Incidental Mutation 'IGL02529:Zfp811'
ID 297241
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp811
Ensembl Gene ENSMUSG00000055202
Gene Name zinc finger protein 811
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL02529
Quality Score
Status
Chromosome 17
Chromosomal Location 33014650-33028905 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 33016789 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 417 (Y417C)
Ref Sequence ENSEMBL: ENSMUSP00000144038 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080905] [ENSMUST00000200914]
AlphaFold A0A0J9YU71
Predicted Effect probably damaging
Transcript: ENSMUST00000080905
AA Change: Y416C

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000079709
Gene: ENSMUSG00000055202
AA Change: Y416C

DomainStartEndE-ValueType
KRAB 3 62 6.26e-16 SMART
ZnF_C2H2 192 215 1.25e-1 SMART
ZnF_C2H2 220 242 1.79e-2 SMART
ZnF_C2H2 248 270 9.08e-4 SMART
ZnF_C2H2 276 298 7.78e-3 SMART
ZnF_C2H2 304 326 3.69e-4 SMART
ZnF_C2H2 332 354 8.47e-4 SMART
ZnF_C2H2 360 382 1.45e-2 SMART
ZnF_C2H2 388 410 6.42e-4 SMART
ZnF_C2H2 416 438 5.9e-3 SMART
ZnF_C2H2 444 466 1.08e-1 SMART
ZnF_C2H2 472 494 2.75e-3 SMART
ZnF_C2H2 500 522 9.44e-2 SMART
ZnF_C2H2 528 551 3.89e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000104150
Predicted Effect probably damaging
Transcript: ENSMUST00000200914
AA Change: Y417C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000144038
Gene: ENSMUSG00000055202
AA Change: Y417C

