Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02525:Ros1'

297040

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ros1

Ensembl Gene

ENSMUSG00000019893

Gene Name

Ros1 proto-oncogene

Synonyms

Ros-1, c-ros

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.142) question?

Stock #

IGL02525

Quality Score

Status

Chromosome

Chromosomal Location

51921817-52071340 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 51992138 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 1362 (T1362A)

Ref Sequence

ENSEMBL: ENSMUSP00000151615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020045] [ENSMUST00000218452] [ENSMUST00000219173] [ENSMUST00000219692]

AlphaFold

Q78DX7

Predicted Effect

probably benign
Transcript: ENSMUST00000020045
AA Change: T1383A

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000020045
Gene: ENSMUSG00000019893
AA Change: T1383A

Domain	Start	End	E-Value	Type
transmembrane domain	7	26	N/A	INTRINSIC
FN3	109	187	1.05e-4	SMART
FN3	205	282	7.45e-10	SMART
LY	369	409	9.17e0	SMART
FN3	568	654	2.24e-4	SMART
LY	734	776	2.28e1	SMART
LY	777	815	4.61e0	SMART
FN3	944	1023	5.53e-4	SMART
FN3	1037	1133	1.07e1	SMART
FN3	1440	1532	1.19e1	SMART
FN3	1551	1637	2.11e0	SMART
FN3	1649	1731	6.8e-4	SMART
FN3	1746	1832	2.7e1	SMART
TyrKc	1938	2208	1.3e-145	SMART
low complexity region	2294	2307	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117992
AA Change: T1362A

PolyPhen 2 Score 0.185 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000112873
Gene: ENSMUSG00000019893
AA Change: T1362A

Domain	Start	End	E-Value	Type
transmembrane domain	7	26	N/A	INTRINSIC
FN3	109	187	1.05e-4	SMART
FN3	205	282	7.45e-10	SMART
LY	369	409	9.17e0	SMART
FN3	547	633	2.24e-4	SMART
LY	713	755	2.28e1	SMART
LY	756	794	4.61e0	SMART
FN3	923	1002	5.53e-4	SMART
FN3	1016	1112	1.07e1	SMART
FN3	1419	1511	1.19e1	SMART
FN3	1530	1616	2.11e0	SMART
FN3	1628	1710	6.8e-4	SMART
FN3	1725	1811	2.7e1	SMART
TyrKc	1917	2187	1.3e-145	SMART
low complexity region	2273	2286	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000177378
AA Change: T1362A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000134905
Gene: ENSMUSG00000019893
AA Change: T1362A

Domain	Start	End	E-Value	Type
transmembrane domain	7	26	N/A	INTRINSIC
FN3	109	187	1.05e-4	SMART
FN3	205	282	7.45e-10	SMART
LY	369	409	9.17e0	SMART
FN3	547	633	2.24e-4	SMART
LY	713	755	2.28e1	SMART
LY	756	794	4.61e0	SMART
FN3	923	1002	5.53e-4	SMART
FN3	1016	1112	1.07e1	SMART
Blast:LY	1190	1236	2e-18	BLAST
FN3	1419	1511	1.19e1	SMART
FN3	1530	1616	2.11e0	SMART
FN3	1628	1710	6.8e-4	SMART
FN3	1725	1811	2.7e1	SMART
transmembrane domain	1832	1854	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177387

Predicted Effect

probably benign
Transcript: ENSMUST00000218452
AA Change: T1362A

PolyPhen 2 Score 0.281 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000219173
AA Change: T1362A

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)

