Incidental Mutation 'IGL02519:Or14a260'
ID 296887
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or14a260
Ensembl Gene ENSMUSG00000055610
Gene Name olfactory receptor family 14 subfamily A member 260
Synonyms Olfr307, GA_x6K02T2NHDJ-9772012-9772953, MOR219-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # IGL02519
Quality Score
Status
Chromosome 7
Chromosomal Location 85984661-85985602 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85984789 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 272 (F272I)
Ref Sequence ENSEMBL: ENSMUSP00000149779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069279] [ENSMUST00000213705] [ENSMUST00000217494]
AlphaFold Q8VFN8
Predicted Effect probably benign
Transcript: ENSMUST00000069279
AA Change: F272I

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000063538
Gene: ENSMUSG00000055610
AA Change: F272I

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
Pfam:7tm_4 29 306 1.6e-42 PFAM
Pfam:7tm_1 39 288 9.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213705
AA Change: F272I

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000217494
AA Change: F272I

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 A T 2: 26,868,687 (GRCm39) I224F probably damaging Het
Adamts17 A G 7: 66,774,721 (GRCm39) T947A possibly damaging Het
Ankfn1 T C 11: 89,296,504 (GRCm39) E75G probably benign Het
Arfgef1 G T 1: 10,279,893 (GRCm39) H225N probably benign Het
Arsi A G 18: 61,050,139 (GRCm39) S341G probably damaging Het
Aspm T A 1: 139,389,665 (GRCm39) probably benign Het
Bltp1 A G 3: 36,949,464 (GRCm39) E370G probably damaging Het
Cacna1i C T 15: 80,246,075 (GRCm39) R490* probably null Het
Cd33 C T 7: 43,178,153 (GRCm39) probably benign Het
Clmn T C 12: 104,758,112 (GRCm39) I135V probably damaging Het
Crebbp A T 16: 3,919,457 (GRCm39) N795K possibly damaging Het
Dhps A G 8: 85,799,928 (GRCm39) D126G probably damaging Het
Dlg2 G T 7: 91,589,323 (GRCm39) V196L possibly damaging Het
Dsg1c T A 18: 20,416,790 (GRCm39) I897N probably damaging Het
Dzip3 A G 16: 48,748,759 (GRCm39) L1059S probably damaging Het
Epha7 A T 4: 28,821,494 (GRCm39) T220S possibly damaging Het
Fgf17 A G 14: 70,875,968 (GRCm39) I88T probably damaging Het
G3bp2 A G 5: 92,214,383 (GRCm39) V137A possibly damaging Het
Gnal G A 18: 67,221,836 (GRCm39) E80K unknown Het
Hectd1 T G 12: 51,815,894 (GRCm39) S1393R probably damaging Het
Igsf6 T C 7: 120,667,496 (GRCm39) I173M possibly damaging Het
Il2ra A C 2: 11,687,901 (GRCm39) E227A possibly damaging Het
Iqcf6 C T 9: 106,504,479 (GRCm39) R48C probably damaging Het
Kdm3a G T 6: 71,588,570 (GRCm39) Q480K probably benign Het
Larp4b C A 13: 9,208,616 (GRCm39) A423E probably benign Het
Magea6 T C X: 153,707,741 (GRCm39) D105G probably benign Het
Nop53 C A 7: 15,673,197 (GRCm39) probably benign Het
Or1j10 T C 2: 36,267,325 (GRCm39) L179P possibly damaging Het
Pgghg A G 7: 140,524,894 (GRCm39) T352A possibly damaging Het
Setd2 T C 9: 110,382,184 (GRCm39) S1464P probably damaging Het
Sspo C A 6: 48,461,762 (GRCm39) T3609N probably damaging Het
Sulf1 T A 1: 12,908,587 (GRCm39) Y533* probably null Het
Thsd7b A G 1: 129,540,932 (GRCm39) S346G probably benign Het
Tmem161b T A 13: 84,442,863 (GRCm39) L261Q probably damaging Het
Tmem63b T A 17: 45,976,134 (GRCm39) T493S possibly damaging Het
Tmprss11d A T 5: 86,454,164 (GRCm39) C214S probably damaging Het
Trim16 A T 11: 62,724,905 (GRCm39) E144V possibly damaging Het
Unc13d T C 11: 115,961,359 (GRCm39) Y356C probably damaging Het
Urgcp A T 11: 5,667,745 (GRCm39) F198I probably benign Het
Vmn2r111 T C 17: 22,767,320 (GRCm39) I726V possibly damaging Het
Zzz3 A T 3: 152,133,027 (GRCm39) E28D probably damaging Het
Other mutations in Or14a260
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Or14a260 APN 7 85,985,269 (GRCm39) missense probably benign 0.00
IGL02419:Or14a260 APN 7 85,984,870 (GRCm39) missense probably damaging 0.98
IGL02750:Or14a260 APN 7 85,984,752 (GRCm39) missense probably damaging 1.00
R0123:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R0134:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R0225:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R1025:Or14a260 UTSW 7 85,985,113 (GRCm39) missense probably benign 0.09
R1511:Or14a260 UTSW 7 85,985,553 (GRCm39) missense possibly damaging 0.49
R1674:Or14a260 UTSW 7 85,984,765 (GRCm39) missense probably damaging 1.00
R2011:Or14a260 UTSW 7 85,984,955 (GRCm39) nonsense probably null
R4588:Or14a260 UTSW 7 85,984,852 (GRCm39) missense probably benign 0.00
R5637:Or14a260 UTSW 7 85,984,812 (GRCm39) missense probably benign 0.00
R6163:Or14a260 UTSW 7 85,985,592 (GRCm39) missense possibly damaging 0.84
R6407:Or14a260 UTSW 7 85,985,277 (GRCm39) missense possibly damaging 0.90
R7342:Or14a260 UTSW 7 85,985,295 (GRCm39) missense probably benign 0.00
R8066:Or14a260 UTSW 7 85,985,014 (GRCm39) missense probably benign 0.00
R8155:Or14a260 UTSW 7 85,985,386 (GRCm39) missense probably damaging 1.00
R8158:Or14a260 UTSW 7 85,984,885 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16