Incidental Mutation 'IGL02523:Fcgbp'
ID 296945
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fcgbp
Ensembl Gene ENSMUSG00000047730
Gene Name Fc fragment of IgG binding protein
Synonyms A430096B05Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02523
Quality Score
Status
Chromosome 7
Chromosomal Location 27770661-27820287 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 27804157 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 1755 (A1755E)
Ref Sequence ENSEMBL: ENSMUSP00000114271 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076648] [ENSMUST00000138392]
AlphaFold E9Q0B5
Predicted Effect probably benign
Transcript: ENSMUST00000076648
AA Change: A1755E

PolyPhen 2 Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000075945
Gene: ENSMUSG00000047730
AA Change: A1755E

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
FOLN 27 49 2.3e-4 SMART
VWD 46 211 5.26e-45 SMART
low complexity region 226 237 N/A INTRINSIC
C8 251 326 1.17e-34 SMART
Pfam:TIL 329 383 1.2e-12 PFAM
VWC 385 431 2.34e-1 SMART
FOLN 418 441 3.48e1 SMART
VWD 438 603 6.85e-35 SMART
C8 642 717 1.4e-32 SMART
Pfam:TIL 720 773 4.7e-14 PFAM
VWC 775 829 9.42e-1 SMART
VWD 824 990 7.86e-44 SMART
C8 1034 1109 1.66e-34 SMART
Pfam:TIL 1112 1165 6.7e-13 PFAM
VWC 1167 1225 9.8e-3 SMART
FOLN 1198 1220 9.55e-1 SMART
FOLN 1224 1246 2.41e0 SMART
VWD 1243 1411 6.59e-37 SMART
C8 1451 1527 5.6e-32 SMART
low complexity region 1541 1551 N/A INTRINSIC
EGF_like 1558 1581 6.15e1 SMART
VWC 1589 1682 1.6e-2 SMART
VWD 1640 1807 5.15e-39 SMART
C8 1839 1914 4.62e-33 SMART
EGF_like 1942 1965 4.46e1 SMART
VWC 1972 2064 1.92e-1 SMART
VWD 2024 2180 6.34e-39 SMART
low complexity region 2201 2214 N/A INTRINSIC
C8 2221 2296 3.7e-32 SMART
Pfam:TIL 2299 2352 5e-12 PFAM
VWC 2354 2413 8.29e-1 SMART
FOLN 2385 2407 4.96e1 SMART
VWD 2404 2566 1.89e-5 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000138392
AA Change: A1755E

PolyPhen 2 Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000114271
Gene: ENSMUSG00000047730
AA Change: A1755E

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
FOLN 27 49 2.3e-4 SMART
VWD 46 211 5.26e-45 SMART
low complexity region 226 237 N/A INTRINSIC
C8 251 326 1.17e-34 SMART
Pfam:TIL 329 383 8.4e-13 PFAM
VWC 385 431 2.34e-1 SMART
FOLN 418 441 3.48e1 SMART
VWD 438 603 7.99e-36 SMART
C8 642 717 1.4e-32 SMART
Pfam:TIL 720 773 3.3e-14 PFAM
VWC 775 829 9.42e-1 SMART
VWD 824 990 7.86e-44 SMART
C8 1034 1109 1.66e-34 SMART
Pfam:TIL 1112 1165 6.9e-13 PFAM
VWC 1167 1225 9.8e-3 SMART
FOLN 1198 1220 9.55e-1 SMART
FOLN 1224 1246 2.41e0 SMART
VWD 1243 1411 6.59e-37 SMART
C8 1451 1527 5.6e-32 SMART
low complexity region 1541 1551 N/A INTRINSIC
EGF_like 1558 1581 6.15e1 SMART
VWC 1589 1682 1.6e-2 SMART
VWD 1640 1807 5.15e-39 SMART
C8 1839 1914 4.62e-33 SMART
EGF_like 1942 1965 4.46e1 SMART
