Incidental Mutation 'IGL02519:Trim16'
ID 296896
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim16
Ensembl Gene ENSMUSG00000047821
Gene Name tripartite motif-containing 16
Synonyms 9130006M08Rik, EBBP
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02519
Quality Score
Status
Chromosome 11
Chromosomal Location 62711034-62733774 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 62724905 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 144 (E144V)
Ref Sequence ENSEMBL: ENSMUSP00000104343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055006] [ENSMUST00000072639] [ENSMUST00000108703]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000055006
AA Change: E231V

PolyPhen 2 Score 0.280 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000055542
Gene: ENSMUSG00000047821
AA Change: E231V

DomainStartEndE-ValueType
Blast:BBOX 64 113 6e-24 BLAST
BBOX 117 157 3.24e-4 SMART
coiled coil region 171 196 N/A INTRINSIC
coiled coil region 237 265 N/A INTRINSIC
PRY 364 417 1.41e-22 SMART
SPRY 418 543 6.4e-27 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000072639
AA Change: E231V

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000072432
Gene: ENSMUSG00000047821
AA Change: E231V

DomainStartEndE-ValueType
Blast:BBOX 64 113 5e-24 BLAST
BBOX 117 157 3.24e-4 SMART
coiled coil region 171 196 N/A INTRINSIC
coiled coil region 237 265 N/A INTRINSIC
PRY 364 417 1.41e-22 SMART
Pfam:SPRY 418 483 1.4e-6 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000108703
AA Change: E144V

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000104343
Gene: ENSMUSG00000047821
AA Change: E144V

