Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02536:Cdk10'

297525

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdk10

Ensembl Gene

ENSMUSG00000033862

Gene Name

cyclin dependent kinase 10

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.164) question?

Stock #

IGL02536

Quality Score

Status

Chromosome

Chromosomal Location

123951581-123958989 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123953754 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 77 (D77G)

Ref Sequence

ENSEMBL: ENSMUSP00000148436 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036880] [ENSMUST00000060133] [ENSMUST00000127664] [ENSMUST00000212193] [ENSMUST00000212361] [ENSMUST00000213005] [ENSMUST00000212523] [ENSMUST00000212637]

AlphaFold

Q3UMM4

Predicted Effect

probably benign
Transcript: ENSMUST00000036880
AA Change: D77G

PolyPhen 2 Score 0.140 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000045527
Gene: ENSMUSG00000033862
AA Change: D77G

Domain	Start	End	E-Value	Type
S_TKc	39	323	1.52e-87	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000060133

SMART Domains

Protein: ENSMUSP00000058002
Gene: ENSMUSG00000048478

Domain	Start	End	E-Value	Type
low complexity region	4	28	N/A	INTRINSIC
Pfam:DUF4609	63	130	3.4e-42	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000127664

SMART Domains

Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

Domain	Start	End	E-Value	Type
Pfam:Glycos_transf_2	104	287	7.4e-31	PFAM
Pfam:Glyco_transf_7C	261	331	4.9e-8	PFAM
RICIN	406	531	9.28e-27	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211845

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211876

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212021

Predicted Effect

unknown
Transcript: ENSMUST00000212028
AA Change: D75G

Predicted Effect

probably benign
Transcript: ENSMUST00000212193
AA Change: D77G

PolyPhen 2 Score 0.188 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000212361
AA Change: D77G

PolyPhen 2 Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)

