GRCm39) missense probably damaging 0.99
R5474:Or8g51 UTSW 9 38,609,609 (GRCm39) missense possibly damaging 0.69
R5532:Or8g51 UTSW 9 38,608,943 (GRCm39) missense probably damaging 1.00
R5635:Or8g51 UTSW 9 38,609,455 (GRCm39) missense possibly damaging 0.64
R5940:Or8g51 UTSW 9 38,609,007 (GRCm39) nonsense probably null
R6820:Or8g51 UTSW 9 38,608,771 (GRCm39) missense possibly damaging 0.88
R7164:Or8g51 UTSW 9 38,609,515 (GRCm39) missense possibly damaging 0.95
R7337:Or8g51 UTSW 9 38,609,161 (GRCm39) missense probably benign 0.12
R7806:Or8g51 UTSW 9 38,609,567 (GRCm39) missense probably benign 0.39
R8287:Or8g51 UTSW 9 38,609,633 (GRCm39) missense probably benign 0.06
R9120:Or8g51 UTSW 9 38,608,735 (GRCm39) missense probably benign 0.01
Z1176:Or8g51 UTSW 9 38,609,224 (GRCm39) missense possibly damaging 0.76
Posted On 2015-04-16