VWC 1972 2064 1.92e-1 SMART
VWD 2024 2180 6.34e-39 SMART
low complexity region 2201 2214 N/A INTRINSIC
C8 2221 2296 3.7e-32 SMART
Pfam:TIL 2299 2352 1e-11 PFAM
VWC 2354 2413 8.29e-1 SMART
FOLN 2385 2407 4.96e1 SMART
VWD 2404 2566 1.89e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148946
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asah1 T C 8: 41,804,984 (GRCm39) D109G probably benign Het
Ces2c C A 8: 105,574,746 (GRCm39) P68T probably damaging Het
Csl G A 10: 99,594,675 (GRCm39) T130I probably benign Het
Cyp2g1 C T 7: 26,518,612 (GRCm39) R376W probably damaging Het
Ddb1 T C 19: 10,604,996 (GRCm39) L1029P probably damaging Het
Dennd4c T C 4: 86,692,490 (GRCm39) probably benign Het
Eya2 C T 2: 165,596,356 (GRCm39) probably benign Het
Fars2 G T 13: 36,388,676 (GRCm39) G55V probably damaging Het
Ggt7 T A 2: 155,356,623 (GRCm39) E32V probably damaging Het
Heg1 C A 16: 33,558,992 (GRCm39) T1071K probably damaging Het
Hpca A G 4: 129,012,368 (GRCm39) F56S probably damaging Het
Hyal4 T A 6: 24,765,968 (GRCm39) Y441N probably damaging Het
Igsf8 T A 1: 172,146,980 (GRCm39) probably benign Het
Ints13 A G 6: 146,459,109 (GRCm39) S301P probably benign Het
Krt33a G A 11: 99,902,518 (GRCm39) T374I probably benign Het
Nav3 T C 10: 109,605,157 (GRCm39) D972G probably damaging Het
Npc1 T C 18: 12,334,629 (GRCm39) T708A probably benign Het
Or10ag52 A T 2: 87,043,664 (GRCm39) N143Y probably benign Het
Or13p10 A T 4: 118,523,238 (GRCm39) N175Y probably benign Het
Or1l8 T C 2: 36,817,967 (GRCm39) D53G probably damaging Het
Or6d14 A T 6: 116,534,054 (GRCm39) I223L probably benign Het
P2rx2 A G 5: 110,489,908 (GRCm39) S87P probably damaging Het
Pdxdc1 A T 16: 13,699,799 (GRCm39) L62H probably damaging Het
Plekhj1 A T 10: 80,633,683 (GRCm39) probably null Het
Ptbp2 A T 3: 119,534,136 (GRCm39) Y244* probably null Het
Ralbp1 T C 17: 66,166,086 (GRCm39) E366G probably damaging Het
Rergl T A 6: 139,473,458 (GRCm39) probably benign Het
Slc25a45 T A 19: 5,934,637 (GRCm39) probably null Het
Spop G A 11: 95,376,747 (GRCm39) D267N possibly damaging Het
Tars2 T C 3: 95,648,705 (GRCm39) D625G probably damaging Het
Tlk2 A G 11: 105,166,773 (GRCm39) K593R probably damaging Het
Tlr3 T A 8: 45,851,428 (GRCm39) probably null Het
Tmem205 C T 9: 21,832,584 (GRCm39) R109H probably benign Het
Tmem41b A G 7: 109,581,935 (GRCm39) I56T probably damaging Het
Ube2q2 T C 9: 55,099,163 (GRCm39) V168A probably damaging Het
Ufsp2 T A 8: 46,436,585 (GRCm39) M112K probably damaging Het
Wipi2 T A 5: 142,646,787 (GRCm39) V208E probably damaging Het
Xkr9 A G 1: 13,754,474 (GRCm39) E156G probably benign Het
Other mutations in Fcgbp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Fcgbp APN 7 27,784,555 (GRCm39) missense probably damaging 1.00
IGL00331:Fcgbp APN 7 27,800,966 (GRCm39) splice site probably benign
