Incidental Mutation 'IGL02535:Zmym5'
| ID |
297485 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zmym5
|
| Ensembl Gene |
ENSMUSG00000040123 |
| Gene Name |
zinc finger, MYM-type 5 |
| Synonyms |
9830124H08Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.185)
|
| Stock # |
IGL02535
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
14 |
| Chromosomal Location |
57028042-57049173 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 57035123 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134057
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039812]
[ENSMUST00000111285]
[ENSMUST00000173954]
[ENSMUST00000225699]
|
| AlphaFold |
Q3U2E2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000039812
|
| SMART Domains |
Protein: ENSMUSP00000043625
Gene: ENSMUSG00000040123
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
91 |
103 |
N/A |
INTRINSIC |
|
TRASH
|
213 |
249 |
2.69e-5 |
SMART |
|
TRASH
|
306 |
341 |
1e3 |
SMART |
|
TRASH
|
348 |
385 |
3.32e-5 |
SMART |
|
low complexity region
|
426 |
436 |
N/A |
INTRINSIC |
|
ZnF_TTF
|
528 |
604 |
4.14e-2 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000111285
|
| SMART Domains |
Protein: ENSMUSP00000106916
Gene: ENSMUSG00000040123
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
91 |
103 |
N/A |
INTRINSIC |
|
TRASH
|
213 |
249 |
2.69e-5 |
SMART |
|
TRASH
|
306 |
341 |
1e3 |
SMART |
|
TRASH
|
348 |
385 |
3.32e-5 |
SMART |
|
low complexity region
|
426 |
436 |
N/A |
INTRINSIC |
|
ZnF_TTF
|
528 |
604 |
4.14e-2 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000173954
|
| SMART Domains |
Protein: ENSMUSP00000134057
Gene: ENSMUSG00000040123
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
91 |
103 |
N/A |
INTRINSIC |
|
TRASH
|
213 |
249 |
2.69e-5 |
SMART |
|
TRASH
|
306 |
341 |
1e3 |
SMART |
|
TRASH
|
348 |
385 |
3.32e-5 |
SMART |
|
low complexity region
|
426 |
436 |
N/A |
INTRINSIC |
|
ZnF_TTF
|
528 |
604 |
4.14e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224498
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000225699
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc9 |
G |
T |
6: 142,574,152 (GRCm39) |
D993E |
probably benign |
Het |
| Acap1 |
T |
C |
11: 69,773,520 (GRCm39) |
N430D |
probably benign |
Het |
| Actl11 |
T |
A |
9: 107,807,136 (GRCm39) |
D486E |
possibly damaging |
Het |
| Adh6a |
A |
G |
3: 138,033,151 (GRCm39) |
N281D |
probably benign |
Het |
| Apon |
A |
T |
10: 128,090,823 (GRCm39) |
E167V |
probably damaging |
Het |
| Bahcc1 |
T |
A |
11: 120,178,362 (GRCm39) |
M2307K |
possibly damaging |
Het |
| Cdca3 |
A |
G |
6: 124,807,521 (GRCm39) |
T10A |
probably damaging |
Het |
| Cplane1 |
T |
G |
15: 8,204,322 (GRCm39) |
V65G |
probably damaging |
Het |
| Dusp16 |
T |
C |
6: 134,695,790 (GRCm39) |
E347G |
probably benign |
Het |
| Dysf |
A |
T |
6: 84,126,679 (GRCm39) |
Y1298F |
possibly damaging |
Het |
| F12 |
T |
C |
13: 55,574,157 (GRCm39) |
D25G |
possibly damaging |
Het |
| F5 |
T |
A |
1: 164,026,302 (GRCm39) |
S1625T |
probably damaging |
Het |
| Fbxl2 |
T |
C |
9: 113,808,575 (GRCm39) |
E372G |
probably benign |
Het |
| Flrt1 |
T |
C |
19: 7,074,098 (GRCm39) |
I150V |
probably benign |
Het |
| Grin2b |
T |
A |
6: 135,756,367 (GRCm39) |
I453F |
possibly damaging |
Het |
| Hivep2 |
C |
T |
10: 14,015,241 (GRCm39) |
R1803C |
probably damaging |
Het |
| Il33 |
A |
G |
19: 29,930,147 (GRCm39) |
N81D |
probably benign |
Het |
| Ipo7 |
T |
C |
7: 109,653,233 (GRCm39) |
Y977H |
probably damaging |
Het |
| Lyst |
T |
C |
13: 13,824,927 (GRCm39) |
V1514A |
probably benign |
Het |
| Map1a |
C |
A |
2: 121,132,658 (GRCm39) |
S920* |
probably null |
