Incidental Mutation 'R0355:Or10g7'
ID 29771
Institutional Source Beutler Lab
Gene Symbol Or10g7
Ensembl Gene ENSMUSG00000044292
Gene Name olfactory receptor family 10 subfamily G member 7
Synonyms GA_x6K02T2PVTD-33692287-33693222, MOR223-3, Olfr978
MMRRC Submission 038561-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R0355 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 39905108-39906043 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39905459 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 118 (S118T)
Ref Sequence ENSEMBL: ENSMUSP00000151115 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057161] [ENSMUST00000215523] [ENSMUST00000217600]
AlphaFold E9Q985
Predicted Effect possibly damaging
Transcript: ENSMUST00000057161
AA Change: S118T

PolyPhen 2 Score 0.488 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000060106
Gene: ENSMUSG00000044292
AA Change: S118T

Pfam:7tm_4 29 303 3.2e-56 PFAM
Pfam:7tm_1 39 287 1.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215523
Predicted Effect possibly damaging
Transcript: ENSMUST00000217600
AA Change: S118T

PolyPhen 2 Score 0.717 (Sensitivity: 0.86; Specificity: 0.92)
Meta Mutation Damage Score 0.2591 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 95.3%
  • 20x: 90.2%
Validation Efficiency 100% (76/76)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T G 7: 120,023,021 (GRCm39) I52M possibly damaging Het
Agbl5 G T 5: 31,049,335 (GRCm39) probably null Het
Akt2 T C 7: 27,336,334 (GRCm39) probably benign Het
Arl6ip5 T A 6: 97,209,378 (GRCm39) S138T probably damaging Het
Atp9b A G 18: 80,952,800 (GRCm39) probably benign Het
Ccdc171 A T 4: 83,553,919 (GRCm39) N422Y probably damaging Het
Ccr5 C T 9: 123,924,951 (GRCm39) P185S possibly damaging Het
Cep63 G T 9: 102,500,759 (GRCm39) Q38K probably benign Het
Cgn T C 3: 94,682,242 (GRCm39) S446G probably benign Het
Col16a1 T A 4: 129,952,206 (GRCm39) probably benign Het
Csmd1 T A 8: 15,968,330 (GRCm39) Q3099L probably damaging Het
Dcc G A 18: 71,708,279 (GRCm39) T479I possibly damaging Het
Dclre1a A G 19: 56,535,067 (GRCm39) probably null Het
Dlg1 T A 16: 31,502,992 (GRCm39) C66* probably null Het
Dnah12 T A 14: 26,427,272 (GRCm39) probably null Het
Dnajb9 T A 12: 44,253,987 (GRCm39) H140L probably damaging Het
Dnase1 G A 16: 3,857,413 (GRCm39) V237M probably damaging Het
Dscam C A 16: 96,456,105 (GRCm39) E1274D probably benign Het
Epb41 T C 4: 131,727,572 (GRCm39) H243R probably damaging Het
Evc T A 5: 37,473,656 (GRCm39) probably benign Het
Fcgrt T A 7: 44,752,493 (GRCm39) M1L unknown Het
Flii T C 11: 60,610,506 (GRCm39) probably null Het
Gen1 A G 12: 11,298,355 (GRCm39) probably benign Het
Gm10447 T C 11: 53,347,257 (GRCm39) probably benign Het
Gm57858 A G 3: 36,101,054 (GRCm39) probably benign Het
Gm8674 A T 13: 50,055,975 (GRCm39) noncoding transcript Het
Gpr137 G C 19: 6,916,491 (GRCm39) D253E probably damaging Het
Grid2ip A T 5: 143,343,652 (GRCm39) D116V probably benign Het
Grin2c A G 11: 115,151,554 (GRCm39) probably benign Het
Havcr1 A G 11: 46,647,051 (GRCm39) T162A possibly damaging Het
Hspa1l A T 17: 35,196,386 (GRCm39) T142S probably benign Het
Ift140 T A 17: 25,267,409 (GRCm39) Y602* probably null Het
Il18 T A 9: 50,490,575 (GRCm39) probably benign Het
Ilf3 T C 9: 21,309,266 (GRCm39) V474A probably damaging Het
Inppl1 T C 7: 101,476,664 (GRCm39) Y771C probably damaging Het
Ints2 T C 11: 86,125,575 (GRCm39) T542A probably benign Het
Ipo7 T C 7: 109,648,868 (GRCm39) Y714H probably benign Het
Itgbl1 T A 14: 124,077,997 (GRCm39) C162* probably null Het