DomainStartEndE-ValueType
Blast:BBOX 1 26 9e-10 BLAST
BBOX 30 70 3.24e-4 SMART
coiled coil region 84 109 N/A INTRINSIC
coiled coil region 150 178 N/A INTRINSIC
PRY 277 330 1.41e-22 SMART
SPRY 331 456 6.4e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128623
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 A T 2: 26,868,687 (GRCm39) I224F probably damaging Het
Adamts17 A G 7: 66,774,721 (GRCm39) T947A possibly damaging Het
Ankfn1 T C 11: 89,296,504 (GRCm39) E75G probably benign Het
Arfgef1 G T 1: 10,279,893 (GRCm39) H225N probably benign Het
Arsi A G 18: 61,050,139 (GRCm39) S341G probably damaging Het
Aspm T A 1: 139,389,665 (GRCm39) probably benign Het
Bltp1 A G 3: 36,949,464 (GRCm39) E370G probably damaging Het
Cacna1i C T 15: 80,246,075 (GRCm39) R490* probably null Het
Cd33 C T 7: 43,178,153 (GRCm39) probably benign Het
Clmn T C 12: 104,758,112 (GRCm39) I135V probably damaging Het
Crebbp A T 16: 3,919,457 (GRCm39) N795K possibly damaging Het
Dhps A G 8: 85,799,928 (GRCm39) D126G probably damaging Het
Dlg2 G T 7: 91,589,323 (GRCm39) V196L possibly damaging Het
Dsg1c T A 18: 20,416,790 (GRCm39) I897N probably damaging Het
Dzip3 A G 16: 48,748,759 (GRCm39) L1059S probably damaging Het
Epha7 A T 4: 28,821,494 (GRCm39) T220S possibly damaging Het
Fgf17 A G 14: 70,875,968 (GRCm39) I88T probably damaging Het
G3bp2 A G 5: 92,214,383 (GRCm39) V137A possibly damaging Het
Gnal G A 18: 67,221,836 (GRCm39) E80K unknown Het
Hectd1 T G 12: 51,815,894 (GRCm39) S1393R probably damaging Het
Igsf6 T C 7: 120,667,496 (GRCm39) I173M possibly damaging Het
Il2ra A C 2: 11,687,901 (GRCm39) E227A possibly damaging Het
Iqcf6 C T 9: 106,504,479 (GRCm39) R48C probably damaging Het
Kdm3a G T 6: 71,588,570 (GRCm39) Q480K probably benign Het
Larp4b C A 13: 9,208,616 (GRCm39) A423E probably benign Het
Magea6 T C X: 153,707,741 (GRCm39) D105G probably benign Het
Nop53 C A 7: 15,673,197 (GRCm39) probably benign Het
Or14a260 A T 7: 85,984,789 (GRCm39) F272I probably benign Het
Or1j10 T C 2: 36,267,325 (GRCm39) L179P possibly damaging Het
Pgghg A G 7: 140,524,894 (GRCm39) T352A possibly damaging Het
Setd2 T C 9: 110,382,184 (GRCm39) S1464P probably damaging Het
Sspo C A 6: 48,461,762 (GRCm39) T3609N probably damaging Het
Sulf1 T A 1: 12,908,587 (GRCm39) Y533* probably null Het
Thsd7b A G 1: 129,540,932 (GRCm39) S346G probably benign Het
Tmem161b T A 13: 84,442,863 (GRCm39) L261Q probably damaging Het
Tmem63b T A 17: 45,976,134 (GRCm39) T493S possibly damaging Het
Tmprss11d A T 5: 86,454,164 (GRCm39) C214S probably damaging Het
Unc13d T C 11: 115,961,359 (GRCm39) Y356C probably damaging Het
Urgcp A T 11: 5,667,745 (GRCm39) F198I probably benign Het
Vmn2r111 T C 17: 22,767,320 (GRCm39) I726V possibly damaging Het
Zzz3 A T 3: 152,133,027 (GRCm39) E28D probably damaging Het
Other mutations in Trim16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00661:Trim16 APN 11 62,728,058 (GRCm39) splice site probably benign
IGL01060:Trim16 APN 11 62,711,530 (GRCm39) missense probably benign 0.06
IGL01568:Trim16 APN 11 62,711,684 (GRCm39) missense probably benign 0.05
IGL01659:Trim16 APN 11 62,711,521 (GRCm39) missense probably benign 0.00
IGL02662:Trim16 APN 11 62,731,383 (GRCm39) missense possibly damaging 0.91
FR4589:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
FR4976:Trim16 UTSW 11 62,711,515 (GRCm39) intron probably benign
R0007:Trim16 UTSW 11 62,719,944 (GRCm39) missense probably benign 0.00
R0007:Trim16 UTSW 11 62,719,944 (GRCm39) missense probably benign 0.00
R0346:Trim16 UTSW 11 62,731,520 (GRCm39) missense probably benign 0.00
R0410:Trim16 UTSW 11 62,711,297 (GRCm39) start gained probably benign
R1725:Trim16 UTSW 11 62,711,331 (GRCm39) start codon destroyed possibly damaging 0.91
R3845:Trim16 UTSW 11 62,727,498 (GRCm39) splice site probably benign
R3879:Trim16 UTSW 11 62,731,433 (GRCm39) missense probably damaging 1.00
R5023:Trim16 UTSW 11 62,727,638 (GRCm39) missense probably benign 0.36
R5344:Trim16 UTSW 11 62,711,751 (GRCm39) missense probably damaging 1.00
R6919:Trim16 UTSW 11 62,731,695 (GRCm39) missense possibly damaging 0.86
R7490:Trim16 UTSW 11 62,724,949 (GRCm39) missense probably damaging 1.00
R7525:Trim16 UTSW 11 62,711,580 (GRCm39) missense probably damaging 1.00
R8354:Trim16 UTSW 11 62,727,587 (GRCm39) missense probably benign 0.01
R8439:Trim16 UTSW 11 62,741,414 (GRCm39) missense probably benign 0.10
R8754:Trim16 UTSW 11 62,731,763 (GRCm39) missense probably benign 0.01
R9581:Trim16 UTSW 11 62,727,557 (GRCm39) missense probably damaging 0.98
R9599:Trim16 UTSW 11 62,731,644 (GRCm39) missense probably damaging 0.97
R9789:Trim16 UTSW 11 62,720,026 (GRCm39) critical splice donor site probably null
X0026:Trim16 UTSW 11 62,719,963 (GRCm39) missense probably benign 0.02
Z1186:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1186:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1186:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1186:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1186:Trim16 UTSW 11 62,711,518 (GRCm39) intron probably benign
Z1186:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1186:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1187:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1187:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,520 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1188:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1188:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1188:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1188:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1189:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1189:Trim16 UTSW 11 62,711,520 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,517 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1190:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1190:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,519 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1191:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1191:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1192:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1192:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1192:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1192:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Posted On 2015-04-16