Predicted Effect

probably benign
Transcript: ENSMUST00000219692

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit male infertility due to impaired sperm maturation in the epididymis. Mutant sperm are capable of fertilization in vitro but not in vivo. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam18	C	T	8: 25,101,060 (GRCm39)	V701I	probably benign	Het
Adam18	A	G	8: 25,131,783 (GRCm39)		probably benign	Het
Adamts20	G	T	15: 94,180,959 (GRCm39)		probably null	Het
Adgrf5	G	T	17: 43,760,854 (GRCm39)	V850F	probably damaging	Het
Agap2	T	A	10: 126,919,070 (GRCm39)		probably null	Het
Ap4b1	G	A	3: 103,720,164 (GRCm39)	R62K	probably damaging	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Ccdc12	T	A	9: 110,540,169 (GRCm39)	D120E	probably damaging	Het
Ccdc22	A	G	X: 7,461,249 (GRCm39)	S529P	probably damaging	Het
Cilk1	A	G	9: 78,067,675 (GRCm39)	K390E	probably benign	Het
Col1a2	A	G	6: 4,531,355 (GRCm39)		probably benign	Het
Ddx59	A	T	1: 136,344,743 (GRCm39)	Q138L	probably benign	Het
Dlc1	A	T	8: 37,046,800 (GRCm39)	F1091L	probably damaging	Het
Dnah1	C	T	14: 31,027,790 (GRCm39)	V682M	probably benign	Het
Dock9	C	T	14: 121,877,538 (GRCm39)	D404N	probably damaging	Het
Eif2b4	A	G	5: 31,346,962 (GRCm39)	V402A	probably damaging	Het
Erlin1	T	C	19: 44,027,634 (GRCm39)	H268R	probably benign	Het
Ermard	T	C	17: 15,279,601 (GRCm39)		probably benign	Het
Fam43a	A	G	16: 30,419,596 (GRCm39)	K60R	probably benign	Het
Frmd4b	T	A	6: 97,389,494 (GRCm39)	D78V	probably damaging	Het
Gabrq	A	G	X: 71,880,430 (GRCm39)	T308A	possibly damaging	Het
Gipr	A	G	7: 18,893,690 (GRCm39)	C328R	possibly damaging	Het
Gm17078	T	C	14: 51,848,680 (GRCm39)	N19S	possibly damaging	Het
Gm17541	T	C	12: 4,739,907 (GRCm39)		probably benign	Het
Gm21759	T	C	5: 8,229,967 (GRCm39)		probably benign	Het
Gm7964	A	G	7: 83,405,250 (GRCm39)		noncoding transcript	Het
Gspt1	A	G	16: 11,048,854 (GRCm39)	V318A	probably damaging	Het
Gtf2ird2	A	G	5: 134,245,319 (GRCm39)	S526G	probably benign	Het
Hey2	A	G	10: 30,718,643 (GRCm39)	M1T	probably null	Het
Hipk3	T	C	2: 104,301,757 (GRCm39)	D145G	probably damaging	Het
Itgae	A	G	11: 73,021,777 (GRCm39)	D886G	probably damaging	Het
Ktn1	T	A	14: 47,962,200 (GRCm39)		probably null	Het
Med12l	A	G	3: 58,975,789 (GRCm39)	K239R	probably benign	Het
Milr1	A	T	11: 106,656,101 (GRCm39)	M124L	probably benign	Het
Mon1b	G	T	8: 114,365,455 (GRCm39)	R261L	possibly damaging	Het
Mterf1a	G	A	5: 3,941,583 (GRCm39)	S95F	probably benign	Het
Myef2	C	A	2: 124,955,978 (GRCm39)		probably benign	Het
Nfrkb	T	A	9: 31,325,812 (GRCm39)	I1085N	possibly damaging	Het
Or13f5	A	T	4: 52,825,616 (GRCm39)	Y73F	probably damaging	Het
Or8d2	T	A	9: 38,759,536 (GRCm39)	M42K	possibly damaging	Het
Prodh	G	A	16: 17,890,332 (GRCm39)	Q430*	probably null	Het
Pstk	G	T	7: 130,972,922 (GRCm39)	R7L	probably benign	Het
Ptgr1	C	A	4: 58,978,067 (GRCm39)	E108D	probably benign	Het
Ptpn9	T	A	9: 56,944,009 (GRCm39)	Y294*	probably null	Het
Rnls	C	T	19: 33,115,614 (GRCm39)	V153M	possibly damaging	Het
Samt3	G	A	X: 85,090,527 (GRCm39)	A140T	possibly damaging	Het
Sbpl	T	A	17: 24,173,837 (GRCm39)	M16L	unknown	Het
Sephs1	G	A	2: 4,911,407 (GRCm39)	C327Y	probably damaging	Het
Slc13a1	A	T	6: 24,137,135 (GRCm39)	I93N	probably damaging	Het
Slc34a1	T	C	13: 55,551,051 (GRCm39)		probably benign	Het
Slc7a9	T	C	7: 35,152,860 (GRCm39)	S93P	probably damaging	Het
Slx4	A	G	16: 3,798,461 (GRCm39)	S1444P	probably damaging	Het
Spmap2l	T	A	5: 77,164,400 (GRCm39)	D134E	probably benign	Het
Stk32b	C	T	5: 37,688,977 (GRCm39)	V116M	probably damaging	Het
Supt5	A	G	7: 28,018,372 (GRCm39)		probably benign	Het
Syne2	T	A	12: 76,147,777 (GRCm39)	S6439T	probably damaging	Het
Taar7d	A	G	10: 23,903,994 (GRCm39)	D292G	possibly damaging	Het
Tal2	A	T	4: 53,785,971 (GRCm39)	I51F	probably damaging	Het
Tk2	A	T	8: 104,970,032 (GRCm39)	N77K	probably benign	Het
Tmprss3	T	A	17: 31,413,865 (GRCm39)		probably benign	Het
Tnfrsf10b	T	C	14: 70,019,825 (GRCm39)	M319T	probably damaging	Het
Trim24	A	G	6: 37,922,653 (GRCm39)	R417G	probably damaging	Het
Ttn	C	A	2: 76,594,658 (GRCm39)	G18717*	probably null	Het
Vmn2r102	A	G	17: 19,901,447 (GRCm39)	T525A	probably benign	Het
Wdr38	A	T	2: 38,888,424 (GRCm39)	N7I	probably damaging	Het
Wnt3	C	T	11: 103,703,296 (GRCm39)	R260W	probably damaging	Het
Xdh	T	A	17: 74,231,990 (GRCm39)	Q240L	possibly damaging	Het
Zbtb5	T	C	4: 44,994,731 (GRCm39)	T218A	probably benign	Het
Znfx1	C	T	2: 166,879,457 (GRCm39)	E776K	probably benign	Het

