Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02517:Vmn1r219'

296810

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r219

Ensembl Gene

ENSMUSG00000061376

Gene Name

vomeronasal 1 receptor 219

Synonyms

V1rh13

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL02517

Quality Score

Status

Chromosome

Chromosomal Location

23346813-23347751 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23347266 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 152 (I152L)

Ref Sequence

ENSEMBL: ENSMUSP00000154240 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076180] [ENSMUST00000226845] [ENSMUST00000227388] [ENSMUST00000228113] [ENSMUST00000228666]

AlphaFold

Q8R271

Predicted Effect

probably benign
Transcript: ENSMUST00000076180
AA Change: I152L

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000075537
Gene: ENSMUSG00000061376
AA Change: I152L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	2	301	3.4e-7	PFAM
Pfam:V1R	33	297	3e-32	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226845
AA Change: I152L

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably benign
Transcript: ENSMUST00000227388
AA Change: I152L

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably benign
Transcript: ENSMUST00000228113
AA Change: I152L

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably benign
Transcript: ENSMUST00000228666
AA Change: I152L

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acnat2	T	G	4: 49,380,647 (GRCm39)	M244L	possibly damaging	Het
Acnat2	A	T	4: 49,380,639 (GRCm39)	C228*	probably null	Het
Adam24	T	C	8: 41,133,218 (GRCm39)	S229P	probably damaging	Het
Alpk3	T	C	7: 80,727,643 (GRCm39)	S258P	probably benign	Het
Atad2b	A	G	12: 5,068,037 (GRCm39)	T1012A	probably benign	Het
Bltp1	A	G	3: 37,013,017 (GRCm39)	E1899G	probably damaging	Het
C4b	A	T	17: 34,953,382 (GRCm39)	S1034T	probably benign	Het
Cd300ld2	T	A	11: 114,901,249 (GRCm39)	H277L	possibly damaging	Het
Chrna4	C	T	2: 180,670,926 (GRCm39)	V277I	probably benign	Het
Col3a1	A	G	1: 45,364,963 (GRCm39)		probably null	Het
Dpep2	C	T	8: 106,715,388 (GRCm39)	V369M	probably damaging	Het
Eml2	T	A	7: 18,940,055 (GRCm39)	N815K	probably damaging	Het
Enpp3	A	G	10: 24,685,746 (GRCm39)		probably benign	Het
Git1	T	C	11: 77,390,413 (GRCm39)	V86A	probably benign	Het
Hivep2	C	T	10: 14,006,926 (GRCm39)	P1175S	probably benign	Het
Hydin	T	C	8: 111,293,604 (GRCm39)	I3517T	probably benign	Het
Ift172	T	A	5: 31,410,992 (GRCm39)		probably null	Het
Jmy	A	G	13: 93,589,316 (GRCm39)	I647T	probably benign	Het
Kifap3	T	A	1: 163,653,440 (GRCm39)		probably benign	Het
Lama3	G	A	18: 12,670,915 (GRCm39)		probably null	Het
Lipa	A	C	19: 34,471,522 (GRCm39)	I351S	possibly damaging	Het
Ltbp2	G	T	12: 84,832,091 (GRCm39)	A1631D	probably benign	Het
Masp2	A	G	4: 148,698,477 (GRCm39)	I519M	probably damaging	Het
Mfsd6	A	G	1: 52,702,436 (GRCm39)		probably benign	Het
Numa1	T	G	7: 101,661,216 (GRCm39)	D1846E	probably benign	Het
Oog3	A	T	4: 143,885,920 (GRCm39)	I226K	probably damaging	Het
Or11h6	A	G	14: 50,880,658 (GRCm39)	T301A	probably benign	Het
Or5an6	A	T	19: 12,372,265 (GRCm39)	I213F	probably benign	Het
Or8b3b	T	C	9: 38,584,209 (GRCm39)	Y177C	probably damaging	Het
Or8g53	T	G	9: 39,683,800 (GRCm39)	T99P	probably damaging	Het
Or9s13	A	T	1: 92,548,183 (GRCm39)	Y185F	probably benign	Het
Pkdcc	T	C	17: 83,531,295 (GRCm39)	S435P	probably damaging	Het
Ppm1g	A	G	5: 31,365,425 (GRCm39)	Y70H	probably damaging	Het
Prcc	C	T	3: 87,776,984 (GRCm39)	S330N	probably damaging	Het
Ror2	A	T	13: 53,272,876 (GRCm39)	L251Q	probably damaging	Het
Scn11a	A	G	9: 119,621,464 (GRCm39)	L651P	probably damaging	Het
Skint6	A	T	4: 112,805,737 (GRCm39)		probably benign	Het
Slc23a4	A	G	6: 34,931,917 (GRCm39)	F186L	probably benign	Het
Slc30a8	A	T	15: 52,198,530 (GRCm39)	D325V	probably benign	Het
Son	C	T	16: 91,452,099 (GRCm39)	T282M	possibly damaging	Het
Tas2r118	A	T	6: 23,969,891 (GRCm39)	F57I	probably damaging	Het
Tcf7l1	A	G	6: 72,606,966 (GRCm39)	S447P	probably benign	Het
Thsd1	T	A	8: 22,733,454 (GRCm39)	V167E	probably damaging	Het
Tle3	T	C	9: 61,322,063 (GRCm39)	V696A	probably damaging	Het
Tmem67	A	T	4: 12,069,463 (GRCm39)	I405K	possibly damaging	Het
Tmem71	A	C	15: 66,413,466 (GRCm39)	V202G	probably benign	Het
Trim6	T	C	7: 103,881,564 (GRCm39)		probably benign	Het
Trip12	A	G	1: 84,721,535 (GRCm39)		probably benign	Het
Ubr1	A	C	2: 120,694,854 (GRCm39)	C1693G	possibly damaging	Het
Ush2a	G	A	1: 188,648,195 (GRCm39)	R4600H	probably damaging	Het
Vil1	A	G	1: 74,465,851 (GRCm39)	I547M	probably benign	Het
Vmn1r26	A	G	6: 57,986,127 (GRCm39)	F21L	possibly damaging	Het
Vmn2r45	T	A	7: 8,486,185 (GRCm39)	K368*	probably null	Het
Vmn2r68	C	T	7: 84,871,153 (GRCm39)	W710*	probably null	Het
Zfp808	T	A	13: 62,321,032 (GRCm39)	*754R	probably null	Het
Zyg11b	C	T	4: 108,123,515 (GRCm39)	E151K	probably damaging	Het