IGL00335:Fcgbp APN 7 27,785,560 (GRCm39) missense possibly damaging 0.90
IGL00470:Fcgbp APN 7 27,774,511 (GRCm39) nonsense probably null
IGL00491:Fcgbp APN 7 27,792,827 (GRCm39) missense probably damaging 1.00
IGL00498:Fcgbp APN 7 27,791,222 (GRCm39) missense probably damaging 1.00
IGL01296:Fcgbp APN 7 27,789,072 (GRCm39) missense probably benign 0.15
IGL01582:Fcgbp APN 7 27,793,067 (GRCm39) missense probably benign 0.19
IGL01929:Fcgbp APN 7 27,803,388 (GRCm39) missense probably damaging 1.00
IGL02024:Fcgbp APN 7 27,805,799 (GRCm39) missense probably damaging 1.00
IGL02027:Fcgbp APN 7 27,774,629 (GRCm39) missense probably damaging 1.00
IGL02140:Fcgbp APN 7 27,791,379 (GRCm39) missense probably damaging 1.00
IGL02162:Fcgbp APN 7 27,774,660 (GRCm39) missense probably damaging 1.00
IGL02345:Fcgbp APN 7 27,771,068 (GRCm39) splice site probably benign
IGL02377:Fcgbp APN 7 27,806,395 (GRCm39) missense possibly damaging 0.67
IGL02389:Fcgbp APN 7 27,774,596 (GRCm39) missense probably damaging 1.00
IGL02423:Fcgbp APN 7 27,789,378 (GRCm39) missense probably benign 0.02
IGL02561:Fcgbp APN 7 27,800,599 (GRCm39) intron probably benign
IGL02631:Fcgbp APN 7 27,784,723 (GRCm39) missense probably damaging 1.00
IGL02716:Fcgbp APN 7 27,800,859 (GRCm39) missense probably damaging 0.98
IGL02836:Fcgbp APN 7 27,816,783 (GRCm39) missense possibly damaging 0.91
IGL02957:Fcgbp APN 7 27,791,272 (GRCm39) nonsense probably null
IGL02971:Fcgbp APN 7 27,800,898 (GRCm39) missense probably damaging 1.00
IGL03284:Fcgbp APN 7 27,784,857 (GRCm39) missense possibly damaging 0.93
IGL03379:Fcgbp APN 7 27,789,342 (GRCm39) missense possibly damaging 0.76
bilge UTSW 7 27,816,762 (GRCm39) missense probably benign 0.00
R6548_fcgbp_365 UTSW 7 27,791,343 (GRCm39) missense probably benign 0.00
swill UTSW 7 27,789,159 (GRCm39) missense probably damaging 1.00
G1citation:Fcgbp UTSW 7 27,806,781 (GRCm39) missense probably damaging 1.00
IGL02796:Fcgbp UTSW 7 27,800,576 (GRCm39) intron probably benign
PIT4486001:Fcgbp UTSW 7 27,774,698 (GRCm39) missense possibly damaging 0.52
R0277:Fcgbp UTSW 7 27,784,918 (GRCm39) critical splice donor site probably null
R0387:Fcgbp UTSW 7 27,790,879 (GRCm39) splice site probably benign
R0586:Fcgbp UTSW 7 27,789,138 (GRCm39) missense probably damaging 1.00
R0981:Fcgbp UTSW 7 27,784,535 (GRCm39) nonsense probably null
R0987:Fcgbp UTSW 7 27,793,599 (GRCm39) missense probably damaging 1.00
R1240:Fcgbp UTSW 7 27,819,950 (GRCm39) missense probably damaging 1.00
R1394:Fcgbp UTSW 7 27,792,804 (GRCm39) missense probably damaging 0.98
R1395:Fcgbp UTSW 7 27,792,804 (GRCm39) missense probably damaging 0.98
R1438:Fcgbp UTSW 7 27,803,158 (GRCm39) nonsense probably null
R1474:Fcgbp UTSW 7 27,791,273 (GRCm39) missense probably benign 0.00
