Incidental Mutation 'IGL02531:Medag'
ID297320
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Medag
Ensembl Gene ENSMUSG00000029659
Gene Namemesenteric estrogen dependent adipogenesis
SynonymsMEDA-4, 6330406I15Rik
Accession Numbers

Genbank: NM_027519; MGI: 1917967

Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02531
Quality Score
Status
Chromosome5
Chromosomal Location149411749-149431723 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 149422151 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 99 (N99S)
Ref Sequence ENSEMBL: ENSMUSP00000090798 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093110] [ENSMUST00000201083]
Predicted Effect probably benign
Transcript: ENSMUST00000093110
AA Change: N99S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000090798
Gene: ENSMUSG00000029659
AA Change: N99S

DomainStartEndE-ValueType
low complexity region 32 43 N/A INTRINSIC
low complexity region 58 69 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200931
Predicted Effect probably benign
Transcript: ENSMUST00000201083
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201093
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201588
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201641
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(5) : Targeted, other(4) Gene trapped(1)

Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aak1 C A 6: 86,956,447 H467N unknown Het
Alb A G 5: 90,467,448 D273G probably damaging Het
Arap3 A G 18: 37,989,751 S531P probably damaging Het
Bmpr2 T A 1: 59,845,714 probably null Het
Chd7 G A 4: 8,854,134 R1902H probably damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cyp2b13 A T 7: 26,061,605 H29L possibly damaging Het
Enpp5 G T 17: 44,080,952 V91F probably damaging Het
Fam210b T C 2: 172,352,755 Y176H probably damaging Het
Fam83b T C 9: 76,492,000 E607G possibly damaging Het
Gm4788 T C 1: 139,774,569 K59R probably benign Het
Hhla1 C T 15: 65,967,407 probably benign Het
Kdm3b A G 18: 34,795,729 T178A probably benign Het
Klf1 T A 8: 84,904,808 F334I probably damaging Het
Klra8 A G 6: 130,118,970 S220P possibly damaging Het
Muc6 T C 7: 141,636,940 T2607A possibly damaging Het
Mug2 T G 6: 122,072,771 L921R probably damaging Het
Nacad T C 11: 6,598,580 N1385D possibly damaging Het
Nin A G 12: 70,020,932 F1983L probably benign Het
Nipal4 T C 11: 46,151,325 I176M probably damaging Het
Orc6 T C 8: 85,303,369 S47P probably damaging Het
Ovch2 C T 7: 107,790,198 C341Y probably damaging Het
Polq T A 16: 37,062,374 H1633Q possibly damaging Het
Rab23 T C 1: 33,738,280 probably benign Het
Rai14 A G 15: 10,574,782 S697P probably damaging Het
Rnf213 T C 11: 119,436,802 F1872L probably benign Het
Sdhc T C 1: 171,136,018 H127R probably damaging Het
Snx9 T C 17: 5,891,820 V74A probably benign Het
Spata31d1d A G 13: 59,727,934 S596P possibly damaging Het
Syt14 T C 1: 192,901,934 *78W probably null Het
Thoc1 A G 18: 9,970,258 T203A probably benign Het
Trmt13 A G 3: 116,592,191 probably null Het
Ttc28 A G 5: 111,225,850 I1020V probably damaging Het
Vmn2r16 A G 5: 109,340,268 T336A probably damaging Het
Other mutations in Medag
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01113:Medag APN 5 149429907 missense probably benign 0.23
IGL02817:Medag APN 5 149427038 nonsense probably null
3-1:Medag UTSW 5 149427285 missense probably benign 0.03
PIT4494001:Medag UTSW 5 149427300 missense probably damaging 1.00
R1074:Medag UTSW 5 149412209 missense probably benign 0.10
R1654:Medag UTSW 5 149422135 missense probably damaging 1.00
R1858:Medag UTSW 5 149429794 missense probably damaging 0.99
R1999:Medag UTSW 5 149427252 missense probably damaging 1.00
R3840:Medag UTSW 5 149427423 missense probably damaging 1.00
R3841:Medag UTSW 5 149427423 missense probably damaging 1.00
R4272:Medag UTSW 5 149422163 missense probably damaging 1.00
R4642:Medag UTSW 5 149411979 start codon destroyed probably null 0.85
R5218:Medag UTSW 5 149422254 splice site probably benign
R5593:Medag UTSW 5 149426950 missense probably benign 0.00
R5700:Medag UTSW 5 149422217 missense probably benign 0.00
R6043:Medag UTSW 5 149422207 missense probably benign 0.14
R7009:Medag UTSW 5 149427243 missense probably benign 0.14
R8953:Medag UTSW 5 149427300 missense probably damaging 1.00
RF012:Medag UTSW 5 149411994 missense probably benign 0.23
Z1176:Medag UTSW 5 149427507 critical splice donor site probably null
Posted On2015-04-16