Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02516:Morn3'

296748

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Morn3

Ensembl Gene

ENSMUSG00000029477

Gene Name

MORN repeat containing 3

Synonyms

4930438O03Rik

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.354) question?

Stock #

IGL02516

Quality Score

Status

Chromosome

Chromosomal Location

123035769-123047016 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 123037300 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Stop codon at position 33 (E33*)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031437] [ENSMUST00000045843] [ENSMUST00000132775] [ENSMUST00000145257]

Predicted Effect

probably null
Transcript: ENSMUST00000031437
AA Change: E237*

SMART Domains

Protein: ENSMUSP00000031437
Gene: ENSMUSG00000029477
AA Change: E237*

Domain	Start	End	E-Value	Type
MORN	36	57	3.24e-4	SMART
MORN	60	81	5.18e-3	SMART
MORN	89	110	3.51e0	SMART
MORN	112	133	3.09e-1	SMART
MORN	135	156	1.15e-4	SMART
MORN	158	179	2.57e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000045843

SMART Domains

Protein: ENSMUSP00000041714
Gene: ENSMUSG00000029477

Domain	Start	End	E-Value	Type
MORN	36	57	3.24e-4	SMART
MORN	60	81	5.18e-3	SMART
MORN	89	110	3.51e0	SMART
MORN	112	133	3.09e-1	SMART
MORN	135	156	2.26e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000129934
AA Change: E30*

Predicted Effect

probably benign
Transcript: ENSMUST00000132775

SMART Domains

Protein: ENSMUSP00000120199
Gene: ENSMUSG00000029477

Domain	Start	End	E-Value	Type
MORN	36	57	3.24e-4	SMART
MORN	60	81	5.18e-3	SMART
MORN	89	110	3.51e0	SMART
MORN	112	133	3.09e-1	SMART
MORN	135	156	2.26e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000137490
AA Change: E33*

Predicted Effect

probably benign
Transcript: ENSMUST00000145257

SMART Domains

Protein: ENSMUSP00000122306
Gene: ENSMUSG00000029477

Domain	Start	End	E-Value	Type
MORN	36	57	3.24e-4	SMART
MORN	60	81	5.18e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197455

