Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02537:Vmn2r78'

297533

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r78

Ensembl Gene

ENSMUSG00000091962

Gene Name

vomeronasal 2, receptor 78

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL02537

Quality Score

Status

Chromosome

Chromosomal Location

86915300-86955177 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 86954288 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 558 (Y558F)

Ref Sequence

ENSEMBL: ENSMUSP00000126698 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170835]

Predicted Effect

probably damaging
Transcript: ENSMUST00000170835
AA Change: Y558F

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000126698
Gene: ENSMUSG00000091962
AA Change: Y558F

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	5.9e-31	PFAM
Pfam:NCD3G	507	559	8.1e-21	PFAM
Pfam:7tm_3	592	827	1e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	A	G	5: 99,229,377	S404P	probably damaging	Het
A930011G23Rik	G	A	5: 99,229,382	P402L	probably damaging	Het
Alx3	T	A	3: 107,604,859	M271K	possibly damaging	Het
Ank2	T	C	3: 126,955,916	E488G	probably damaging	Het
Arsk	T	A	13: 76,074,906	R191*	probably null	Het
B230217C12Rik	T	C	11: 97,842,185	S111P	possibly damaging	Het
Bckdhb	A	G	9: 83,989,141	I158V	probably benign	Het
Bub1	G	A	2: 127,801,347	Q1026*	probably null	Het
C8a	A	G	4: 104,845,951	M303T	probably damaging	Het
Cftr	A	G	6: 18,274,597	T905A	probably benign	Het
Col14a1	A	T	15: 55,344,914	K132*	probably null	Het
Depdc5	T	A	5: 32,967,787	L531Q	probably damaging	Het
Dzip1	G	A	14: 118,909,576		probably benign	Het
F5	C	A	1: 164,193,117	L1054I	probably benign	Het
Gm4353	A	T	7: 116,083,752	I198N	probably damaging	Het
Il1a	T	A	2: 129,309,076	E9V	probably damaging	Het
Kif15	A	G	9: 122,993,849	T432A	probably benign	Het
Kndc1	T	C	7: 139,910,410	V276A	probably benign	Het
Mrvi1	A	T	7: 110,871,473	Y678*	probably null	Het
Narfl	C	T	17: 25,778,942		probably benign	Het
Olfr1247	A	C	2: 89,609,395	S236A	possibly damaging	Het
Olfr170	A	T	16: 19,605,799	Y290N	probably damaging	Het
Olfr430	A	T	1: 174,069,454	D52V	possibly damaging	Het
Palld	T	C	8: 61,684,934	S596G	probably benign	Het
Pdc	A	T	1: 150,333,009	D81V	possibly damaging	Het
Plcd4	A	G	1: 74,556,050	K361R	possibly damaging	Het
Plekhm1	T	A	11: 103,397,192	D43V	probably damaging	Het
Prpf31	G	T	7: 3,638,751	G356C	probably damaging	Het
Rbpj	T	A	5: 53,642,143	I100K	probably damaging	Het
Rufy3	A	G	5: 88,640,662		probably benign	Het
Slc40a1	C	T	1: 45,911,393	V300I	probably benign	Het
Slc6a12	A	T	6: 121,360,514	I386F	probably benign	Het
Strip1	C	T	3: 107,616,894	R569H	possibly damaging	Het
Tep1	A	T	14: 50,836,113	D1996E	probably damaging	Het
Tmem68	A	G	4: 3,569,649	S14P	possibly damaging	Het
Trav12-1	C	A	14: 53,538,523	C44*	probably null	Het
Uba1	G	A	X: 20,678,663	R693H	possibly damaging	Het
Ugt2b38	T	C	5: 87,421,731	T246A	possibly damaging	Het
Usp24	A	G	4: 106,392,367	Y1427C	probably damaging	Het
Wdr54	A	G	6: 83,153,391	W221R	possibly damaging	Het
Xpo4	T	C	14: 57,593,833	T773A	probably benign	Het
Zfp518a	G	A	19: 40,914,617	G997R	probably damaging	Het
Zfp518a	T	A	19: 40,915,430	S1268T	probably benign	Het
Znfx1	T	C	2: 167,056,167	D279G	probably benign	Het

