Incidental Mutation 'IGL02534:Rasd1'
ID 297443
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rasd1
Ensembl Gene ENSMUSG00000049892
Gene Name RAS, dexamethasone-induced 1
Synonyms Dexras1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02534
Quality Score
Status
Chromosome 11
Chromosomal Location 59854007-59855770 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59855615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 6 (M6T)
Ref Sequence ENSEMBL: ENSMUSP00000051959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062405] [ENSMUST00000081980]
AlphaFold O35626
Predicted Effect possibly damaging
Transcript: ENSMUST00000062405
AA Change: M6T

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000051959
Gene: ENSMUSG00000049892
AA Change: M6T

DomainStartEndE-ValueType
RAS 22 198 4.81e-81 SMART
low complexity region 217 243 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000081980
SMART Domains Protein: ENSMUSP00000080641
Gene: ENSMUSG00000061650

DomainStartEndE-ValueType
low complexity region 16 52 N/A INTRINSIC
Pfam:Med9 59 135 3.2e-27 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for disruptions in this gene have a reduced ability to entrain to low intensity light with resulting abnormalities in circadian rhythm. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aggf1 C T 13: 95,506,030 (GRCm39) E186K possibly damaging Het
Ajm1 G T 2: 25,467,043 (GRCm39) S956* probably null Het
Anks1b A G 10: 90,730,979 (GRCm39) I932V probably benign Het
Atg2b A G 12: 105,609,526 (GRCm39) Y1361H probably damaging Het
Bcl9 G T 3: 97,122,545 (GRCm39) L85M probably damaging Het
Bcl9l T G 9: 44,417,036 (GRCm39) S291R probably benign Het
Cpa2 T A 6: 30,550,767 (GRCm39) D201E probably benign Het
Efna5 A T 17: 62,920,384 (GRCm39) C164* probably null Het
Fhip2b A T 14: 70,823,128 (GRCm39) H642Q probably damaging Het
Fhip2b T A 14: 70,823,630 (GRCm39) H580L probably benign Het
Gm6316 A G 12: 69,967,763 (GRCm39) probably benign Het
Gucy2g A G 19: 55,229,500 (GRCm39) S57P probably damaging Het
Inf2 C A 12: 112,576,930 (GRCm39) A968E unknown Het
Man2a2 G A 7: 80,009,388 (GRCm39) A822V probably damaging Het
Mcm5 T A 8: 75,840,861 (GRCm39) V222E probably damaging Het
Muc5b A G 7: 141,398,456 (GRCm39) Y287C unknown Het
Or12e9 T G 2: 87,202,598 (GRCm39) S241A probably benign Het
Or13a24 A T 7: 140,154,554 (GRCm39) M163L probably benign Het
Or14c39 G A 7: 86,343,939 (GRCm39) V92M probably benign Het
Or8u10 A G 2: 85,915,713 (GRCm39) M136T probably damaging Het
Pabpc1l A G 2: 163,869,410 (GRCm39) D70G probably damaging Het
Pkhd1 T A 1: 20,187,944 (GRCm39) I3455F probably damaging Het
Ppp1r17 C A 6: 56,003,445 (GRCm39) S86* probably null Het
Rsph14 C A 10: 74,793,466 (GRCm39) V345F probably damaging Het
Slc11a2 T A 15: 100,299,207 (GRCm39) Q121L probably benign Het
Smc5 A T 19: 23,205,536 (GRCm39) probably null Het
Tanc2 T C 11: 105,725,994 (GRCm39) L386P probably damaging Het
Tmem9b A T 7: 109,336,164 (GRCm39) L160Q probably damaging Het
Trim32 A G 4: 65,532,906 (GRCm39) T488A possibly damaging Het
Tubb1 A G 2: 174,297,462 (GRCm39) I24V probably benign Het
Upf1 A T 8: 70,788,302 (GRCm39) probably null Het
Zfp263 T A 16: 3,564,279 (GRCm39) probably benign Het
Other mutations in Rasd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01095:Rasd1 APN 11 59,855,117 (GRCm39) missense probably damaging 1.00
IGL02206:Rasd1 APN 11 59,854,778 (GRCm39) missense possibly damaging 0.69
IGL03306:Rasd1 APN 11 59,855,181 (GRCm39) missense possibly damaging 0.64
R0833:Rasd1 UTSW 11 59,855,379 (GRCm39) missense probably damaging 1.00
R0836:Rasd1 UTSW 11 59,855,379 (GRCm39) missense probably damaging 1.00
R1160:Rasd1 UTSW 11 59,855,547 (GRCm39) missense possibly damaging 0.78
R1647:Rasd1 UTSW 11 59,854,920 (GRCm39) missense probably benign 0.26
R5114:Rasd1 UTSW 11 59,854,933 (GRCm39) missense possibly damaging 0.69
R8234:Rasd1 UTSW 11 59,855,118 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16