Other mutations in Ros1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00236:Ros1	APN	10	52,070,986 (GRCm39)	missense	probably benign	0.01
IGL00338:Ros1	APN	10	52,001,907 (GRCm39)	missense	probably benign
IGL00419:Ros1	APN	10	51,967,150 (GRCm39)	missense	probably damaging	0.97
IGL00840:Ros1	APN	10	52,020,969 (GRCm39)	missense	possibly damaging	0.92
IGL00841:Ros1	APN	10	52,020,969 (GRCm39)	missense	possibly damaging	0.92
IGL00951:Ros1	APN	10	52,019,348 (GRCm39)	missense	probably damaging	0.99
IGL01123:Ros1	APN	10	51,996,905 (GRCm39)	missense	probably damaging	1.00
IGL01128:Ros1	APN	10	52,018,424 (GRCm39)	nonsense	probably null
IGL01300:Ros1	APN	10	51,977,809 (GRCm39)	missense	probably benign	0.01
IGL01316:Ros1	APN	10	51,963,975 (GRCm39)	critical splice donor site	probably null
IGL01349:Ros1	APN	10	51,927,122 (GRCm39)	missense	probably damaging	0.99
IGL01363:Ros1	APN	10	52,042,238 (GRCm39)	missense	probably damaging	1.00
IGL01457:Ros1	APN	10	51,922,426 (GRCm39)	splice site	probably benign
IGL01532:Ros1	APN	10	51,967,034 (GRCm39)	splice site	probably benign
IGL01585:Ros1	APN	10	52,031,198 (GRCm39)	missense	probably damaging	1.00
IGL01650:Ros1	APN	10	52,031,075 (GRCm39)	missense	probably damaging	0.99
IGL01672:Ros1	APN	10	51,977,899 (GRCm39)	missense	possibly damaging	0.92
IGL01904:Ros1	APN	10	51,954,007 (GRCm39)	missense	probably damaging	0.97
IGL02040:Ros1	APN	10	51,992,018 (GRCm39)	missense	probably damaging	0.99
IGL02053:Ros1	APN	10	52,038,816 (GRCm39)	missense	probably damaging	1.00
IGL02147:Ros1	APN	10	51,996,991 (GRCm39)	missense	probably damaging	1.00
IGL02169:Ros1	APN	10	51,958,053 (GRCm39)	critical splice donor site	probably null
IGL02247:Ros1	APN	10	52,005,677 (GRCm39)	missense	probably damaging	0.99
IGL02262:Ros1	APN	10	52,055,065 (GRCm39)	missense	probably damaging	0.96
IGL02307:Ros1	APN	10	52,004,534 (GRCm39)	missense	possibly damaging	0.53
IGL02398:Ros1	APN	10	52,020,980 (GRCm39)	splice site	probably benign
IGL02718:Ros1	APN	10	51,994,328 (GRCm39)	missense	probably damaging	1.00
IGL02721:Ros1	APN	10	52,048,927 (GRCm39)	splice site	probably benign
IGL02808:Ros1	APN	10	52,001,985 (GRCm39)	missense	probably damaging	1.00
IGL03009:Ros1	APN	10	52,022,003 (GRCm39)	missense	probably benign	0.00
IGL03035:Ros1	APN	10	51,952,080 (GRCm39)	splice site	probably benign
IGL03092:Ros1	APN	10	51,974,902 (GRCm39)	missense	probably damaging	0.99
IGL03309:Ros1	APN	10	51,994,357 (GRCm39)	missense	possibly damaging	0.83
IGL03333:Ros1	APN	10	52,031,267 (GRCm39)	missense	probably damaging	1.00
boss	UTSW	10	51,967,091 (GRCm39)	nonsense	probably null
Chuckwagon	UTSW	10	51,994,299 (GRCm39)	missense	probably damaging	1.00