R1521:Fcgbp UTSW 7 27,774,585 (GRCm39) missense probably benign 0.00
R1740:Fcgbp UTSW 7 27,800,674 (GRCm39) missense possibly damaging 0.87
R1750:Fcgbp UTSW 7 27,792,868 (GRCm39) nonsense probably null
R1772:Fcgbp UTSW 7 27,804,600 (GRCm39) missense possibly damaging 0.90
R1804:Fcgbp UTSW 7 27,785,564 (GRCm39) missense probably benign
R1808:Fcgbp UTSW 7 27,784,515 (GRCm39) missense probably benign 0.04
R1819:Fcgbp UTSW 7 27,784,708 (GRCm39) missense probably benign 0.00
R1934:Fcgbp UTSW 7 27,806,518 (GRCm39) missense probably damaging 1.00
R1972:Fcgbp UTSW 7 27,793,617 (GRCm39) missense probably benign 0.11
R2051:Fcgbp UTSW 7 27,819,785 (GRCm39) missense probably damaging 0.97
R2072:Fcgbp UTSW 7 27,819,814 (GRCm39) missense probably damaging 0.98
R2074:Fcgbp UTSW 7 27,819,814 (GRCm39) missense probably damaging 0.98
R2124:Fcgbp UTSW 7 27,791,444 (GRCm39) missense probably benign 0.03
R2155:Fcgbp UTSW 7 27,806,628 (GRCm39) missense probably benign 0.00
R3015:Fcgbp UTSW 7 27,774,838 (GRCm39) splice site probably benign
R3037:Fcgbp UTSW 7 27,802,127 (GRCm39) missense possibly damaging 0.62
R3151:Fcgbp UTSW 7 27,816,665 (GRCm39) missense probably damaging 1.00
R3176:Fcgbp UTSW 7 27,791,086 (GRCm39) missense probably damaging 0.99
R3177:Fcgbp UTSW 7 27,791,086 (GRCm39) missense probably damaging 0.99
R3276:Fcgbp UTSW 7 27,791,086 (GRCm39) missense probably damaging 0.99
R3277:Fcgbp UTSW 7 27,791,086 (GRCm39) missense probably damaging 0.99
R3623:Fcgbp UTSW 7 27,800,701 (GRCm39) missense probably damaging 1.00
R3730:Fcgbp UTSW 7 27,784,882 (GRCm39) missense possibly damaging 0.82
R3935:Fcgbp UTSW 7 27,774,824 (GRCm39) missense probably benign 0.00
R3936:Fcgbp UTSW 7 27,774,824 (GRCm39) missense probably benign 0.00
R4041:Fcgbp UTSW 7 27,813,404 (GRCm39) missense probably benign 0.01
R4056:Fcgbp UTSW 7 27,803,541 (GRCm39) missense probably benign 0.09
R4057:Fcgbp UTSW 7 27,803,541 (GRCm39) missense probably benign 0.09
R4705:Fcgbp UTSW 7 27,806,721 (GRCm39) missense probably benign 0.44
R4708:Fcgbp UTSW 7 27,794,386 (GRCm39) missense probably benign 0.00
R4710:Fcgbp UTSW 7 27,794,386 (GRCm39) missense probably benign 0.00
R4779:Fcgbp UTSW 7 27,794,362 (GRCm39) missense probably damaging 1.00
R4820:Fcgbp UTSW 7 27,813,383 (GRCm39) missense probably damaging 1.00
R4863:Fcgbp UTSW 7 27,785,769 (GRCm39) missense probably benign 0.33
R4926:Fcgbp UTSW 7 27,785,660 (GRCm39) missense probably damaging 0.99
R4947:Fcgbp UTSW 7 27,789,237 (GRCm39) missense probably benign 0.00
R4979:Fcgbp UTSW 7 27,816,995 (GRCm39) missense probably benign 0.06
R5002:Fcgbp UTSW 7 27,785,528 (GRCm39) splice site probably null
R5219:Fcgbp UTSW 7 27,803,510 (GRCm39) missense probably damaging 1.00
R5241:Fcgbp UTSW 7 27,784,624 (GRCm39) missense probably damaging 1.00
R5301:Fcgbp UTSW 7 27,793,099 (GRCm39) missense possibly damaging 0.93
