Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02519:Vmn2r111'

296868

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r111

Ensembl Gene

ENSMUSG00000095093

Gene Name

vomeronasal 2, receptor 111

Synonyms

EG210876

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL02519

Quality Score

Status

Chromosome

Chromosomal Location

22547941-22573273 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22548339 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 726 (I726V)

Ref Sequence

ENSEMBL: ENSMUSP00000090148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092491]

AlphaFold

K7N674

Predicted Effect

possibly damaging
Transcript: ENSMUST00000092491
AA Change: I726V

PolyPhen 2 Score 0.801 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000090148
Gene: ENSMUSG00000095093
AA Change: I726V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.5e-29	PFAM
Pfam:NCD3G	512	565	1.1e-20	PFAM
Pfam:7tm_3	595	833	5.6e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts13	A	T	2: 26,978,675 (GRCm38)	I224F	probably damaging	Het
Adamts17	A	G	7: 67,124,973 (GRCm38)	T947A	possibly damaging	Het
Ankfn1	T	C	11: 89,405,678 (GRCm38)	E75G	probably benign	Het
Arfgef1	G	T	1: 10,209,668 (GRCm38)	H225N	probably benign	Het
Arsi	A	G	18: 60,917,067 (GRCm38)	S341G	probably damaging	Het
Aspm	T	A	1: 139,461,927 (GRCm38)		probably benign	Het
Bltp1	A	G	3: 36,895,315 (GRCm38)	E370G	probably damaging	Het
Cacna1i	C	T	15: 80,361,874 (GRCm38)	R490*	probably null	Het
Cd33	C	T	7: 43,528,729 (GRCm38)		probably benign	Het
Clmn	T	C	12: 104,791,853 (GRCm38)	I135V	probably damaging	Het
Crebbp	A	T	16: 4,101,593 (GRCm38)	N795K	possibly damaging	Het
Dhps	A	G	8: 85,073,299 (GRCm38)	D126G	probably damaging	Het
Dlg2	G	T	7: 91,940,115 (GRCm38)	V196L	possibly damaging	Het
Dsg1c	T	A	18: 20,283,733 (GRCm38)	I897N	probably damaging	Het
Dzip3	A	G	16: 48,928,396 (GRCm38)	L1059S	probably damaging	Het
Epha7	A	T	4: 28,821,494 (GRCm38)	T220S	possibly damaging	Het
Fgf17	A	G	14: 70,638,528 (GRCm38)	I88T	probably damaging	Het
G3bp2	A	G	5: 92,066,524 (GRCm38)	V137A	possibly damaging	Het
Gnal	G	A	18: 67,088,765 (GRCm38)	E80K	unknown	Het
Hectd1	T	G	12: 51,769,111 (GRCm38)	S1393R	probably damaging	Het
Igsf6	T	C	7: 121,068,273 (GRCm38)	I173M	possibly damaging	Het
Il2ra	A	C	2: 11,683,090 (GRCm38)	E227A	possibly damaging	Het
Iqcf6	C	T	9: 106,627,280 (GRCm38)	R48C	probably damaging	Het
Kdm3a	G	T	6: 71,611,586 (GRCm38)	Q480K	probably benign	Het
Larp4b	C	A	13: 9,158,580 (GRCm38)	A423E	probably benign	Het
Magea6	T	C	X: 154,924,745 (GRCm38)	D105G	probably benign	Het
Nop53	C	A	7: 15,939,272 (GRCm38)		probably benign	Het
Or14a260	A	T	7: 86,335,581 (GRCm38)	F272I	probably benign	Het
Or1j10	T	C	2: 36,377,313 (GRCm38)	L179P	possibly damaging	Het
Pgghg	A	G	7: 140,944,981 (GRCm38)	T352A	possibly damaging	Het
Setd2	T	C	9: 110,553,116 (GRCm38)	S1464P	probably damaging	Het
Sspo	C	A	6: 48,484,828 (GRCm38)	T3609N	probably damaging	Het
Sulf1	T	A	1: 12,838,363 (GRCm38)	Y533*	probably null	Het
Thsd7b	A	G	1: 129,613,195 (GRCm38)	S346G	probably benign	Het
Tmem161b	T	A	13: 84,294,744 (GRCm38)	L261Q	probably damaging	Het
Tmem63b	T	A	17: 45,665,208 (GRCm38)	T493S	possibly damaging	Het
Tmprss11d	A	T	5: 86,306,305 (GRCm38)	C214S	probably damaging	Het
Trim16	A	T	11: 62,834,079 (GRCm38)	E144V	possibly damaging	Het
Unc13d	T	C	11: 116,070,533 (GRCm38)	Y356C	probably damaging	Het
Urgcp	A	T	11: 5,717,745 (GRCm38)	F198I	probably benign	Het
Zzz3	A	T	3: 152,427,390 (GRCm38)	E28D	probably damaging	Het