R1005_Ros1_648	UTSW	10	52,004,501 (GRCm39)	splice site	probably benign
R1220_Ros1_012	UTSW	10	51,974,966 (GRCm39)	missense	probably damaging	0.97
R3423_Ros1_122	UTSW	10	52,004,512 (GRCm39)	splice site	probably null
trail	UTSW	10	52,037,991 (GRCm39)	nonsense	probably null
R0049:Ros1	UTSW	10	51,977,857 (GRCm39)	missense	possibly damaging	0.66
R0049:Ros1	UTSW	10	51,977,857 (GRCm39)	missense	possibly damaging	0.66
R0050:Ros1	UTSW	10	51,977,899 (GRCm39)	missense	probably damaging	0.97
R0050:Ros1	UTSW	10	51,977,899 (GRCm39)	missense	probably damaging	0.97
R0057:Ros1	UTSW	10	52,056,287 (GRCm39)	missense	probably benign	0.00
R0057:Ros1	UTSW	10	52,056,287 (GRCm39)	missense	probably benign	0.00
R0106:Ros1	UTSW	10	52,018,363 (GRCm39)	missense	possibly damaging	0.85
R0106:Ros1	UTSW	10	52,018,363 (GRCm39)	missense	possibly damaging	0.85
R0125:Ros1	UTSW	10	52,001,885 (GRCm39)	missense	probably benign	0.38
R0403:Ros1	UTSW	10	52,019,534 (GRCm39)	splice site	probably benign
R0487:Ros1	UTSW	10	52,031,204 (GRCm39)	missense	possibly damaging	0.69
R0502:Ros1	UTSW	10	52,070,919 (GRCm39)	splice site	probably benign
R0557:Ros1	UTSW	10	51,961,359 (GRCm39)	missense	possibly damaging	0.82
R0599:Ros1	UTSW	10	51,999,396 (GRCm39)	missense	probably damaging	1.00
R0620:Ros1	UTSW	10	51,994,444 (GRCm39)	missense	probably damaging	1.00
R0679:Ros1	UTSW	10	51,942,391 (GRCm39)	missense	possibly damaging	0.95
R1005:Ros1	UTSW	10	52,004,501 (GRCm39)	splice site	probably benign
R1073:Ros1	UTSW	10	51,922,221 (GRCm39)	missense	probably damaging	1.00
R1220:Ros1	UTSW	10	51,974,966 (GRCm39)	missense	probably damaging	0.97
R1279:Ros1	UTSW	10	52,018,262 (GRCm39)	missense	possibly damaging	0.81
R1295:Ros1	UTSW	10	51,964,028 (GRCm39)	missense	possibly damaging	0.92
R1336:Ros1	UTSW	10	52,044,758 (GRCm39)	missense	probably damaging	1.00
R1371:Ros1	UTSW	10	51,964,041 (GRCm39)	missense	probably damaging	0.98
R1447:Ros1	UTSW	10	51,974,954 (GRCm39)	missense	possibly damaging	0.66
R1486:Ros1	UTSW	10	52,048,954 (GRCm39)	missense	probably damaging	1.00
R1499:Ros1	UTSW	10	51,974,773 (GRCm39)	missense	possibly damaging	0.92
R1669:Ros1	UTSW	10	52,037,907 (GRCm39)	missense	probably damaging	1.00
R1744:Ros1	UTSW	10	51,999,475 (GRCm39)	missense	probably damaging	0.99
R1759:Ros1	UTSW	10	51,996,922 (GRCm39)	missense	probably damaging	1.00
R1791:Ros1	UTSW	10	51,976,183 (GRCm39)	missense	probably benign	0.00
R1794:Ros1	UTSW	10	52,000,199 (GRCm39)	nonsense	probably null
R2031:Ros1	UTSW	10	51,943,164 (GRCm39)	missense	possibly damaging	0.88
R2115:Ros1	UTSW	10	52,004,651 (GRCm39)	missense	probably benign	0.00
R2219:Ros1	UTSW	10	52,042,175 (GRCm39)	missense	probably damaging	1.00
R2290:Ros1	UTSW	10	51,994,477 (GRCm39)	missense	probably damaging	0.96
