Incidental Mutation 'IGL02535:Flrt1'
| ID |
297459 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Flrt1
|
| Ensembl Gene |
ENSMUSG00000047787 |
| Gene Name |
fibronectin leucine rich transmembrane protein 1 |
| Synonyms |
D630040I23Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.185)
|
| Stock # |
IGL02535
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
7069366-7083094 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 7074098 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 150
(I150V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109010
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040261]
[ENSMUST00000113383]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040261
|
| SMART Domains |
Protein: ENSMUSP00000039507
Gene: ENSMUSG00000036278
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
25 |
41 |
N/A |
INTRINSIC |
|
low complexity region
|
59 |
74 |
N/A |
INTRINSIC |
|
A1pp
|
151 |
281 |
7.67e-46 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113383
AA Change: I150V
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000109010
Gene: ENSMUSG00000047787
AA Change: I150V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
28 |
N/A |
INTRINSIC |
|
LRRNT
|
53 |
85 |
4.11e-6 |
SMART |
|
LRR
|
127 |
149 |
2.61e1 |
SMART |
|
LRR
|
150 |
175 |
4.71e1 |
SMART |
|
LRR
|
177 |
199 |
1.76e1 |
SMART |
|
LRR
|
200 |
220 |
7.36e0 |
SMART |
|
LRR
|
221 |
246 |
1.49e1 |
SMART |
|
LRR
|
247 |
270 |
9.77e1 |
SMART |
|
LRR
|
271 |
292 |
1.53e1 |
SMART |
|
LRR_TYP
|
293 |
316 |
3.55e-6 |
SMART |
|
LRRCT
|
328 |
379 |
5.19e-9 |
SMART |
|
low complexity region
|
381 |
392 |
N/A |
INTRINSIC |
|
FN3
|
434 |
515 |
1.49e0 |
SMART |
|
transmembrane domain
|
556 |
578 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
PHENOTYPE: No notable phenotype was detected in a high-throughput screen of homozygous mice. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc9 |
G |
T |
6: 142,574,152 (GRCm39) |
D993E |
probably benign |
Het |
| Acap1 |
T |
C |
11: 69,773,520 (GRCm39) |
N430D |
probably benign |
Het |
| Actl11 |
T |
A |
9: 107,807,136 (GRCm39) |
D486E |
possibly damaging |
Het |
| Adh6a |
A |
G |
3: 138,033,151 (GRCm39) |
N281D |
probably benign |
Het |
| Apon |
A |
T |
10: 128,090,823 (GRCm39) |
E167V |
probably damaging |
Het |
| Bahcc1 |
T |
A |
11: 120,178,362 (GRCm39) |
M2307K |
possibly damaging |
Het |
| Cdca3 |
A |
G |
6: 124,807,521 (GRCm39) |
T10A |
probably damaging |
Het |
| Cplane1 |
T |
G |
15: 8,204,322 (GRCm39) |
V65G |
probably damaging |
Het |
| Dusp16 |
T |
C |
6: 134,695,790 (GRCm39) |
E347G |
probably benign |
Het |
| Dysf |
A |
T |
6: 84,126,679 (GRCm39) |
Y1298F |
possibly damaging |
Het |
| F12 |
T |
C |
13: 55,574,157 (GRCm39) |
D25G |
possibly damaging |
Het |
| F5 |
T |
A |
1: 164,026,302 (GRCm39) |
S1625T |
probably damaging |
Het |
| Fbxl2 |
T |
C |
9: 113,808,575 (GRCm39) |
E372G |
probably benign |
Het |
| Grin2b |
T |
A |
6: 135,756,367 (GRCm39) |
I453F |
possibly damaging |
Het |
| Hivep2 |
C |
T |
10: 14,015,241 (GRCm39) |
R1803C |
probably damaging |
Het |
| Il33 |
A |
G |
19: 29,930,147 (GRCm39) |
N81D |
probably benign |
Het |
| Ipo7 |
T |
C |
7: 109,653,233 (GRCm39) |
Y977H |
probably damaging |
Het |
| Lyst |
T |
C |
13: 13,824,927 (GRCm39) |
V1514A |
probably benign |
Het |
| Map1a |
C |
A |
2: 121,132,658 (GRCm39) |
S920* |