R5306:Fcgbp UTSW 7 27,791,243 (GRCm39) missense probably damaging 1.00
R5335:Fcgbp UTSW 7 27,789,159 (GRCm39) missense probably damaging 1.00
R5399:Fcgbp UTSW 7 27,804,480 (GRCm39) missense probably benign 0.05
R5418:Fcgbp UTSW 7 27,784,738 (GRCm39) missense probably damaging 1.00
R5527:Fcgbp UTSW 7 27,793,060 (GRCm39) missense probably benign
R5583:Fcgbp UTSW 7 27,791,004 (GRCm39) missense probably damaging 1.00
R5698:Fcgbp UTSW 7 27,791,447 (GRCm39) missense possibly damaging 0.95
R5780:Fcgbp UTSW 7 27,784,643 (GRCm39) missense probably benign 0.02
R5813:Fcgbp UTSW 7 27,800,919 (GRCm39) missense possibly damaging 0.64
R5910:Fcgbp UTSW 7 27,784,928 (GRCm39) splice site probably benign
R5936:Fcgbp UTSW 7 27,786,117 (GRCm39) missense probably damaging 0.98
R5992:Fcgbp UTSW 7 27,819,959 (GRCm39) missense probably benign 0.05
R6091:Fcgbp UTSW 7 27,804,390 (GRCm39) missense possibly damaging 0.90
R6372:Fcgbp UTSW 7 27,806,433 (GRCm39) missense probably damaging 1.00
R6488:Fcgbp UTSW 7 27,792,963 (GRCm39) missense probably damaging 0.96
R6548:Fcgbp UTSW 7 27,791,343 (GRCm39) missense probably benign 0.00
R6553:Fcgbp UTSW 7 27,813,404 (GRCm39) missense possibly damaging 0.79
R6585:Fcgbp UTSW 7 27,813,404 (GRCm39) missense possibly damaging 0.79
R6695:Fcgbp UTSW 7 27,785,695 (GRCm39) nonsense probably null
R6711:Fcgbp UTSW 7 27,789,098 (GRCm39) missense probably damaging 0.99
R6803:Fcgbp UTSW 7 27,802,637 (GRCm39) missense probably benign 0.00
R6822:Fcgbp UTSW 7 27,806,781 (GRCm39) missense probably damaging 1.00
R6907:Fcgbp UTSW 7 27,784,443 (GRCm39) missense probably damaging 1.00
R6912:Fcgbp UTSW 7 27,789,129 (GRCm39) missense probably benign 0.15
R6924:Fcgbp UTSW 7 27,793,248 (GRCm39) missense probably benign
R6943:Fcgbp UTSW 7 27,791,477 (GRCm39) missense probably benign 0.22
R7060:Fcgbp UTSW 7 27,791,358 (GRCm39) missense probably benign 0.20
R7103:Fcgbp UTSW 7 27,784,387 (GRCm39) missense probably benign 0.00
R7208:Fcgbp UTSW 7 27,803,446 (GRCm39) missense probably benign 0.01
R7291:Fcgbp UTSW 7 27,800,817 (GRCm39) missense probably benign 0.00
R7301:Fcgbp UTSW 7 27,792,861 (GRCm39) missense possibly damaging 0.65
R7404:Fcgbp UTSW 7 27,800,932 (GRCm39) missense probably damaging 1.00
R7426:Fcgbp UTSW 7 27,785,949 (GRCm39) missense probably benign 0.00
R7459:Fcgbp UTSW 7 27,806,710 (GRCm39) missense possibly damaging 0.65
R7475:Fcgbp UTSW 7 27,802,401 (GRCm39) missense probably damaging 0.99
R7505:Fcgbp UTSW 7 27,789,099 (GRCm39) missense probably damaging 0.97
R7517:Fcgbp UTSW 7 27,784,794 (GRCm39) missense probably damaging 1.00
R7519:Fcgbp UTSW 7 27,785,724 (GRCm39) missense probably damaging 1.00
R7524:Fcgbp UTSW 7 27,802,391 (GRCm39) missense probably damaging 1.00
R7649:Fcgbp UTSW 7 27,790,928 (GRCm39) missense possibly damaging 0.88
R7782:Fcgbp UTSW 7 27,784,460 (GRCm39) nonsense probably null
R7820:Fcgbp UTSW 7 27,819,784 (GRCm39) missense probably benign 0.01
R7831:Fcgbp UTSW 7 27,806,404 (GRCm39) missense probably damaging 0.98
R7835:Fcgbp UTSW 7 27,816,632 (GRCm39) missense possibly damaging 0.64
R7947:Fcgbp UTSW 7 27,803,595 (GRCm39) critical splice donor site probably null
R8086:Fcgbp UTSW 7 27,813,389 (GRCm39) missense probably damaging 1.00
R8137:Fcgbp UTSW 7 27,804,496 (GRCm39) missense probably damaging 1.00
R8154:Fcgbp UTSW 7 27,784,507 (GRCm39) missense probably benign 0.00
R8169:Fcgbp UTSW 7 27,784,919 (GRCm39) critical splice donor site probably null
R8176:Fcgbp UTSW 7 27,791,174 (GRCm39) missense possibly damaging 0.88
R8193:Fcgbp UTSW 7 27,804,276 (GRCm39) missense probably damaging 1.00
R8313:Fcgbp UTSW 7 27,785,769 (GRCm39) missense probably benign 0.00
R8350:Fcgbp UTSW 7 27,793,614 (GRCm39) missense probably benign 0.02
R8382:Fcgbp UTSW 7 27,816,762 (GRCm39) missense probably benign 0.00
R8393:Fcgbp UTSW 7 27,806,815 (GRCm39) missense probably benign 0.18
R8438:Fcgbp UTSW 7 27,789,231 (GRCm39) missense probably benign 0.25
R8489:Fcgbp UTSW 7 27,804,435 (GRCm39) missense possibly damaging 0.94
R8495:Fcgbp UTSW 7 27,785,978 (GRCm39) missense probably damaging 1.00
R8707:Fcgbp UTSW 7 27,819,920 (GRCm39) missense probably benign 0.01
R8736:Fcgbp UTSW 7 27,805,621 (GRCm39) missense probably benign 0.05
R8816:Fcgbp UTSW 7 27,784,412 (GRCm39) missense probably benign 0.09
R8905:Fcgbp UTSW 7 27,785,934 (GRCm39) missense probably damaging 1.00
R9031:Fcgbp UTSW 7 27,790,908 (GRCm39) missense possibly damaging 0.89
R9063:Fcgbp UTSW 7 27,791,277 (GRCm39) missense probably damaging 1.00
R9180:Fcgbp UTSW 7 27,803,198 (GRCm39) nonsense probably null
R9262:Fcgbp UTSW 7 27,819,952 (GRCm39) missense probably damaging 1.00
R9439:Fcgbp UTSW 7 27,803,436 (GRCm39) missense possibly damaging 0.60
R9526:Fcgbp UTSW 7 27,790,937 (GRCm39) missense probably damaging 1.00
R9603:Fcgbp UTSW 7 27,802,563 (GRCm39) missense probably damaging 1.00
R9635:Fcgbp UTSW 7 27,800,832 (GRCm39) missense probably benign 0.40
R9703:Fcgbp UTSW 7 27,806,400 (GRCm39) missense probably damaging 0.98
R9711:Fcgbp UTSW 7 27,793,000 (GRCm39) missense probably benign 0.00
R9733:Fcgbp UTSW 7 27,803,012 (GRCm39) missense probably damaging 1.00
RF002:Fcgbp UTSW 7 27,789,180 (GRCm39) missense probably benign
X0028:Fcgbp UTSW 7 27,803,445 (GRCm39) missense possibly damaging 0.48
Z1186:Fcgbp UTSW 7 27,791,072 (GRCm39) missense probably benign
Z1186:Fcgbp UTSW 7 27,789,180 (GRCm39) missense probably benign
Z1186:Fcgbp UTSW 7 27,785,616 (GRCm39) missense probably benign
Z1186:Fcgbp UTSW 7 27,803,309 (GRCm39) missense probably benign 0.09
Z1186:Fcgbp UTSW 7 27,792,770 (GRCm39) missense probably benign
Posted On 2015-04-16