Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02529:3425401B19Rik'

297218

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

3425401B19Rik

Ensembl Gene

ENSMUSG00000071540

Gene Name

RIKEN cDNA 3425401B19 gene

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL02529

Quality Score

Status

Chromosome

Chromosomal Location

32659119-32685293 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 32661233 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 925 (H925L)

Ref Sequence

ENSEMBL: ENSMUSP00000093741 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000096038]

AlphaFold

D3Z1D3

Predicted Effect

probably benign
Transcript: ENSMUST00000096038
AA Change: H925L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000093741
Gene: ENSMUSG00000071540
AA Change: H925L

Domain	Start	End	E-Value	Type
low complexity region	135	145	N/A	INTRINSIC
low complexity region	162	175	N/A	INTRINSIC
low complexity region	386	399	N/A	INTRINSIC
low complexity region	587	602	N/A	INTRINSIC
low complexity region	605	624	N/A	INTRINSIC
low complexity region	728	744	N/A	INTRINSIC
low complexity region	1002	1015	N/A	INTRINSIC
low complexity region	1086	1097	N/A	INTRINSIC
low complexity region	1147	1158	N/A	INTRINSIC
low complexity region	1161	1176	N/A	INTRINSIC
Pfam:DUF4585	1251	1322	6.5e-30	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agpat5	T	A	8: 18,881,754	Y297N	possibly damaging	Het
Apobec3	C	T	15: 79,897,687		probably benign	Het
Atpaf1	C	A	4: 115,791,269	A161E	probably damaging	Het
Bnc1	A	T	7: 81,977,368	D91E	probably damaging	Het
Capg	G	A	6: 72,555,846	V98I	probably benign	Het
Ccdc7b	C	T	8: 129,178,225	L115F	possibly damaging	Het
Ces2a	T	A	8: 104,737,219		probably benign	Het
Cldn6	T	G	17: 23,681,317	V85G	probably damaging	Het
Clec2e	T	C	6: 129,098,496		probably benign	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Dhx38	T	C	8: 109,559,013	E396G	probably benign	Het
Dock8	A	T	19: 25,100,926	K532*	probably null	Het
Efr3b	C	T	12: 3,983,391	V139I	probably benign	Het
Gmip	G	A	8: 69,816,789	G537E	probably damaging	Het
Hacd1	T	C	2: 14,045,202	H64R	probably damaging	Het
Hdac3	G	T	18: 37,944,132	Q230K	probably benign	Het
Htt	C	T	5: 34,819,043		probably benign	Het
Il18r1	A	G	1: 40,487,059	D255G	possibly damaging	Het
Krt82	T	A	15: 101,550,396	R70*	probably null	Het
Krt9	G	T	11: 100,189,966	H353Q	probably damaging	Het
Kyat3	T	C	3: 142,720,474	I57T	probably benign	Het
L1td1	A	G	4: 98,737,421	K618E	probably benign	Het
Limch1	C	A	5: 67,002,613	N617K	possibly damaging	Het
Lsm8	T	C	6: 18,851,652	F34S	probably damaging	Het
Man2a2	G	A	7: 80,359,640	A822V	probably damaging	Het
Mmrn2	C	A	14: 34,398,613	A480E	possibly damaging	Het
Mthfd1	A	G	12: 76,303,709	I474V	probably benign	Het
Mycl	A	G	4: 122,996,977	K152R	probably damaging	Het
Numa1	A	G	7: 101,999,953		probably null	Het
Olfr474	G	T	7: 107,955,216	V192F	possibly damaging	Het
Otog	A	C	7: 46,259,957	D617A	probably damaging	Het
Ppef2	A	G	5: 92,244,737	I267T	probably damaging	Het
Ptprq	A	G	10: 107,635,365	Y1392H	probably benign	Het
Rasgrp3	G	T	17: 75,525,102	K639N	possibly damaging	Het
Rgs19	C	T	2: 181,689,150	R203H	probably benign	Het
Scnn1g	C	A	7: 121,742,446		probably benign	Het
Tmem181b-ps	T	C	17: 6,466,921		noncoding transcript	Het
Vmn2r118	A	G	17: 55,610,870	V214A	possibly damaging	Het
Zfp811	T	C	17: 32,797,815	Y417C	probably damaging	Het

Other mutations in 3425401B19Rik

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00839:3425401B19Rik	APN	14	32660916	missense	probably benign	0.18
IGL00844:3425401B19Rik	APN	14	32662999	nonsense	probably null
IGL01292:3425401B19Rik	APN	14	32660874	missense	probably benign	0.18
IGL01295:3425401B19Rik	APN	14	32661936	missense	possibly damaging	0.53
IGL01457:3425401B19Rik	APN	14	32660951	missense	probably benign
IGL01470:3425401B19Rik	APN	14	32660457	missense	possibly damaging	0.53
IGL01612:3425401B19Rik	APN	14	32660031	missense	possibly damaging	0.53
IGL01974:3425401B19Rik	APN	14	32659805	missense	possibly damaging	0.85
IGL02095:3425401B19Rik	APN	14	32661626	missense	probably benign	0.33
IGL02138:3425401B19Rik	APN	14	32662715	missense	possibly damaging	0.83
IGL02178:3425401B19Rik	APN	14	32662461	missense	possibly damaging	0.83
IGL02245:3425401B19Rik	APN	14	32659815	missense	probably benign	0.03
IGL03401:3425401B19Rik	APN	14	32662266	nonsense	probably null
PIT4515001:3425401B19Rik	UTSW	14	32661111	nonsense	probably null
R0233:3425401B19Rik	UTSW	14	32663373	missense	probably benign
R0233:3425401B19Rik	UTSW	14	32663373	missense	probably benign
R0320:3425401B19Rik	UTSW	14	32662614	missense	probably benign	0.19
R0519:3425401B19Rik	UTSW	14	32662962	missense	possibly damaging	0.92
R0551:3425401B19Rik	UTSW	14	32662641	missense	probably benign	0.03
R0759:3425401B19Rik	UTSW	14	32662497	missense	possibly damaging	0.93
R0831:3425401B19Rik	UTSW	14	32662271	missense	probably benign	0.01
R1124:3425401B19Rik	UTSW	14	32662082	missense	possibly damaging	0.53
R1346:3425401B19Rik	UTSW	14	32660814	missense	probably benign	0.07
R1997:3425401B19Rik	UTSW	14	32660048	missense	possibly damaging	0.71
R2055:3425401B19Rik	UTSW	14	32662551	missense	probably benign
R2212:3425401B19Rik	UTSW	14	32661602	missense	probably benign	0.33
R2416:3425401B19Rik	UTSW	14	32663834	missense	probably benign	0.04
R2441:3425401B19Rik	UTSW	14	32663492	missense	possibly damaging	0.53
R2513:3425401B19Rik	UTSW	14	32661852	missense	possibly damaging	0.53
R3414:3425401B19Rik	UTSW	14	32661602	missense	probably benign	0.33
R3800:3425401B19Rik	UTSW	14	32663068	missense	possibly damaging	0.83
R3809:3425401B19Rik	UTSW	14	32663693	missense	possibly damaging	0.96
R4166:3425401B19Rik	UTSW	14	32660955	missense	possibly damaging	0.53
R4581:3425401B19Rik	UTSW	14	32661871	missense	possibly damaging	0.73
R4721:3425401B19Rik	UTSW	14	32663150	missense	probably benign	0.01
R4769:3425401B19Rik	UTSW	14	32660217	missense	probably benign	0.32
R4809:3425401B19Rik	UTSW	14	32662631	missense	probably benign	0.19
R4919:3425401B19Rik	UTSW	14	32663288	missense	possibly damaging	0.85
R4925:3425401B19Rik	UTSW	14	32663180	missense	possibly damaging	0.86
R4972:3425401B19Rik	UTSW	14	32661404	missense	possibly damaging	0.73
R5068:3425401B19Rik	UTSW	14	32661792	missense	possibly damaging	0.73
R5069:3425401B19Rik	UTSW	14	32661792	missense	possibly damaging	0.73
R5070:3425401B19Rik	UTSW	14	32661792	missense	possibly damaging	0.73
R5258:3425401B19Rik	UTSW	14	32663309	missense	probably damaging	0.98
R5435:3425401B19Rik	UTSW	14	32661456	missense	probably benign	0.18
R5549:3425401B19Rik	UTSW	14	32663036	missense	possibly damaging	0.68
R5678:3425401B19Rik	UTSW	14	32662053	missense	probably damaging	0.97
R5680:3425401B19Rik	UTSW	14	32662053	missense	probably damaging	0.97
R5872:3425401B19Rik	UTSW	14	32660352	missense	possibly damaging	0.73
R5896:3425401B19Rik	UTSW	14	32661675	nonsense	probably null
R5940:3425401B19Rik	UTSW	14	32662688	missense	possibly damaging	0.91
R6044:3425401B19Rik	UTSW	14	32660657	missense	possibly damaging	0.53
R6136:3425401B19Rik	UTSW	14	32662282	missense	possibly damaging	0.70
R6277:3425401B19Rik	UTSW	14	32663694	missense	possibly damaging	0.86
R6385:3425401B19Rik	UTSW	14	32661279	missense	probably benign	0.01
R6728:3425401B19Rik	UTSW	14	32662688	missense	possibly damaging	0.91
R6984:3425401B19Rik	UTSW	14	32661980	missense	probably benign	0.00
R7047:3425401B19Rik	UTSW	14	32660174	missense	possibly damaging	0.89
R7249:3425401B19Rik	UTSW	14	32663314	missense	possibly damaging	0.73
R7493:3425401B19Rik	UTSW	14	32663300	missense	possibly damaging	0.96
R7575:3425401B19Rik	UTSW	14	32662632	missense	probably benign	0.03
R7742:3425401B19Rik	UTSW	14	32662757	missense	possibly damaging	0.68
R7747:3425401B19Rik	UTSW	14	32663069	missense	possibly damaging	0.83
R7784:3425401B19Rik	UTSW	14	32659840	missense	probably benign	0.00
R8098:3425401B19Rik	UTSW	14	32662661	missense	probably damaging	0.99
R8111:3425401B19Rik	UTSW	14	32660309	nonsense	probably null
R8171:3425401B19Rik	UTSW	14	32662025	missense	probably benign
R8276:3425401B19Rik	UTSW	14	32663928	missense	probably damaging	0.97
R8330:3425401B19Rik	UTSW	14	32659793	missense	probably damaging	0.98
R8422:3425401B19Rik	UTSW	14	32662297	missense	possibly damaging	0.84
R8464:3425401B19Rik	UTSW	14	32659977	missense	possibly damaging	0.53
R8880:3425401B19Rik	UTSW	14	32660880	missense	probably benign	0.33
R8898:3425401B19Rik	UTSW	14	32661044	nonsense	probably null
R8911:3425401B19Rik	UTSW	14	32661669	missense	possibly damaging	0.53
R8934:3425401B19Rik	UTSW	14	32660657	missense	possibly damaging	0.53
R9094:3425401B19Rik	UTSW	14	32660657	missense	possibly damaging	0.53
R9399:3425401B19Rik	UTSW	14	32662658	missense	probably damaging	0.98
R9435:3425401B19Rik	UTSW	14	32660605	missense	probably benign	0.08
R9485:3425401B19Rik	UTSW	14	32661443	missense	possibly damaging	0.85
R9766:3425401B19Rik	UTSW	14	32663831	missense	probably benign	0.00
X0025:3425401B19Rik	UTSW	14	32662469	missense	probably damaging	0.98
Z1177:3425401B19Rik	UTSW	14	32659808	missense	possibly damaging	0.86
Z1177:3425401B19Rik	UTSW	14	32661398	missense	probably damaging	0.99

Posted On

2015-04-16