Incidental Mutation 'R0355:Il18'
ID 29773
Institutional Source Beutler Lab
Gene Symbol Il18
Ensembl Gene ENSMUSG00000039217
Gene Name interleukin 18
Synonyms Il-18, Igif
MMRRC Submission 038561-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0355 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 50466127-50493140 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 50490575 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059081] [ENSMUST00000180021] [ENSMUST00000213916] [ENSMUST00000214117]
AlphaFold P70380
Predicted Effect probably benign
Transcript: ENSMUST00000059081
SMART Domains Protein: ENSMUSP00000054591
Gene: ENSMUSG00000039217

DomainStartEndE-ValueType
IL1 49 187 7.09e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000180021
SMART Domains Protein: ENSMUSP00000137193
Gene: ENSMUSG00000039217

DomainStartEndE-ValueType
IL1 49 187 7.09e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213916
Predicted Effect probably benign
Transcript: ENSMUST00000214117
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 95.3%
  • 20x: 90.2%
Validation Efficiency 100% (76/76)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for null alleles are deficient in producing IFN-gamma in response to infectious agents and have other impairments of the immune system. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T G 7: 120,023,021 (GRCm39) I52M possibly damaging Het
Agbl5 G T 5: 31,049,335 (GRCm39) probably null Het
Akt2 T C 7: 27,336,334 (GRCm39) probably benign Het
Arl6ip5 T A 6: 97,209,378 (GRCm39) S138T probably damaging Het
Atp9b A G 18: 80,952,800 (GRCm39) probably benign Het
Ccdc171 A T 4: 83,553,919 (GRCm39) N422Y probably damaging Het
Ccr5 C T 9: 123,924,951 (GRCm39) P185S possibly damaging Het
Cep63 G T 9: 102,500,759 (GRCm39) Q38K probably benign Het
Cgn T C 3: 94,682,242 (GRCm39) S446G probably benign Het
Col16a1 T A 4: 129,952,206 (GRCm39) probably benign Het
Csmd1 T A 8: 15,968,330 (GRCm39) Q3099L probably damaging Het
Dcc G A 18: 71,708,279 (GRCm39) T479I possibly damaging Het
Dclre1a A G 19: 56,535,067 (GRCm39) probably null Het
Dlg1 T A 16: 31,502,992 (GRCm39) C66* probably null Het
Dnah12 T A 14: 26,427,272 (GRCm39) probably null Het
Dnajb9 T A 12: 44,253,987 (GRCm39) H140L probably damaging Het
Dnase1 G A 16: 3,857,413 (GRCm39) V237M probably damaging Het
Dscam C A 16: 96,456,105 (GRCm39) E1274D probably benign Het
Epb41 T C 4: 131,727,572 (GRCm39) H243R probably damaging Het
Evc T A 5: 37,473,656 (GRCm39) probably benign Het
Fcgrt T A 7: 44,752,493 (GRCm39) M1L unknown Het
Flii T C 11: 60,610,506 (GRCm39) probably null Het
Gen1 A G 12: 11,298,355 (GRCm39) probably benign Het
Gm10447 T C 11: 53,347,257 (GRCm39) probably benign Het
Gm57858 A G 3: 36,101,054 (GRCm39) probably benign Het
Gm8674 A T 13: 50,055,975 (GRCm39) noncoding transcript Het
Gpr137 G C 19: 6,916,491 (GRCm39) D253E probably damaging Het
Grid2ip A T 5: 143,343,652 (GRCm39) D116V probably benign Het
Grin2c A G 11: 115,151,554 (GRCm39) probably benign Het
Havcr1 A G 11: 46,647,051 (GRCm39) T162A possibly damaging Het
Hspa1l A T 17: 35,196,386 (GRCm39) T142S probably benign Het
Ift140 T A 17: 25,267,409 (GRCm39) Y602* probably null Het
Ilf3 T C 9: 21,309,266 (GRCm39) V474A probably damaging Het
Inppl1 T C 7: 101,476,664 (GRCm39) Y771C probably damaging Het
Ints2 T C 11: 86,125,575 (GRCm39) T542A probably benign Het
Ipo7 T C 7: 109,648,868 (GRCm39) Y714H probably benign Het
Itgbl1 T A 14: 124,077,997 (GRCm39) C162* probably null Het
Kcp T C 6: 29,496,926 (GRCm39) H561R possibly damaging Het
Krt23 G T 11: 99,376,613 (GRCm39) T181N probably benign Het