Other mutations in Vmn2r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01302:Vmn2r78	APN	7	86915361	missense	unknown
IGL01473:Vmn2r78	APN	7	86920312	missense	possibly damaging	0.61
IGL01767:Vmn2r78	APN	7	86954435	missense	probably benign	0.28
IGL02322:Vmn2r78	APN	7	86921479	missense	probably damaging	0.96
IGL03297:Vmn2r78	APN	7	86920761	nonsense	probably null
ANU74:Vmn2r78	UTSW	7	86921065	missense	possibly damaging	0.62
R0035:Vmn2r78	UTSW	7	86920205	missense	probably benign	0.22
R0081:Vmn2r78	UTSW	7	86923027	missense	probably benign	0.35
R0401:Vmn2r78	UTSW	7	86921311	missense	probably benign	0.04
R0751:Vmn2r78	UTSW	7	86954380	missense	possibly damaging	0.77
R1341:Vmn2r78	UTSW	7	86922269	missense	possibly damaging	0.71
R1386:Vmn2r78	UTSW	7	86915407	missense	unknown
R1526:Vmn2r78	UTSW	7	86922257	splice site	probably null
R1712:Vmn2r78	UTSW	7	86954924	missense	probably damaging	1.00
R1739:Vmn2r78	UTSW	7	86920789	missense	probably benign
R1812:Vmn2r78	UTSW	7	86920787	missense	probably benign	0.38
R2011:Vmn2r78	UTSW	7	86955079	missense	possibly damaging	0.52
R2144:Vmn2r78	UTSW	7	86954482	missense	probably damaging	1.00
R2197:Vmn2r78	UTSW	7	86921327	missense	probably damaging	0.96
R2291:Vmn2r78	UTSW	7	86920154	missense	probably damaging	1.00
R2409:Vmn2r78	UTSW	7	86920745	splice site	probably benign
R3023:Vmn2r78	UTSW	7	86954966	missense	probably damaging	1.00
R4486:Vmn2r78	UTSW	7	86920751	critical splice acceptor site	probably null
R4512:Vmn2r78	UTSW	7	86920244	missense	probably benign	0.00
R4515:Vmn2r78	UTSW	7	86954258	missense	probably damaging	0.99
R4544:Vmn2r78	UTSW	7	86921191	missense	probably benign
R4546:Vmn2r78	UTSW	7	86954603	missense	probably damaging	1.00
R4872:Vmn2r78	UTSW	7	86954708	missense	possibly damaging	0.87
R4928:Vmn2r78	UTSW	7	86954627	missense	probably damaging	1.00
R5101:Vmn2r78	UTSW	7	86922355	missense	probably damaging	1.00
R5265:Vmn2r78	UTSW	7	86920124	missense	probably damaging	1.00
R5328:Vmn2r78	UTSW	7	86921030	missense	probably damaging	0.98
R5442:Vmn2r78	UTSW	7	86920122	missense	possibly damaging	0.95
R5567:Vmn2r78	UTSW	7	86921529	missense	probably benign	0.17
R5572:Vmn2r78	UTSW	7	86915512	missense	probably benign	0.01
R5636:Vmn2r78	UTSW	7	86954429	missense	probably damaging	0.99
R5901:Vmn2r78	UTSW	7	86954588	missense	probably damaging	1.00
R5977:Vmn2r78	UTSW	7	86920333	missense	possibly damaging	0.74
R5977:Vmn2r78	UTSW	7	86954907	missense	probably benign	0.00
R6276:Vmn2r78	UTSW	7	86921110	missense	probably benign	0.00
R6386:Vmn2r78	UTSW	7	86922337	nonsense	probably null
R6724:Vmn2r78	UTSW	7	86954258	missense	probably damaging	0.99
R6852:Vmn2r78	UTSW	7	86954603	missense	probably damaging	1.00
R6896:Vmn2r78	UTSW	7	86922350	missense	probably benign	0.10
R7385:Vmn2r78	UTSW	7	86922425	missense	probably benign	0.18
R7578:Vmn2r78	UTSW	7	86954344	nonsense	probably null
R7680:Vmn2r78	UTSW	7	86954941	missense	probably damaging	1.00
R7748:Vmn2r78	UTSW	7	86921135	missense	probably benign	0.00
R7852:Vmn2r78	UTSW	7	86920170	nonsense	probably null
R8031:Vmn2r78	UTSW	7	86954867	missense	probably damaging	1.00
R8070:Vmn2r78	UTSW	7	86922487	missense	probably benign	0.01
R8085:Vmn2r78	UTSW	7	86954790	missense	probably benign	0.00
R8163:Vmn2r78	UTSW	7	86954452	missense	probably damaging	1.00
RF018:Vmn2r78	UTSW	7	86954431	nonsense	probably null
Z1177:Vmn2r78	UTSW	7	86921207	missense	probably benign	0.44
Z1177:Vmn2r78	UTSW	7	86954774	missense	probably benign	0.02

Posted On

2015-04-16