Incidental Mutation 'IGL02527:Olah'
ID 297157
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olah
Ensembl Gene ENSMUSG00000026645
Gene Name oleoyl-ACP hydrolase
Synonyms Thedc1, E230009B14Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02527
Quality Score
Status
Chromosome 2
Chromosomal Location 3343019-3367964 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 3343979 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 211 (E211G)
Ref Sequence ENSEMBL: ENSMUSP00000141485 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027955] [ENSMUST00000115087] [ENSMUST00000115089] [ENSMUST00000194918] [ENSMUST00000228935]
AlphaFold Q8R197
Predicted Effect probably damaging
Transcript: ENSMUST00000027955
AA Change: E211G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027955
Gene: ENSMUSG00000026645
AA Change: E211G

DomainStartEndE-ValueType
Pfam:Thioesterase 27 257 1.7e-53 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115087
AA Change: E211G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000110739
Gene: ENSMUSG00000026645
AA Change: E211G

DomainStartEndE-ValueType
Pfam:Thioesterase 27 256 3.8e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115089
SMART Domains Protein: ENSMUSP00000110741
Gene: ENSMUSG00000026644

DomainStartEndE-ValueType
Pfam:ACBP 4 84 3.2e-30 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000194918
AA Change: E211G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000141485
Gene: ENSMUSG00000026645
AA Change: E211G

DomainStartEndE-ValueType
Pfam:Thioesterase 27 256 3.8e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000228935
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,638,392 (GRCm39) V868A probably damaging Het
Adam25 T A 8: 41,206,785 (GRCm39) I17K possibly damaging Het
Arap2 A T 5: 62,906,650 (GRCm39) M123K probably benign Het
Asic3 A G 5: 24,621,275 (GRCm39) M332V probably benign Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Cand1 A T 10: 119,042,712 (GRCm39) M1126K probably damaging Het
Capn3 A G 2: 120,334,966 (GRCm39) T818A probably damaging Het
Cda G A 4: 138,070,832 (GRCm39) Q104* probably null Het
Cfhr4 T C 1: 139,680,783 (GRCm39) N245S probably damaging Het
Cpeb1 T C 7: 81,009,635 (GRCm39) D234G probably damaging Het
Cpq A G 15: 33,302,509 (GRCm39) Y220C probably damaging Het
Diaph3 T C 14: 87,047,795 (GRCm39) K1026R possibly damaging Het
Dpep1 T C 8: 123,925,487 (GRCm39) F47L probably damaging Het
Dppa4 G T 16: 48,109,456 (GRCm39) R66L possibly damaging Het
Elac1 C A 18: 73,880,304 (GRCm39) E31* probably null Het
Fggy A G 4: 95,585,306 (GRCm39) K62E probably damaging Het
Ficd T A 5: 113,875,027 (GRCm39) M32K probably benign Het
Foxd4 A G 19: 24,877,178 (GRCm39) S341P probably benign Het
Gnb4 G T 3: 32,644,015 (GRCm39) T181K probably benign Het
Grin2b T A 6: 135,900,389 (GRCm39) Y164F probably damaging Het
Hmmr A G 11: 40,598,932 (GRCm39) L564P probably damaging Het
Hsd17b4 G A 18: 50,293,231 (GRCm39) V257I probably benign Het
Itga10 C A 3: 96,562,940 (GRCm39) probably benign Het
Kcnk18 T C 19: 59,223,707 (GRCm39) V284A probably damaging Het
Klf11 T A 12: 24,705,322 (GRCm39) S259T probably benign Het
Kmt2d C T 15: 98,739,628 (GRCm39) probably benign Het
Manea A G 4: 26,336,619 (GRCm39) probably null Het
Mybl1 T C 1: 9,760,373 (GRCm39) H75R probably damaging Het
Neb G A 2: 52,153,959 (GRCm39) T2384M probably damaging Het
Neb A G 2: 52,039,225 (GRCm39) I6938T probably benign Het
Ntrk3 T C 7: 78,101,697 (GRCm39) D412G probably benign Het
Or10ag2 T C 2: 87,249,181 (GRCm39) L261S probably damaging Het
Paxbp1 A T 16: 90,834,161 (GRCm39) N208K possibly damaging Het
Prrc1 T A 18: 57,522,419 (GRCm39) M417K probably benign Het
Ptprq G A 10: 107,522,424 (GRCm39) T543M probably benign Het
Rasal1 T C 5: 120,804,469 (GRCm39) V447A probably damaging Het
Rbl1 T C 2: 157,035,968 (GRCm39) E287G probably benign Het
Rusf1 T A 7: 127,875,403 (GRCm39) T317S possibly damaging Het
Tec A G 5: 72,936,758 (GRCm39) probably null Het
Tex26 A G 5: 149,380,407 (GRCm39) D61G probably damaging Het
Tgfb1i1 G A 7: 127,851,734 (GRCm39) probably benign Het
Tmem132c T C 5: 127,436,675 (GRCm39) Y55H possibly damaging Het
Tmem63a T A 1: 180,780,539 (GRCm39) probably null Het
Umod C T 7: 119,068,690 (GRCm39) G452D probably damaging Het
Vcan G A 13: 89,838,776 (GRCm39) T2256I possibly damaging Het
Vmn1r31 A T 6: 58,449,778 (GRCm39) I29K probably benign Het
Vmn2r117 A G 17: 23,696,199 (GRCm39) Y403H possibly damaging Het
Vmn2r124 A T 17: 18,286,764 (GRCm39) probably null Het
Vmn2r65 T A 7: 84,595,724 (GRCm39) K320M possibly damaging Het
Other mutations in Olah
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0331:Olah UTSW 2 3,343,511 (GRCm39) missense probably damaging 1.00
R2153:Olah UTSW 2 3,366,306 (GRCm39) missense probably benign 0.19
R6865:Olah UTSW 2 3,343,964 (GRCm39) missense possibly damaging 0.91
R8460:Olah UTSW 2 3,362,762 (GRCm39) missense probably damaging 1.00
R9080:Olah UTSW 2 3,349,389 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16