Incidental Mutation 'IGL02527:Or10ag2'
ID 297129
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ag2
Ensembl Gene ENSMUSG00000043274
Gene Name olfactory receptor family 10 subfamily AG member 2
Synonyms Olfr1123, MOR264-17, GA_x6K02T2Q125-48917235-48918206
Accession Numbers
Essential gene? Probably non essential (E-score: 0.244) question?
Stock # IGL02527
Quality Score
Status
Chromosome 2
Chromosomal Location 87248394-87249365 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87249181 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 261 (L261S)
Ref Sequence ENSEMBL: ENSMUSP00000154459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054974] [ENSMUST00000216208]
AlphaFold A2AT85
Predicted Effect probably damaging
Transcript: ENSMUST00000054974
AA Change: L263S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000058786
Gene: ENSMUSG00000043274
AA Change: L263S

DomainStartEndE-ValueType
Pfam:7tm_4 44 321 4.4e-52 PFAM
Pfam:7tm_1 54 303 2.6e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213950
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214663
Predicted Effect probably damaging
Transcript: ENSMUST00000216208
AA Change: L261S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,638,392 (GRCm39) V868A probably damaging Het
Adam25 T A 8: 41,206,785 (GRCm39) I17K possibly damaging Het
Arap2 A T 5: 62,906,650 (GRCm39) M123K probably benign Het
Asic3 A G 5: 24,621,275 (GRCm39) M332V probably benign Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Cand1 A T 10: 119,042,712 (GRCm39) M1126K probably damaging Het
Capn3 A G 2: 120,334,966 (GRCm39) T818A probably damaging Het
Cda G A 4: 138,070,832 (GRCm39) Q104* probably null Het
Cfhr4 T C 1: 139,680,783 (GRCm39) N245S probably damaging Het
Cpeb1 T C 7: 81,009,635 (GRCm39) D234G probably damaging Het
Cpq A G 15: 33,302,509 (GRCm39) Y220C probably damaging Het
Diaph3 T C 14: 87,047,795 (GRCm39) K1026R possibly damaging Het
Dpep1 T C 8: 123,925,487 (GRCm39) F47L probably damaging Het
Dppa4 G T 16: 48,109,456 (GRCm39) R66L possibly damaging Het
Elac1 C A 18: 73,880,304 (GRCm39) E31* probably null Het
Fggy A G 4: 95,585,306 (GRCm39) K62E probably damaging Het
Ficd T A 5: 113,875,027 (GRCm39) M32K probably benign Het
Foxd4 A G 19: 24,877,178 (GRCm39) S341P probably benign Het
Gnb4 G T 3: 32,644,015 (GRCm39) T181K probably benign Het
Grin2b T A 6: 135,900,389 (GRCm39) Y164F probably damaging Het
Hmmr A G 11: 40,598,932 (GRCm39) L564P probably damaging Het
Hsd17b4 G A 18: 50,293,231 (GRCm39) V257I probably benign Het
Itga10 C A 3: 96,562,940 (GRCm39) probably benign Het
Kcnk18 T C 19: 59,223,707 (GRCm39) V284A probably damaging Het
Klf11 T A 12: 24,705,322 (GRCm39) S259T probably benign Het
Kmt2d C T 15: 98,739,628 (GRCm39) probably benign Het
Manea A G 4: 26,336,619 (GRCm39) probably null Het
Mybl1 T C 1: 9,760,373 (GRCm39) H75R probably damaging Het
Neb G A 2: 52,153,959 (GRCm39) T2384M probably damaging Het
Neb A G 2: 52,039,225 (GRCm39) I6938T probably benign Het
Ntrk3 T C 7: 78,101,697 (GRCm39) D412G probably benign Het
Olah T C 2: 3,343,979 (GRCm39) E211G probably damaging Het
Paxbp1 A T 16: 90,834,161 (GRCm39) N208K possibly damaging Het
Prrc1 T A 18: 57,522,419 (GRCm39) M417K probably benign Het
Ptprq G A 10: 107,522,424 (GRCm39) T543M probably benign Het
Rasal1 T C 5: 120,804,469 (GRCm39) V447A probably damaging Het
Rbl1 T C 2: 157,035,968 (GRCm39) E287G probably benign Het
Rusf1 T A 7: 127,875,403 (GRCm39) T317S possibly damaging Het
Tec A G 5: 72,936,758 (GRCm39) probably null Het
Tex26 A G 5: 149,380,407 (GRCm39) D61G probably damaging Het
Tgfb1i1 G A 7: 127,851,734 (GRCm39) probably benign Het
Tmem132c T C 5: 127,436,675 (GRCm39) Y55H possibly damaging Het
Tmem63a T A 1: 180,780,539 (GRCm39) probably null Het
Umod C T 7: 119,068,690 (GRCm39) G452D probably damaging Het
Vcan G A 13: 89,838,776 (GRCm39) T2256I possibly damaging Het
Vmn1r31 A T 6: 58,449,778 (GRCm39) I29K probably benign Het
Vmn2r117 A G 17: 23,696,199 (GRCm39) Y403H possibly damaging Het
Vmn2r124 A T 17: 18,286,764 (GRCm39) probably null Het
Vmn2r65 T A 7: 84,595,724 (GRCm39) K320M possibly damaging Het
Other mutations in Or10ag2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Or10ag2 APN 2 87,248,910 (GRCm39) missense possibly damaging 0.75
IGL01067:Or10ag2 APN 2 87,248,714 (GRCm39) missense probably benign 0.00
IGL01526:Or10ag2 APN 2 87,249,319 (GRCm39) missense probably damaging 0.99
IGL01580:Or10ag2 APN 2 87,248,880 (GRCm39) missense probably benign 0.06
IGL01986:Or10ag2 APN 2 87,248,880 (GRCm39) missense probably benign 0.00
IGL02503:Or10ag2 APN 2 87,248,636 (GRCm39) missense probably benign 0.03
IGL02731:Or10ag2 APN 2 87,249,051 (GRCm39) missense probably benign 0.00
IGL03215:Or10ag2 APN 2 87,248,412 (GRCm39) missense probably benign 0.05
IGL03366:Or10ag2 APN 2 87,248,587 (GRCm39) missense possibly damaging 0.88
R0645:Or10ag2 UTSW 2 87,248,612 (GRCm39) nonsense probably null
R1857:Or10ag2 UTSW 2 87,248,992 (GRCm39) missense probably damaging 1.00
R2175:Or10ag2 UTSW 2 87,248,500 (GRCm39) missense probably damaging 1.00
R3691:Or10ag2 UTSW 2 87,248,514 (GRCm39) missense probably benign 0.20
R4082:Or10ag2 UTSW 2 87,248,801 (GRCm39) nonsense probably null
R4635:Or10ag2 UTSW 2 87,249,043 (GRCm39) missense probably benign 0.05
R4877:Or10ag2 UTSW 2 87,248,907 (GRCm39) nonsense probably null
R5190:Or10ag2 UTSW 2 87,249,187 (GRCm39) missense probably damaging 1.00
R5253:Or10ag2 UTSW 2 87,249,012 (GRCm39) missense possibly damaging 0.64
R6266:Or10ag2 UTSW 2 87,249,350 (GRCm39) missense probably benign 0.01
R6784:Or10ag2 UTSW 2 87,248,796 (GRCm39) missense probably benign 0.20
R6909:Or10ag2 UTSW 2 87,248,959 (GRCm39) missense probably damaging 1.00
R7255:Or10ag2 UTSW 2 87,249,286 (GRCm39) missense probably damaging 0.96
R8076:Or10ag2 UTSW 2 87,248,889 (GRCm39) missense probably benign 0.00
R8116:Or10ag2 UTSW 2 87,249,081 (GRCm39) missense probably damaging 1.00
R8315:Or10ag2 UTSW 2 87,248,995 (GRCm39) missense probably damaging 1.00
R8888:Or10ag2 UTSW 2 87,248,659 (GRCm39) missense probably benign 0.00
R8895:Or10ag2 UTSW 2 87,248,659 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16