Incidental Mutation 'IGL02535:Vmn1r54'
ID297447
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r54
Ensembl Gene ENSMUSG00000047203
Gene Namevomeronasal 1 receptor 54
SynonymsV1ra9, VN7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL02535
Quality Score
Status
Chromosome6
Chromosomal Location90246300-90271213 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 90269278 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 58 (I58N)
Ref Sequence ENSEMBL: ENSMUSP00000154354 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058039] [ENSMUST00000226921]
Predicted Effect possibly damaging
Transcript: ENSMUST00000058039
AA Change: I58N

PolyPhen 2 Score 0.778 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000063052
Gene: ENSMUSG00000047203
AA Change: I58N

DomainStartEndE-ValueType
Pfam:TAS2R 11 307 1.2e-11 PFAM
Pfam:V1R 38 301 5.5e-94 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226921
AA Change: I58N

PolyPhen 2 Score 0.778 (Sensitivity: 0.85; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik T G 15: 8,174,838 V65G probably damaging Het
Abcc9 G T 6: 142,628,426 D993E probably benign Het
Acap1 T C 11: 69,882,694 N430D probably benign Het
Actl11 T A 9: 107,929,937 D486E possibly damaging Het
Adh6a A G 3: 138,327,390 N281D probably benign Het
Apon A T 10: 128,254,954 E167V probably damaging Het
Bahcc1 T A 11: 120,287,536 M2307K possibly damaging Het
Cdca3 A G 6: 124,830,558 T10A probably damaging Het
D330045A20Rik A T X: 139,492,647 K217I probably damaging Het
Dusp16 T C 6: 134,718,827 E347G probably benign Het
Dysf A T 6: 84,149,697 Y1298F possibly damaging Het
F12 T C 13: 55,426,344 D25G possibly damaging Het
F5 T A 1: 164,198,733 S1625T probably damaging Het
Fbxl2 T C 9: 113,979,507 E372G probably benign Het
Flrt1 T C 19: 7,096,733 I150V probably benign Het
Grin2b T A 6: 135,779,369 I453F possibly damaging Het
Hivep2 C T 10: 14,139,497 R1803C probably damaging Het
Il33 A G 19: 29,952,747 N81D probably benign Het
Ipo7 T C 7: 110,054,026 Y977H probably damaging Het
Lyst T C 13: 13,650,342 V1514A probably benign Het
Map1a C A 2: 121,302,177 S920* probably null Het
Nlrp9c T C 7: 26,372,097 N862S probably damaging Het
Olfr1054 A G 2: 86,332,675 M227T probably damaging Het
Olfr1413 C A 1: 92,573,221 Q17K probably benign Het
Olfr389 A G 11: 73,776,616 V237A probably benign Het
P2rx2 T A 5: 110,342,353 T134S probably benign Het
Papolg T C 11: 23,890,245 D77G probably benign Het
Pkd1l3 A T 8: 109,640,890 R1240* probably null Het
Slc22a8 A T 19: 8,610,203 T514S probably benign Het
Slc39a5 T C 10: 128,399,330 D136G probably benign Het
Tnn T C 1: 160,122,652 probably null Het
Trav8d-2 A T 14: 53,042,684 S44C probably damaging Het
Tubb1 A G 2: 174,457,566 N347S probably benign Het
Ubap1 C T 4: 41,379,667 R294* probably null Het
Ube2o C T 11: 116,541,765 V792M probably benign Het
Usp13 A G 3: 32,837,926 S85G probably benign Het
Vmac C T 17: 56,715,550 M61I probably benign Het
Zmym5 A G 14: 56,797,666 probably null Het
Other mutations in Vmn1r54
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01912:Vmn1r54 APN 6 90269460 missense probably damaging 1.00
IGL02421:Vmn1r54 APN 6 90269151 missense probably benign 0.01
IGL03083:Vmn1r54 APN 6 90269872 missense possibly damaging 0.82
R0646:Vmn1r54 UTSW 6 90269653 missense probably benign 0.00
R2047:Vmn1r54 UTSW 6 90269988 missense probably damaging 1.00
R4409:Vmn1r54 UTSW 6 90269882 nonsense probably null
R4467:Vmn1r54 UTSW 6 90269271 missense probably damaging 1.00
R4812:Vmn1r54 UTSW 6 90269325 missense probably benign 0.22
R5042:Vmn1r54 UTSW 6 90269440 missense possibly damaging 0.53
R5555:Vmn1r54 UTSW 6 90269365 missense probably benign 0.02
R6183:Vmn1r54 UTSW 6 90269290 missense possibly damaging 0.61
R6393:Vmn1r54 UTSW 6 90269322 missense probably benign 0.45
R7216:Vmn1r54 UTSW 6 90269665 missense probably damaging 1.00
R7480:Vmn1r54 UTSW 6 90269178 missense possibly damaging 0.58
Posted On2015-04-16