Het |
| Nlrp9c |
T |
C |
7: 26,071,522 (GRCm39) |
N862S |
probably damaging |
Het |
| Or1e29 |
A |
G |
11: 73,667,442 (GRCm39) |
V237A |
probably benign |
Het |
| Or8k22 |
A |
G |
2: 86,163,019 (GRCm39) |
M227T |
probably damaging |
Het |
| Or9s23 |
C |
A |
1: 92,500,943 (GRCm39) |
Q17K |
probably benign |
Het |
| P2rx2 |
T |
A |
5: 110,490,219 (GRCm39) |
T134S |
probably benign |
Het |
| Papolg |
T |
C |
11: 23,840,245 (GRCm39) |
D77G |
probably benign |
Het |
| Pkd1l3 |
A |
T |
8: 110,367,522 (GRCm39) |
R1240* |
probably null |
Het |
| Radx |
A |
T |
X: 138,393,396 (GRCm39) |
K217I |
probably damaging |
Het |
| Slc22a8 |
A |
T |
19: 8,587,567 (GRCm39) |
T514S |
probably benign |
Het |
| Slc39a5 |
T |
C |
10: 128,235,199 (GRCm39) |
D136G |
probably benign |
Het |
| Tnn |
T |
C |
1: 159,950,222 (GRCm39) |
|
probably null |
Het |
| Trav8d-2 |
A |
T |
14: 53,280,141 (GRCm39) |
S44C |
probably damaging |
Het |
| Tubb1 |
A |
G |
2: 174,299,359 (GRCm39) |
N347S |
probably benign |
Het |
| Ubap1 |
C |
T |
4: 41,379,667 (GRCm39) |
R294* |
probably null |
Het |
| Ube2o |
C |
T |
11: 116,432,591 (GRCm39) |
V792M |
probably benign |
Het |
| Usp13 |
A |
G |
3: 32,892,075 (GRCm39) |
S85G |
probably benign |
Het |
| Vmac |
C |
T |
17: 57,022,550 (GRCm39) |
M61I |
probably benign |
Het |
| Vmn1r54 |
T |
A |
6: 90,246,260 (GRCm39) |
I58N |
possibly damaging |
Het |
|
| Other mutations in Zmym5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01933:Zmym5
|
APN |
14 |
57,041,617 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02028:Zmym5
|
APN |
14 |
57,041,617 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
cerveza
|
UTSW |
14 |
57,031,918 (GRCm39) |
nonsense |
probably null |
|
|
Yeast
|
UTSW |
14 |
57,049,618 (GRCm39) |
unclassified |
probably benign |
|
|
R0391:Zmym5
|
UTSW |
14 |
57,041,908 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1692:Zmym5
|
UTSW |
14 |
57,041,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1939:Zmym5
|
UTSW |
14 |
57,036,577 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1997:Zmym5
|
UTSW |
14 |
57,035,210 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3790:Zmym5
|
UTSW |
14 |
57,031,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Zmym5
|
UTSW |
14 |
57,035,268 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4345:Zmym5
|
UTSW |
14 |
57,034,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4622:Zmym5
|
UTSW |
14 |
57,049,693 (GRCm39) |
unclassified |
probably benign |
|
|
R4686:Zmym5
|
UTSW |
14 |
57,049,618 (GRCm39) |
unclassified |
probably benign |
|
|
R5092:Zmym5
|
UTSW |
14 |
57,034,236 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5344:Zmym5
|
UTSW |
14 |
57,031,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6356:Zmym5
|
UTSW |
14 |
57,031,622 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7074:Zmym5
|
UTSW |
14 |
57,042,255 (GRCm39) |
missense |
probably benign |
|
|
R7358:Zmym5
|
UTSW |
14 |
57,031,597 (GRCm39) |
nonsense |
probably null |
|
|
R7657:Zmym5
|
UTSW |
14 |
57,041,653 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7811:Zmym5
|
UTSW |
14 |
57,036,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8013:Zmym5
|
UTSW |
14 |
57,031,883 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8014:Zmym5
|
UTSW |
14 |
57,031,883 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8174:Zmym5
|
UTSW |
14 |
57,031,918 (GRCm39) |
nonsense |
probably null |
|
|
R9260:Zmym5
|
UTSW |
14 |
57,041,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Zmym5
|
UTSW |
14 |
57,035,277 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2015-04-16 |
Incidental Mutation