Other mutations in Vmn2r111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Vmn2r111	APN	17	22,548,753 (GRCm38)	missense	probably benign	0.00
IGL01306:Vmn2r111	APN	17	22,568,984 (GRCm38)	missense	probably damaging	0.99
IGL01309:Vmn2r111	APN	17	22,569,016 (GRCm38)	missense	possibly damaging	0.51
IGL01457:Vmn2r111	APN	17	22,571,985 (GRCm38)	nonsense	probably null
IGL01465:Vmn2r111	APN	17	22,548,737 (GRCm38)	missense	probably benign	0.00
IGL01505:Vmn2r111	APN	17	22,548,572 (GRCm38)	missense	probably benign	0.00
IGL01571:Vmn2r111	APN	17	22,571,392 (GRCm38)	missense	probably damaging	0.99
IGL01715:Vmn2r111	APN	17	22,569,073 (GRCm38)	splice site	probably benign
IGL01962:Vmn2r111	APN	17	22,548,284 (GRCm38)	missense	possibly damaging	0.90
IGL02190:Vmn2r111	APN	17	22,570,773 (GRCm38)	missense	probably benign	0.00
IGL02496:Vmn2r111	APN	17	22,568,856 (GRCm38)	missense	probably benign
IGL02616:Vmn2r111	APN	17	22,571,050 (GRCm38)	missense	possibly damaging	0.67
IGL02641:Vmn2r111	APN	17	22,573,224 (GRCm38)	missense	possibly damaging	0.82
IGL02690:Vmn2r111	APN	17	22,559,042 (GRCm38)	critical splice donor site	probably null
IGL02698:Vmn2r111	APN	17	22,571,245 (GRCm38)	missense	probably damaging	1.00
IGL03017:Vmn2r111	APN	17	22,570,858 (GRCm38)	missense	probably damaging	1.00
R0046:Vmn2r111	UTSW	17	22,548,009 (GRCm38)	missense	probably benign
R0064:Vmn2r111	UTSW	17	22,572,072 (GRCm38)	missense	probably benign	0.00
R0519:Vmn2r111	UTSW	17	22,573,121 (GRCm38)	missense	probably benign	0.02
R1439:Vmn2r111	UTSW	17	22,571,116 (GRCm38)	missense	probably benign	0.00
R1467:Vmn2r111	UTSW	17	22,571,047 (GRCm38)	missense	probably damaging	0.99
R1467:Vmn2r111	UTSW	17	22,571,047 (GRCm38)	missense	probably damaging	0.99
R1636:Vmn2r111	UTSW	17	22,571,399 (GRCm38)	missense	probably damaging	1.00
R1647:Vmn2r111	UTSW	17	22,569,061 (GRCm38)	missense	probably benign	0.03
R1648:Vmn2r111	UTSW	17	22,569,061 (GRCm38)	missense	probably benign	0.03
R1697:Vmn2r111	UTSW	17	22,548,060 (GRCm38)	missense	probably benign	0.26
R1996:Vmn2r111	UTSW	17	22,548,081 (GRCm38)	missense	probably benign	0.21
R2040:Vmn2r111	UTSW	17	22,548,414 (GRCm38)	missense	probably damaging	1.00
R2075:Vmn2r111	UTSW	17	22,559,062 (GRCm38)	missense	probably damaging	1.00
R2134:Vmn2r111	UTSW	17	22,573,104 (GRCm38)	missense	possibly damaging	0.68
R2357:Vmn2r111	UTSW	17	22,559,170 (GRCm38)	splice site	probably benign
R3700:Vmn2r111	UTSW	17	22,571,161 (GRCm38)	nonsense	probably null
R3782:Vmn2r111	UTSW	17	22,571,320 (GRCm38)	missense	possibly damaging	0.89
R4085:Vmn2r111	UTSW	17	22,559,115 (GRCm38)	missense	probably benign	0.00
R4323:Vmn2r111	UTSW	17	22,573,178 (GRCm38)	missense	probably benign	0.02
R4900:Vmn2r111	UTSW	17	22,548,656 (GRCm38)	missense	possibly damaging	0.94
R5072:Vmn2r111	UTSW	17	22,548,041 (GRCm38)	missense	probably damaging	0.99
R5123:Vmn2r111	UTSW	17	22,571,143 (GRCm38)	missense	possibly damaging	0.82
R5181:Vmn2r111	UTSW	17	22,571,020 (GRCm38)	missense	possibly damaging	0.56
R5357:Vmn2r111	UTSW	17	22,548,102 (GRCm38)	nonsense	probably null
R5398:Vmn2r111	UTSW	17	22,573,271 (GRCm38)	start codon destroyed	probably null	0.88
R5434:Vmn2r111	UTSW	17	22,548,489 (GRCm38)	missense	probably damaging	0.99
R5462:Vmn2r111	UTSW	17	22,548,257 (GRCm38)	missense	probably damaging	1.00
R6149:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6149:Vmn2r111	UTSW	17	22,548,815 (GRCm38)	missense	probably benign	0.00
R6207:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6281:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6282:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6283:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6307:Vmn2r111	UTSW	17	22,573,089 (GRCm38)	missense	probably benign	0.00
R6323:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6325:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6367:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6368:Vmn2r111	UTSW	17	22,571,908 (GRCm38)	missense	probably benign	0.38