R2329:Ros1	UTSW	10	52,038,983 (GRCm39)	missense	probably damaging	1.00
R2371:Ros1	UTSW	10	52,039,991 (GRCm39)	missense	possibly damaging	0.66
R2879:Ros1	UTSW	10	52,048,936 (GRCm39)	critical splice donor site	probably null
R3154:Ros1	UTSW	10	51,927,077 (GRCm39)	missense	probably benign
R3423:Ros1	UTSW	10	52,004,512 (GRCm39)	splice site	probably null
R3424:Ros1	UTSW	10	52,004,512 (GRCm39)	splice site	probably null
R3425:Ros1	UTSW	10	52,004,512 (GRCm39)	splice site	probably null
R3433:Ros1	UTSW	10	51,967,204 (GRCm39)	missense	probably benign	0.45
R3522:Ros1	UTSW	10	51,967,091 (GRCm39)	nonsense	probably null
R3686:Ros1	UTSW	10	52,021,912 (GRCm39)	missense	probably damaging	1.00
R3710:Ros1	UTSW	10	52,037,991 (GRCm39)	nonsense	probably null
R3771:Ros1	UTSW	10	52,005,087 (GRCm39)	missense	probably damaging	0.97
R3808:Ros1	UTSW	10	51,996,944 (GRCm39)	missense	probably benign	0.08
R3930:Ros1	UTSW	10	52,070,944 (GRCm39)	missense	possibly damaging	0.92
R3950:Ros1	UTSW	10	51,942,484 (GRCm39)	missense	probably damaging	1.00
R3981:Ros1	UTSW	10	51,996,974 (GRCm39)	missense	possibly damaging	0.46
R4007:Ros1	UTSW	10	51,994,328 (GRCm39)	missense	probably damaging	1.00
R4346:Ros1	UTSW	10	52,044,705 (GRCm39)	missense	possibly damaging	0.92
R4382:Ros1	UTSW	10	51,997,055 (GRCm39)	missense	possibly damaging	0.46
R4414:Ros1	UTSW	10	52,038,800 (GRCm39)	critical splice donor site	probably null
R4450:Ros1	UTSW	10	51,954,038 (GRCm39)	missense	probably damaging	0.98
R4468:Ros1	UTSW	10	51,994,452 (GRCm39)	missense	probably damaging	1.00
R4569:Ros1	UTSW	10	52,040,090 (GRCm39)	missense	probably damaging	0.99
R4649:Ros1	UTSW	10	52,005,764 (GRCm39)	missense	possibly damaging	0.66
R4684:Ros1	UTSW	10	52,005,192 (GRCm39)	missense	probably damaging	1.00
R4706:Ros1	UTSW	10	51,977,990 (GRCm39)	missense	possibly damaging	0.95
R4731:Ros1	UTSW	10	52,018,325 (GRCm39)	missense	probably damaging	1.00
R4748:Ros1	UTSW	10	51,992,093 (GRCm39)	missense	probably benign	0.00
R4806:Ros1	UTSW	10	51,972,271 (GRCm39)	missense	probably damaging	0.96
R4865:Ros1	UTSW	10	52,048,966 (GRCm39)	missense	probably damaging	0.99
R4973:Ros1	UTSW	10	52,031,087 (GRCm39)	missense	probably damaging	0.98
R5022:Ros1	UTSW	10	52,000,171 (GRCm39)	missense	possibly damaging	0.46
R5033:Ros1	UTSW	10	52,004,512 (GRCm39)	critical splice donor site	probably null
R5082:Ros1	UTSW	10	52,040,037 (GRCm39)	missense	possibly damaging	0.66
R5083:Ros1	UTSW	10	52,040,037 (GRCm39)	missense	possibly damaging	0.66
R5130:Ros1	UTSW	10	52,040,037 (GRCm39)	missense	possibly damaging	0.66
R5269:Ros1	UTSW	10	51,927,104 (GRCm39)	missense	probably damaging	1.00
R5399:Ros1	UTSW	10	51,967,040 (GRCm39)	critical splice donor site	probably null
