Incidental Mutation 'IGL02535:Cdca3'
ID297482
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdca3
Ensembl Gene ENSMUSG00000023505
Gene Namecell division cycle associated 3
SynonymsTOME-1, 2410005A12Rik, Grcc8
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.483) question?
Stock #IGL02535
Quality Score
Status
Chromosome6
Chromosomal Location124829547-124833701 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 124830558 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 10 (T10A)
Ref Sequence ENSEMBL: ENSMUSP00000116849 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024206] [ENSMUST00000024270] [ENSMUST00000047510] [ENSMUST00000122110] [ENSMUST00000131847] [ENSMUST00000142058] [ENSMUST00000150120] [ENSMUST00000151674] [ENSMUST00000153306]
Predicted Effect probably benign
Transcript: ENSMUST00000024206
SMART Domains Protein: ENSMUSP00000024206
Gene: ENSMUSG00000023439

DomainStartEndE-ValueType
WD40 44 83 4.91e-8 SMART
WD40 86 125 1.61e-3 SMART
WD40 132 170 5.1e-6 SMART
WD40 173 212 3.99e-8 SMART
WD40 215 254 2.67e-9 SMART
WD40 263 298 2e-1 SMART
WD40 301 340 3.87e-6 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000024270
AA Change: T10A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000047510
SMART Domains Protein: ENSMUSP00000041299
Gene: ENSMUSG00000038429

DomainStartEndE-ValueType
low complexity region 2 11 N/A INTRINSIC
Blast:ZnF_UBP 29 78 4e-19 BLAST
ZnF_UBP 198 253 6.47e-27 SMART
low complexity region 497 516 N/A INTRINSIC
UBA 656 694 3.12e-7 SMART
UBA 724 761 8.63e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000122110
SMART Domains Protein: ENSMUSP00000114000
Gene: ENSMUSG00000038429

DomainStartEndE-ValueType
low complexity region 2 11 N/A INTRINSIC
Blast:ZnF_UBP 29 78 4e-19 BLAST
ZnF_UBP 198 253 6.47e-27 SMART
low complexity region 497 516 N/A INTRINSIC
UBA 633 671 3.12e-7 SMART
UBA 701 738 8.63e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129251
Predicted Effect probably damaging
Transcript: ENSMUST00000131847
AA Change: T10A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134637
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136692
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140233
Predicted Effect probably benign
Transcript: ENSMUST00000142058
SMART Domains Protein: ENSMUSP00000117439
Gene: ENSMUSG00000038429

DomainStartEndE-ValueType
low complexity region 2 11 N/A INTRINSIC
Blast:ZnF_UBP 29 78 4e-20 BLAST
ZnF_UBP 180 235 6.47e-27 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000150120
AA Change: T10A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect possibly damaging
Transcript: ENSMUST00000151674
AA Change: T10A

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect probably benign
Transcript: ENSMUST00000153306
SMART Domains Protein: ENSMUSP00000118200
Gene: ENSMUSG00000038429

DomainStartEndE-ValueType
Blast:ZnF_UBP 1 32 3e-7 BLAST
ZnF_UBP 152 207 6.47e-27 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik T G 15: 8,174,838 V65G probably damaging Het
Abcc9 G T 6: 142,628,426 D993E probably benign Het
Acap1 T C 11: 69,882,694 N430D probably benign Het
Actl11 T A 9: 107,929,937 D486E possibly damaging Het
Adh6a A G 3: 138,327,390 N281D probably benign Het
Apon A T 10: 128,254,954 E167V probably damaging Het
Bahcc1 T A 11: 120,287,536 M2307K possibly damaging Het
D330045A20Rik A T X: 139,492,647 K217I probably damaging Het
Dusp16 T C 6: 134,718,827 E347G probably benign Het
Dysf A T 6: 84,149,697 Y1298F possibly damaging Het
F12 T C 13: 55,426,344 D25G possibly damaging Het
F5 T A 1: 164,198,733 S1625T probably damaging Het
Fbxl2 T C 9: 113,979,507 E372G probably benign Het
Flrt1 T C 19: 7,096,733 I150V probably benign Het
Grin2b T A 6: 135,779,369 I453F possibly damaging Het
Hivep2 C T 10: 14,139,497 R1803C probably damaging Het
Il33 A G 19: 29,952,747 N81D probably benign Het
Ipo7 T C 7: 110,054,026 Y977H probably damaging Het
Lyst T C 13: 13,650,342 V1514A probably benign Het
Map1a C A 2: 121,302,177 S920* probably null Het
Nlrp9c T C 7: 26,372,097 N862S probably damaging Het
Olfr1054 A G 2: 86,332,675 M227T probably damaging Het
Olfr1413 C A 1: 92,573,221 Q17K probably benign Het
Olfr389 A G 11: 73,776,616 V237A probably benign Het
P2rx2 T A 5: 110,342,353 T134S probably benign Het
Papolg T C 11: 23,890,245 D77G probably benign Het
Pkd1l3 A T 8: 109,640,890 R1240* probably null Het
Slc22a8 A T 19: 8,610,203 T514S probably benign Het
Slc39a5 T C 10: 128,399,330 D136G probably benign Het
Tnn T C 1: 160,122,652 probably null Het
Trav8d-2 A T 14: 53,042,684 S44C probably damaging Het
Tubb1 A G 2: 174,457,566 N347S probably benign Het
Ubap1 C T 4: 41,379,667 R294* probably null Het
Ube2o C T 11: 116,541,765 V792M probably benign Het
Usp13 A G 3: 32,837,926 S85G probably benign Het
Vmac C T 17: 56,715,550 M61I probably benign Het
Vmn1r54 T A 6: 90,269,278 I58N possibly damaging Het
Zmym5 A G 14: 56,797,666 probably null Het
Other mutations in Cdca3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0206:Cdca3 UTSW 6 124832551 unclassified probably benign
R2193:Cdca3 UTSW 6 124831446 missense probably damaging 1.00
R2975:Cdca3 UTSW 6 124830653 splice site probably null
R4720:Cdca3 UTSW 6 124832164 missense probably damaging 0.97
R6275:Cdca3 UTSW 6 124832664 splice site probably null
R6384:Cdca3 UTSW 6 124832419 missense probably damaging 0.96
R7376:Cdca3 UTSW 6 124832575 missense probably benign
Posted On2015-04-16