DomainStartEndE-ValueType
KRAB 4 63 2.6e-18 SMART
ZnF_C2H2 193 216 5.4e-4 SMART
ZnF_C2H2 221 243 7.8e-5 SMART
ZnF_C2H2 249 271 3.8e-6 SMART
ZnF_C2H2 277 299 3.3e-5 SMART
ZnF_C2H2 305 327 1.6e-6 SMART
ZnF_C2H2 333 355 3.8e-6 SMART
ZnF_C2H2 361 383 6.1e-5 SMART
ZnF_C2H2 389 411 2.7e-6 SMART
ZnF_C2H2 417 439 2.5e-5 SMART
ZnF_C2H2 445 467 4.6e-4 SMART
ZnF_C2H2 473 495 1.2e-5 SMART
ZnF_C2H2 501 523 4e-4 SMART
ZnF_C2H2 529 552 1.7e-5 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,383,190 (GRCm39) H925L probably benign Het
Agpat5 T A 8: 18,931,770 (GRCm39) Y297N possibly damaging Het
Apobec3 C T 15: 79,781,888 (GRCm39) probably benign Het
Atpaf1 C A 4: 115,648,466 (GRCm39) A161E probably damaging Het
Bnc1 A T 7: 81,627,116 (GRCm39) D91E probably damaging Het
Capg G A 6: 72,532,829 (GRCm39) V98I probably benign Het
Ccdc7b C T 8: 129,904,706 (GRCm39) L115F possibly damaging Het
Ces2a T A 8: 105,463,851 (GRCm39) probably benign Het
Cldn6 T G 17: 23,900,291 (GRCm39) V85G probably damaging Het
Clec2e T C 6: 129,075,459 (GRCm39) probably benign Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Dhx38 T C 8: 110,285,645 (GRCm39) E396G probably benign Het
Dock8 A T 19: 25,078,290 (GRCm39) K532* probably null Het
Efr3b C T 12: 4,033,391 (GRCm39) V139I probably benign Het
Gmip G A 8: 70,269,439 (GRCm39) G537E probably damaging Het
Hacd1 T C 2: 14,050,013 (GRCm39) H64R probably damaging Het
Hdac3 G T 18: 38,077,185 (GRCm39) Q230K probably benign Het
Htt C T 5: 34,976,387 (GRCm39) probably benign Het
Il18r1 A G 1: 40,526,219 (GRCm39) D255G possibly damaging Het
Krt82 T A 15: 101,458,831 (GRCm39) R70* probably null Het
Krt9 G T 11: 100,080,792 (GRCm39) H353Q probably damaging Het
Kyat3 T C 3: 142,426,235 (GRCm39) I57T probably benign Het
L1td1 A G 4: 98,625,658 (GRCm39) K618E probably benign Het
Limch1 C A 5: 67,159,956 (GRCm39) N617K possibly damaging Het
Lsm8 T C 6: 18,851,651 (GRCm39) F34S probably damaging Het
Man2a2 G A 7: 80,009,388 (GRCm39) A822V probably damaging Het
Mmrn2 C A 14: 34,120,570 (GRCm39) A480E possibly damaging Het
Mthfd1 A G 12: 76,350,483 (GRCm39) I474V probably benign Het
Mycl A G 4: 122,890,770 (GRCm39) K152R probably damaging Het
Numa1 A G 7: 101,649,160 (GRCm39) probably null Het
Or5p54 G T 7: 107,554,423 (GRCm39) V192F possibly damaging Het
Otog A C 7: 45,909,381 (GRCm39) D617A probably damaging Het
Ppef2 A G 5: 92,392,596 (GRCm39) I267T probably damaging Het
Ptprq A G 10: 107,471,226 (GRCm39) Y1392H probably benign Het
Rasgrp3 G T 17: 75,832,097 (GRCm39) K639N possibly damaging Het
Rgs19 C T 2: 181,330,943 (GRCm39) R203H probably benign Het
Scnn1g C A 7: 121,341,669 (GRCm39) probably benign Het
Tmem181b-ps T C 17: 6,734,320 (GRCm39) noncoding transcript Het
Vmn2r118 A G 17: 55,917,870 (GRCm39) V214A possibly damaging Het
Other mutations in Zfp811
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01394:Zfp811 APN 17 33,016,794 (GRCm39) missense probably damaging 1.00
IGL02227:Zfp811 APN 17 33,017,616 (GRCm39) nonsense probably null
IGL03190:Zfp811 APN 17 33,017,855 (GRCm39) splice site probably benign
R0112:Zfp811 UTSW 17 33,016,738 (GRCm39) missense probably damaging 0.96
R1025:Zfp811 UTSW 17 33,017,618 (GRCm39) missense probably benign 0.00
R1522:Zfp811 UTSW 17 33,016,622 (GRCm39) missense probably damaging 1.00
R1829:Zfp811 UTSW 17 33,017,116 (GRCm39) missense possibly damaging 0.72
R1861:Zfp811 UTSW 17 33,016,399 (GRCm39) missense probably damaging 1.00
R2181:Zfp811 UTSW 17 33,016,695 (GRCm39) missense probably damaging 0.96
R4360:Zfp811 UTSW 17 33,017,432 (GRCm39) missense probably benign 0.01
R4425:Zfp811 UTSW 17 33,016,521 (GRCm39) nonsense probably null
R4657:Zfp811 UTSW 17 33,019,897 (GRCm39) nonsense probably null
R6066:Zfp811 UTSW 17 33,017,801 (GRCm39) missense possibly damaging 0.73
R6109:Zfp811 UTSW 17 33,016,348 (GRCm39) splice site probably null
R6702:Zfp811 UTSW 17 33,016,816 (GRCm39) missense probably damaging 1.00
R6714:Zfp811 UTSW 17 33,016,736 (GRCm39) missense probably damaging 1.00
R6826:Zfp811 UTSW 17 33,016,762 (GRCm39) missense probably damaging 1.00
R6983:Zfp811 UTSW 17 33,016,406 (GRCm39) nonsense probably null
R7276:Zfp811 UTSW 17 33,017,755 (GRCm39) missense probably benign 0.00
R7343:Zfp811 UTSW 17 33,016,487 (GRCm39) missense probably damaging 0.98
R7432:Zfp811 UTSW 17 33,017,733 (GRCm39) missense possibly damaging 0.73
R7523:Zfp811 UTSW 17 33,016,726 (GRCm39) missense probably benign 0.10
R7894:Zfp811 UTSW 17 33,017,821 (GRCm39) missense possibly damaging 0.85
R8737:Zfp811 UTSW 17 33,017,197 (GRCm39) missense possibly damaging 0.92
R8962:Zfp811 UTSW 17 33,017,622 (GRCm39) missense probably benign
R8987:Zfp811 UTSW 17 33,017,801 (GRCm39) missense possibly damaging 0.53
R9612:Zfp811 UTSW 17 33,017,740 (GRCm39) missense probably benign 0.33
Posted On 2015-04-16