Kcp T C 6: 29,496,926 (GRCm39) H561R possibly damaging Het
Krt23 G T 11: 99,376,613 (GRCm39) T181N probably benign Het
Lrrc40 A T 3: 157,746,108 (GRCm39) D61V probably damaging Het
Lypd4 T A 7: 24,564,691 (GRCm39) H149L probably benign Het
Map3k4 A G 17: 12,473,058 (GRCm39) F953L probably damaging Het
Mctp1 C T 13: 76,972,982 (GRCm39) P405S probably damaging Het
Mfsd2a G A 4: 122,845,632 (GRCm39) T173I possibly damaging Het
Mtus1 T C 8: 41,535,965 (GRCm39) T584A probably benign Het
Nell2 A G 15: 95,330,782 (GRCm39) V213A probably benign Het
Nipsnap1 G A 11: 4,839,957 (GRCm39) G226E probably damaging Het
Nudt15 T C 14: 73,760,824 (GRCm39) Y89C probably damaging Het
Or10h28 T A 17: 33,488,109 (GRCm39) M137K probably damaging Het
Or13p3 T A 4: 118,566,808 (GRCm39) M68K probably benign Het
Or7a37 T G 10: 78,806,267 (GRCm39) S261R probably damaging Het
Phf24 A C 4: 42,933,891 (GRCm39) E91A probably damaging Het
Plbd1 T A 6: 136,618,165 (GRCm39) N17I possibly damaging Het
Por C T 5: 135,761,438 (GRCm39) S308L probably benign Het
Prmt8 T A 6: 127,688,837 (GRCm39) K178* probably null Het
Rev3l A G 10: 39,693,282 (GRCm39) N454S probably damaging Het
Rps6ka2 T C 17: 7,539,009 (GRCm39) V309A probably benign Het
Slc15a5 A G 6: 137,995,112 (GRCm39) probably benign Het
Slc30a6 G A 17: 74,730,198 (GRCm39) V363I probably benign Het
Snf8 G A 11: 95,930,125 (GRCm39) M42I probably benign Het
Stom T C 2: 35,215,371 (GRCm39) I65V probably benign Het
Tacr3 C T 3: 134,637,989 (GRCm39) T382I probably benign Het
Tenm3 A G 8: 48,682,010 (GRCm39) V2540A probably damaging Het
Trabd A G 15: 88,969,816 (GRCm39) T314A possibly damaging Het
Tyk2 T C 9: 21,025,486 (GRCm39) probably null Het
Ube4a T C 9: 44,856,099 (GRCm39) probably benign Het
Unc80 A G 1: 66,589,015 (GRCm39) H1060R possibly damaging Het
Virma A T 4: 11,528,626 (GRCm39) K1288* probably null Het
Vmn2r100 A C 17: 19,751,582 (GRCm39) I542L probably benign Het
Vwde T C 6: 13,187,806 (GRCm39) probably benign Het
Zfc3h1 T C 10: 115,245,018 (GRCm39) I797T possibly damaging Het
Zfp74 C T 7: 29,653,466 (GRCm39) probably benign Het
Zkscan7 T A 9: 122,717,872 (GRCm39) L89Q probably damaging Het
Other mutations in Or10g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01570:Or10g7 APN 9 39,905,625 (GRCm39) missense probably damaging 0.99
IGL02429:Or10g7 APN 9 39,905,138 (GRCm39) missense probably benign
IGL02887:Or10g7 APN 9 39,905,109 (GRCm39) start codon destroyed probably null 0.99
R0190:Or10g7 UTSW 9 39,905,840 (GRCm39) missense probably benign 0.01
R1348:Or10g7 UTSW 9 39,905,124 (GRCm39) missense probably benign
R1856:Or10g7 UTSW 9 39,905,655 (GRCm39) missense probably benign 0.29
R3853:Or10g7 UTSW 9 39,905,450 (GRCm39) missense probably damaging 0.99
R3886:Or10g7 UTSW 9 39,905,835 (GRCm39) missense probably damaging 1.00
R5678:Or10g7 UTSW 9 39,905,199 (GRCm39) missense probably benign 0.00
R5994:Or10g7 UTSW 9 39,905,519 (GRCm39) nonsense probably null
R6185:Or10g7 UTSW 9 39,905,420 (GRCm39) missense probably benign 0.19
R6721:Or10g7 UTSW 9 39,905,603 (GRCm39) missense possibly damaging 0.55
R7414:Or10g7 UTSW 9 39,905,349 (GRCm39) missense possibly damaging 0.53
R7556:Or10g7 UTSW 9 39,905,978 (GRCm39) missense probably damaging 1.00
R8192:Or10g7 UTSW 9 39,905,467 (GRCm39) missense probably damaging 1.00
R8422:Or10g7 UTSW 9 39,905,850 (GRCm39) missense probably damaging 0.99
R9323:Or10g7 UTSW 9 39,905,360 (GRCm39) missense possibly damaging 0.88
X0025:Or10g7 UTSW 9 39,905,240 (GRCm39) missense possibly damaging 0.62
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2013-04-24