Incidental Mutation 'IGL02540:Vmn1r172'
ID297664
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r172
Ensembl Gene ENSMUSG00000035523
Gene Namevomeronasal 1 receptor 172
SynonymsV1rd9, V3R9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.104) question?
Stock #IGL02540
Quality Score
Status
Chromosome7
Chromosomal Location23658316-23668447 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 23659925 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 78 (F78L)
Ref Sequence ENSEMBL: ENSMUSP00000133887 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038694] [ENSMUST00000173101]
Predicted Effect probably benign
Transcript: ENSMUST00000038694
AA Change: F78L

PolyPhen 2 Score 0.248 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000041653
Gene: ENSMUSG00000035523
AA Change: F78L

DomainStartEndE-ValueType
Pfam:TAS2R 8 301 7.1e-9 PFAM
Pfam:7tm_1 30 268 3.6e-9 PFAM
Pfam:V1R 43 301 7.2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173101
AA Change: F78L

PolyPhen 2 Score 0.248 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000133887
Gene: ENSMUSG00000035523
AA Change: F78L

DomainStartEndE-ValueType
Pfam:TAS2R 8 301 7.2e-9 PFAM
Pfam:V1R 43 301 7.2e-18 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adipor2 C A 6: 119,359,495 R169L probably benign Het
AI314180 A T 4: 58,805,534 probably benign Het
Arhgap1 C T 2: 91,670,239 T371I probably damaging Het
Brpf3 C T 17: 28,828,354 P1031S probably damaging Het
Cenpu A G 8: 46,578,319 H245R probably damaging Het
Dhx36 A G 3: 62,506,888 S18P probably benign Het
Dst A G 1: 34,135,204 T217A probably damaging Het
Entpd8 A G 2: 25,084,719 probably null Het
Fez1 A G 9: 36,850,399 R122G probably damaging Het
Heatr5b A T 17: 78,773,572 M1417K probably damaging Het
Higd1c T C 15: 100,365,366 probably benign Het
Icosl G A 10: 78,069,536 probably null Het
Il24 T C 1: 130,887,303 probably benign Het
Kank3 T A 17: 33,819,187 probably benign Het
Lrriq1 A G 10: 103,215,019 L624P probably benign Het
Mov10l1 C A 15: 89,018,211 T768K probably benign Het
Olfr259 A T 2: 87,108,042 L115Q probably damaging Het
Olfr304 T A 7: 86,386,178 T161S possibly damaging Het
Olfr995 A G 2: 85,438,915 M81T probably benign Het
Pkn2 A T 3: 142,809,704 F649I probably benign Het
Pld1 A G 3: 28,029,160 probably benign Het
Prrc2c G A 1: 162,723,137 S86L probably damaging Het
Rai1 G A 11: 60,186,924 A605T probably benign Het
Reln T A 5: 22,034,752 Q839L probably damaging Het
Rrp9 T C 9: 106,483,547 probably benign Het
Tanc1 G T 2: 59,833,258 G1120C probably damaging Het
Tmtc2 A T 10: 105,413,339 C178S probably benign Het
Zfpm1 A G 8: 122,332,120 S160G possibly damaging Het
Other mutations in Vmn1r172
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02295:Vmn1r172 APN 7 23659917 missense probably benign 0.30
IGL02407:Vmn1r172 APN 7 23659803 missense probably damaging 1.00
IGL03090:Vmn1r172 APN 7 23660038 missense probably damaging 0.98
R0396:Vmn1r172 UTSW 7 23660532 missense probably benign 0.06
R1087:Vmn1r172 UTSW 7 23660248 missense possibly damaging 0.92
R1502:Vmn1r172 UTSW 7 23660256 nonsense probably null
R1701:Vmn1r172 UTSW 7 23660104 missense probably damaging 1.00
R1882:Vmn1r172 UTSW 7 23660226 missense probably damaging 1.00
R2272:Vmn1r172 UTSW 7 23660191 missense probably damaging 0.98
R4646:Vmn1r172 UTSW 7 23660494 missense probably benign 0.03
R4653:Vmn1r172 UTSW 7 23660572 missense probably damaging 0.96
R4709:Vmn1r172 UTSW 7 23660181 missense probably benign 0.25
R4937:Vmn1r172 UTSW 7 23659887 missense possibly damaging 0.92
R4945:Vmn1r172 UTSW 7 23660320 missense possibly damaging 0.79
R5840:Vmn1r172 UTSW 7 23660175 missense probably benign 0.03
R6154:Vmn1r172 UTSW 7 23660158 missense probably damaging 0.96
R6317:Vmn1r172 UTSW 7 23660317 missense probably damaging 1.00
R7206:Vmn1r172 UTSW 7 23660157 missense possibly damaging 0.69
R7290:Vmn1r172 UTSW 7 23660623 missense unknown
R7362:Vmn1r172 UTSW 7 23660416 missense probably damaging 1.00
R7369:Vmn1r172 UTSW 7 23660605 missense unknown
R7528:Vmn1r172 UTSW 7 23659764 missense probably damaging 1.00
U24488:Vmn1r172 UTSW 7 23659746 missense probably benign 0.02
Posted On2015-04-16