Incidental Mutation 'IGL02515:Dapk3'
ID296740
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dapk3
Ensembl Gene ENSMUSG00000034974
Gene Namedeath-associated protein kinase 3
SynonymsZIP kinase
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02515
Quality Score
Status
Chromosome10
Chromosomal Location81183005-81193197 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 81189929 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047665] [ENSMUST00000178422] [ENSMUST00000218157] [ENSMUST00000219133] [ENSMUST00000219850]
Predicted Effect probably benign
Transcript: ENSMUST00000047665
SMART Domains Protein: ENSMUSP00000035962
Gene: ENSMUSG00000034974

DomainStartEndE-ValueType
S_TKc 13 275 1.93e-98 SMART
low complexity region 288 299 N/A INTRINSIC
low complexity region 331 347 N/A INTRINSIC
low complexity region 349 411 N/A INTRINSIC
coiled coil region 419 444 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129834
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129950
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150782
Predicted Effect probably benign
Transcript: ENSMUST00000178422
SMART Domains Protein: ENSMUSP00000137333
Gene: ENSMUSG00000034974

DomainStartEndE-ValueType
S_TKc 13 275 1.93e-98 SMART
low complexity region 288 299 N/A INTRINSIC
low complexity region 331 347 N/A INTRINSIC
low complexity region 349 411 N/A INTRINSIC
coiled coil region 419 444 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217936
Predicted Effect probably benign
Transcript: ENSMUST00000218157
Predicted Effect probably benign
Transcript: ENSMUST00000218227
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218698
Predicted Effect probably benign
Transcript: ENSMUST00000219133
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219329
Predicted Effect probably benign
Transcript: ENSMUST00000219850
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219944
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220076
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene-trapped allele exhibit embryonic lethality after blastocyst implantation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca A G 11: 84,262,403 D879G probably benign Het
Atp6v0d2 A T 4: 19,880,063 F278Y possibly damaging Het
C330027C09Rik A G 16: 49,005,733 T388A possibly damaging Het
Dpysl4 A T 7: 139,096,735 D367V probably damaging Het
E330034G19Rik T A 14: 24,297,984 D101E possibly damaging Het
Epb41l1 G A 2: 156,537,013 E811K probably damaging Het
Fsd1 T A 17: 55,996,303 V424E probably null Het
Ggt5 G A 10: 75,589,770 V21I probably benign Het
Gm5239 A G 18: 35,536,734 E51G probably damaging Het
Gpr156 A G 16: 38,005,679 S753G probably damaging Het
Grid1 A T 14: 35,452,345 Y648F probably damaging Het
Hmgcr T C 13: 96,666,512 probably benign Het
Insc A G 7: 114,769,008 D11G probably damaging Het
Mmp9 A G 2: 164,948,956 D88G probably damaging Het
Mtmr10 C T 7: 64,337,511 R600W probably damaging Het
Nlrc3 C A 16: 3,949,459 probably benign Het
Olfr1471 T A 19: 13,445,108 I32N probably damaging Het
Olfr919 T C 9: 38,697,791 T196A probably benign Het
Pdcd11 A T 19: 47,125,077 D1323V probably damaging Het
Rgl3 T C 9: 21,974,100 R645G possibly damaging Het
Rnf2 A T 1: 151,471,695 D137E probably benign Het
Smchd1 T C 17: 71,440,957 H430R probably damaging Het
Sptb A G 12: 76,606,487 V1534A possibly damaging Het
Stip1 T C 19: 7,022,119 T432A probably benign Het
Tnfsf14 T C 17: 57,192,600 D84G probably benign Het
Ube2o A G 11: 116,543,699 V601A probably damaging Het
Vmn1r215 T C 13: 23,075,820 I10T probably benign Het
Vtn A T 11: 78,501,654 I353F probably damaging Het
Other mutations in Dapk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00944:Dapk3 APN 10 81184076 critical splice donor site probably null
IGL02076:Dapk3 APN 10 81190297 missense probably damaging 1.00
IGL02329:Dapk3 APN 10 81190165 missense probably benign 0.42
IGL03002:Dapk3 APN 10 81190603 nonsense probably null
R0131:Dapk3 UTSW 10 81192307 missense probably benign 0.05
R0727:Dapk3 UTSW 10 81190262 missense probably damaging 1.00
R1628:Dapk3 UTSW 10 81191809 missense possibly damaging 0.79
R5084:Dapk3 UTSW 10 81190318 splice site probably null
R5222:Dapk3 UTSW 10 81192460 missense probably damaging 0.98
R6112:Dapk3 UTSW 10 81184030 missense probably benign 0.43
R6799:Dapk3 UTSW 10 81190262 missense probably damaging 1.00
R6884:Dapk3 UTSW 10 81191754 splice site probably null
Z1177:Dapk3 UTSW 10 81191769 frame shift probably null
Posted On2015-04-16