probably null |
Het |
| Nlrp9c |
T |
C |
7: 26,071,522 (GRCm39) |
N862S |
probably damaging |
Het |
| Or1e29 |
A |
G |
11: 73,667,442 (GRCm39) |
V237A |
probably benign |
Het |
| Or8k22 |
A |
G |
2: 86,163,019 (GRCm39) |
M227T |
probably damaging |
Het |
| Or9s23 |
C |
A |
1: 92,500,943 (GRCm39) |
Q17K |
probably benign |
Het |
| P2rx2 |
T |
A |
5: 110,490,219 (GRCm39) |
T134S |
probably benign |
Het |
| Papolg |
T |
C |
11: 23,840,245 (GRCm39) |
D77G |
probably benign |
Het |
| Pkd1l3 |
A |
T |
8: 110,367,522 (GRCm39) |
R1240* |
probably null |
Het |
| Radx |
A |
T |
X: 138,393,396 (GRCm39) |
K217I |
probably damaging |
Het |
| Slc22a8 |
A |
T |
19: 8,587,567 (GRCm39) |
T514S |
probably benign |
Het |
| Slc39a5 |
T |
C |
10: 128,235,199 (GRCm39) |
D136G |
probably benign |
Het |
| Tnn |
T |
C |
1: 159,950,222 (GRCm39) |
|
probably null |
Het |
| Trav8d-2 |
A |
T |
14: 53,280,141 (GRCm39) |
S44C |
probably damaging |
Het |
| Tubb1 |
A |
G |
2: 174,299,359 (GRCm39) |
N347S |
probably benign |
Het |
| Ubap1 |
C |
T |
4: 41,379,667 (GRCm39) |
R294* |
probably null |
Het |
| Ube2o |
C |
T |
11: 116,432,591 (GRCm39) |
V792M |
probably benign |
Het |
| Usp13 |
A |
G |
3: 32,892,075 (GRCm39) |
S85G |
probably benign |
Het |
| Vmac |
C |
T |
17: 57,022,550 (GRCm39) |
M61I |
probably benign |
Het |
| Vmn1r54 |
T |
A |
6: 90,246,260 (GRCm39) |
I58N |
possibly damaging |
Het |
| Zmym5 |
A |
G |
14: 57,035,123 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Flrt1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Flrt1
|
APN |
19 |
7,074,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01082:Flrt1
|
APN |
19 |
7,073,339 (GRCm39) |
missense |
probably benign |
|
|
R0240:Flrt1
|
UTSW |
19 |
7,074,475 (GRCm39) |
intron |
probably benign |
|
|
R0240:Flrt1
|
UTSW |
19 |
7,074,475 (GRCm39) |
intron |
probably benign |
|
|
R0403:Flrt1
|
UTSW |
19 |
7,073,284 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0645:Flrt1
|
UTSW |
19 |
7,074,508 (GRCm39) |
intron |
probably benign |
|
|
R0677:Flrt1
|
UTSW |
19 |
7,073,544 (GRCm39) |
nonsense |
probably null |
|
|
R1818:Flrt1
|
UTSW |
19 |
7,072,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2191:Flrt1
|
UTSW |
19 |
7,073,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2228:Flrt1
|
UTSW |
19 |
7,072,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2471:Flrt1
|
UTSW |
19 |
7,073,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4978:Flrt1
|
UTSW |
19 |
7,074,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5460:Flrt1
|
UTSW |
19 |
7,073,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5630:Flrt1
|
UTSW |
19 |
7,073,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Flrt1
|
UTSW |
19 |
7,073,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Flrt1
|
UTSW |
19 |
7,073,524 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6905:Flrt1
|
UTSW |
19 |
7,072,757 (GRCm39) |
nonsense |
probably null |
|
|
R7239:Flrt1
|
UTSW |
19 |
7,073,329 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7799:Flrt1
|
UTSW |
19 |
7,073,229 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8168:Flrt1
|
UTSW |
19 |
7,074,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0024:Flrt1
|
UTSW |
19 |
7,073,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Flrt1
|
UTSW |
19 |
7,074,244 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation