Incidental Mutation 'IGL02516:Olfr93'
ID 296768
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr93
Ensembl Gene ENSMUSG00000091601
Gene Name olfactory receptor 93
Synonyms GA_x6K02T2PSCP-1592036-1591098, MOR256-39P
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # IGL02516
Quality Score
Chromosome 17
Chromosomal Location 37140423-37161494 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37151272 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 79 (R79S)
Ref Sequence ENSEMBL: ENSMUSP00000146548 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171679] [ENSMUST00000208003] [ENSMUST00000219235]
AlphaFold Q6UAH1
Predicted Effect possibly damaging
Transcript: ENSMUST00000171679
AA Change: R233S

PolyPhen 2 Score 0.596 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000125907
Gene: ENSMUSG00000091601
AA Change: R233S

Pfam:7tm_4 29 306 5.7e-50 PFAM
Pfam:7tm_1 39 288 3.3e-28 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000208003
AA Change: R79S

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000219235
AA Change: R233S

PolyPhen 2 Score 0.596 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 C T 8: 24,898,596 (GRCm38) S364N probably damaging Het
AI314180 T C 4: 58,877,102 (GRCm38) E111G probably damaging Het
Ano8 C T 8: 71,485,077 (GRCm38) G47D probably damaging Het
App T C 16: 84,955,417 (GRCm38) T743A probably damaging Het
Armc3 A G 2: 19,300,506 (GRCm38) K692E possibly damaging Het
Arpp21 T C 9: 112,185,661 (GRCm38) N25S probably damaging Het
Avpr1b G A 1: 131,600,629 (GRCm38) V297I probably damaging Het
Bpi A G 2: 158,267,731 (GRCm38) I200V possibly damaging Het
Cacna2d4 C T 6: 119,271,870 (GRCm38) probably benign Het
Cbarp A G 10: 80,135,545 (GRCm38) Y149H probably damaging Het
Ccdc85c T C 12: 108,274,901 (GRCm38) N78S unknown Het
Cdcp1 G T 9: 123,173,637 (GRCm38) L790M possibly damaging Het
Cdkn2d T A 9: 21,289,143 (GRCm38) I111F probably benign Het
Ctsr A G 13: 61,163,178 (GRCm38) V18A probably benign Het
Dapk1 A G 13: 60,696,347 (GRCm38) D60G probably damaging Het
Daw1 A C 1: 83,209,228 (GRCm38) N253T probably benign Het
Dcaf7 T A 11: 106,051,872 (GRCm38) I215N probably damaging Het
Ddc A C 11: 11,829,125 (GRCm38) L333R probably damaging Het
Dennd1a A G 2: 37,852,394 (GRCm38) probably null Het
Dnah10 C A 5: 124,787,331 (GRCm38) T2200K probably damaging Het
Dock6 T C 9: 21,802,585 (GRCm38) Y1883C probably damaging Het
Eif2ak4 T A 2: 118,436,254 (GRCm38) I752N probably damaging Het
Fcho2 A G 13: 98,730,212 (GRCm38) I740T probably benign Het
Flnc A G 6: 29,450,841 (GRCm38) D1496G probably damaging Het
Fn1 A G 1: 71,637,323 (GRCm38) V583A possibly damaging Het
Grasp G A 15: 101,229,051 (GRCm38) V137I probably damaging Het
Greb1l A C 18: 10,537,064 (GRCm38) T1010P probably benign Het
Hs3st6 T C 17: 24,758,131 (GRCm38) L195P probably damaging Het
Hyi A G 4: 118,362,483 (GRCm38) E239G probably damaging Het
Ighv2-3 G T 12: 113,611,198 (GRCm38) Y112* probably null Het
Ints3 A G 3: 90,403,108 (GRCm38) F495S probably damaging Het
Itih2 T A 2: 10,097,917 (GRCm38) H802L probably benign Het
Jag2 C T 12: 112,910,566 (GRCm38) V990M probably damaging Het
Kat6b T C 14: 21,609,868 (GRCm38) probably benign Het
Krtap4-8 C T 11: 99,780,342 (GRCm38) probably benign Het
Lhx4 A G 1: 155,702,257 (GRCm38) S380P probably damaging Het
Morn3 C A 5: 123,037,300 (GRCm38) E33* probably null Het
Mug2 C T 6: 122,070,843 (GRCm38) A771V probably damaging Het
N4bp3 A T 11: 51,644,334 (GRCm38) S343T probably benign Het
Nlrp1a T C 11: 71,114,460 (GRCm38) N643S probably damaging Het
Olfr15 A C 16: 3,839,336 (GRCm38) D121A probably damaging Het
Olfr767 T A 10: 129,079,793 (GRCm38) M57L possibly damaging Het
Phc3 A G 3: 30,948,793 (GRCm38) F192S probably damaging Het
Pigq C T 17: 25,937,247 (GRCm38) R69H probably benign Het
Plk3 A G 4: 117,131,989 (GRCm38) C222R probably damaging Het
Pomt2 T C 12: 87,119,646 (GRCm38) T490A probably benign Het
Prss29 T C 17: 25,320,901 (GRCm38) I91T probably damaging Het
Ralgapb A T 2: 158,465,815 (GRCm38) probably benign Het
Sccpdh G A 1: 179,681,691 (GRCm38) G75D probably damaging Het
Serpine2 T C 1: 79,794,997 (GRCm38) probably benign Het
Sfr1 T G 19: 47,732,990 (GRCm38) probably null Het
Slc22a23 C A 13: 34,203,955 (GRCm38) C386F probably benign Het
Slc22a27 T C 19: 7,864,811 (GRCm38) K433R probably damaging Het
Slc39a12 T C 2: 14,400,335 (GRCm38) L246P probably damaging Het
Slc4a11 A G 2: 130,691,393 (GRCm38) I191T possibly damaging Het
Slc9c1 A G 16: 45,577,875 (GRCm38) N668D probably damaging Het
Supt16 A T 14: 52,183,964 (GRCm38) D41E possibly damaging Het
Ugt2b37 A G 5: 87,240,882 (GRCm38) S491P probably damaging Het
Urb1 G T 16: 90,772,695 (GRCm38) T1381N possibly damaging Het
Usp8 A G 2: 126,742,174 (GRCm38) I423M probably benign Het
Vmn1r191 T A 13: 22,179,540 (GRCm38) I15F probably benign Het
Zbtb5 A T 4: 44,993,798 (GRCm38) Y529N probably damaging Het
Zfp541 T A 7: 16,082,993 (GRCm38) probably null Het
Other mutations in Olfr93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01087:Olfr93 APN 17 37,151,441 (GRCm38) missense probably damaging 1.00
IGL02369:Olfr93 APN 17 37,151,774 (GRCm38) missense probably damaging 1.00
IGL02392:Olfr93 APN 17 37,151,088 (GRCm38) missense probably benign 0.03
IGL03089:Olfr93 APN 17 37,151,643 (GRCm38) missense probably damaging 1.00
PIT4515001:Olfr93 UTSW 17 37,151,379 (GRCm38) missense probably benign
R0396:Olfr93 UTSW 17 37,151,555 (GRCm38) missense probably damaging 1.00
R2276:Olfr93 UTSW 17 37,151,254 (GRCm38) nonsense probably null
R2278:Olfr93 UTSW 17 37,151,254 (GRCm38) nonsense probably null
R3419:Olfr93 UTSW 17 37,151,351 (GRCm38) missense probably damaging 0.99
R4254:Olfr93 UTSW 17 37,151,639 (GRCm38) missense possibly damaging 0.90
R4353:Olfr93 UTSW 17 37,151,337 (GRCm38) missense probably damaging 1.00
R4530:Olfr93 UTSW 17 37,151,607 (GRCm38) missense possibly damaging 0.84
R4666:Olfr93 UTSW 17 37,151,379 (GRCm38) missense possibly damaging 0.61
R5583:Olfr93 UTSW 17 37,151,594 (GRCm38) missense probably benign 0.00
R5834:Olfr93 UTSW 17 37,151,799 (GRCm38) missense probably damaging 1.00
R6348:Olfr93 UTSW 17 37,151,606 (GRCm38) missense probably damaging 0.96
R6461:Olfr93 UTSW 17 37,151,471 (GRCm38) missense probably damaging 1.00
R6788:Olfr93 UTSW 17 37,151,822 (GRCm38) missense probably damaging 0.98
R7969:Olfr93 UTSW 17 37,151,186 (GRCm38) missense possibly damaging 0.95
R8374:Olfr93 UTSW 17 37,151,745 (GRCm38) missense probably damaging 0.97
R9126:Olfr93 UTSW 17 37,151,232 (GRCm38) missense possibly damaging 0.90
R9298:Olfr93 UTSW 17 37,151,681 (GRCm38) missense probably damaging 1.00
Z1177:Olfr93 UTSW 17 37,151,825 (GRCm38) missense probably damaging 0.99
Posted On 2015-04-16