Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02527:Vmn2r117'

297137

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

IGL02527

Quality Score

Status

Chromosome

Chromosomal Location

23459675-23479597 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23477225 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 403 (Y403H)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171996
AA Change: Y403H

PolyPhen 2 Score 0.650 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: Y403H

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	C	6: 121,661,433	V868A	probably damaging	Het
Adam25	T	A	8: 40,753,748	I17K	possibly damaging	Het
Arap2	A	T	5: 62,749,307	M123K	probably benign	Het
Asic3	A	G	5: 24,416,277	M332V	probably benign	Het
Atp2a3	C	A	11: 72,975,339	H262N	probably benign	Het
BC017158	T	A	7: 128,276,231	T317S	possibly damaging	Het
Cand1	A	T	10: 119,206,807	M1126K	probably damaging	Het
Capn3	A	G	2: 120,504,485	T818A	probably damaging	Het
Cda	G	A	4: 138,343,521	Q104*	probably null	Het
Cpeb1	T	C	7: 81,359,887	D234G	probably damaging	Het
Cpq	A	G	15: 33,302,363	Y220C	probably damaging	Het
Diaph3	T	C	14: 86,810,359	K1026R	possibly damaging	Het
Dpep1	T	C	8: 123,198,748	F47L	probably damaging	Het
Dppa4	G	T	16: 48,289,093	R66L	possibly damaging	Het
Elac1	C	A	18: 73,747,233	E31*	probably null	Het
Fggy	A	G	4: 95,697,069	K62E	probably damaging	Het
Ficd	T	A	5: 113,736,966	M32K	probably benign	Het
Foxd4	A	G	19: 24,899,814	S341P	probably benign	Het
Gm4788	T	C	1: 139,753,045	N245S	probably damaging	Het
Gnb4	G	T	3: 32,589,866	T181K	probably benign	Het
Grin2b	T	A	6: 135,923,391	Y164F	probably damaging	Het
Hmmr	A	G	11: 40,708,105	L564P	probably damaging	Het
Hsd17b4	G	A	18: 50,160,164	V257I	probably benign	Het
Itga10	C	A	3: 96,655,624		probably benign	Het
Kcnk18	T	C	19: 59,235,275	V284A	probably damaging	Het
Klf11	T	A	12: 24,655,323	S259T	probably benign	Het
Kmt2d	C	T	15: 98,841,747		probably benign	Het
Manea	A	G	4: 26,336,619		probably null	Het
Mybl1	T	C	1: 9,690,148	H75R	probably damaging	Het
Neb	G	A	2: 52,263,947	T2384M	probably damaging	Het
Neb	A	G	2: 52,149,213	I6938T	probably benign	Het
Ntrk3	T	C	7: 78,451,949	D412G	probably benign	Het
Olah	T	C	2: 3,342,942	E211G	probably damaging	Het
Olfr1123	T	C	2: 87,418,837	L261S	probably damaging	Het
Paxbp1	A	T	16: 91,037,273	N208K	possibly damaging	Het
Prrc1	T	A	18: 57,389,347	M417K	probably benign	Het
Ptprq	G	A	10: 107,686,563	T543M	probably benign	Het
Rasal1	T	C	5: 120,666,404	V447A	probably damaging	Het
Rbl1	T	C	2: 157,194,048	E287G	probably benign	Het
Tec	A	G	5: 72,779,415		probably null	Het
Tex26	A	G	5: 149,456,942	D61G	probably damaging	Het
Tgfb1i1	G	A	7: 128,252,562		probably benign	Het
Tmem132c	T	C	5: 127,359,611	Y55H	possibly damaging	Het
Tmem63a	T	A	1: 180,952,974		probably null	Het
Umod	C	T	7: 119,469,467	G452D	probably damaging	Het
Vcan	G	A	13: 89,690,657	T2256I	possibly damaging	Het
Vmn1r31	A	T	6: 58,472,793	I29K	probably benign	Het
Vmn2r124	A	T	17: 18,066,502		probably null	Het
Vmn2r65	T	A	7: 84,946,516	K320M	possibly damaging	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23477840	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23475429	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23479546	missense	probably benign
IGL01078:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23478382	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23477241	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23475382	missense	probably damaging	0.99
IGL02612:Vmn2r117	APN	17	23459784	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23475578	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23477707	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23460165	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23475514	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23475503	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23460553	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23478473	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23477455	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23478389	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23477480	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23477644	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23460256	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23459911	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23460106	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23459877	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23478416	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23477885	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23459838	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23460148	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23477874	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23477202	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23479561	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23460114	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23460219	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23460049	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23478308	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23479563	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23477203	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23475385	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23475565	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23460133	missense	probably benign	0.25
R7443:Vmn2r117	UTSW	17	23460345	missense	probably damaging	1.00
R7449:Vmn2r117	UTSW	17	23459895	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23477291	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23460126	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23479407	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23477770	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23460537	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23479468	missense	probably benign
R8723:Vmn2r117	UTSW	17	23477369	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23460169	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23460471	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23459944	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23477615	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23477604	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23478476	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23477840	missense	probably damaging	1.00
V5622:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
Z1176:Vmn2r117	UTSW	17	23459766	missense	probably benign	0.00

Posted On

2015-04-16