R6369:Vmn2r111	UTSW	17	22,548,602 (GRCm38)	missense	probably damaging	1.00
R6489:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6490:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6546:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6547:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6557:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6654:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6655:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6657:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6659:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6660:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6664:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6798:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6799:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6801:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6893:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6895:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6897:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6922:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6923:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6944:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6945:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7017:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7018:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7024:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7031:Vmn2r111	UTSW	17	22,571,245 (GRCm38)	missense	probably damaging	1.00
R7039:Vmn2r111	UTSW	17	22,548,184 (GRCm38)	missense	probably damaging	1.00
R7053:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7054:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7055:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7056:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7145:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7146:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7246:Vmn2r111	UTSW	17	22,548,714 (GRCm38)	missense	probably damaging	1.00
R7259:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7260:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7327:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7401:Vmn2r111	UTSW	17	22,571,086 (GRCm38)	missense	possibly damaging	0.93
R7514:Vmn2r111	UTSW	17	22,548,399 (GRCm38)	missense	probably benign	0.05
R7651:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7781:Vmn2r111	UTSW	17	22,570,733 (GRCm38)	missense	probably benign	0.17
R7816:Vmn2r111	UTSW	17	22,573,102 (GRCm38)	missense	probably damaging	0.97
R7821:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7838:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8078:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8080:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8117:Vmn2r111	UTSW	17	22,571,488 (GRCm38)	missense	probably benign	0.12
R8171:Vmn2r111	UTSW	17	22,573,092 (GRCm38)	missense	probably benign	0.10
R8195:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8197:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8411:Vmn2r111	UTSW	17	22,548,581 (GRCm38)	missense	probably benign	0.03
R8539:Vmn2r111	UTSW	17	22,571,293 (GRCm38)	missense	probably benign	0.23
R8540:Vmn2r111	UTSW	17	22,559,043 (GRCm38)	missense	probably damaging	1.00
R8540:Vmn2r111	UTSW	17	22,559,042 (GRCm38)	critical splice donor site	probably null
R8557:Vmn2r111	UTSW	17	22,571,929 (GRCm38)	nonsense	probably null
R8720:Vmn2r111	UTSW	17	22,573,213 (GRCm38)	missense	possibly damaging	0.88
R8729:Vmn2r111	UTSW	17	22,548,258 (GRCm38)	missense	probably damaging	1.00
R8843:Vmn2r111	UTSW	17	22,548,030 (GRCm38)	missense	probably benign	0.00
R9184:Vmn2r111	UTSW	17	22,571,841 (GRCm38)	missense	probably benign
R9374:Vmn2r111	UTSW	17	22,568,878 (GRCm38)	missense	probably benign	0.17
R9452:Vmn2r111	UTSW	17	22,559,151 (GRCm38)	missense	probably damaging	1.00
X0026:Vmn2r111	UTSW	17	22,548,695 (GRCm38)	missense	probably damaging	0.98

Posted On

2015-04-16