Predicted Effect

probably benign
Transcript: ENSMUST00000213005
AA Change: D6G

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212749

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212784

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212904

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212035

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212271

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212532

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212497

Predicted Effect

probably benign
Transcript: ENSMUST00000212523

Predicted Effect

probably benign
Transcript: ENSMUST00000212637

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930449A18Rik	T	A	3: 59,685,665 (GRCm39)		noncoding transcript	Het
Abca8b	C	T	11: 109,872,574 (GRCm39)	R9H	probably benign	Het
Adamts8	T	A	9: 30,873,368 (GRCm39)	S858T	probably benign	Het
Alg1	C	T	16: 5,057,023 (GRCm39)	Q245*	probably null	Het
Ankmy1	T	C	1: 92,813,910 (GRCm39)	Y423C	probably damaging	Het
Anp32a	A	T	9: 62,279,110 (GRCm39)	T55S	probably damaging	Het
Arhgef9	A	C	X: 94,102,443 (GRCm39)	V406G	probably damaging	Het
Bdkrb1	T	C	12: 105,571,259 (GRCm39)	F275S	possibly damaging	Het
Card9	C	T	2: 26,248,844 (GRCm39)	V102I	possibly damaging	Het
Ccdc81	A	T	7: 89,526,788 (GRCm39)		probably benign	Het
Cd101	T	A	3: 100,910,913 (GRCm39)	D915V	probably damaging	Het
Ctnnd1	T	C	2: 84,435,540 (GRCm39)	T827A	probably benign	Het
Dspp	A	C	5: 104,323,531 (GRCm39)	T225P	probably damaging	Het
Evpl	T	C	11: 116,112,035 (GRCm39)	E1885G	probably damaging	Het
Fstl4	C	T	11: 53,024,851 (GRCm39)		probably benign	Het
Gm5930	T	A	14: 44,575,015 (GRCm39)	N57I	probably damaging	Het
Gnl2	C	T	4: 124,946,401 (GRCm39)	Q541*	probably null	Het
Igkv3-1	T	C	6: 70,681,035 (GRCm39)	V78A	probably benign	Het
Inpp5a	T	C	7: 139,147,338 (GRCm39)	I321T	probably benign	Het
Kif20b	T	A	19: 34,951,959 (GRCm39)	S1746T	probably benign	Het
Lrrc8c	T	C	5: 105,755,038 (GRCm39)	I271T	probably benign	Het
Mrps10	T	C	17: 47,685,928 (GRCm39)	Y152H	probably damaging	Het
Myl9	C	T	2: 156,620,469 (GRCm39)	S2L	probably damaging	Het
Myof	A	T	19: 37,938,103 (GRCm39)	H870Q	probably damaging	Het
Nfatc4	A	T	14: 56,067,367 (GRCm39)	I456F	probably damaging	Het
Notch2	A	G	3: 98,009,723 (GRCm39)	H550R	probably benign	Het
Or13f5	T	A	4: 52,825,817 (GRCm39)	V140D	possibly damaging	Het
Or14j2	T	A	17: 37,885,817 (GRCm39)	I166F	probably damaging	Het
Or51v8	T	A	7: 103,320,164 (GRCm39)	I25F	possibly damaging	Het
Or8b47	T	C	9: 38,435,460 (GRCm39)	L144P	probably damaging	Het
P2rx1	A	T	11: 72,903,300 (GRCm39)	I230F	probably damaging	Het
Pcnt	A	G	10: 76,216,063 (GRCm39)	V2275A	possibly damaging	Het
Pip5k1a	G	A	3: 94,971,707 (GRCm39)	T465I	probably benign	Het
Pnkd	G	A	1: 74,391,059 (GRCm39)	R415H	probably damaging	Het
Prdx4	T	A	X: 154,115,443 (GRCm39)	I132F	probably damaging	Het
Pvr	A	G	7: 19,652,717 (GRCm39)	M66T	probably benign	Het
Rnf216	A	G	5: 143,065,995 (GRCm39)	I531T	probably benign	Het
Rps6ka4	A	T	19: 6,809,439 (GRCm39)	F405Y	probably damaging	Het
Serpinb2	A	G	1: 107,452,679 (GRCm39)		probably benign	Het
Sfxn1	A	G	13: 54,239,513 (GRCm39)	K12R	probably benign	Het
Slc17a7	A	G	7: 44,820,370 (GRCm39)	E275G	probably damaging	Het
Tnpo2	A	T	8: 85,771,696 (GRCm39)	I245F	probably benign	Het
Ush2a	A	T	1: 188,689,463 (GRCm39)		probably null	Het
Yju2b	A	T	8: 84,987,245 (GRCm39)	Y109*	probably null	Het
Zcchc4	C	T	5: 52,965,658 (GRCm39)	R321W	probably damaging	Het

Other mutations in Cdk10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Cdk10	APN	8	123,957,063 (GRCm39)	missense	possibly damaging	0.78
IGL01613:Cdk10	APN	8	123,955,126 (GRCm39)	missense	probably damaging	0.99
IGL01682:Cdk10	APN	8	123,954,397 (GRCm39)	critical splice acceptor site	probably null
R0612:Cdk10	UTSW	8	123,957,419 (GRCm39)	missense	probably benign	0.16
R1159:Cdk10	UTSW	8	123,955,062 (GRCm39)	splice site	probably benign
R2356:Cdk10	UTSW	8	123,955,908 (GRCm39)	missense	probably damaging	0.99
R4838:Cdk10	UTSW	8	123,957,353 (GRCm39)	missense	probably damaging	1.00
R5453:Cdk10	UTSW	8	123,953,131 (GRCm39)	missense	probably benign	0.42
R5517:Cdk10	UTSW	8	123,957,326 (GRCm39)	splice site	probably null
R5804:Cdk10	UTSW	8	123,955,579 (GRCm39)	splice site	probably null
R6930:Cdk10	UTSW	8	123,957,347 (GRCm39)	missense	probably damaging	1.00
R6971:Cdk10	UTSW	8	123,954,413 (GRCm39)	missense	probably damaging	1.00
R7910:Cdk10	UTSW	8	123,953,105 (GRCm39)	missense	probably damaging	1.00
R8356:Cdk10	UTSW	8	123,955,096 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16