R5414:Ros1	UTSW	10	52,031,189 (GRCm39)	missense	probably damaging	1.00
R5659:Ros1	UTSW	10	52,019,482 (GRCm39)	missense	possibly damaging	0.92
R5742:Ros1	UTSW	10	52,018,234 (GRCm39)	critical splice donor site	probably null
R5780:Ros1	UTSW	10	52,070,953 (GRCm39)	missense	probably damaging	1.00
R5805:Ros1	UTSW	10	51,999,385 (GRCm39)	missense	probably damaging	1.00
R5843:Ros1	UTSW	10	52,042,293 (GRCm39)	missense	possibly damaging	0.92
R5881:Ros1	UTSW	10	52,057,894 (GRCm39)	missense	probably benign	0.26
R6027:Ros1	UTSW	10	52,040,064 (GRCm39)	missense	possibly damaging	0.82
R6035:Ros1	UTSW	10	51,954,067 (GRCm39)	missense	probably benign
R6035:Ros1	UTSW	10	51,954,067 (GRCm39)	missense	probably benign
R6052:Ros1	UTSW	10	52,039,999 (GRCm39)	missense	probably benign	0.39
R6175:Ros1	UTSW	10	51,977,881 (GRCm39)	missense	probably benign	0.02
R6315:Ros1	UTSW	10	51,994,306 (GRCm39)	missense	probably benign
R6342:Ros1	UTSW	10	52,031,351 (GRCm39)	missense	probably damaging	1.00
R6470:Ros1	UTSW	10	52,042,140 (GRCm39)	critical splice donor site	probably null
R6527:Ros1	UTSW	10	52,019,473 (GRCm39)	missense	possibly damaging	0.66
R6568:Ros1	UTSW	10	52,038,908 (GRCm39)	missense	probably damaging	1.00
R6573:Ros1	UTSW	10	52,031,106 (GRCm39)	missense	possibly damaging	0.84
R6653:Ros1	UTSW	10	52,018,299 (GRCm39)	missense	probably damaging	1.00
R6959:Ros1	UTSW	10	52,040,090 (GRCm39)	missense	probably damaging	0.99
R7011:Ros1	UTSW	10	52,056,272 (GRCm39)	missense	probably damaging	1.00
R7111:Ros1	UTSW	10	52,057,906 (GRCm39)	missense	probably benign	0.02
R7243:Ros1	UTSW	10	51,999,477 (GRCm39)	missense	probably damaging	1.00
R7355:Ros1	UTSW	10	52,042,175 (GRCm39)	missense	probably damaging	1.00
R7385:Ros1	UTSW	10	52,031,222 (GRCm39)	missense	probably benign	0.00
R7460:Ros1	UTSW	10	51,994,299 (GRCm39)	missense	probably damaging	1.00
R7549:Ros1	UTSW	10	52,021,930 (GRCm39)	missense	probably damaging	0.96
R7573:Ros1	UTSW	10	52,046,072 (GRCm39)	missense	probably benign	0.03
R7650:Ros1	UTSW	10	51,922,305 (GRCm39)	missense	probably benign	0.00
R7667:Ros1	UTSW	10	52,040,067 (GRCm39)	missense	probably damaging	1.00
R7696:Ros1	UTSW	10	52,018,379 (GRCm39)	missense	probably damaging	1.00
R7785:Ros1	UTSW	10	52,038,944 (GRCm39)	missense	probably damaging	1.00
R7814:Ros1	UTSW	10	51,972,233 (GRCm39)	missense	probably benign	0.28
R7830:Ros1	UTSW	10	52,031,030 (GRCm39)	missense	probably damaging	0.99
R7832:Ros1	UTSW	10	52,020,957 (GRCm39)	missense	probably damaging	0.99
R7854:Ros1	UTSW	10	52,004,563 (GRCm39)	missense	probably damaging	1.00
R7912:Ros1	UTSW	10	52,044,791 (GRCm39)	missense	probably damaging	1.00
R7972:Ros1	UTSW	10	52,030,926 (GRCm39)	nonsense	probably null
R7993:Ros1	UTSW	10	51,999,443 (GRCm39)	missense	probably benign	0.34
R8036:Ros1	UTSW	10	52,041,439 (GRCm39)	missense	probably benign
R8137:Ros1	UTSW	10	52,001,933 (GRCm39)	missense	possibly damaging	0.87
R8169:Ros1	UTSW	10	51,940,768 (GRCm39)	critical splice donor site	probably null
R8199:Ros1	UTSW	10	51,977,813 (GRCm39)	nonsense	probably null
R8293:Ros1	UTSW	10	51,964,014 (GRCm39)	missense	probably damaging	1.00
R8368:Ros1	UTSW	10	51,940,833 (GRCm39)	missense	probably damaging	1.00
R8406:Ros1	UTSW	10	51,977,941 (GRCm39)	missense	possibly damaging	0.56
R8471:Ros1	UTSW	10	51,997,078 (GRCm39)	missense	probably benign	0.00
R8498:Ros1	UTSW	10	52,055,047 (GRCm39)	missense	probably damaging	0.99
R8532:Ros1	UTSW	10	51,974,852 (GRCm39)	missense	possibly damaging	0.92
R8678:Ros1	UTSW	10	51,963,998 (GRCm39)	missense	probably benign
R8726:Ros1	UTSW	10	51,954,769 (GRCm39)	missense	possibly damaging	0.46
R8789:Ros1	UTSW	10	51,999,328 (GRCm39)	missense	probably damaging	0.99
R8799:Ros1	UTSW	10	51,922,143 (GRCm39)	missense	probably benign	0.08
R8915:Ros1	UTSW	10	51,977,805 (GRCm39)	splice site	probably benign
R8958:Ros1	UTSW	10	51,972,190 (GRCm39)	missense	probably damaging	1.00
R8972:Ros1	UTSW	10	51,999,333 (GRCm39)	missense	probably benign	0.05
R9020:Ros1	UTSW	10	52,031,023 (GRCm39)	missense	probably benign	0.32
R9147:Ros1	UTSW	10	51,927,039 (GRCm39)	missense	probably benign
R9154:Ros1	UTSW	10	51,922,301 (GRCm39)	missense	possibly damaging	0.87
R9189:Ros1	UTSW	10	52,019,502 (GRCm39)	missense	probably damaging	0.99
R9341:Ros1	UTSW	10	51,972,116 (GRCm39)	critical splice donor site	probably null
R9343:Ros1	UTSW	10	51,972,116 (GRCm39)	critical splice donor site	probably null
R9407:Ros1	UTSW	10	51,994,491 (GRCm39)	missense	probably damaging	1.00
R9428:Ros1	UTSW	10	51,958,061 (GRCm39)	missense	probably benign	0.00
R9502:Ros1	UTSW	10	52,000,174 (GRCm39)	missense	probably benign	0.00
R9531:Ros1	UTSW	10	52,007,063 (GRCm39)	missense	probably damaging	1.00
R9546:Ros1	UTSW	10	51,994,215 (GRCm39)	critical splice donor site	probably null
R9562:Ros1	UTSW	10	51,943,170 (GRCm39)	missense	probably damaging	1.00
R9565:Ros1	UTSW	10	51,943,170 (GRCm39)	missense	probably damaging	1.00
R9604:Ros1	UTSW	10	51,994,249 (GRCm39)	missense	probably damaging	1.00
R9645:Ros1	UTSW	10	51,948,148 (GRCm39)	critical splice donor site	probably null
R9658:Ros1	UTSW	10	51,967,069 (GRCm39)	missense	probably damaging	0.99
R9664:Ros1	UTSW	10	51,996,931 (GRCm39)	missense	probably benign	0.18
RF018:Ros1	UTSW	10	52,031,217 (GRCm39)	missense	probably benign
Z1176:Ros1	UTSW	10	51,967,205 (GRCm39)	missense	possibly damaging	0.89
Z1177:Ros1	UTSW	10	52,044,767 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16