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam32	C	T	8: 24,898,596	S364N	probably damaging	Het
AI314180	T	C	4: 58,877,102	E111G	probably damaging	Het
Ano8	C	T	8: 71,485,077	G47D	probably damaging	Het
App	T	C	16: 84,955,417	T743A	probably damaging	Het
Armc3	A	G	2: 19,300,506	K692E	possibly damaging	Het
Arpp21	T	C	9: 112,185,661	N25S	probably damaging	Het
Avpr1b	G	A	1: 131,600,629	V297I	probably damaging	Het
Bpi	A	G	2: 158,267,731	I200V	possibly damaging	Het
Cacna2d4	C	T	6: 119,271,870		probably benign	Het
Cbarp	A	G	10: 80,135,545	Y149H	probably damaging	Het
Ccdc85c	T	C	12: 108,274,901	N78S	unknown	Het
Cdcp1	G	T	9: 123,173,637	L790M	possibly damaging	Het
Cdkn2d	T	A	9: 21,289,143	I111F	probably benign	Het
Ctsr	A	G	13: 61,163,178	V18A	probably benign	Het
Dapk1	A	G	13: 60,696,347	D60G	probably damaging	Het
Daw1	A	C	1: 83,209,228	N253T	probably benign	Het
Dcaf7	T	A	11: 106,051,872	I215N	probably damaging	Het
Ddc	A	C	11: 11,829,125	L333R	probably damaging	Het
Dennd1a	A	G	2: 37,852,394		probably null	Het
Dnah10	C	A	5: 124,787,331	T2200K	probably damaging	Het
Dock6	T	C	9: 21,802,585	Y1883C	probably damaging	Het
Eif2ak4	T	A	2: 118,436,254	I752N	probably damaging	Het
Fcho2	A	G	13: 98,730,212	I740T	probably benign	Het
Flnc	A	G	6: 29,450,841	D1496G	probably damaging	Het
Fn1	A	G	1: 71,637,323	V583A	possibly damaging	Het
Grasp	G	A	15: 101,229,051	V137I	probably damaging	Het
Greb1l	A	C	18: 10,537,064	T1010P	probably benign	Het
Hs3st6	T	C	17: 24,758,131	L195P	probably damaging	Het
Hyi	A	G	4: 118,362,483	E239G	probably damaging	Het
Ighv2-3	G	T	12: 113,611,198	Y112*	probably null	Het
Ints3	A	G	3: 90,403,108	F495S	probably damaging	Het
Itih2	T	A	2: 10,097,917	H802L	probably benign	Het
Jag2	C	T	12: 112,910,566	V990M	probably damaging	Het
Kat6b	T	C	14: 21,609,868		probably benign	Het
Krtap4-8	C	T	11: 99,780,342		probably benign	Het
Lhx4	A	G	1: 155,702,257	S380P	probably damaging	Het
Mug2	C	T	6: 122,070,843	A771V	probably damaging	Het
N4bp3	A	T	11: 51,644,334	S343T	probably benign	Het
Nlrp1a	T	C	11: 71,114,460	N643S	probably damaging	Het
Olfr15	A	C	16: 3,839,336	D121A	probably damaging	Het
Olfr767	T	A	10: 129,079,793	M57L	possibly damaging	Het
Olfr93	T	A	17: 37,151,272	R79S	possibly damaging	Het
Phc3	A	G	3: 30,948,793	F192S	probably damaging	Het
Pigq	C	T	17: 25,937,247	R69H	probably benign	Het
Plk3	A	G	4: 117,131,989	C222R	probably damaging	Het
Pomt2	T	C	12: 87,119,646	T490A	probably benign	Het
Prss29	T	C	17: 25,320,901	I91T	probably damaging	Het
Ralgapb	A	T	2: 158,465,815		probably benign	Het
Sccpdh	G	A	1: 179,681,691	G75D	probably damaging	Het
Serpine2	T	C	1: 79,794,997		probably benign	Het
Sfr1	T	G	19: 47,732,990		probably null	Het
Slc22a23	C	A	13: 34,203,955	C386F	probably benign	Het
Slc22a27	T	C	19: 7,864,811	K433R	probably damaging	Het
Slc39a12	T	C	2: 14,400,335	L246P	probably damaging	Het
Slc4a11	A	G	2: 130,691,393	I191T	possibly damaging	Het
Slc9c1	A	G	16: 45,577,875	N668D	probably damaging	Het
Supt16	A	T	14: 52,183,964	D41E	possibly damaging	Het
Ugt2b37	A	G	5: 87,240,882	S491P	probably damaging	Het
Urb1	G	T	16: 90,772,695	T1381N	possibly damaging	Het
Usp8	A	G	2: 126,742,174	I423M	probably benign	Het
Vmn1r191	T	A	13: 22,179,540	I15F	probably benign	Het
Zbtb5	A	T	4: 44,993,798	Y529N	probably damaging	Het
Zfp541	T	A	7: 16,082,993		probably null	Het

Other mutations in Morn3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01925:Morn3	APN	5	123046762	missense	probably damaging	1.00
IGL02257:Morn3	APN	5	123037725	missense	probably damaging	1.00
R0052:Morn3	UTSW	5	123046663	missense	probably damaging	1.00
R0052:Morn3	UTSW	5	123046663	missense	probably damaging	1.00
R0433:Morn3	UTSW	5	123039333	missense	probably benign	0.01
R1854:Morn3	UTSW	5	123046629	critical splice donor site	probably null
R4893:Morn3	UTSW	5	123037682	missense	probably damaging	1.00
R5854:Morn3	UTSW	5	123041115	missense	probably damaging	1.00
R5899:Morn3	UTSW	5	123041103	missense	probably damaging	1.00
R5983:Morn3	UTSW	5	123037788	missense	possibly damaging	0.80
R6106:Morn3	UTSW	5	123046760	missense	possibly damaging	0.83
R6766:Morn3	UTSW	5	123041207	missense	probably damaging	0.98
R7512:Morn3	UTSW	5	123037280	critical splice donor site	probably null

Posted On

2015-04-16