Other mutations in Vmn1r219

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03339:Vmn1r219	APN	13	23,347,580 (GRCm39)	missense	possibly damaging	0.88
R0662:Vmn1r219	UTSW	13	23,347,623 (GRCm39)	missense	possibly damaging	0.51
R1144:Vmn1r219	UTSW	13	23,347,383 (GRCm39)	missense	probably damaging	1.00
R4036:Vmn1r219	UTSW	13	23,347,272 (GRCm39)	missense	probably benign	0.00
R4762:Vmn1r219	UTSW	13	23,346,999 (GRCm39)	nonsense	probably null
R5311:Vmn1r219	UTSW	13	23,347,063 (GRCm39)	missense	probably damaging	1.00
R6488:Vmn1r219	UTSW	13	23,347,135 (GRCm39)	missense	probably benign	0.02
R7157:Vmn1r219	UTSW	13	23,347,525 (GRCm39)	missense	probably damaging	1.00
R7305:Vmn1r219	UTSW	13	23,347,314 (GRCm39)	missense	probably benign
R7875:Vmn1r219	UTSW	13	23,347,363 (GRCm39)	missense	possibly damaging	0.58
R8753:Vmn1r219	UTSW	13	23,347,191 (GRCm39)	missense	probably damaging	1.00
R9290:Vmn1r219	UTSW	13	23,347,399 (GRCm39)	missense	probably damaging	1.00
R9345:Vmn1r219	UTSW	13	23,346,769 (GRCm39)	start gained	probably benign
R9353:Vmn1r219	UTSW	13	23,346,902 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16