Lrrc40 A T 3: 157,746,108 (GRCm39) D61V probably damaging Het
Lypd4 T A 7: 24,564,691 (GRCm39) H149L probably benign Het
Map3k4 A G 17: 12,473,058 (GRCm39) F953L probably damaging Het
Mctp1 C T 13: 76,972,982 (GRCm39) P405S probably damaging Het
Mfsd2a G A 4: 122,845,632 (GRCm39) T173I possibly damaging Het
Mtus1 T C 8: 41,535,965 (GRCm39) T584A probably benign Het
Nell2 A G 15: 95,330,782 (GRCm39) V213A probably benign Het
Nipsnap1 G A 11: 4,839,957 (GRCm39) G226E probably damaging Het
Nudt15 T C 14: 73,760,824 (GRCm39) Y89C probably damaging Het
Or10g7 T A 9: 39,905,459 (GRCm39) S118T possibly damaging Het
Or10h28 T A 17: 33,488,109 (GRCm39) M137K probably damaging Het
Or13p3 T A 4: 118,566,808 (GRCm39) M68K probably benign Het
Or7a37 T G 10: 78,806,267 (GRCm39) S261R probably damaging Het
Phf24 A C 4: 42,933,891 (GRCm39) E91A probably damaging Het
Plbd1 T A 6: 136,618,165 (GRCm39) N17I possibly damaging Het
Por C T 5: 135,761,438 (GRCm39) S308L probably benign Het
Prmt8 T A 6: 127,688,837 (GRCm39) K178* probably null Het
Rev3l A G 10: 39,693,282 (GRCm39) N454S probably damaging Het
Rps6ka2 T C 17: 7,539,009 (GRCm39) V309A probably benign Het
Slc15a5 A G 6: 137,995,112 (GRCm39) probably benign Het
Slc30a6 G A 17: 74,730,198 (GRCm39) V363I probably benign Het
Snf8 G A 11: 95,930,125 (GRCm39) M42I probably benign Het
Stom T C 2: 35,215,371 (GRCm39) I65V probably benign Het
Tacr3 C T 3: 134,637,989 (GRCm39) T382I probably benign Het
Tenm3 A G 8: 48,682,010 (GRCm39) V2540A probably damaging Het
Trabd A G 15: 88,969,816 (GRCm39) T314A possibly damaging Het
Tyk2 T C 9: 21,025,486 (GRCm39) probably null Het
Ube4a T C 9: 44,856,099 (GRCm39) probably benign Het
Unc80 A G 1: 66,589,015 (GRCm39) H1060R possibly damaging Het
Virma A T 4: 11,528,626 (GRCm39) K1288* probably null Het
Vmn2r100 A C 17: 19,751,582 (GRCm39) I542L probably benign Het
Vwde T C 6: 13,187,806 (GRCm39) probably benign Het
Zfc3h1 T C 10: 115,245,018 (GRCm39) I797T possibly damaging Het
Zfp74 C T 7: 29,653,466 (GRCm39) probably benign Het
Zkscan7 T A 9: 122,717,872 (GRCm39) L89Q probably damaging Het
Other mutations in Il18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01095:Il18 APN 9 50,490,629 (GRCm39) missense probably damaging 1.00
IGL02258:Il18 APN 9 50,488,003 (GRCm39) missense probably benign 0.00
R0091:Il18 UTSW 9 50,488,013 (GRCm39) splice site probably benign
R0504:Il18 UTSW 9 50,486,628 (GRCm39) missense probably damaging 0.99
R2295:Il18 UTSW 9 50,490,635 (GRCm39) missense probably benign 0.33
R4162:Il18 UTSW 9 50,490,712 (GRCm39) missense probably damaging 1.00
R5117:Il18 UTSW 9 50,492,809 (GRCm39) missense possibly damaging 0.72
R5160:Il18 UTSW 9 50,489,193 (GRCm39) critical splice donor site probably null
R7361:Il18 UTSW 9 50,490,614 (GRCm39) missense probably damaging 1.00
R7462:Il18 UTSW 9 50,476,673 (GRCm39) unclassified probably benign
R7522:Il18 UTSW 9 50,486,640 (GRCm39) missense probably damaging 1.00
R7654:Il18 UTSW 9 50,490,701 (GRCm39) missense possibly damaging 0.86
R8220:Il18 UTSW 9 50,486,616 (GRCm39) missense possibly damaging 0.54
R8319:Il18 UTSW 9 50,492,818 (GRCm39) missense possibly damaging 0.73
R8720:Il18 UTSW 9 50,476,684 (GRCm39) unclassified probably benign
R8988:Il18 UTSW 9 50,489,178 (GRCm39) missense probably damaging 1.00
R9052:Il18 UTSW 9 50,489,090 (GRCm39) missense possibly damaging 0.92
R9585:Il18 UTSW 9 50,490,661 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCAACGGGGCATTATGTCTGTCAAC -3'
(R):5'- GCTGCAACTGGGTCTTATCCGAAC -3'

Sequencing Primer
(F):5'- CTGTCTGACCAAAACTGAGTG -3'
(R):5'- tgggagtagagatggaaggg -3'
Posted On 2013-04-24